RO115415B1 - Intercellular adhesion molecule-3 (icam-3), recombinant dna-molecule encoding the intercellular adhesion molecule -3, its antibodies, method for modelling biological functions, supression, identification, diagnosis and pharmaceutical compositions - Google Patents

Intercellular adhesion molecule-3 (icam-3), recombinant dna-molecule encoding the intercellular adhesion molecule -3, its antibodies, method for modelling biological functions, supression, identification, diagnosis and pharmaceutical compositions

Info

Publication number
RO115415B1
RO115415B1 RO93-01672A RO9301672A RO115415B1 RO 115415 B1 RO115415 B1 RO 115415B1 RO 9301672 A RO9301672 A RO 9301672A RO 115415 B1 RO115415 B1 RO 115415B1
Authority
RO
Romania
Prior art keywords
icam
molecule
intercellular adhesion
binding
fragment
Prior art date
Application number
RO93-01672A
Other languages
Romanian (ro)
Inventor
Fougerolles Antonin R. De
Timothy A. Springer
Original Assignee
Center For Blood Research, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Center For Blood Research, Inc. filed Critical Center For Blood Research, Inc.
Publication of RO115415B1 publication Critical patent/RO115415B1/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6881—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for tissue or cell typing, e.g. human leukocyte antigen [HLA] probes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70525—ICAM molecules, e.g. CD50, CD54, CD102
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2821—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against ICAM molecules, e.g. CD50, CD54, CD102
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Genetics & Genomics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Analytical Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Rheumatology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Toxicology (AREA)
  • Pain & Pain Management (AREA)
  • General Engineering & Computer Science (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

The present invention relates to an intercellular adhesion molecules-3 ( ICAM-3 ) or a functional derivative of said molecule which, substantially free of natural contaminants, said derivative comprising a fragment of ICAM-3 selected from the group consisting of following sequences of aminoacids : the ID sequence, numbers 2,4 and 6, the functional derivative of the adhesion molecule-3 contains a sequence of aminoacids selected from the group consisting of D1, D1-2, D1-3, D1-4 and D1-5 of ICAM-3. the recombinant DNA molecule capable of encoding ICAM-3 or a functional derivative of it includes at least one fragment selected from the group consisting of the following sequences of nucleotides; the ID sequence, numbers 1, 3 and 5. This DNA recombinant molecule is capable of expressing ICAM-3 or a functional derivatives thereof in a cell. The characteristics of monoclonal antibody or the antibody fragment capable of binding to a molecule selected from the group consisting of ICAM-3 or a functional derivatives thereof lies in that the binding of this antibody to the molecule affects the capability of binding to a receptor molecule. The receptor is selected from LFA-1, MAC-1 and p 150.95. The hybridoma cell is capable of producing the said monoclonal antibody. The pharmaceutical compositions include an agent selected from a group which consists of an antibody capable binding to ICAM-3 ; a fragment of said antibody, said fragment being capable of binding to ICAM-3; ICAM-3; a functional derivative of ICAM-3 and a non-imunoglobulinic antagonist of ICAM-3, other than ICAM-1, ICAM-2 or a member of the CD-18 family. The pharmaceutical composition also comprises an immunosupressive agent.
RO93-01672A 1991-06-11 1992-06-11 Intercellular adhesion molecule-3 (icam-3), recombinant dna-molecule encoding the intercellular adhesion molecule -3, its antibodies, method for modelling biological functions, supression, identification, diagnosis and pharmaceutical compositions RO115415B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US71287991A 1991-06-11 1991-06-11
PCT/US1992/004896 WO1992022323A1 (en) 1991-06-11 1992-06-11 Intercellular adhesion molecule-3 and its binding ligands

Publications (1)

Publication Number Publication Date
RO115415B1 true RO115415B1 (en) 2000-02-28

Family

ID=24863928

Family Applications (1)

Application Number Title Priority Date Filing Date
RO93-01672A RO115415B1 (en) 1991-06-11 1992-06-11 Intercellular adhesion molecule-3 (icam-3), recombinant dna-molecule encoding the intercellular adhesion molecule -3, its antibodies, method for modelling biological functions, supression, identification, diagnosis and pharmaceutical compositions

Country Status (21)

