KR940014800A - 인돌로피롤로카르바졸 유도체의 제조방법 - Google Patents

인돌로피롤로카르바졸 유도체의 제조방법 Download PDF

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KR940014800A
KR940014800A KR1019930027662A KR930027662A KR940014800A KR 940014800 A KR940014800 A KR 940014800A KR 1019930027662 A KR1019930027662 A KR 1019930027662A KR 930027662 A KR930027662 A KR 930027662A KR 940014800 A KR940014800 A KR 940014800A
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South Korea
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group
formula
compound
microorganism
lower alkyl
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KR1019930027662A
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KR100293578B1 (ko
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가쓰히사 고지리
하지메 스즈끼
히사오 곤도오
히로유끼 스다
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도오야마 노리유끼
반유세이야꾸 가부시끼가이샤
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • C12P19/28—N-glycosides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales

Abstract

수득된 식 (I)의 화합물은 항종양 활성을 갖는다.
하기 식(II)로 효시되는 화합물의 글리코실화 능력을 가진 미생물을 하기 식(II)의 화합물을 함유한 영양 배지 중에서 배양시키고, 이 배양배지로부터 식 (I)의 형성된 화합물을 회수함을 특징으로 하는 하기 식 (I)로 표시되는 화합물의 제조 방법:
X1및 X2는 각각 독립적으로 수수원자, 할로겐 원자, 아미노기, 모노- 및 디-저급 알킬 아미노기, 히드록실기, 저급 알콕시기, 아르알콕시기, 카르복실기, 저급 알콕시 카르보닐기 저급 알카노일옥시기 또는 저급 알킬기를 나타내고, R은 수소원자, 아미노기, 포르말아미노기, 저급 알카노일아미노기, 모노- 또는 디-저급 알킬아미노기, 히드록실기, 저급 알콕시기, 아르알콕시기, 아르알킬기 또는 저급 알킬기를 나타낸다

Description

인돌로피롤로카르바졸 유도체의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (6)

  1. 하기 식(II)로 표시되는 화합물의 글리코실화 능력을 가진 미생물을 가진 식(II)의 화합물을 함유한 영양배지중에서 배양시키고, 이 배양지로부터 식(I)의 형성된 화합물을 회수함을 특징으로 하는 하기 식(I)로 표시되는 화합물의 제조 방법:
    〔상기식에서, X1및 X2는 각각 독립적으로 수수원자, 할로겐 원자, 아미노기, 모노- 및 디-저급 알킬 아미노기, 히드록실기, 저급 알콕시기, 아르알콕시기, 카르복실기, 저급 알콕시 카르보닐기 저급 알카노일옥시기 또는 저급 알킬기를 나타내고, R은 수소원자, 아미노기, 포르밀아미노기, 저급 알카노일아미노기, 모노- 또는 디-저급 알킬아미노기, 히드록실기, 저급 알콕시기, 아르알콕시기, 아르알킬기 또는 저급 알킬기를 나타낸다.〕
  2. 제1항에 있어서, 글리코실화 능력을 가진 미생물이 미크로테트라스포라 (Microtetraspora), 사카로트릭스(Saccharothrix)속에 속하는 미생물 또는 이들의 변이주임을 특징으로 하는 제조방법.
  3. 제1항에 있어서, 글리코실화 능력을 가진 미생물이 미크로테트라스포라종 A 34549 균주, 사카로트릭스 에어로콜로니게네스(Saccharothrixaerocolonigenes) ATCC 39243 균주 또는 이들의 변이주임을 특징으로 하는 제조방법.
  4. 제1항에 있어서, X1및X2가 히드록실기이고, R이 수소원자, 아미노기 또는 저급알킬기인 식(I)의 화합물이 제조되고, 하기식
    으로 표시되는 기가 글루코스 잔기임을 특징으로 하는 제조방법.
  5. 제1항에 나탄내 식(II)의 화합물을 식(I)의 화합물로 전환시키는 능력을 가진, 미크로테트라스포라 속 또는 그의 변이주에 속하는 미생물.
  6. 제5항에 있어서, 미생물이 미크로테트라스포라 종 A 34549 균주 또는 그의 변이주인 미생물.
    ※참고사항:최초출원 내용에 의하여 공개하는 것임.
KR1019930027662A 1992-12-14 1993-12-14 인돌로피롤로카르바졸유도체의제조방법 KR100293578B1 (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP35362392 1992-12-14
JP92-353623 1992-12-14
JP93-53035 1993-02-18
JP5303593 1993-02-18

Publications (2)

