RS49991B - Pluraflavini i njihovi derivati, postupci njihovog dobijanja i upotrebe - Google Patents

Pluraflavini i njihovi derivati, postupci njihovog dobijanja i upotrebe

Info

Publication number
RS49991B
RS49991B YUP-576/02A YUP57602A RS49991B RS 49991 B RS49991 B RS 49991B YU P57602 A YUP57602 A YU P57602A RS 49991 B RS49991 B RS 49991B
Authority
RS
Serbia
Prior art keywords
group
groups
alkenyl
alkyl
independently selected
Prior art date
Application number
YUP-576/02A
Other languages
English (en)
Inventor
Laszlo Vertesy
Klaus Ehrlich
Joachim Wink
Martin Knauf
Francis P. Barbone
Elaine A. Powers
Elizabeth A. Cashman
Original Assignee
Sanofi-Aventis Deutschland Gmbh.,
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi-Aventis Deutschland Gmbh., filed Critical Sanofi-Aventis Deutschland Gmbh.,
Publication of YU57602A publication Critical patent/YU57602A/sh
Publication of RS49991B publication Critical patent/RS49991B/sr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/58—Preparation of O-glycosides, e.g. glucosides having an oxygen atom of the saccharide radical directly bound through only acyclic carbon atoms to a non-saccharide heterocyclic ring, e.g. bleomycin, phleomycin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

Jedinjenje formule I naznačeno time, što su: R1 je šećema grupa, R2 je -COOH ili -CH2-0-(R7)m, gde je R7 šećema grupa, R3 se bira između grupa koje sadrže epoksid, C1-Cs-alkil grupa i C2-Cs-alkenil grupa, pri čemu su pomenute alkil i alkenil grupe opciono supstituisane sa najmanje jednom OH grupom, R5 se bira između atoma vodonika, C1-C6-alkil grupa, C2-C6-alkenil grupa i C2-C6-alkinil grupa, R4, R6, R8 i R10 se, svaki nezavisno, biraju između atorna vodonika, C1-C6- alkil grupa, C2-C6-alkenil grupa, C2-C6-alkinil grupa, -X2H qrupa, gde je H direktno vezan za prvi atom u X2 i -X2R12 grupa, gde je R12 direktno vezan za prvi atom X2, i opciono R4 i R6 zajedno su dvostruko vezana-X2grupa, i opciono R8 i R10 zajedno su dvostruko vezana-xaqrupa, X2 se nezavisno bira između atoma kiseonika, -NH grupa, -N-C1-Cs-alkil grupa, -N-C2-C6-alkenil grupa, -N-C2-C6-alkinil grupa i atorna sumpora, R12 se nezavisno bira između C1-C6-alkil grupa, C2-C6ralkenil grupa, C2-C6- alkinil grupa, aril grupa ili acil grupa, i m i n se biraju svaki nezavisno, između 1 i 2, i svi njegovi stereohemijski oblici i smeše ovih oblika u bilo kom odnosu, njegove fiziološki prihvatljive soli i derivati. Prijava sdaži 26 zahteva.
YUP-576/02A 2000-02-18 2001-02-15 Pluraflavini i njihovi derivati, postupci njihovog dobijanja i upotrebe RS49991B (sr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP00103540A EP1125944A1 (de) 2000-02-18 2000-02-18 Pluraflavine und Derivate davon, Verfahren zu ihrer Herstellung und Verwendung derselben

Publications (2)

Publication Number Publication Date
YU57602A YU57602A (sh) 2005-11-28
RS49991B true RS49991B (sr) 2008-09-29

Family

ID=8167898

Family Applications (1)

Application Number Title Priority Date Filing Date
YUP-576/02A RS49991B (sr) 2000-02-18 2001-02-15 Pluraflavini i njihovi derivati, postupci njihovog dobijanja i upotrebe

Country Status (31)

