PT96789B - Processo de preparacao de um medicamento a base de lisados bacterianos - Google Patents
Processo de preparacao de um medicamento a base de lisados bacterianos Download PDFInfo
- Publication number
- PT96789B PT96789B PT96789A PT9678991A PT96789B PT 96789 B PT96789 B PT 96789B PT 96789 A PT96789 A PT 96789A PT 9678991 A PT9678991 A PT 9678991A PT 96789 B PT96789 B PT 96789B
- Authority
- PT
- Portugal
- Prior art keywords
- nctc
- bacterial
- lysate
- bacterial lysate
- process according
- Prior art date
Links
- 239000003814 drug Substances 0.000 title claims abstract description 22
- 230000001580 bacterial effect Effects 0.000 title claims abstract description 19
- 238000002360 preparation method Methods 0.000 title claims description 7
- 229940079593 drug Drugs 0.000 title abstract description 12
- 239000006166 lysate Substances 0.000 claims abstract description 21
- 206010012438 Dermatitis atopic Diseases 0.000 claims abstract description 13
- 201000008937 atopic dermatitis Diseases 0.000 claims abstract description 13
- 241000588747 Klebsiella pneumoniae Species 0.000 claims abstract description 5
- 241000588744 Klebsiella pneumoniae subsp. ozaenae Species 0.000 claims abstract description 5
- 241000588653 Neisseria Species 0.000 claims abstract description 5
- 241000191967 Staphylococcus aureus Species 0.000 claims abstract description 5
- 241000193998 Streptococcus pneumoniae Species 0.000 claims abstract description 5
- 241000606768 Haemophilus influenzae Species 0.000 claims abstract description 4
- 241000588655 Moraxella catarrhalis Species 0.000 claims abstract description 4
- 241001312524 Streptococcus viridans Species 0.000 claims abstract description 4
- 229940047650 haemophilus influenzae Drugs 0.000 claims abstract description 3
- 238000000034 method Methods 0.000 claims description 8
- 239000002775 capsule Substances 0.000 claims description 7
- 241000193996 Streptococcus pyogenes Species 0.000 claims description 3
- 239000001963 growth medium Substances 0.000 claims description 3
- 239000000203 mixture Substances 0.000 claims description 2
- 241000894006 Bacteria Species 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 abstract description 3
- 108060003951 Immunoglobulin Proteins 0.000 description 4
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 4
- 239000012141 concentrate Substances 0.000 description 4
- 102000018358 immunoglobulin Human genes 0.000 description 4
- 229940072221 immunoglobulins Drugs 0.000 description 4
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 3
- 244000052616 bacterial pathogen Species 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 239000008103 glucose Substances 0.000 description 3
- 239000002609 medium Substances 0.000 description 3
- 210000002966 serum Anatomy 0.000 description 3
- 208000035473 Communicable disease Diseases 0.000 description 2
- 201000004624 Dermatitis Diseases 0.000 description 2
- 231100000111 LD50 Toxicity 0.000 description 2
- PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 description 2
- 208000003251 Pruritus Diseases 0.000 description 2
- 239000004480 active ingredient Substances 0.000 description 2
- 229940041514 candida albicans extract Drugs 0.000 description 2
- 230000007812 deficiency Effects 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 239000000284 extract Substances 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 210000002345 respiratory system Anatomy 0.000 description 2
- 239000011780 sodium chloride Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 239000012138 yeast extract Substances 0.000 description 2
- CYDQOEWLBCCFJZ-UHFFFAOYSA-N 4-(4-fluorophenyl)oxane-4-carboxylic acid Chemical compound C=1C=C(F)C=CC=1C1(C(=O)O)CCOCC1 CYDQOEWLBCCFJZ-UHFFFAOYSA-N 0.000 description 1
- 239000004251 Ammonium lactate Substances 0.000 description 1
- 208000017667 Chronic Disease Diseases 0.000 description 1
- 208000006313 Delayed Hypersensitivity Diseases 0.000 description 1
- 206010024438 Lichenification Diseases 0.000 description 1
- 241000699670 Mus sp. Species 0.000 description 1
- 206010067482 No adverse event Diseases 0.000 description 1
- VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 description 1
- 231100000215 acute (single dose) toxicity testing Toxicity 0.000 description 1
- 239000013566 allergen Substances 0.000 description 1
- 229940059265 ammonium lactate Drugs 0.000 description 1
- 235000019286 ammonium lactate Nutrition 0.000 description 1
- RZOBLYBZQXQGFY-HSHFZTNMSA-N azanium;(2r)-2-hydroxypropanoate Chemical compound [NH4+].C[C@@H](O)C([O-])=O RZOBLYBZQXQGFY-HSHFZTNMSA-N 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000007969 cellular immunity Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 238000011443 conventional therapy Methods 0.000 description 1
- 230000009089 cytolysis Effects 0.000 description 1
- 238000011118 depth filtration Methods 0.000 description 1
- BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 238000003306 harvesting Methods 0.000 description 1
- 230000000951 immunodiffusion Effects 0.000 description 1
- 206010022000 influenza Diseases 0.000 description 1
