RO115415B1 - Intercellular adhesion molecule-3 (icam-3), recombinant dna-molecule encoding the intercellular adhesion molecule -3, its antibodies, method for modelling biological functions, supression, identification, diagnosis and pharmaceutical compositions - Google Patents
Intercellular adhesion molecule-3 (icam-3), recombinant dna-molecule encoding the intercellular adhesion molecule -3, its antibodies, method for modelling biological functions, supression, identification, diagnosis and pharmaceutical compositionsInfo
- Publication number
- RO115415B1 RO115415B1 RO93-01672A RO9301672A RO115415B1 RO 115415 B1 RO115415 B1 RO 115415B1 RO 9301672 A RO9301672 A RO 9301672A RO 115415 B1 RO115415 B1 RO 115415B1
- Authority
- RO
- Romania
- Prior art keywords
- icam
- molecule
- intercellular adhesion
- binding
- fragment
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6881—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for tissue or cell typing, e.g. human leukocyte antigen [HLA] probes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70525—ICAM molecules, e.g. CD50, CD54, CD102
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2821—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against ICAM molecules, e.g. CD50, CD54, CD102
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
Abstract
The present invention relates to an intercellular adhesion molecules-3 ( ICAM-3 ) or a functional derivative of said molecule which, substantially free of natural contaminants, said derivative comprising a fragment of ICAM-3 selected from the group consisting of following sequences of aminoacids : the ID sequence, numbers 2,4 and 6, the functional derivative of the adhesion molecule-3 contains a sequence of aminoacids selected from the group consisting of D1, D1-2, D1-3, D1-4 and D1-5 of ICAM-3. the recombinant DNA molecule capable of encoding ICAM-3 or a functional derivative of it includes at least one fragment selected from the group consisting of the following sequences of nucleotides; the ID sequence, numbers 1, 3 and 5. This DNA recombinant molecule is capable of expressing ICAM-3 or a functional derivatives thereof in a cell. The characteristics of monoclonal antibody or the antibody fragment capable of binding to a molecule selected from the group consisting of ICAM-3 or a functional derivatives thereof lies in that the binding of this antibody to the molecule affects the capability of binding to a receptor molecule. The receptor is selected from LFA-1, MAC-1 and p 150.95. The hybridoma cell is capable of producing the said monoclonal antibody. The pharmaceutical compositions include an agent selected from a group which consists of an antibody capable binding to ICAM-3 ; a fragment of said antibody, said fragment being capable of binding to ICAM-3; ICAM-3; a functional derivative of ICAM-3 and a non-imunoglobulinic antagonist of ICAM-3, other than ICAM-1, ICAM-2 or a member of the CD-18 family. The pharmaceutical composition also comprises an immunosupressive agent.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US71287991A | 1991-06-11 | 1991-06-11 | |
PCT/US1992/004896 WO1992022323A1 (en) | 1991-06-11 | 1992-06-11 | Intercellular adhesion molecule-3 and its binding ligands |
Publications (1)
Publication Number | Publication Date |
---|---|
RO115415B1 true RO115415B1 (en) | 2000-02-28 |
Family
ID=24863928
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RO93-01672A RO115415B1 (en) | 1991-06-11 | 1992-06-11 | Intercellular adhesion molecule-3 (icam-3), recombinant dna-molecule encoding the intercellular adhesion molecule -3, its antibodies, method for modelling biological functions, supression, identification, diagnosis and pharmaceutical compositions |
Country Status (21)
Country | Link |
---|---|
EP (1) | EP0590051A4 (en) |