Country Link
US (1) US6500936B2 (sr)
EP (2) EP1125944A1 (sr)
JP (1) JP4801307B2 (sr)
KR (1) KR100743380B1 (sr)
CN (1) CN1162441C (sr)
AR (1) AR027436A1 (sr)
AT (1) ATE255120T1 (sr)
AU (2) AU4240401A (sr)
BR (1) BR0108128A (sr)
CA (1) CA2400237C (sr)
CZ (1) CZ303810B6 (sr)
DE (1) DE60101313T2 (sr)
DK (1) DK1259523T3 (sr)
EE (1) EE05137B1 (sr)
ES (1) ES2207609T3 (sr)
HK (1) HK1052709B (sr)
HR (1) HRP20020672B1 (sr)
HU (1) HU228332B1 (sr)
IL (2) IL151216A0 (sr)
ME (1) ME00179B (sr)
MX (1) MXPA02006919A (sr)
NO (1) NO323413B1 (sr)
PL (1) PL204842B1 (sr)
PT (1) PT1259523E (sr)
RS (1) RS49991B (sr)
RU (1) RU2255940C2 (sr)
SI (1) SI1259523T1 (sr)
SK (1) SK286691B6 (sr)
TR (1) TR200302180T4 (sr)
WO (1) WO2001060832A2 (sr)
ZA (1) ZA200206795B (sr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6989386B2 (en) * 2002-04-30 2006-01-24 Dana-Farber Cancer Institute Pharmaceutically active ornithine derivatives, ammonium salts thereof and methods of making same
CN101921300B (zh) * 2009-06-10 2014-04-02 上海来益生物药物研究开发中心有限责任公司 一种异黄酮苷类化合物及其制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3782930T2 (de) * 1986-07-21 1993-04-29 Kyowa Hakko Kogyo Kk Neue mittel dc-92b und dc-92d, sowie deren verfahren zur herstellung.
WO1990000935A1 (en) * 1988-07-22 1990-02-08 Masco Corporation Of Indiana A small hand-held shower head for domestic sinks connected to a faucet
US5001058A (en) * 1988-09-19 1991-03-19 Bristol-Myers Company BU-3839T antibiotic
PT93070A (pt) * 1989-02-07 1990-08-31 Abbott Lab Processo de preparacao de altromicinas e de composicoes farmaceuticas que as contem
US5168100A (en) * 1990-03-16 1992-12-01 Sapporo Breweries Limited Hp530 compounds and process for preparing the same
WO2009009435A2 (en) * 2007-07-06 2009-01-15 Rite-Hite Holding Corporation Retractable safety barriers and methods of operating same

Also Published As

Publication number Publication date
EE05137B1 (et) 2009-02-16
AU4240401A (en) 2001-08-27
BR0108128A (pt) 2003-02-25
NO20023845L (no) 2002-10-10
HRP20020672A2 (en) 2004-12-31
DE60101313T2 (de) 2004-09-30
CA2400237C (en) 2008-12-30
IL151216A (en) 2009-12-24
HK1052709A1 (en) 2003-11-21
PL204842B1 (pl) 2010-02-26
MEP28608A (en) 2010-10-10
US6500936B2 (en) 2002-12-31
HRP20020672B1 (en) 2010-12-31
HUP0204393A3 (en) 2007-10-29
JP4801307B2 (ja) 2011-10-26
YU57602A (sh) 2005-11-28
ZA200206795B (en) 2003-11-19
DK1259523T3 (da) 2004-03-22
CN1404484A (zh) 2003-03-19
ATE255120T1 (de) 2003-12-15
ME00179B (me) 2011-02-10
RU2255940C2 (ru) 2005-07-10
SK11802002A3 (sk) 2003-02-04
SI1259523T1 (en) 2004-04-30
PT1259523E (pt) 2004-04-30
WO2001060832A2 (en) 2001-08-23
KR100743380B1 (ko) 2007-07-30
EP1259523A2 (en) 2002-11-27
SK286691B6 (sk) 2009-03-05
DE60101313D1 (de) 2004-01-08
EP1125944A1 (de) 2001-08-22
NO323413B1 (no) 2007-04-30
CN1162441C (zh) 2004-08-18
IL151216A0 (en) 2003-04-10
MXPA02006919A (es) 2004-04-05
CZ20022826A3 (cs) 2002-11-13
AR027436A1 (es) 2003-03-26
PL358297A1 (en) 2004-08-09
KR20020086539A (ko) 2002-11-18
TR200302180T4 (tr) 2004-03-22
HUP0204393A2 (hu) 2003-07-28
ES2207609T3 (es) 2004-06-01
WO2001060832A3 (en) 2002-01-31
JP2003523346A (ja) 2003-08-05
HK1052709B (zh) 2005-02-04
NO20023845D0 (no) 2002-08-14
CZ303810B6 (cs) 2013-05-15
RU2002124772A (ru) 2004-02-20
EP1259523B1 (en) 2003-11-26
HU228332B1 (en) 2013-03-28
US20020028921A1 (en) 2002-03-07
CA2400237A1 (en) 2001-08-23
EE200200438A (et) 2003-12-15
AU2001242404B2 (en) 2005-04-14

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