PT98842B - Processo para a preparacao de derivados de fenilalanina e de fenetilamina n-substituidos com cicloalquilo e policicloalquilo, alfa-substituidos com arilo e heteroarilo e de composicoes farmaceuticas que os contem - Google Patents

Processo para a preparacao de derivados de fenilalanina e de fenetilamina n-substituidos com cicloalquilo e policicloalquilo, alfa-substituidos com arilo e heteroarilo e de composicoes farmaceuticas que os contem Download PDF

Info

Publication number
PT98842B
PT98842B PT98842A PT9884291A PT98842B PT 98842 B PT98842 B PT 98842B PT 98842 A PT98842 A PT 98842A PT 9884291 A PT9884291 A PT 9884291A PT 98842 B PT98842 B PT 98842B
Authority
PT
Portugal
Prior art keywords
methyl
compound
amino
mmol
acid
Prior art date
Application number
PT98842A
Other languages
English (en)
Portuguese (pt)
Other versions
PT98842A (pt
Inventor
David Christopher Herwell
David Charles Rees
Reginald Stewart Richardsen
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Publication of PT98842A publication Critical patent/PT98842A/pt
Publication of PT98842B publication Critical patent/PT98842B/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/595—Gastrins; Cholecystokinins [CCK]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/20—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals substituted additionally by nitrogen atoms, e.g. tryptophane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C07K5/06156—Dipeptides with the first amino acid being heterocyclic and Trp-amino acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Endocrinology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Indole Compounds (AREA)
PT98842A 1990-08-31 1991-08-30 Processo para a preparacao de derivados de fenilalanina e de fenetilamina n-substituidos com cicloalquilo e policicloalquilo, alfa-substituidos com arilo e heteroarilo e de composicoes farmaceuticas que os contem PT98842B (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US57662890A 1990-08-31 1990-08-31
US72665591A 1991-07-12 1991-07-12

Publications (2)

Publication Number Publication Date
PT98842A PT98842A (pt) 1992-08-31
PT98842B true PT98842B (pt) 1999-01-29

Family

ID=27077012

Family Applications (1)

Application Number Title Priority Date Filing Date
PT98842A PT98842B (pt) 1990-08-31 1991-08-30 Processo para a preparacao de derivados de fenilalanina e de fenetilamina n-substituidos com cicloalquilo e policicloalquilo, alfa-substituidos com arilo e heteroarilo e de composicoes farmaceuticas que os contem

Country Status (9)

Country Link
EP (1) EP0547178A4 (fr)
JP (1) JPH06502627A (fr)
KR (1) KR100222634B1 (fr)
CA (1) CA2088195A1 (fr)
IE (1) IE67290B1 (fr)
NO (1) NO312298B1 (fr)
NZ (1) NZ239595A (fr)
PT (1) PT98842B (fr)
WO (1) WO1992004045A1 (fr)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5217957A (en) * 1991-08-20 1993-06-08 Warner-Lambert Company Cholecystokinin antagonists useful for treating depression
US5380872A (en) * 1992-07-14 1995-01-10 Glaxo Inc. Modulators of cholecystokinin
WO1994018229A1 (fr) * 1993-02-03 1994-08-18 Fisons Corporation Derives de 1,2,4 triazone et leur utilisation en therapeutique
GB9304500D0 (en) * 1993-03-05 1993-04-21 Glaxo Spa Heterocyclic compounds
JP2001500850A (ja) 1996-08-22 2001-01-23 ワーナー―ランバート・コンパニー 非―ペプチドボンベシン受容体アンタゴニスト
US6645968B2 (en) 1999-08-03 2003-11-11 Abbott Laboratories Potassium channel openers
US6846836B2 (en) 2003-04-18 2005-01-25 Bristol-Myers Squibb Company N-substituted phenylurea inhibitors of mitochondrial F1F0 ATP hydrolase
WO2005077344A2 (fr) 2003-08-29 2005-08-25 The Brigham And Women's Hospital, Inc. Inhibiteurs de la necrose cellulaire
US8604244B2 (en) 2010-07-02 2013-12-10 Reviva Pharmaceuticals, Inc. Compositions, synthesis, and methods of using cycloalkylmethylamine derivatives
EP2066329B1 (fr) 2006-09-15 2017-09-06 Reviva Pharmaceuticals, Inc. Synthèse, utilisation et compositions de cyclobutylméthylamines
EP3000468A1 (fr) 2008-12-23 2016-03-30 President and Fellows of Harvard College Inhibiteurs à petite molécule de la nécroptose
GB0919194D0 (en) 2009-11-02 2009-12-16 Lytix Biopharma As Compounds
US20160024098A1 (en) 2013-03-15 2016-01-28 President And Fellows Of Harvard College Hybrid necroptosis inhibitors
WO2016094846A1 (fr) 2014-12-11 2016-06-16 President And Fellows Of Harvard College Inhibiteurs de nécrose cellulaire et procédés associés

