RS50891B - Postupak za pripremanje rastvora albumina - Google Patents
Postupak za pripremanje rastvora albuminaInfo
- Publication number
- RS50891B RS50891B YUP-2005/0624A YUP20050624A RS50891B RS 50891 B RS50891 B RS 50891B YU P20050624 A YUP20050624 A YU P20050624A RS 50891 B RS50891 B RS 50891B
- Authority
- RS
- Serbia
- Prior art keywords
- albumin solution
- stabilizer
- optionally
- groups
- hydrophobic
- Prior art date
Links
- 102000009027 Albumins Human genes 0.000 title abstract 5
- 108010088751 Albumins Proteins 0.000 title abstract 5
- 238000000034 method Methods 0.000 title abstract 2
- 239000003381 stabilizer Substances 0.000 abstract 4
- SIKJAQJRHWYJAI-UHFFFAOYSA-N Indole Chemical compound C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 abstract 2
- 239000003153 chemical reaction reagent Substances 0.000 abstract 2
- 239000011159 matrix material Substances 0.000 abstract 2
- 125000001931 aliphatic group Chemical group 0.000 abstract 1
- 235000001014 amino acid Nutrition 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 238000004587 chromatography analysis Methods 0.000 abstract 1
- 230000001419 dependent effect Effects 0.000 abstract 1
- 235000014113 dietary fatty acids Nutrition 0.000 abstract 1
- 238000000605 extraction Methods 0.000 abstract 1
- 239000000194 fatty acid Substances 0.000 abstract 1
- 229930195729 fatty acid Natural products 0.000 abstract 1
- 150000004665 fatty acids Chemical class 0.000 abstract 1
- 230000002209 hydrophobic effect Effects 0.000 abstract 1
- 125000001165 hydrophobic group Chemical group 0.000 abstract 1
- 238000004191 hydrophobic interaction chromatography Methods 0.000 abstract 1
- PZOUSPYUWWUPPK-UHFFFAOYSA-N indole Natural products CC1=CC=CC2=C1C=CN2 PZOUSPYUWWUPPK-UHFFFAOYSA-N 0.000 abstract 1
- RKJUIXBNRJVNHR-UHFFFAOYSA-N indolenine Natural products C1=CC=C2CC=NC2=C1 RKJUIXBNRJVNHR-UHFFFAOYSA-N 0.000 abstract 1
- 238000004806 packaging method and process Methods 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 238000011146 sterile filtration Methods 0.000 abstract 1
- 235000000346 sugar Nutrition 0.000 abstract 1
- 150000005846 sugar alcohols Chemical class 0.000 abstract 1
- 150000008163 sugars Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/38—Albumins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
Abstract
Postupak pripremanja albumina, naznačen time, što se sastoji od kombinacije sledećih koraka:(a) podvrgavanje prvog vodenog rastvora albumina tretmanu za virus-dezaktiviranje putem SD postupka njegovim kontaktiranjem sa SD reagensima na temperaturi ispod 45°C;(b) uklanjanje, bar suštinski, SD reagensa putem ekstrakcije ulja praćene hromatografijom hidrofobične interakcije, pri čemu je hidrofobična matrica, posebno matrica za koju hidrofobične grupe mogu opciono biti vezane, upotrebljene za navedenu hromatografiju, pod uslovom da su navedene grupe alifatične grupe sa više od 24 atoma ugljenika, da se dobije drugi rastvor albumina za koji se(c) dodaju opciono jedan ili više stabilizatora odabranih iz grupe šećera, amino kiselina i šećernih alkohola, pod uslovom da se ne upošljavaju kao navedeni stabilizator indol stabilizator i C6-C10 masna kiselina, nakon čega(d) se navedeni drugi rastvor albumina kome je stabilizator opciono dodat podvrgne konačnom pakovanju i sterilnom filtriranju i opciono puni u konačne kontejnere.Prijava sadrži još 17 zavisnih patentnih zahteva.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AT2182003 | 2003-02-13 | ||
PCT/EP2004/001397 WO2004071524A1 (de) | 2003-02-13 | 2004-02-13 | Albuminlösung und verfahren zu ihrer herstellung |
Publications (2)
Publication Number | Publication Date |
---|---|
RS20050624A RS20050624A (en) | 2007-06-04 |
RS50891B true RS50891B (sr) | 2010-08-31 |
Family
ID=32854882
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
YUP-2005/0624A RS50891B (sr) | 2003-02-13 | 2004-02-13 | Postupak za pripremanje rastvora albumina |
Country Status (22)
Country | Link |
---|---|
EP (1) | EP1592439B1 (sr) |
JP (1) | JP2006517938A (sr) |
KR (1) | KR20050103292A (sr) |
CN (1) | CN100384471C (sr) |
AT (1) | ATE362376T1 (sr) |
AU (1) | AU2004212324B2 (sr) |
BR (1) | BRPI0407458A (sr) |
CA (1) | CA2514163A1 (sr) |
CY (1) | CY1106793T1 (sr) |
DE (1) | DE502004003834D1 (sr) |
DK (1) | DK1592439T3 (sr) |
ES (1) | ES2285427T3 (sr) |
IL (1) | IL169828A0 (sr) |
MX (1) | MXPA05008276A (sr) |
NO (1) | NO20053677L (sr) |
PL (1) | PL376644A1 (sr) |
PT (1) | PT1592439E (sr) |