JP (1) | JP3288042B2 (en) |
KR (2) | KR100291844B1 (en) |
CN (1) | CN1188528C (en) |
BG (1) | BG61682B1 (en) |
BR (1) | BR9206142A (en) |
CA (1) | CA2110387A1 (en) |
CZ (1) | CZ283478B6 (en) |
FI (1) | FI935500A (en) |
HU (1) | HU217176B (en) |
IE (1) | IE921893A1 (en) |
IL (1) | IL102176A (en) |
MX (1) | MX9202804A (en) |
NO (1) | NO317658B1 (en) |
NZ (1) | NZ243114A (en) |
RO (1) | RO115415B1 (en) |
RU (1) | RU2130782C1 (en) |
SK (1) | SK279937B6 (en) |
UA (1) | UA27763C2 (en) |
WO (1) | WO1992022323A1 (en) |
ZA (1) | ZA924276B (en) |
Families Citing this family (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5891841A (en) * | 1991-06-11 | 1999-04-06 | The Center For Blood Research, Inc. | Methods of using intercellular adhesion molecule-3 (ICAM-3), antibodies thereto, and soluble fragments thereof |
US6818743B1 (en) | 1992-01-27 | 2004-11-16 | Icos Corporation | I-CAM related protein |
JP3616090B2 (en) * | 1992-01-27 | 2005-02-02 | イコス コーポレイション | Intercellular adhesion molecule-related protein |
US5532127A (en) * | 1992-01-27 | 1996-07-02 | Icos Corporation | Assay for 1-CAM related protein expression |
US5837822A (en) * | 1992-01-27 | 1998-11-17 | Icos Corporation | Humanized antibodies specific for ICAM related protein |
US5525487A (en) * | 1992-01-27 | 1996-06-11 | Icos Corporation | DNA encoding I-CAM related protein |
US5989843A (en) * | 1992-01-27 | 1999-11-23 | Icos Corporation | Methods for identifying modulators of protein kinase C phosphorylation of ICAM-related protein |
US5702917A (en) * | 1992-01-27 | 1997-12-30 | Icos Corporation | Polynucleotides encoding human ICAM-4 |
WO1999018441A1 (en) * | 1992-01-27 | 1999-04-15 | Icos Corporation | Icam-4 and diagnostic uses thereof |
US6100383A (en) * | 1992-01-27 | 2000-08-08 | Icos Corporation | Fusion proteins comprising ICAM-R polypeptides and immunoglobulin constant regions |
US5811517A (en) * | 1992-01-27 | 1998-09-22 | Icos Corporation | ICAM-related protein variants |
US6153395A (en) * | 1992-01-27 | 2000-11-28 | Icos Corporation | ICAM-related protein |
JPH07506007A (en) * | 1993-01-22 | 1995-07-06 | イコス コーポレイション | ICAM-related proteins |
US6027922A (en) * | 1993-11-02 | 2000-02-22 | Innogenetics N.V. | Human foam cells and methods for preparing them, monoclonal antibodies to said foam cells and their pharmaceutical and diagnostic use |
US5681699A (en) * | 1994-02-11 | 1997-10-28 | Cedars-Sinai Medical Center | Methods of diagnosing ulcerative colitis and Crohn's disease |
US6884590B1 (en) | 1994-02-11 | 2005-04-26 | Cedars-Sinai Medical Center | Methods of screening for ulcerative colitis and crohn's disease |
US5914112A (en) * | 1996-01-23 | 1999-06-22 | Genentech, Inc. | Anti-CD18 antibodies in stroke |
US20020081294A1 (en) | 1996-01-23 | 2002-06-27 | Genentech, Inc. | Co-administration of a thrombolytic and an anti-CD18 antibody in stroke |
AU735917B2 (en) * | 1997-10-02 | 2001-07-19 | Icos Corporation | ICAM-4 and diagnostic uses thereof |
CA2380817A1 (en) | 1999-08-13 | 2001-02-22 | Biogen, Inc. | Cell adhesion inhibitors |
US8980568B2 (en) | 2001-10-11 | 2015-03-17 | Aviva Biosciences Corporation | Methods and compositions for detecting non-hematopoietic cells from a blood sample |
US8986944B2 (en) | 2001-10-11 | 2015-03-24 | Aviva Biosciences Corporation | Methods and compositions for separating rare cells from fluid samples |
US7691591B2 (en) * | 2002-09-20 | 2010-04-06 | Stichting Katholieke Universiteit | Methods of identifying and isolating cells expressing DC-sign |
US7196112B2 (en) | 2004-07-16 | 2007-03-27 | Biogen Idec Ma Inc. | Cell adhesion inhibitors |
WO2008008515A2 (en) | 2006-07-14 | 2008-01-17 | Aviva Biosciences Corporation | Methods and compositions for detecting rare cells from a biological sample |
