PT97363A - Processo de preparacao de benzimidazoles substituidos e de composicoes farmaceuticas que os contem - Google Patents

Processo de preparacao de benzimidazoles substituidos e de composicoes farmaceuticas que os contem

Info

Publication number
PT97363A
PT97363A PT97363A PT9736391A PT97363A PT 97363 A PT97363 A PT 97363A PT 97363 A PT97363 A PT 97363A PT 9736391 A PT9736391 A PT 9736391A PT 97363 A PT97363 A PT 97363A
Authority
PT
Portugal
Prior art keywords
contain
pharmaceutical compositions
preparing substituted
substituted benzimidazoles
benzimidazoles
Prior art date
Application number
PT97363A
Other languages
English (en)
Other versions
PT97363B (pt
Inventor
Joseph Weinstock
Robert Gene Franz
Original Assignee
Smithkline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp
Publication of PT97363A publication Critical patent/PT97363A/pt
Publication of PT97363B publication Critical patent/PT97363B/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/08—Radicals containing only hydrogen and carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
PT97363A 1990-04-13 1991-04-12 Processo de preparacao de benzimidazoles substituidos e de composicoes farmaceuticas que os contem PT97363B (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US50926890A 1990-04-13 1990-04-13

Publications (2)

Publication Number Publication Date
PT97363A true PT97363A (pt) 1992-01-31
PT97363B PT97363B (pt) 1998-08-31

Family

ID=24025931

Family Applications (1)

Application Number Title Priority Date Filing Date
PT97363A PT97363B (pt) 1990-04-13 1991-04-12 Processo de preparacao de benzimidazoles substituidos e de composicoes farmaceuticas que os contem

Country Status (10)