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KR940014800A true KR940014800A (ko) 1994-07-19
KR100293578B1 KR100293578B1 (ko) 2001-09-17

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EP (1) EP0602597B1 (ko)
JP (1) JP3603322B2 (ko)
KR (1) KR100293578B1 (ko)
AT (1) ATE184053T1 (ko)
AU (1) AU669584B2 (ko)
CA (1) CA2111283C (ko)
DE (1) DE69326222T2 (ko)
DK (1) DK0602597T3 (ko)
ES (1) ES2135441T3 (ko)
GR (1) GR3031359T3 (ko)

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US5437992A (en) * 1994-04-28 1995-08-01 Genencor International, Inc. Five thermostable xylanases from microtetraspora flexuosa for use in delignification and/or bleaching of pulp
DK0760375T3 (da) * 1994-05-09 2003-12-29 Banyu Pharma Co Ltd Antitumor-indolopyrrolocarbazolderivater
US5922860A (en) * 1994-05-09 1999-07-13 Banyu Pharmaceutical Co., Ltd. Antitumor indolopyrrolocarbazole derivatives
WO1995034663A1 (fr) * 1994-06-13 1995-12-21 Banyu Pharmaceutical Co., Ltd. Gene codant la glycosyl-transferase et utilisation de ce gene
WO1996004293A1 (fr) * 1994-08-02 1996-02-15 Banyu Pharmaceutical Co., Ltd. Indolopyrrolocarbazoles antitumoraux
WO2000064917A2 (en) * 1999-04-26 2000-11-02 Advanced Life Sciences Inc. Synthetic indolocarbazole regioisomers and uses thereof
US6610727B2 (en) 2000-10-06 2003-08-26 Bristol-Myers Squibb Company Anhydro sugar derivatives of indolocarbazoles
US6677450B2 (en) 2000-10-06 2004-01-13 Bristol-Myers Squibb Company Topoisomerase inhibitors
US6653290B2 (en) 2000-10-06 2003-11-25 Bristol-Myers Squibb Company Tumor proliferation inhibitors
WO2002077255A1 (en) 2001-03-22 2002-10-03 Bristol-Myers Squibb Company Topoisomerase i selective cytotoxic sugar derivatives of indolopyrrolocarbazoles
US6559299B2 (en) * 2001-03-29 2003-05-06 Merck & Co., Inc. Preparation and isolation of indolocarbazole glycosides
CA2398828A1 (en) 2002-08-09 2004-02-09 Merck & Co., Inc. A pharmaceutical composition containing an indolopyrrolocarbazole derivative
JPWO2005026185A1 (ja) * 2003-09-16 2006-11-16 萬有製薬株式会社 抗腫瘍性新規インドロピロロカルバゾール誘導体
ES2326459B1 (es) 2008-04-08 2010-05-28 Universidad De Oviedo Indolocarbazoles glicosilados, su procedimiento de obtencion y sus usos.
CN106478643B (zh) * 2016-09-07 2018-07-10 河南师范大学 吲哚[2,3-a]吡咯[3,4-c]咔唑-5,7-二酮-6-芳腙类化合物及其制备方法和在抗癌药物中的应用
CN106432250B (zh) * 2016-09-07 2018-07-10 河南师范大学 具有抗癌活性的吲哚[2,3-a]吡咯[3,4-c]咔唑-5,7-二酮-6-缩氨基硫脲类化合物及其制备方法和应用

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US4524145A (en) * 1984-09-04 1985-06-18 Bristol-Myers Company 4'-Deschlororebeccamycin pharmaceutical composition and method of use
US4785085A (en) * 1986-11-21 1988-11-15 Bristol-Myers Company Rebeccamycin analogs
IL97233A (en) * 1990-03-06 1995-03-30 Bristol Myers Squibb Co Analogs of rabamycin, their manufacture and pharmaceutical preparations containing them

Also Published As

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CA2111283C (en) 2004-10-26
AU669584B2 (en) 1996-06-13
DK0602597T3 (da) 2000-02-28
DE69326222D1 (de) 1999-10-07
EP0602597A2 (en) 1994-06-22
JP3603322B2 (ja) 2004-12-22
EP0602597B1 (en) 1999-09-01
ES2135441T3 (es) 1999-11-01
JPH06296494A (ja) 1994-10-25
EP0602597A3 (en) 1995-04-19
DE69326222T2 (de) 1999-12-30
AU5235493A (en) 1994-06-23
ATE184053T1 (de) 1999-09-15
CA2111283A1 (en) 1994-06-15
GR3031359T3 (en) 2000-01-31
KR100293578B1 (ko) 2001-09-17

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