RO81056B - Process for preparing n-(3-(1', 3'-oxapenthiamethylenaminoethylidenamino)2, 4, 6-triiodinebenzoyl)-beta-amino-alpha methylpropionic acid - Google Patents

Process for preparing n-(3-(1', 3'-oxapenthiamethylenaminoethylidenamino)2, 4, 6-triiodinebenzoyl)-beta-amino-alpha methylpropionic acid

Info

Publication number
RO81056B
RO81056B RO103041A RO10304180A RO81056B RO 81056 B RO81056 B RO 81056B RO 103041 A RO103041 A RO 103041A RO 10304180 A RO10304180 A RO 10304180A RO 81056 B RO81056 B RO 81056B
Authority
RO
Romania
Prior art keywords
molar equivalents
beta
alpha
amino
methylpropionic acid
Prior art date
Application number
RO103041A
Other languages
Romanian (ro)
Other versions
RO81056A (en
Inventor
Josef Wieser
Josef Krieger
Original Assignee
Chemie Linz Aktiengesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chemie Linz Aktiengesellschaft filed Critical Chemie Linz Aktiengesellschaft
Publication of RO81056B publication Critical patent/RO81056B/en
Publication of RO81056A publication Critical patent/RO81056A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/195—Radicals derived from nitrogen analogues of carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Conform inventiei, procedeul pentru prepararea acidului N-[3-(1*-3*-oxapentametilenamino-etilidenamino)-2,4,6-triiodbenzioil]-beta-amino-alfa-metilpropionic cu formula generala I: (vezi formula) consta în aceea ca, se trateaza (vezi formula) cu 1 pîna la 3 echivalenti molari, de preferinta 2 pîna la 3 echivalenti molari, N-acetilmorfolina si 1 pîna la 6 echivalenti molari, de preferinta 2 pîna la 6 echivalenti molari, oxiclorura de fosfor la o temperatura de 0 pîna 10 degree C, de preferinta 0...5 degree C, si se lasa reactantii sa reactioneze la temperaturi cuprinse între 10 degree C si punctul de fierbere al amestecului de reactie obtinut în apa în timpul sau dupa evaporarea solventului, se separa eventual partile insolubile existente de solutia acida rezultata si se precipita prin alcalinizare la un pH de cel putin 8, nitrilul cu formula II: (vezi formula) care se izoleaza si eventual se purifica, dupa care se trece acest nitril în acidul liber, prin metode în sine cunoscute.According to the invention, the process for the preparation of N- [3- (1'-3'-oxapentamethyleneamino-ethylideneamino) -2,4,6-triiodobenzoyl] -beta-amino-alpha-methylpropionic acid of general formula I in that 1 to 3 molar equivalents, preferably 2 to 3 molar equivalents, N-acetylmorpholine and 1 to 6 molar equivalents, preferably 2 to 6 molar equivalents, are treated (see formula) with phosphorous oxychloride at a temperature of 0 to 10 ° C, preferably 0-5 ° C, and let the reactants react at temperatures between 10 ° C and the boiling point of the reaction mixture obtained in the water during or after evaporation of the solvent , eventually separating the insoluble parts of the resulting acidic solution and precipitating by alkalinisation to a pH of at least 8, the nitrile of the formula II: (see formula) which is isolated and eventually purified, and then this nitrile is passed into the free acid , by methods known per se ute.

RO80103041A 1980-01-04 1980-12-30 PROCESS FOR PREPARATION OF N- (3- (1 ', 3'-OXAPENTIAMETHENAMINOETILIDENAMINO) -2,4,6-TRIODOBENZOYL) -BETA-AMINO-ALFA-METHYLPROPIONIC ACID RO81056A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19803000215 DE3000215A1 (en) 1980-01-04 1980-01-04 Iomorinic acid prodn. useful as X=ray contrast agent - by reacting amino-tri:iodo:benzoyl-amino-methyl propionitrile with N-acetyl:morpholine followed by hydrolysis

Publications (2)

Publication Number Publication Date
RO81056B true RO81056B (en) 1983-05-30
RO81056A RO81056A (en) 1983-06-01

Family

ID=6091548

Family Applications (1)

Application Number Title Priority Date Filing Date
RO80103041A RO81056A (en) 1980-01-04 1980-12-30 PROCESS FOR PREPARATION OF N- (3- (1 ', 3'-OXAPENTIAMETHENAMINOETILIDENAMINO) -2,4,6-TRIODOBENZOYL) -BETA-AMINO-ALFA-METHYLPROPIONIC ACID

Country Status (10)

Country Link
CS (1) CS216545B2 (en)
DD (1) DD155901A1 (en)
DE (1) DE3000215A1 (en)
ES (1) ES8201148A1 (en)
HU (1) HU180185B (en)
PL (1) PL127295B1 (en)
PT (1) PT72221B (en)
RO (1) RO81056A (en)
SU (1) SU980618A3 (en)
YU (1) YU309780A (en)

Also Published As

Publication number Publication date
DD155901A1 (en) 1982-07-14
PT72221B (en) 1981-11-02
ES498238A0 (en) 1981-12-01
PT72221A (en) 1981-01-01
RO81056A (en) 1983-06-01
PL127295B1 (en) 1983-10-31
HU180185B (en) 1983-02-28
CS216545B2 (en) 1982-11-26
SU980618A3 (en) 1982-12-07
YU309780A (en) 1983-01-21
PL229041A1 (en) 1981-10-16
DE3000215A1 (en) 1981-07-09
ES8201148A1 (en) 1981-12-01

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