DE69913257D1 - Detektor und Siebvorrichtung für Ionenkanäle - Google Patents

Detektor und Siebvorrichtung für Ionenkanäle

Info

Publication number
DE69913257D1
DE69913257D1 DE69913257T DE69913257T DE69913257D1 DE 69913257 D1 DE69913257 D1 DE 69913257D1 DE 69913257 T DE69913257 T DE 69913257T DE 69913257 T DE69913257 T DE 69913257T DE 69913257 D1 DE69913257 D1 DE 69913257D1
Authority
DE
Germany
Prior art keywords
detector
optical
ion channels
ball lens
sieving device
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69913257T
Other languages
English (en)
Other versions
DE69913257T2 (de
Inventor
Roger Y Tsien
Peter J Coassin
Andrew A Pham
Alec Tate Harootunian
Minh Vuong
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Vertex Pharmaceuticals San Diego LLC
Original Assignee
Vertex Pharmaceuticals San Diego LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/118,728 external-priority patent/US6608671B2/en
Priority claimed from US09/122,544 external-priority patent/US6349160B2/en
Application filed by Vertex Pharmaceuticals San Diego LLC filed Critical Vertex Pharmaceuticals San Diego LLC
Application granted granted Critical
Publication of DE69913257D1 publication Critical patent/DE69913257D1/de
Publication of DE69913257T2 publication Critical patent/DE69913257T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6452—Individual samples arranged in a regular 2D-array, e.g. multiwell plates
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N2021/6417—Spectrofluorimetric devices
    • G01N2021/6419—Excitation at two or more wavelengths
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N2021/6417—Spectrofluorimetric devices
    • G01N2021/6421—Measuring at two or more wavelengths
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N2021/6463—Optics
    • G01N2021/6478—Special lenses
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N2021/6484—Optical fibres
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2201/00—Features of devices classified in G01N21/00
    • G01N2201/06—Illumination; Optics
    • G01N2201/063—Illuminating optical parts
    • G01N2201/0638—Refractive parts
    • G01N2201/0639—Sphere lens
DE69913257T 1998-07-17 1999-07-16 Detektor und Siebvorrichtung für Ionenkanäle Expired - Lifetime DE69913257T2 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US118728 1998-07-17
US09/118,728 US6608671B2 (en) 1998-07-17 1998-07-17 Detector and screening device for ion channels
US122544 1998-07-24
US09/122,544 US6349160B2 (en) 1998-07-24 1998-07-24 Detector and screening device for ion channels

Publications (2)

Publication Number Publication Date
DE69913257D1 true DE69913257D1 (de) 2004-01-15
DE69913257T2 DE69913257T2 (de) 2004-09-02

Family

ID=26816682

Family Applications (2)

Application Number Title Priority Date Filing Date
DE69937126T Expired - Lifetime DE69937126T2 (de) 1998-07-17 1999-07-16 Detektor und Siebvorrichtung für Ionenkanäle
DE69913257T Expired - Lifetime DE69913257T2 (de) 1998-07-17 1999-07-16 Detektor und Siebvorrichtung für Ionenkanäle

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE69937126T Expired - Lifetime DE69937126T2 (de) 1998-07-17 1999-07-16 Detektor und Siebvorrichtung für Ionenkanäle

Country Status (10)

Country Link
EP (2) EP1403645B1 (de)
JP (1) JP2002520615A (de)
AT (2) ATE373241T1 (de)
AU (1) AU5108199A (de)
CA (1) CA2278045A1 (de)
DE (2) DE69937126T2 (de)
DK (1) DK0973040T3 (de)
ES (1) ES2210911T3 (de)
PT (1) PT973040E (de)
WO (1) WO2000004366A1 (de)

