PT973040E - Detector e dispositivo de discriminacao de canais de ioes - Google Patents

Detector e dispositivo de discriminacao de canais de ioes

Info

Publication number
PT973040E
PT973040E PT99113933T PT99113933T PT973040E PT 973040 E PT973040 E PT 973040E PT 99113933 T PT99113933 T PT 99113933T PT 99113933 T PT99113933 T PT 99113933T PT 973040 E PT973040 E PT 973040E
Authority
PT
Portugal
Prior art keywords
detector
optical
ioes
channels
ball lens
Prior art date
Application number
PT99113933T
Other languages
English (en)
Inventor
Peter J Coassin
Roger Y Tsien
Andrew A Pham
Alec Tate Harootunian
Minh Vuong
Original Assignee
Vertex Pharma San Diego Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/118,728 external-priority patent/US6608671B2/en
Priority claimed from US09/122,544 external-priority patent/US6349160B2/en
Application filed by Vertex Pharma San Diego Llc filed Critical Vertex Pharma San Diego Llc
Publication of PT973040E publication Critical patent/PT973040E/pt

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6452—Individual samples arranged in a regular 2D-array, e.g. multiwell plates
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N2021/6417—Spectrofluorimetric devices
    • G01N2021/6419—Excitation at two or more wavelengths
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N2021/6417—Spectrofluorimetric devices
    • G01N2021/6421—Measuring at two or more wavelengths
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N2021/6463—Optics
    • G01N2021/6478—Special lenses
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N2021/6484—Optical fibres
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2201/00—Features of devices classified in G01N21/00
    • G01N2201/06—Illumination; Optics
    • G01N2201/063—Illuminating optical parts
    • G01N2201/0638—Refractive parts
    • G01N2201/0639—Sphere lens

Landscapes

  • Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Physics & Mathematics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Analysing Materials By The Use Of Radiation (AREA)
  • Testing Of Optical Devices Or Fibers (AREA)
  • Treatment Of Water By Ion Exchange (AREA)
  • Optical Measuring Cells (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Inspection Of Paper Currency And Valuable Securities (AREA)
  • Alarm Systems (AREA)
  • Burglar Alarm Systems (AREA)
  • Light Guides In General And Applications Therefor (AREA)
PT99113933T 1998-07-17 1999-07-16 Detector e dispositivo de discriminacao de canais de ioes PT973040E (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/118,728 US6608671B2 (en) 1998-07-17 1998-07-17 Detector and screening device for ion channels
US09/122,544 US6349160B2 (en) 1998-07-24 1998-07-24 Detector and screening device for ion channels

Publications (1)

Publication Number Publication Date
PT973040E true PT973040E (pt) 2004-04-30

Family

ID=26816682

Family Applications (1)

Application Number Title Priority Date Filing Date
PT99113933T PT973040E (pt) 1998-07-17 1999-07-16 Detector e dispositivo de discriminacao de canais de ioes

Country Status (10)

Country Link
EP (2) EP0973040B1 (pt)
JP (1) JP2002520615A (pt)
AT (2) ATE255727T1 (pt)
AU (1) AU5108199A (pt)
CA (1) CA2278045A1 (pt)
DE (2) DE69913257T2 (pt)
DK (1) DK0973040T3 (pt)
ES (1) ES2210911T3 (pt)
PT (1) PT973040E (pt)
WO (1) WO2000004366A1 (pt)