US20110229471A1 (en) | 2008-11-26 | 2011-09-22 | Cedars-Sinai Medical Center | Methods of determining responsiveness to anti-tnf alpha therapy in inflammatory bowel disease |
US9580752B2 (en) | 2008-12-24 | 2017-02-28 | Cedars-Sinai Medical Center | Methods of predicting medically refractive ulcerative colitis (MR-UC) requiring colectomy |
GB201016864D0 (en) | 2010-10-06 | 2010-11-17 | Univ Aston | Therapeutic methods |
EP4285988A3 (en) | 2013-03-27 | 2024-03-06 | Cedars-Sinai Medical Center | Treating fibrosis by inhibiting tl1a |
WO2015010108A1 (en) | 2013-07-19 | 2015-01-22 | Cedars-Sinai Medical Center | Signature of tl1a (tnfsf15) signaling pathway |
CN109462996A (en) | 2016-03-17 | 2019-03-12 | 西达-赛奈医疗中心 | The method for diagnosing inflammatory bowel disease by RNASET2 |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NZ232833A (en) * | 1989-03-09 | 1993-05-26 | Blood Res Center | Intercellular adhesion molecule-2 (icam-2) and functional derivatives thereof |
-
1992
- 1992-06-11 KR KR1019930703828A patent/KR100291844B1/en not_active IP Right Cessation
- 1992-06-11 WO PCT/US1992/004896 patent/WO1992022323A1/en not_active Application Discontinuation
- 1992-06-11 ZA ZA924276A patent/ZA924276B/en unknown
- 1992-06-11 KR KR1020007000978A patent/KR100333120B1/en not_active IP Right Cessation
- 1992-06-11 CA CA002110387A patent/CA2110387A1/en not_active Abandoned
- 1992-06-11 UA UA93003881A patent/UA27763C2/en unknown
- 1992-06-11 JP JP50099993A patent/JP3288042B2/en not_active Expired - Fee Related
- 1992-06-11 CZ CS932702A patent/CZ283478B6/en not_active IP Right Cessation
- 1992-06-11 IL IL10217692A patent/IL102176A/en not_active IP Right Cessation
- 1992-06-11 RO RO93-01672A patent/RO115415B1/en unknown
- 1992-06-11 CN CNB921051263A patent/CN1188528C/en not_active Expired - Fee Related
- 1992-06-11 SK SK1395-93A patent/SK279937B6/en unknown
- 1992-06-11 MX MX9202804A patent/MX9202804A/en not_active Application Discontinuation
- 1992-06-11 RU RU93058655A patent/RU2130782C1/en not_active IP Right Cessation
- 1992-06-11 EP EP19920914138 patent/EP0590051A4/en not_active Ceased
- 1992-06-11 BR BR9206142A patent/BR9206142A/en not_active Application Discontinuation
- 1992-06-11 NZ NZ243114A patent/NZ243114A/en unknown
- 1992-07-01 IE IE189392A patent/IE921893A1/en not_active Application Discontinuation
-
1993
- 1993-12-08 FI FI935500A patent/FI935500A/en unknown
- 1993-12-09 NO NO934491A patent/NO317658B1/en not_active IP Right Cessation
- 1993-12-10 HU HU9303529A patent/HU217176B/en not_active IP Right Cessation
- 1993-12-10 BG BG98287A patent/BG61682B1/en unknown
Also Published As
Publication number | Publication date |
---|---|
CN1188528C (en) | 2005-02-09 |
ZA924276B (en) | 1993-03-31 |
SK279937B6 (en) | 1999-06-11 |
EP0590051A4 (en) | 1994-10-12 |
UA27763C2 (en) | 2000-10-16 |
MX9202804A (en) | 1992-12-01 |
NO934491L (en) | 1994-02-11 |
WO1992022323A1 (en) | 1992-12-23 |
BR9206142A (en) | 1994-12-27 |
IL102176A (en) | 2001-09-13 |
EP0590051A1 (en) | 1994-04-06 |
KR100333120B1 (en) | 2002-04-18 |
FI935500A (en) | 1994-02-09 |
JPH06509706A (en) | 1994-11-02 |
RU2130782C1 (en) | 1999-05-27 |
NO317658B1 (en) | 2004-11-29 |
HU9303529D0 (en) | 1994-04-28 |
KR100291844B1 (en) | 2001-09-17 |
BG61682B1 (en) | 1998-03-31 |
AU670243B2 (en) | 1996-07-11 |
CN1069522A (en) | 1993-03-03 |
CA2110387A1 (en) | 1992-12-23 |
HU217176B (en) | 1999-12-28 |
BG98287A (en) | 1994-08-30 |
IL102176A0 (en) | 1993-01-14 |
SK139593A3 (en) | 1994-10-05 |
NZ243114A (en) | 1995-03-28 |
CZ283478B6 (en) | 1998-04-15 |
NO934491D0 (en) | 1993-12-09 |
AU2237692A (en) | 1993-01-12 |
JP3288042B2 (en) | 2002-06-04 |
HUT66617A (en) | 1994-12-28 |
CZ270293A3 (en) | 1994-08-17 |
IE921893A1 (en) | 1992-12-16 |
FI935500A0 (en) | 1993-12-08 |
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