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US6214563B1 (en) 1997-08-01 2001-04-10 Aurora Biosciences Corporation Photon reducing agents for reducing undesired light emission in assays
US6221612B1 (en) 1997-08-01 2001-04-24 Aurora Biosciences Corporation Photon reducing agents for use in fluorescence assays
US6200762B1 (en) 1997-08-01 2001-03-13 Aurora Biosciences Corporation Photon reducing agents and compositions for fluorescence assays
US6519032B1 (en) * 1998-04-03 2003-02-11 Symyx Technologies, Inc. Fiber optic apparatus and use thereof in combinatorial material science
GB9915034D0 (en) * 1999-06-29 1999-08-25 Cambridge Imaging Ltd Improved assay analysis
PT1081495E (pt) * 1999-09-01 2004-06-30 Invitrogen Corp Agentes de reducao de fotoes para ensaios de fluorescencia
US6784982B1 (en) 1999-11-04 2004-08-31 Regents Of The University Of Minnesota Direct mapping of DNA chips to detector arrays
US6867851B2 (en) 1999-11-04 2005-03-15 Regents Of The University Of Minnesota Scanning of biological samples
WO2001042770A1 (de) * 1999-12-11 2001-06-14 Qualico Gmbh Vorrichtung zum erfassen von eigenschaften einer bewegten papierbahn
WO2002093144A1 (en) * 2001-05-10 2002-11-21 Regents Of The University Of Minnesota Imaging of biological samples using electronic light detector
CA2453489A1 (en) 2001-07-12 2003-01-23 Merck & Co., Inc. Electrical field stimulation of eukaryotic cells
ATE537438T1 (de) 2002-05-17 2011-12-15 Life Technologies Corp Vorrichtung und verfahren zur unterscheidung mehrerer fluoreszenzsignale anhand ihrer anregungswellenlänge
DE10322443A1 (de) * 2003-05-19 2004-12-30 PRO DESIGN Gesellschaft für Produktentwicklung mbH Multifunktioneller Reader für Biochips
ITMI20050114A1 (it) * 2005-01-27 2006-07-28 Milano Politecnico Apparato e metodo per la stimolazione e la rilevazione ottica in maniera non invasiva dell'attivita' elettrica di almeno una cellula
US7924425B2 (en) 2005-06-27 2011-04-12 The United States Of America As Represented By The Department Of Health And Human Services Spatially selective fixed-optics multicolor fluorescence detection system for a multichannel microfluidic device, and method for detection
DE102007047093B4 (de) * 2007-10-01 2010-07-01 Ferton Holding S.A. Vorrichtung zur Messung von Fluoreszenzstrahlung an biologischen Substanzen mit einer Halbleitersensorenanordnung
US20120053084A1 (en) 2008-09-04 2012-03-01 Galenea Corp. Synaptic vesicle cycling assays and systems
DE102010016382B4 (de) * 2010-04-09 2022-06-02 Leica Microsystems Cms Gmbh Fluoreszenzmikroskop und Verfahren zur Durchführung von Multipositionierungen in einer Screening-Applikation
JP5420725B2 (ja) * 2011-06-28 2014-02-19 株式会社イマック 光学測定装置
DE102011108180B4 (de) * 2011-07-20 2014-12-24 Sensor Instruments Entwicklungs- Und Vertriebs Gmbh Verfahren und Vorrichtung zum Identifizieren eines photolumineszierenden Materials
US9182336B2 (en) * 2012-03-02 2015-11-10 Laxco, Inc. Multichannel analytical instruments for use with specimen holders
US9387451B2 (en) 2014-02-03 2016-07-12 International Business Machines Corporation Flow cell array and uses thereof
DE102016200271A1 (de) * 2016-01-13 2017-07-13 Institut Dr. Foerster Gmbh & Co. Kg Vorrichtung zur Erzeugung und Messung einer Emission
CN110428193B (zh) * 2019-06-14 2022-03-04 上海中旖能源科技有限公司 基于车辆轨迹数据的多模式液化天然气运输车辆筛选方法
WO2021170364A1 (en) * 2020-02-26 2021-09-02 Robert Bosch Gmbh An optical filter holder for a bio-analyte device

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4984456A (de) * 1972-12-19 1974-08-14
DE3036638C2 (de) * 1980-09-29 1983-11-03 Vanzetti Infrared & Computer Systems, Inc., Canton, Mass. Bandverhältnis-Radiometer
FR2567538B1 (fr) * 1984-07-12 1986-12-26 Inst Nat Sante Rech Med Automate pour l'analyse et le clonage de cultures cellulaires ainsi que pour l'analyse bacteriologique
DE3673378D1 (de) * 1986-01-30 1990-09-13 Dow Chemical Co Faseroptische sonde.
AU635269B2 (en) * 1989-05-03 1993-03-18 Abbott Laboratories Method of forming agglutinates in blood samples
FR2661986B1 (fr) * 1990-05-14 1992-07-17 Commissariat Energie Atomique Appareil autonome de lecture d'un capteur chimique actif a au moins une fibre optique et procede pour sa mise en óoeuvre.
US5086220A (en) * 1991-02-05 1992-02-04 The Babcock & Wilcox Company Radiation imaging fiber optic temperature distribution monitor
US5217285A (en) * 1991-03-15 1993-06-08 The United States Of America As Represented By United States Department Of Energy Apparatus for synthesis of a solar spectrum
JP2912957B2 (ja) * 1991-06-18 1999-06-28 東ソー株式会社 酵素活性測定方法及び装置
US5670113A (en) * 1991-12-20 1997-09-23 Sibia Neurosciences, Inc. Automated analysis equipment and assay method for detecting cell surface protein and/or cytoplasmic receptor function using same
US5436718A (en) * 1993-07-30 1995-07-25 Biolumin Corporation Mutli-functional photometer with movable linkage for routing optical fibers

Also Published As

Publication number Publication date
ES2210911T3 (es) 2004-07-01
JP2002520615A (ja) 2002-07-09
EP1403645A1 (de) 2004-03-31
DK0973040T3 (da) 2004-03-29
EP1403645B1 (de) 2007-09-12
DE69937126T2 (de) 2008-06-12
EP0973040B1 (de) 2003-12-03
EP0973040A2 (de) 2000-01-19
PT973040E (pt) 2004-04-30
WO2000004366A1 (en) 2000-01-27
DE69913257T2 (de) 2004-09-02
ATE255727T1 (de) 2003-12-15
DE69937126D1 (de) 2007-10-25
AU5108199A (en) 2000-02-07
CA2278045A1 (en) 2000-01-17
WO2000004366A9 (en) 2000-06-02
EP0973040A3 (de) 2000-03-15
ATE373241T1 (de) 2007-09-15

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