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4757151A (en) * 1985-11-14 1988-07-12 Warner-Lambert Company 2-substituted-[2-substituted-amino]-N-arylalkyl-3-[indol-3-yl]
CA1291031C (fr) * 1985-12-23 1991-10-22 Nikolaas C.J. De Jaeger Methode pour la detection de liants specifiques et des substances liables par ceux-ci
US4814463A (en) * 1985-12-31 1989-03-21 Biomeasure, Inc. CCK antagonists
FR2606963B1 (fr) * 1986-11-14 1989-01-13 Cit Alcatel Boitier de repeteur sous-marin
WO1989010355A1 (fr) * 1988-04-05 1989-11-02 Abbott Laboratories Derives de tryptophan utilises comme antagonistes cck
NZ234264A (en) * 1989-06-29 1993-05-26 Warner Lambert Co N-substituted cycloalkyl and polycycloalkyl alpha-substituted trp-phe- and phenethylamine derivatives, and pharmaceutical compositions
US5244915A (en) * 1990-08-31 1993-09-14 Warner-Lambert Company Amico acid derivatives cyclized at the c-terminal

Also Published As

Publication number Publication date
NO930709D0 (no) 1993-02-26
CA2088195A1 (fr) 1992-03-01
NO312298B1 (no) 2002-04-22
EP0547178A4 (en) 1994-07-06
NZ239595A (en) 1994-06-27
AU651390B2 (en) 1994-07-21
JPH06502627A (ja) 1994-03-24
WO1992004045A1 (fr) 1992-03-19
KR930703349A (ko) 1993-11-29
PT98842A (pt) 1992-08-31
KR100222634B1 (ko) 1999-10-01
IE67290B1 (en) 1996-03-20
IE913077A1 (en) 1992-03-11
EP0547178A1 (fr) 1993-06-23
NO930709L (no) 1993-04-15
AU8749291A (en) 1992-03-30

Similar Documents

Publication Publication Date Title
AU658377B2 (en) Alpha-substituted tryptophane dipeptoid derivatives
ES2229202T3 (es) Derivados n-sustituidos cicloalqilo y policicloalquilo de trp-phe- y fenetilamina alfa sustituidas.
PT98842B (pt) Processo para a preparacao de derivados de fenilalanina e de fenetilamina n-substituidos com cicloalquilo e policicloalquilo, alfa-substituidos com arilo e heteroarilo e de composicoes farmaceuticas que os contem
US5622983A (en) N-substituted cycloalkyl and polycycloalkyl α-substituted Trp-Phe- and phenethylamine derivatives
CA2088980C (fr) Pro-medicaments pour des antagonistes de la cck
US5846942A (en) Cholecystokinin antagonists, their preparation and therapeutic use
US5278316A (en) N-substituted cycloalkyl and polycycloalkyl alpha-substituted Trp-Phe- and phenethylamine derivatives
US5574013A (en) N-substituted cycloalkyl and polycycloalkyl alpha-substituted Trp derivatives
US5244905A (en) N-substituted cycloalkyl and polycycloalkyl polyhydro-β-carboline-phenylalanine- and phenethylamine derivatives
PT98841A (pt) Processo para a preparacao de analogos de aminoacidos como antagonistas da colecistoquinina central (cck) e de composicoes farmaceuticas que os contem
US5340825A (en) Pro drugs for CCK antagonists
US5580896A (en) Treatment of pain and colorectal cancer with dipeptoids of α-substituted Trp-Phe derivatives
AU651390C (en) Novel cholecystokinin antagonists, their preparation and therapeutic use

Legal Events

Date Code Title Description
BB1A Laying open of patent application

Effective date: 19920424

FG3A Patent granted, date of granting

Effective date: 19981030

MM3A Annulment or lapse

Effective date: 20060502