RO86375B1 - Procedeu pentru prepararea antibioticului a 41030 - Google Patents
Procedeu pentru prepararea antibioticului a 41030Info
- Publication number
- RO86375B1 RO86375B1 RO116350A RO11635083A RO86375B1 RO 86375 B1 RO86375 B1 RO 86375B1 RO 116350 A RO116350 A RO 116350A RO 11635083 A RO11635083 A RO 11635083A RO 86375 B1 RO86375 B1 RO 86375B1
- Authority
- RO
- Romania
- Prior art keywords
- flour
- antibiotic
- galactose
- represents hydrogen
- streptomyces virginiae
- Prior art date
Links
- 230000003115 biocidal effect Effects 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title 1
- 235000013312 flour Nutrition 0.000 abstract 4
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 241000187122 Streptomyces virginiae Species 0.000 abstract 2
- 229910052799 carbon Inorganic materials 0.000 abstract 2
- 229930182830 galactose Natural products 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 229920001817 Agar Polymers 0.000 abstract 1
- KJTFTWQSEBLIPM-UHFFFAOYSA-N Antibiotic A 41030A Natural products N1C(=O)C(NC(C(N)C=2C=C(O3)C(O)=CC=2)=O)CC(C=C2Cl)=CC=C2OC(C=2O)=CC4=CC=2OC(C(=C2)Cl)=CC=C2C(O)C(C(NC(C2=CC(O)=CC(O)=C2C=2C(O)=C(Cl)C=C5C=2)C(O)=O)=O)NC(=O)C5NC(=O)C4NC(=O)C1C1=CC3=CC(O)=C1 KJTFTWQSEBLIPM-UHFFFAOYSA-N 0.000 abstract 1
- 235000017060 Arachis glabrata Nutrition 0.000 abstract 1
- 244000105624 Arachis hypogaea Species 0.000 abstract 1
- 235000010777 Arachis hypogaea Nutrition 0.000 abstract 1
- 235000018262 Arachis monticola Nutrition 0.000 abstract 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 1
- WQZGKKKJIJFFOK-QTVWNMPRSA-N D-mannopyranose Chemical compound OC[C@H]1OC(O)[C@@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-QTVWNMPRSA-N 0.000 abstract 1
- 229920001353 Dextrin Polymers 0.000 abstract 1
- 239000004375 Dextrin Substances 0.000 abstract 1
- 235000019733 Fish meal Nutrition 0.000 abstract 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 abstract 1
- 239000001888 Peptone Substances 0.000 abstract 1
- 108010080698 Peptones Proteins 0.000 abstract 1
- 235000010627 Phaseolus vulgaris Nutrition 0.000 abstract 1
- 244000046052 Phaseolus vulgaris Species 0.000 abstract 1
- 229920002472 Starch Polymers 0.000 abstract 1
- 239000008272 agar Substances 0.000 abstract 1
- WQZGKKKJIJFFOK-PHYPRBDBSA-N alpha-D-galactose Chemical compound OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@H]1O WQZGKKKJIJFFOK-PHYPRBDBSA-N 0.000 abstract 1
- 235000015278 beef Nutrition 0.000 abstract 1
- 239000008280 blood Substances 0.000 abstract 1
- 210000004369 blood Anatomy 0.000 abstract 1
- 229940041514 candida albicans extract Drugs 0.000 abstract 1
- 239000005018 casein Substances 0.000 abstract 1
- BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 abstract 1
- 235000021240 caseins Nutrition 0.000 abstract 1
- 239000000460 chlorine Substances 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 125000001309 chloro group Chemical group Cl* 0.000 abstract 1
- -1 cornflakes Substances 0.000 abstract 1
- 235000012343 cottonseed oil Nutrition 0.000 abstract 1
- 239000002385 cottonseed oil Substances 0.000 abstract 1
- 235000019425 dextrin Nutrition 0.000 abstract 1
- AIUDWMLXCFRVDR-UHFFFAOYSA-N dimethyl 2-(3-ethyl-3-methylpentyl)propanedioate Chemical class CCC(C)(CC)CCC(C(=O)OC)C(=O)OC AIUDWMLXCFRVDR-UHFFFAOYSA-N 0.000 abstract 1
- 239000000284 extract Substances 0.000 abstract 1
- 239000004467 fishmeal Substances 0.000 abstract 1
- 239000012634 fragment Substances 0.000 abstract 1
- 239000008103 glucose Substances 0.000 abstract 1
- 235000011187 glycerol Nutrition 0.000 abstract 1
- 239000001963 growth medium Substances 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 235000013372 meat Nutrition 0.000 abstract 1
- 244000005700 microbiome Species 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 235000016709 nutrition Nutrition 0.000 abstract 1
