ES8201148A1 - Iomorinic acid prodn. useful as X=ray contrast agent - by reacting amino-tri:iodo:benzoyl-amino-methyl propionitrile with N-acetyl:morpholine followed by hydrolysis - Google Patents

Iomorinic acid prodn. useful as X=ray contrast agent - by reacting amino-tri:iodo:benzoyl-amino-methyl propionitrile with N-acetyl:morpholine followed by hydrolysis

Info

Publication number
ES8201148A1
ES8201148A1 ES498238A ES498238A ES8201148A1 ES 8201148 A1 ES8201148 A1 ES 8201148A1 ES 498238 A ES498238 A ES 498238A ES 498238 A ES498238 A ES 498238A ES 8201148 A1 ES8201148 A1 ES 8201148A1
Authority
ES
Spain
Prior art keywords
amino
useful
contrast agent
ray contrast
iodo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES498238A
Other languages
Spanish (es)
Other versions
ES498238A0 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Patheon Austria GmbH and Co KG
Original Assignee
Chemie Linz AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chemie Linz AG filed Critical Chemie Linz AG
Publication of ES8201148A1 publication Critical patent/ES8201148A1/en
Publication of ES498238A0 publication Critical patent/ES498238A0/en
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/195—Radicals derived from nitrogen analogues of carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Prodn. of iomorinic acid (I) comprises first mixing N-(3-amino-2,4,6-triiodobenzoyl) -beta-amino-alpha- methylpropionitrile (II) with N-acetylmorpholine and POCl3 at 0-10 deg.C, then reacting at 10 deg.C to b.pt. The reaction mixt. is taken up in water (during or after evapn. of solvent) opt. insolubles removed from the resulting acid soln., and pH adjusted to at least 8 to ppte. cpd. (II). This is isolated, opt. purified, then hydrolysed to (I) with alkali or acid. (I) is an X-ray contrast agent when given orally as its Na salt it is esp. useful for rapid cholecystography. Yields of very pure (I) of almost 90% are obtd. (II) is almost insoluble in aq. alkali so is easy to purify and can be hydrolysed to (I) without damaging effects on the amidino gp. and without loss of iodine.
ES498238A 1980-01-04 1980-12-30 PROCEDURE FOR THE OBTAINING OF ACID N- (3- (1'-3 '' - OXA- PENTAMETILENAMINO-ETILIDENAMINO) -2,4,6-TRIYODOBENZOIL) -B- AMINO - @ - METHYL-PROPIONIC Granted ES498238A0 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19803000215 DE3000215A1 (en) 1980-01-04 1980-01-04 Iomorinic acid prodn. useful as X=ray contrast agent - by reacting amino-tri:iodo:benzoyl-amino-methyl propionitrile with N-acetyl:morpholine followed by hydrolysis

Publications (2)

Publication Number Publication Date
ES8201148A1 true ES8201148A1 (en) 1981-12-01
ES498238A0 ES498238A0 (en) 1981-12-01

Family

ID=6091548

Family Applications (1)

Application Number Title Priority Date Filing Date
ES498238A Granted ES498238A0 (en) 1980-01-04 1980-12-30 PROCEDURE FOR THE OBTAINING OF ACID N- (3- (1'-3 '' - OXA- PENTAMETILENAMINO-ETILIDENAMINO) -2,4,6-TRIYODOBENZOIL) -B- AMINO - @ - METHYL-PROPIONIC

Country Status (10)

Country Link
CS (1) CS216545B2 (en)
DD (1) DD155901A1 (en)
DE (1) DE3000215A1 (en)
ES (1) ES498238A0 (en)
HU (1) HU180185B (en)
PL (1) PL127295B1 (en)
PT (1) PT72221B (en)
RO (1) RO81056A (en)
SU (1) SU980618A3 (en)
YU (1) YU309780A (en)

Also Published As

Publication number Publication date
YU309780A (en) 1983-01-21
RO81056B (en) 1983-05-30
PT72221A (en) 1981-01-01
DD155901A1 (en) 1982-07-14
PT72221B (en) 1981-11-02
SU980618A3 (en) 1982-12-07
PL127295B1 (en) 1983-10-31
PL229041A1 (en) 1981-10-16
HU180185B (en) 1983-02-28
CS216545B2 (en) 1982-11-26
RO81056A (en) 1983-06-01
DE3000215A1 (en) 1981-07-09
ES498238A0 (en) 1981-12-01

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