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US6221612B1 (en) 1997-08-01 2001-04-24 Aurora Biosciences Corporation Photon reducing agents for use in fluorescence assays
US6214563B1 (en) 1997-08-01 2001-04-10 Aurora Biosciences Corporation Photon reducing agents for reducing undesired light emission in assays
US6200762B1 (en) 1997-08-01 2001-03-13 Aurora Biosciences Corporation Photon reducing agents and compositions for fluorescence assays
US6519032B1 (en) * 1998-04-03 2003-02-11 Symyx Technologies, Inc. Fiber optic apparatus and use thereof in combinatorial material science
GB9915034D0 (en) 1999-06-29 1999-08-25 Cambridge Imaging Ltd Improved assay analysis
DK1081495T3 (da) * 1999-09-01 2004-06-14 Invitrogen Corp Fotondæmpende midler til fluorescensassays
US6784982B1 (en) 1999-11-04 2004-08-31 Regents Of The University Of Minnesota Direct mapping of DNA chips to detector arrays
US6867851B2 (en) 1999-11-04 2005-03-15 Regents Of The University Of Minnesota Scanning of biological samples
DE10057245A1 (de) * 1999-12-11 2001-06-13 Qualico Gmbh Vorrichtung zum Erfassen von Eigenschaften einer bewegten Papierbahn
WO2002093144A1 (en) * 2001-05-10 2002-11-21 Regents Of The University Of Minnesota Imaging of biological samples using electronic light detector
WO2003006103A2 (en) * 2001-07-12 2003-01-23 Merck & Co., Inc. Electrical field stimulation of eukaryotic cells
AU2003245302A1 (en) * 2002-05-17 2003-12-02 Applera Corporation Apparatus and method for differentiating multiple fluorescence signals by excitation wavelength
DE10322443A1 (de) * 2003-05-19 2004-12-30 PRO DESIGN Gesellschaft für Produktentwicklung mbH Multifunktioneller Reader für Biochips
ITMI20050114A1 (it) * 2005-01-27 2006-07-28 Milano Politecnico Apparato e metodo per la stimolazione e la rilevazione ottica in maniera non invasiva dell'attivita' elettrica di almeno una cellula
US7924425B2 (en) 2005-06-27 2011-04-12 The United States Of America As Represented By The Department Of Health And Human Services Spatially selective fixed-optics multicolor fluorescence detection system for a multichannel microfluidic device, and method for detection
DE102007047093B4 (de) * 2007-10-01 2010-07-01 Ferton Holding S.A. Vorrichtung zur Messung von Fluoreszenzstrahlung an biologischen Substanzen mit einer Halbleitersensorenanordnung
EP2329275A2 (en) 2008-09-04 2011-06-08 Galenea Corporation Synaptic vesicle cycling assays and systems
DE102010016382B4 (de) * 2010-04-09 2022-06-02 Leica Microsystems Cms Gmbh Fluoreszenzmikroskop und Verfahren zur Durchführung von Multipositionierungen in einer Screening-Applikation
JP5420725B2 (ja) * 2011-06-28 2014-02-19 株式会社イマック 光学測定装置
DE102011108180B4 (de) 2011-07-20 2014-12-24 Sensor Instruments Entwicklungs- Und Vertriebs Gmbh Verfahren und Vorrichtung zum Identifizieren eines photolumineszierenden Materials
WO2013131017A1 (en) * 2012-03-02 2013-09-06 Laxco, Inc. Multichannel analytical instruments for use with specimen holders
US9387451B2 (en) 2014-02-03 2016-07-12 International Business Machines Corporation Flow cell array and uses thereof
DE102016200271A1 (de) 2016-01-13 2017-07-13 Institut Dr. Foerster Gmbh & Co. Kg Vorrichtung zur Erzeugung und Messung einer Emission
CN110428193B (zh) * 2019-06-14 2022-03-04 上海中旖能源科技有限公司 基于车辆轨迹数据的多模式液化天然气运输车辆筛选方法
WO2021170364A1 (en) * 2020-02-26 2021-09-02 Robert Bosch Gmbh An optical filter holder for a bio-analyte device
JP2023530965A (ja) * 2020-06-17 2023-07-20 ナノペック， インコーポレイテッド 高密度バイオアッセイ多重化アレイのためのナノ多孔質セラミックフィルム

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JPS4984456A (pt) * 1972-12-19 1974-08-14
DE3036638C2 (de) * 1980-09-29 1983-11-03 Vanzetti Infrared & Computer Systems, Inc., Canton, Mass. Bandverhältnis-Radiometer
EP0230679B1 (en) * 1986-01-30 1990-08-08 The Dow Chemical Company Fiber-optic probe
FR2567538B1 (fr) * 1984-07-12 1986-12-26 Inst Nat Sante Rech Med Automate pour l'analyse et le clonage de cultures cellulaires ainsi que pour l'analyse bacteriologique
AU635269B2 (en) * 1989-05-03 1993-03-18 Abbott Laboratories Method of forming agglutinates in blood samples
FR2661986B1 (fr) * 1990-05-14 1992-07-17 Commissariat Energie Atomique Appareil autonome de lecture d'un capteur chimique actif a au moins une fibre optique et procede pour sa mise en óoeuvre.
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JP2912957B2 (ja) * 1991-06-18 1999-06-28 東ソー株式会社 酵素活性測定方法及び装置
US5670113A (en) * 1991-12-20 1997-09-23 Sibia Neurosciences, Inc. Automated analysis equipment and assay method for detecting cell surface protein and/or cytoplasmic receptor function using same
US5436718A (en) * 1993-07-30 1995-07-25 Biolumin Corporation Mutli-functional photometer with movable linkage for routing optical fibers

Also Published As

Publication number Publication date
DE69913257T2 (de) 2004-09-02
JP2002520615A (ja) 2002-07-09
ES2210911T3 (es) 2004-07-01
WO2000004366A9 (en) 2000-06-02
WO2000004366A1 (en) 2000-01-27
EP1403645B1 (en) 2007-09-12
ATE255727T1 (de) 2003-12-15
EP0973040A3 (en) 2000-03-15
DE69937126D1 (de) 2007-10-25
AU5108199A (en) 2000-02-07
EP0973040A2 (en) 2000-01-19
DE69937126T2 (de) 2008-06-12
ATE373241T1 (de) 2007-09-15
CA2278045A1 (en) 2000-01-17
EP0973040B1 (en) 2003-12-03
DE69913257D1 (de) 2004-01-15
EP1403645A1 (en) 2004-03-31
DK0973040T3 (da) 2004-03-29

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