- 235000020232 peanut Nutrition 0.000 abstract 1
- 235000019319 peptone Nutrition 0.000 abstract 1
- 229940066779 peptones Drugs 0.000 abstract 1
- 235000015277 pork Nutrition 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000008107 starch Substances 0.000 abstract 1
- 235000019698 starch Nutrition 0.000 abstract 1
- 239000012138 yeast extract Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/16—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing two or more hetero rings
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/195—Antibiotics
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/30—Feeding-stuffs specially adapted for particular animals for swines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
- C07K9/006—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure
- C07K9/008—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure directly attached to a hetero atom of the saccharide radical, e.g. actaplanin, avoparcin, ristomycin, vancomycin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
- C12N1/205—Bacterial isolates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
- C12R2001/465—Streptomyces
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Polymers & Plastics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biochemistry (AREA)
- Wood Science & Technology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Biotechnology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Animal Husbandry (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Dermatology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Diabetes (AREA)
- Oncology (AREA)
- Birds (AREA)
- Communicable Diseases (AREA)
- Obesity (AREA)
- Virology (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
Procedeu pentru prepararea antibioticului A 41030 cu formula generala (I) în care R1 reprezinta hidrogen sau clor, R2 reprezinta hidrogen sau clor iar R3 reprezinta hidoxil, galactoza sau galacozil-galactoza, caracterizat prin aceea ca microorganismul ales dintre Streptomyces virginiae NRRL 12525 sau Streptomyces virginiae NRRL 15156 este cultivat în conditii submersibile anaerobe într-un mediu de cultura care contine surse asimilabile de carbon, azot si saruri anorganice nutritive alese dintredextrina, amidon, manoza, glicerna, extract de drojdie, cazeina agar, extract de carne de vita, glucoza, ape de la înmuierea porumbului, ulei din semnte de bumbac, faina sau fragmente de fasole, faina de arahide, faina de peste, peptone din care, faina din sânge de porc, faina de carne, la temperaturi cuprinse între 10 si 34 degree C, preferabil la 30 degree C, la un pH cuprins între 6,5 si 7,3 timp de 48...210h, eventual, antibioticul putându-se separa prin metode bine cunoscute.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US36130282A | 1982-03-24 | 1982-03-24 | |
| US36130182A | 1982-03-24 | 1982-03-24 | |
| US44349682A | 1982-11-22 | 1982-11-22 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RO86375B1 true RO86375B1 (ro) | 1985-04-01 |
Family
ID=27408509
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RO116350A RO86375B1 (ro) | 1982-03-24 | 1983-03-16 | Procedeu pentru prepararea antibioticului a 41030 |
| RO83110350A RO86375A (ro) | 1982-03-24 | 1983-03-16 | Procedeu pentru prepararea antibioticului a 41030 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RO83110350A RO86375A (ro) | 1982-03-24 | 1983-03-16 | Procedeu pentru prepararea antibioticului a 41030 |
Country Status (17)
| Country | Link |
|---|---|
| EP (1) | EP0090578B1 (ro) |
| JP (1) | JPH0771478B2 (ro) |
| KR (1) | KR860001048B1 (ro) |
| AR (1) | AR229888A1 (ro) |
| AU (1) | AU557104B2 (ro) |
| DD (1) | DD210308A5 (ro) |
| DE (1) | DE3380160D1 (ro) |
| DK (1) | DK132883A (ro) |
| ES (1) | ES8500635A1 (ro) |
| FI (1) | FI75190C (ro) |
| GB (1) | GB2117763B (ro) |
| HU (1) | HU192129B (ro) |
| IE (1) | IE54899B1 (ro) |
| NZ (1) | NZ203604A (ro) |
