RO86851B - Procedeu pentru prepararea unor derivati de piperazin-2-ona - Google Patents

Procedeu pentru prepararea unor derivati de piperazin-2-ona

Info

Publication number
RO86851B
RO86851B RO111170A RO11117083A RO86851B RO 86851 B RO86851 B RO 86851B RO 111170 A RO111170 A RO 111170A RO 11117083 A RO11117083 A RO 11117083A RO 86851 B RO86851 B RO 86851B
Authority
RO
Romania
Prior art keywords
general formula
hydrogen
sodium
compound
derivatives
Prior art date
Application number
RO111170A
Other languages
English (en)
Romanian (ro)
Other versions
RO86851A (ro
Inventor
John Colin Emmett
William John Coates
Robert Antony Slater
Brian Herbert Warrington
Original Assignee
Smith Kline & French Laboratoires Ltd Welwyn Garden City
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB838300476A external-priority patent/GB8300476D0/en
Application filed by Smith Kline & French Laboratoires Ltd Welwyn Garden City filed Critical Smith Kline & French Laboratoires Ltd Welwyn Garden City
Publication of RO86851A publication Critical patent/RO86851A/ro
Publication of RO86851B publication Critical patent/RO86851B/ro

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D241/00Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/18Oxygen or sulfur atoms
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
RO111170A 1982-06-05 1983-06-03 Procedeu pentru prepararea unor derivati de piperazin-2-ona RO86851B (ro)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB8216437 1982-06-05
GB838300476A GB8300476D0 (en) 1983-01-08 1983-01-08 Heterocyclic compounds

Publications (2)

Publication Number Publication Date
RO86851A RO86851A (ro) 1985-05-20
RO86851B true RO86851B (ro) 1985-05-31

Family

ID=26283037

Family Applications (1)

Application Number Title Priority Date Filing Date
RO111170A RO86851B (ro) 1982-06-05 1983-06-03 Procedeu pentru prepararea unor derivati de piperazin-2-ona

Country Status (15)

Country Link
US (2) US4556711A (OSRAM)
EP (1) EP0096517A3 (OSRAM)
KR (1) KR840005111A (OSRAM)
AU (1) AU1527583A (OSRAM)
DD (1) DD209818A5 (OSRAM)
DK (1) DK247783A (OSRAM)
ES (2) ES522962A0 (OSRAM)
FI (1) FI831998A7 (OSRAM)
GR (1) GR79299B (OSRAM)
JO (1) JO1255B1 (OSRAM)
NO (1) NO832016L (OSRAM)
PL (1) PL242354A1 (OSRAM)
PT (1) PT76791B (OSRAM)
RO (1) RO86851B (OSRAM)
ZW (1) ZW12783A1 (OSRAM)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4657906A (en) * 1982-06-05 1987-04-14 Smith Kline & French Laboratories Ltd. Heterocyclic compounds having inotropic activity
GB8332313D0 (en) * 1983-12-02 1984-01-11 Smith Kline French Lab Chemical compounds
US4697016A (en) * 1984-10-26 1987-09-29 Ciba-Geigy Corporation Intermediates for the preparation of a carboxylic acid
US4595766A (en) * 1984-10-26 1986-06-17 Ciba-Geigy Corporation Process for the preparation of an indoline carboxylic acid
JPS62198671A (ja) * 1986-02-25 1987-09-02 Toyo Jozo Co Ltd 1−置換アルキル1,2−ジヒドロ−2−ピラジノン誘導体
US7772188B2 (en) 2003-01-28 2010-08-10 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
ES2559319T3 (es) 2007-06-04 2016-02-11 Synergy Pharmaceuticals Inc. Agonistas de guanilato cliclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros trastornos
CA2726917C (en) 2008-06-04 2018-06-26 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
WO2010009319A2 (en) 2008-07-16 2010-01-21 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders
JP2013502429A (ja) * 2009-08-19 2013-01-24 アムビト ビオスシエンセス コルポラチオン ビアリール化合物及びその使用方法
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
DK2681236T3 (en) 2011-03-01 2018-04-16 Synergy Pharmaceuticals Inc PROCEDURE FOR MANUFACTURING GUANYLATE CYCLASE-C-AGONISTS
RU2632915C2 (ru) 2012-06-12 2017-10-11 Эббви Инк. Производные пиридинона и пиридазинона
JP6499591B2 (ja) 2013-02-25 2019-04-10 シナジー ファーマシューティカルズ インコーポレイテッド 結腸洗浄において用いるためのグアニル酸シクラーゼ受容体アゴニスト
CA2905438A1 (en) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase and their uses
AU2014235209B2 (en) 2013-03-15 2018-06-14 Bausch Health Ireland Limited Guanylate cyclase receptor agonists combined with other drugs
WO2014197720A2 (en) 2013-06-05 2014-12-11 Synergy Pharmaceuticals, Inc. Ultra-pure agonists of guanylate cyclase c, method of making and using same
CN105979959B (zh) 2013-08-09 2021-11-30 阿德利克斯公司 用于抑制磷酸盐转运的化合物和方法
WO2020237096A1 (en) 2019-05-21 2020-11-26 Ardelyx, Inc. Combination for lowering serum phosphate in a patient

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3745161A (en) * 1970-04-20 1973-07-10 Merck & Co Inc Phenyl-hydroxy-pyrazine carboxylic acids and derivatives

Also Published As

Publication number Publication date
ES8707507A1 (es) 1985-12-01
KR840005111A (ko) 1984-11-03
PT76791B (en) 1986-01-24
FI831998L (fi) 1983-12-06
EP0096517A2 (en) 1983-12-21
FI831998A7 (fi) 1983-12-06
AU1527583A (en) 1983-12-08
FI831998A0 (fi) 1983-06-03
GR79299B (OSRAM) 1984-10-22
JO1255B1 (en) 1985-04-20
DD209818A5 (de) 1984-05-23
DK247783A (da) 1983-12-06
RO86851A (ro) 1985-05-20
ES8500244A1 (es) 1984-10-01
ES530024A0 (es) 1985-12-01
PL242354A1 (en) 1984-12-17
US4514568A (en) 1985-04-30
ZW12783A1 (en) 1983-08-24
US4556711A (en) 1985-12-03
PT76791A (en) 1983-07-01
DK247783D0 (da) 1983-06-01
ES522962A0 (es) 1984-10-01
EP0096517A3 (en) 1985-04-03
NO832016L (no) 1983-12-06

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