RS (1) | RS50891B (sr) |
RU (1) | RU2305556C2 (sr) |
UA (1) | UA80469C2 (sr) |
WO (1) | WO2004071524A1 (sr) |
ZA (1) | ZA200506452B (sr) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE102005023155A1 (de) * | 2005-05-13 | 2006-11-16 | Albutec Gmbh | Albuminlösung |
US20100168000A1 (en) | 2005-12-22 | 2010-07-01 | Peter Kiessling | Octanoate-Reduced Human Albumin |
ES2332846B1 (es) | 2007-10-26 | 2010-07-08 | Grifols, S.A. | Utilizacion de albumina humana terapeutica para la preparacion de un medicamento para el tratamiento de pacientes afectados por desordenes cognitivos. |
ES2294976B1 (es) | 2007-11-12 | 2008-12-16 | Grifols, S.A. | "procedimiento de obtencion de albumina humana de alta eficacia para su uso en terapia de detoxificacion". |
EP2382993A1 (en) | 2010-04-19 | 2011-11-02 | KTB Tumorforschungsgesellschaft mbH | Combination of drugs with protein-binding prodrugs |
CN111195351A (zh) * | 2020-01-20 | 2020-05-26 | 华兰生物工程重庆有限公司 | 5%低浓度人血白蛋白的制备方法 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0669961B2 (ja) * | 1984-09-25 | 1994-09-07 | 株式会社ミドリ十字 | 免疫グロブリンの加熱処理方法 |
US5094960A (en) * | 1988-10-07 | 1992-03-10 | New York Blood Center, Inc. | Removal of process chemicals from labile biological mixtures by hydrophobic interaction chromatography |
US5250662A (en) * | 1989-10-05 | 1993-10-05 | Alpha Therapeutic Corporation | Albumin purification |
DE19729778A1 (de) * | 1997-07-11 | 1999-01-21 | Blutspendedienst Der Drk Lande | Verfahren zur Herstellung von virusinaktivierten biologischen Flüssigkeiten |
US5919907A (en) * | 1997-12-22 | 1999-07-06 | Shanbrom Technologies Llc | Preparation and utilization of a novel sterile albumin |
IL136552A (en) * | 2000-06-05 | 2005-05-17 | Omrix Biopharmaceuticals Ltd | Method for the inactivation of viruses by a solvent - detergent combination and by nanofiltration |
-
2004
- 2004-02-13 WO PCT/EP2004/001397 patent/WO2004071524A1/de active IP Right Grant
- 2004-02-13 AU AU2004212324A patent/AU2004212324B2/en not_active Ceased
- 2004-02-13 RS YUP-2005/0624A patent/RS50891B/sr unknown
- 2004-02-13 DK DK04710818T patent/DK1592439T3/da active
- 2004-02-13 BR BR0407458-0A patent/BRPI0407458A/pt not_active IP Right Cessation
- 2004-02-13 PL PL376644A patent/PL376644A1/pl unknown
- 2004-02-13 MX MXPA05008276A patent/MXPA05008276A/es active IP Right Grant
- 2004-02-13 DE DE502004003834T patent/DE502004003834D1/de not_active Expired - Lifetime
- 2004-02-13 CA CA002514163A patent/CA2514163A1/en not_active Abandoned
- 2004-02-13 PT PT04710818T patent/PT1592439E/pt unknown
- 2004-02-13 EP EP04710818A patent/EP1592439B1/de not_active Expired - Lifetime
- 2004-02-13 RU RU2005128507/15A patent/RU2305556C2/ru not_active IP Right Cessation
- 2004-02-13 CN CNB2004800038643A patent/CN100384471C/zh not_active Expired - Fee Related
- 2004-02-13 JP JP2006501841A patent/JP2006517938A/ja active Pending
- 2004-02-13 ES ES04710818T patent/ES2285427T3/es not_active Expired - Lifetime
- 2004-02-13 UA UAA200508678A patent/UA80469C2/uk unknown
- 2004-02-13 KR KR1020057014946A patent/KR20050103292A/ko not_active Application Discontinuation
- 2004-02-13 AT AT04710818T patent/ATE362376T1/de not_active IP Right Cessation
-
2005
- 2005-07-21 IL IL169828A patent/IL169828A0/en unknown
- 2005-07-29 NO NO20053677A patent/NO20053677L/no not_active Application Discontinuation
- 2005-08-12 ZA ZA200506452A patent/ZA200506452B/en unknown
-
2007
- 2007-08-07 CY CY20071101052T patent/CY1106793T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
EP1592439A1 (de) | 2005-11-09 |
JP2006517938A (ja) | 2006-08-03 |
CN1798573A (zh) | 2006-07-05 |
BRPI0407458A (pt) | 2006-01-31 |
AU2004212324B2 (en) | 2009-05-07 |
RU2005128507A (ru) | 2006-01-20 |
WO2004071524A1 (de) | 2004-08-26 |
CY1106793T1 (el) | 2012-05-23 |
KR20050103292A (ko) | 2005-10-28 |
DE502004003834D1 (de) | 2007-06-28 |
RS20050624A (en) | 2007-06-04 |
NO20053677L (no) | 2005-10-31 |
ATE362376T1 (de) | 2007-06-15 |
RU2305556C2 (ru) | 2007-09-10 |
CN100384471C (zh) | 2008-04-30 |
AU2004212324A1 (en) | 2004-08-26 |
PT1592439E (pt) | 2007-06-22 |
DK1592439T3 (da) | 2007-09-10 |
ES2285427T3 (es) | 2007-11-16 |
PL376644A1 (pl) | 2006-01-09 |
ZA200506452B (en) | 2007-01-31 |
CA2514163A1 (en) | 2004-08-26 |
MXPA05008276A (es) | 2006-03-21 |
NO20053677D0 (no) | 2005-07-29 |
IL169828A0 (en) | 2011-08-01 |
UA80469C2 (en) | 2007-09-25 |
EP1592439B1 (de) | 2007-05-16 |
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