| PL (1) | PL241142A1 (ro) |
| PT (1) | PT76410B (ro) |
| RO (2) | RO86375B1 (ro) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8307847D0 (en) * | 1983-03-22 | 1983-04-27 | Lepetit Spa | Antibiotics l 17054 and l 17046 |
| US4521335A (en) * | 1983-07-13 | 1985-06-04 | Smithkline Beckman Corporation | Aglycone and pseudo-aglycones of the AAD 216 antibiotics |
| AU579120B2 (en) * | 1983-12-16 | 1988-11-17 | Gruppo Lepetit S.P.A. | Chemical process for preparing antibiotic L 17392 (deglucoteicoplanin) and its salts |
| GB8333624D0 (en) * | 1983-12-16 | 1984-01-25 | Lepetit Spa | Antibiotics l 17054 and l 17392 |
| GB8415093D0 (en) * | 1984-06-13 | 1984-07-18 | Lepetit Spa | Antibiotic l 17392 |
| GB8415092D0 (en) * | 1984-06-13 | 1984-07-18 | Lepetit Spa | Ester derivatives |
| DE3511753A1 (de) * | 1985-03-30 | 1986-10-02 | Bayer Ag, 5090 Leverkusen | Verwendung von efomycinen als wachstumsfoerderer, efomycine und ihre herstellung |
| GB8608809D0 (en) * | 1986-04-11 | 1986-05-14 | Lepetit Spa | Antibiotic |
| DK363587A (da) * | 1986-07-30 | 1988-01-31 | Smithkline Beckman Corp | Antibiotika og fremstilling heraf under anvendelseaf actinomadura parvosata |
| GB8726859D0 (en) * | 1987-11-17 | 1987-12-23 | Lepetit Spa | 22-dechlorotei-coplanins |
| CN105820974A (zh) * | 2016-03-30 | 2016-08-03 | 原巍俊 | 一种生防放线菌的发酵方法及应用 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4322406A (en) * | 1980-12-18 | 1982-03-30 | Eli Lilly And Company | Antibiotic A-4696 factors B1, B2, B3, C1a, C3 and E1 |
| US4322343A (en) * | 1980-12-18 | 1982-03-30 | Eli Lilly And Company | Pseudo-aglycone of actaplanin |
-
1983
- 1983-03-16 RO RO116350A patent/RO86375B1/ro unknown
- 1983-03-16 FI FI830878A patent/FI75190C/fi not_active IP Right Cessation
- 1983-03-16 RO RO83110350A patent/RO86375A/ro unknown
- 1983-03-16 AR AR292407A patent/AR229888A1/es active
- 1983-03-17 NZ NZ203604A patent/NZ203604A/en unknown
- 1983-03-17 PT PT76410A patent/PT76410B/pt unknown
- 1983-03-21 DD DD83249013A patent/DD210308A5/de unknown
- 1983-03-22 DE DE8383301584T patent/DE3380160D1/de not_active Expired
- 1983-03-22 KR KR1019830001148A patent/KR860001048B1/ko not_active Expired
- 1983-03-22 IE IE620/83A patent/IE54899B1/en unknown
- 1983-03-22 EP EP83301584A patent/EP0090578B1/en not_active Expired
- 1983-03-22 GB GB08307807A patent/GB2117763B/en not_active Expired
- 1983-03-23 PL PL24114283A patent/PL241142A1/xx unknown
- 1983-03-23 ES ES520866A patent/ES8500635A1/es not_active Expired
- 1983-03-23 DK DK132883A patent/DK132883A/da not_active Application Discontinuation
- 1983-03-23 HU HU83975A patent/HU192129B/hu unknown
- 1983-03-23 AU AU12739/83A patent/AU557104B2/en not_active Ceased
-
1991
- 1991-11-27 JP JP3312353A patent/JPH0771478B2/ja not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| DK132883A (da) | 1983-09-25 |
| KR840004168A (ko) | 1984-10-10 |
| FI830878L (fi) | 1983-09-25 |
| AU557104B2 (en) | 1986-12-04 |
| EP0090578A2 (en) | 1983-10-05 |
| GB8307807D0 (en) | 1983-04-27 |
| GB2117763A (en) | 1983-10-19 |
| NZ203604A (en) | 1986-08-08 |
| KR860001048B1 (ko) | 1986-08-01 |
| AR229888A1 (es) | 1983-12-30 |
| JPH05192134A (ja) | 1993-08-03 |
| GB2117763B (en) | 1986-02-26 |
| HU192129B (en) | 1987-05-28 |
| FI75190B (fi) | 1988-01-29 |
| ES520866A0 (es) | 1984-11-01 |
| PT76410A (en) | 1983-04-01 |
| DE3380160D1 (en) | 1989-08-17 |
| JPH0771478B2 (ja) | 1995-08-02 |
| AU1273983A (en) | 1983-09-29 |
| EP0090578A3 (en) | 1985-05-22 |
| RO86375A (ro) | 1985-03-15 |
| IE830620L (en) | 1983-09-24 |
| PT76410B (en) | 1986-02-04 |
| DD210308A5 (de) | 1984-06-06 |
| PL241142A1 (en) | 1983-12-05 |
| IE54899B1 (en) | 1990-03-14 |
| ES8500635A1 (es) | 1984-11-01 |
| EP0090578B1 (en) | 1989-07-12 |
| FI830878A0 (fi) | 1983-03-16 |
| FI75190C (fi) | 1988-05-09 |
| DK132883D0 (da) | 1983-03-23 |
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