Country Link
EP (1) EP0590051A4 (en)
JP (1) JP3288042B2 (en)
KR (2) KR100333120B1 (en)
CN (1) CN1188528C (en)
BG (1) BG61682B1 (en)
BR (1) BR9206142A (en)
CA (1) CA2110387A1 (en)
CZ (1) CZ283478B6 (en)
FI (1) FI935500A (en)
HU (1) HU217176B (en)
IE (1) IE921893A1 (en)
IL (1) IL102176A (en)
MX (1) MX9202804A (en)
NO (1) NO317658B1 (en)
NZ (1) NZ243114A (en)
RO (1) RO115415B1 (en)
RU (1) RU2130782C1 (en)
SK (1) SK279937B6 (en)
UA (1) UA27763C2 (en)
WO (1) WO1992022323A1 (en)
ZA (1) ZA924276B (en)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5629162A (en) * 1991-06-11 1997-05-13 The Center For Blood Research Method of identifying agents which modulate ICAM-3 binding to LFA-1
US5525487A (en) * 1992-01-27 1996-06-11 Icos Corporation DNA encoding I-CAM related protein
US5811517A (en) * 1992-01-27 1998-09-22 Icos Corporation ICAM-related protein variants
US5702917A (en) * 1992-01-27 1997-12-30 Icos Corporation Polynucleotides encoding human ICAM-4
WO1999018441A1 (en) * 1992-01-27 1999-04-15 Icos Corporation Icam-4 and diagnostic uses thereof
US6153395A (en) * 1992-01-27 2000-11-28 Icos Corporation ICAM-related protein
US5837822A (en) * 1992-01-27 1998-11-17 Icos Corporation Humanized antibodies specific for ICAM related protein
US5532127A (en) * 1992-01-27 1996-07-02 Icos Corporation Assay for 1-CAM related protein expression
US6818743B1 (en) 1992-01-27 2004-11-16 Icos Corporation I-CAM related protein
US5989843A (en) * 1992-01-27 1999-11-23 Icos Corporation Methods for identifying modulators of protein kinase C phosphorylation of ICAM-related protein
WO1993014776A1 (en) * 1992-01-27 1993-08-05 Icos Corporation Icam-related protein
US6100383A (en) * 1992-01-27 2000-08-08 Icos Corporation Fusion proteins comprising ICAM-R polypeptides and immunoglobulin constant regions
JPH07506007A (en) * 1993-01-22 1995-07-06 イコス　コーポレイション ICAM-related proteins
US6027922A (en) * 1993-11-02 2000-02-22 Innogenetics N.V. Human foam cells and methods for preparing them, monoclonal antibodies to said foam cells and their pharmaceutical and diagnostic use
US6884590B1 (en) 1994-02-11 2005-04-26 Cedars-Sinai Medical Center Methods of screening for ulcerative colitis and crohn's disease
US5681699A (en) * 1994-02-11 1997-10-28 Cedars-Sinai Medical Center Methods of diagnosing ulcerative colitis and Crohn's disease
US20020081294A1 (en) 1996-01-23 2002-06-27 Genentech, Inc. Co-administration of a thrombolytic and an anti-CD18 antibody in stroke
US5914112A (en) * 1996-01-23 1999-06-22 Genentech, Inc. Anti-CD18 antibodies in stroke
CN1132014C (en) * 1997-10-02 2003-12-24 艾科斯有限公司 ICAM-4 and diagnostic uses thereof
ES2270868T3 (en) 1999-08-13 2007-04-16 Biogen Idec Ma Inc. INHIBITORS OF CELL ADHESION.
US8980568B2 (en) 2001-10-11 2015-03-17 Aviva Biosciences Corporation Methods and compositions for detecting non-hematopoietic cells from a blood sample
US8986944B2 (en) 2001-10-11 2015-03-24 Aviva Biosciences Corporation Methods and compositions for separating rare cells from fluid samples
US7691591B2 (en) * 2002-09-20 2010-04-06 Stichting Katholieke Universiteit Methods of identifying and isolating cells expressing DC-sign
US7196112B2 (en) 2004-07-16 2007-03-27 Biogen Idec Ma Inc. Cell adhesion inhibitors
CA2657621A1 (en) 2006-07-14 2008-01-17 Aviva Biosciences Corporation Methods and compositions for detecting rare cells from a biological sample
WO2010062960A2 (en) 2008-11-26 2010-06-03 Cedars-Sinai Medical Center METHODS OF DETERMINING RESPONSIVENESS TO ANTI-TNFα THERAPY IN INFLAMMATORY BOWEL DISEASE
US9580752B2 (en) 2008-12-24 2017-02-28 Cedars-Sinai Medical Center Methods of predicting medically refractive ulcerative colitis (MR-UC) requiring colectomy
GB201016864D0 (en) 2010-10-06 2010-11-17 Univ Aston Therapeutic methods
KR20210157418A (en) 2013-03-27 2021-12-28 세다르스-신나이 메디칼 센터 Mitigation and reversal of fibrosis and inflammation by inhibition of tl1a function and related signaling pathways
WO2015010108A1 (en) 2013-07-19 2015-01-22 Cedars-Sinai Medical Center Signature of tl1a (tnfsf15) signaling pathway
KR102464372B1 (en) 2016-03-17 2022-11-04 세다르스-신나이 메디칼 센터 Methods of diagnosing inflammatory bowel disease through rnaset2

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE146222T1 (en) * 1989-03-09 1996-12-15 Blood Res Center INTERCELLULAR ADHESION MOLECULE-2 AND ITS BINDING LIGANDS

Also Published As

Publication number Publication date
FI935500A (en) 1994-02-09
KR100333120B1 (en) 2002-04-18
BG61682B1 (en) 1998-03-31
HU9303529D0 (en) 1994-04-28
IL102176A (en) 2001-09-13
RU2130782C1 (en) 1999-05-27
WO1992022323A1 (en) 1992-12-23
CZ283478B6 (en) 1998-04-15
CZ270293A3 (en) 1994-08-17
NZ243114A (en) 1995-03-28
BR9206142A (en) 1994-12-27
HUT66617A (en) 1994-12-28
JP3288042B2 (en) 2002-06-04
IE921893A1 (en) 1992-12-16
EP0590051A4 (en) 1994-10-12
UA27763C2 (en) 2000-10-16
NO317658B1 (en) 2004-11-29
IL102176A0 (en) 1993-01-14
SK139593A3 (en) 1994-10-05
BG98287A (en) 1994-08-30
CA2110387A1 (en) 1992-12-23
SK279937B6 (en) 1999-06-11
AU2237692A (en) 1993-01-12
JPH06509706A (en) 1994-11-02
FI935500A0 (en) 1993-12-08
MX9202804A (en) 1992-12-01
NO934491L (en) 1994-02-11
AU670243B2 (en) 1996-07-11
CN1069522A (en) 1993-03-03
NO934491D0 (en) 1993-12-09
KR100291844B1 (en) 2001-09-17
HU217176B (en) 1999-12-28
CN1188528C (en) 2005-02-09
ZA924276B (en) 1993-03-31
EP0590051A1 (en) 1994-04-06

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