Country Link
US (1) US5294631A (pt)
EP (1) EP0525129A4 (pt)
JP (1) JPH05507469A (pt)
AU (1) AU7759591A (pt)
CA (1) CA2077897A1 (pt)
IE (1) IE911220A1 (pt)
NZ (1) NZ237790A (pt)
PT (1) PT97363B (pt)
WO (1) WO1991016313A1 (pt)
ZA (1) ZA912656B (pt)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU653524B2 (en) * 1990-06-08 1994-10-06 Roussel-Uclaf New imidazole derivatives, their preparation process, the new intermediates obtained, their use as medicaments and the pharmaceutical compositions containing them
GB9027211D0 (en) 1990-12-14 1991-02-06 Smithkline Beecham Plc Medicaments
GB9027212D0 (en) 1990-12-14 1991-02-06 Smithkline Beecham Plc Medicaments
TW284688B (pt) * 1991-11-20 1996-09-01 Takeda Pharm Industry Co Ltd
JP2682353B2 (ja) * 1991-11-20 1997-11-26 武田薬品工業株式会社 経口用医薬組成物およびその製造法
GB9200245D0 (en) * 1992-01-07 1992-02-26 British Bio Technology Compounds
DK40192D0 (da) * 1992-03-26 1992-03-26 Neurosearch As Imidazolforbindelser, deres fremstilling og anvendelse
WO1994020460A1 (en) * 1993-03-11 1994-09-15 Smithkline Beecham Corporation Chemical compounds
CZ154994A3 (en) * 1993-07-02 1995-09-13 Senju Pharma Co Visual hypotensive agent
ZA945190B (en) * 1993-07-30 1995-02-24 Kotobuki Seiyaku Co Ltd Carboxymethylidenecycloheptimidazole derivatives method or manufacturing the same and therapeutic agents containing these compounds
KR100516080B1 (ko) * 1995-12-28 2006-09-20 후지사와 야꾸힝 고교 가부시키가이샤 벤즈이미다졸유도체
EA002357B1 (ru) * 1995-12-28 2002-04-25 Фудзисава Фармасьютикал Ко., Лтд. Производные бензимидазола
EP2223920A3 (en) 1996-06-19 2011-09-28 Aventis Pharma Limited Substituted azabicyclic compounds
US6184235B1 (en) 1996-08-14 2001-02-06 Warner-Lambert Company 2-phenyl benzimidazole derivatives as MCP-1 antagonists
AU7270798A (en) * 1997-05-01 1998-11-24 Eli Lilly And Company Antithrombotic agents
TW453999B (en) 1997-06-27 2001-09-11 Fujisawa Pharmaceutical Co Benzimidazole derivatives
RU2243226C2 (ru) * 1999-06-22 2004-12-27 НьюроСёрч А/С Новые производные бензимидазола и содержащие эти соединения фармацевтические композиции
ATE253915T1 (de) 1999-06-30 2003-11-15 Merck & Co Inc Src-kinase hemmende verbindungen
JP2003503354A (ja) 1999-06-30 2003-01-28 メルク エンド カムパニー インコーポレーテッド Ｓｒｃキナーゼ阻害剤化合物
AU6605200A (en) 1999-06-30 2001-01-31 Merck & Co., Inc. Src kinase inhibitor compounds
SE9903028D0 (sv) 1999-08-27 1999-08-27 Astra Ab New use
US6448281B1 (en) 2000-07-06 2002-09-10 Boehringer Ingelheim (Canada) Ltd. Viral polymerase inhibitors
AU2003902860A0 (en) * 2003-06-06 2003-06-26 Daicel Chemical Industries, Ltd Benzimidazole compounds
WO2005002520A2 (en) * 2003-07-01 2005-01-13 Merck & Co., Inc. Ophthalmic compositions for treating ocular hypertension
EP2626354A1 (en) 2004-02-20 2013-08-14 Boehringer Ingelheim International GmbH Viral polymerase inhibitors
AU2005286717A1 (en) * 2004-09-21 2006-03-30 Wyeth Benzimidazole acetic acids exhibiting CRTH2 receptor antagonism and uses thereof
EP1828144A2 (en) * 2004-11-12 2007-09-05 OSI Pharmaceuticals, Inc. Integrin antagonists useful as anticancer agents
ES2264641B1 (es) * 2005-06-17 2008-03-01 Quimica Sintetica, S.A. Procedimiento para la obtencion de derivados de bencimidazol y sus intermedios.
AU2007227681A1 (en) * 2006-03-15 2007-09-27 Wyeth N-substituted-azacyclylamines as histamine-3 antagonists
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
EP2170930B3 (en) 2007-06-04 2013-10-02 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
TWI406850B (zh) * 2007-06-05 2013-09-01 Theravance Inc 雙效苯并咪唑抗高血壓劑
US20100190826A1 (en) * 2007-07-24 2010-07-29 Akio Kakefuda Benzimidazole derivative
JP2011522828A (ja) 2008-06-04 2011-08-04 シナジー ファーマシューティカルズ インコーポレイテッド 胃腸障害、炎症、癌、およびその他の障害の治療のために有用なグアニル酸シクラーゼのアゴニスト
AU2009270833B2 (en) 2008-07-16 2015-02-19 Bausch Health Ireland Limited Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
CA2905435A1 (en) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Compositions useful for the treatment of gastrointestinal disorders
WO2014151206A1 (en) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase and their uses
EP3004138B1 (en) 2013-06-05 2024-03-13 Bausch Health Ireland Limited Ultra-pure agonists of guanylate cyclase c, method of making and using same
WO2015005615A1 (en) * 2013-07-09 2015-01-15 Cj Healthcare Corporation Method for preparation of benzimidazole derivatives
KR101472686B1 (ko) 2013-07-09 2014-12-16 씨제이헬스케어 주식회사 벤즈이미다졸 유도체의 제조방법
WO2023160569A1 (en) * 2022-02-24 2023-08-31 Guangdong Newopp Biopharmaceuticals Co., Ltd. Carboxamide compounds as pge2 receptor antagonists
CN117720472A (zh) * 2022-09-09 2024-03-19 苏州沪云新药研发股份有限公司 一种苯并咪唑类化合物及其制备方法和应用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5179112A (en) * 1985-04-17 1993-01-12 Ici Americas Inc. Heterocyclic amide derivatives and pharmaceutical use
US4714762A (en) * 1986-10-31 1987-12-22 Warner-Lambert Company Antiarteriosclerotic substituted benzimidazol-2-yl-and 3H-imidazo[4,5-b]pyridin-2-yl-phenoxy-alkanoic acids and salts and esters thereof
DE3928177A1 (de) * 1989-04-08 1991-02-28 Thomae Gmbh Dr K Benzimidazole, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
GB8911854D0 (en) * 1989-05-23 1989-07-12 Ici Plc Heterocyclic compounds
US5128359A (en) * 1990-02-16 1992-07-07 Laboratoires Upsa Benzimidazole and azabenzimidazole derivatives which are thromboxane receptor antagonists, their methods of preparation
US5191086A (en) * 1991-03-19 1993-03-02 E.R. Squibb & Sons, Inc. Imidazole and benzimidazole derivatives
US5177074A (en) * 1991-03-26 1993-01-05 Merck & Co., Inc. Angiotensin ii antagonists incorporating a substituted thiophene or furan

Also Published As

Publication number Publication date
US5294631A (en) 1994-03-15
NZ237790A (en) 1993-12-23
EP0525129A1 (en) 1993-02-03
PT97363B (pt) 1998-08-31
EP0525129A4 (en) 1993-03-24
JPH05507469A (ja) 1993-10-28
AU7759591A (en) 1991-11-11
ZA912656B (en) 1992-03-25
CA2077897A1 (en) 1991-10-14
WO1991016313A1 (en) 1991-10-31
IE911220A1 (en) 1991-10-23

Similar Documents

Publication Publication Date Title
PT97363A (pt) Processo de preparacao de benzimidazoles substituidos e de composicoes farmaceuticas que os contem
PT96438A (pt) Processo para preparacao de anti-oxidante lipideo-selectivos e de composicoes farmaceuticas que os contem
PT98369A (pt) Processo para a preparacao de azois substituidos e de composicoes farmaceuticas que os contem
PT89793A (pt) Processo de preparacao de derivados de quinolina substituidos e de composicoes farmaceuticas que os contem
PT99671A (pt) Processo para a preparacao de heparosanos-n,o-sulfatados e de composicoes farmaceuticas que os contem
PT93094A (pt) Processo para a preparacao de 1,3-oxatiolanos substituidos e de composicoes farmaceuticas que os contem
PT99227A (pt) Processo para a preparacao de derivados da quinazolina e de composicoes farmaceuticas que os contem
PT97899A (pt) Processo para a preparacao de novos derivados de imidazol e de composicoes farmaceuticas que os contem
PT88993A (pt) Processo de preparacao de compostos azaciclicos e de composicoes farmaceuticas que os contem
PT84569B (pt) Processo para a preparacao de tiazepinas e de composicoes farmaceuticas que os contem
MX9203027A (es) Derivados heterociclicos de acilaminotiazoles y composicines farmaceuticas que los contienen.
PT97520A (pt) Processo para a preparacao de analogos de nucleosidos derivados de 1,3-oxatiolano e de composicoes farmaceuticas que os contem
PT97437A (pt) Processo de preparacao de derivados de hidrato de carbono e de composicoes farmaceuticas que os contem
PT97114A (pt) Processo para a preparacao de derivados de hidantoina e de composicoes farmaceuticas que os contem
PT98365A (pt) Processo para a preparacao de novos derivados de oxalilo e de composicoes farmaceuticas que os contem
PT98529A (pt) Processo para a preparacao de derivados de acetamida e de composicoes farmaceuticas que os contem
PT93067A (pt) Processo para a preparacao de derivados de 2-hidroxiacidos alifaticos e de eteres de 1-benzil-3-hidroximetilindazol, e de composicoes farmaceuticas que os contem
PT98059A (pt) Processo de preparacao d derivados de tetrapeptidos agonistas do receptor da colecistoquinina e de composicoes farmaceuticas que os contem
PT93290A (pt) Processo para a preparacao de novos eteres heterociclicos e de composicoes farmaceuticas que os contem
PT89659A (pt) Processo para a preparacao de {(5(6) (1h-azole-1-ilmetil)benzimidazole}-carbamatos e de composicoes farmaceuticas que os contem
PT89792A (pt) Processo de preparacao de derivados da quinolina substituidos e de composicoes farmaceuticas que os contem
PT89790A (pt) Processo de preparacao de derivados da quinolina substituidos e de composicoes farmaceuticas que os contem
PT98816A (pt) Processo para a preparacao de tienodiazepinas e de composicoes farmaceuticas que as contem
PT97133A (pt) Processo para a preparacao de derivados da xantina que constituem agentes selectivos receptores da adenosina e de composicoes farmaceuticas que os contem
PT98697A (pt) Processo para a preparacao de compostos macrociclicos e de composicoes farmaceuticas que os contem

Legal Events

Date Code Title Description
BB1A Laying open of patent application

Effective date: 19910912

FG3A Patent granted, date of granting

Effective date: 19980504

MM3A Annulment or lapse

Free format text: LAPSE DUE TO NON-PAYMENT OF FEES

Effective date: 19991130