- 230000007803 itching Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 235000013372 meat Nutrition 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 230000002906 microbiologic effect Effects 0.000 description 1
- 235000001968 nicotinic acid Nutrition 0.000 description 1
- 229960003512 nicotinic acid Drugs 0.000 description 1
- 239000011664 nicotinic acid Substances 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 238000003908 quality control method Methods 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 239000001632 sodium acetate Substances 0.000 description 1
- 235000017281 sodium acetate Nutrition 0.000 description 1
- 229940005581 sodium lactate Drugs 0.000 description 1
- 239000001540 sodium lactate Substances 0.000 description 1
- 235000011088 sodium lactate Nutrition 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 235000019157 thiamine Nutrition 0.000 description 1
- JZRWCGZRTZMZEH-UHFFFAOYSA-N thiamine Chemical compound CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N JZRWCGZRTZMZEH-UHFFFAOYSA-N 0.000 description 1
- 239000011721 thiamine Substances 0.000 description 1
- 231100000820 toxicity test Toxicity 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
- A61K35/741—Probiotics
- A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Mycology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Dermatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines Containing Plant Substances (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH497/90A CH680045A5 (OSRAM) | 1990-02-16 | 1990-02-16 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PT96789A PT96789A (pt) | 1991-10-31 |
| PT96789B true PT96789B (pt) | 1998-08-31 |
Family
ID=4188357
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT96789A PT96789B (pt) | 1990-02-16 | 1991-02-15 | Processo de preparacao de um medicamento a base de lisados bacterianos |
Country Status (13)
| Country | Link |
|---|---|
| JP (1) | JP3002552B2 (OSRAM) |
| KR (1) | KR0169982B1 (OSRAM) |
| AT (1) | AT402152B (OSRAM) |
| BE (1) | BE1005589A3 (OSRAM) |
| CH (1) | CH680045A5 (OSRAM) |
| DE (1) | DE4104728C2 (OSRAM) |
| EG (1) | EG19540A (OSRAM) |
| FR (1) | FR2658419B1 (OSRAM) |
| GB (1) | GB2240922A (OSRAM) |
| HU (1) | HU210834B (OSRAM) |
| IT (1) | IT1244743B (OSRAM) |
| PL (1) | PL289084A1 (OSRAM) |
| PT (1) | PT96789B (OSRAM) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2098109C1 (ru) * | 1996-09-26 | 1997-12-10 | Александр Григорьевич Чучалин | Противоаллергическое, противовоспалительное средство, способ его получения, лечебное и косметическое средства с его использованием |
| WO1999048510A1 (en) * | 1998-03-24 | 1999-09-30 | Tayca Corporation | Immunoglobulin m antibody production inhibitor and anti-rheumatoid arthritis drug |
| JP2008529960A (ja) | 2003-06-23 | 2008-08-07 | バイオテック トゥールス ソシエテ アノニム | エピトープ組成物 |
| UA72065C2 (en) * | 2004-09-10 | 2005-01-17 | Viridans Ltd Liability Company | Strain aerococcus viridans 167k imb b-7069 with antibacterial activity and "viabac" preparation comprising this strain |
| FR2969657B1 (fr) | 2010-12-22 | 2014-02-07 | Fabre Pierre Dermo Cosmetique | Nouvelle bacterie et extraits de ladite bacterie et leur utilisation en dermatologie |
| GB201318170D0 (en) * | 2013-10-14 | 2013-11-27 | Univ Edinburgh | Proteins with Diagnostic and Therapeutic Uses |
| JP7356742B2 (ja) * | 2019-04-26 | 2023-10-05 | エムディー ヘルスケア インコーポレイテッド | ストレプトコッカスパイオジェネス細菌由来タンパク質及びその用途 |
| KR102437436B1 (ko) | 2019-04-26 | 2022-08-30 | 주식회사 엠디헬스케어 | 스트렙토코커스 파이오제네스 세균 유래 단백질 및 이의 용도 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH633188A5 (fr) * | 1978-05-26 | 1982-11-30 | Om Laboratoires Sa | Medicament contre des maladies infectieuses des voies respiratoires. |
-
1990
- 1990-02-16 CH CH497/90A patent/CH680045A5/fr not_active IP Right Cessation
-
1991
- 1991-02-13 KR KR1019910002437A patent/KR0169982B1/ko not_active Expired - Fee Related
- 1991-02-14 IT ITMI910381A patent/IT1244743B/it active IP Right Grant
- 1991-02-14 EG EG9191A patent/EG19540A/xx active
- 1991-02-15 PL PL28908491A patent/PL289084A1/xx unknown
- 1991-02-15 JP JP3022109A patent/JP3002552B2/ja not_active Expired - Lifetime
- 1991-02-15 DE DE4104728A patent/DE4104728C2/de not_active Expired - Fee Related
- 1991-02-15 HU HU91511A patent/HU210834B/hu not_active IP Right Cessation
- 1991-02-15 GB GB9103278A patent/GB2240922A/en not_active Withdrawn
- 1991-02-15 AT AT0032291A patent/AT402152B/de not_active IP Right Cessation
- 1991-02-15 PT PT96789A patent/PT96789B/pt not_active IP Right Cessation
- 1991-02-15 BE BE9100144A patent/BE1005589A3/fr active
- 1991-02-15 FR FR9102058A patent/FR2658419B1/fr not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| FR2658419B1 (fr) | 1995-01-27 |
| GB2240922A (en) | 1991-08-21 |
| PL289084A1 (en) | 1991-11-04 |
| HUT61201A (en) | 1992-12-28 |
| IT1244743B (it) | 1994-08-08 |
| HU210834B (en) | 1995-08-28 |
| GB9103278D0 (en) | 1991-04-03 |
| DE4104728C2 (de) | 1999-01-14 |
| KR910015306A (ko) | 1991-09-30 |
| JP3002552B2 (ja) | 2000-01-24 |
| ATA32291A (de) | 1996-07-15 |
| DE4104728A1 (de) | 1991-08-22 |
| JPH04211017A (ja) | 1992-08-03 |
| FR2658419A1 (fr) | 1991-08-23 |
| CH680045A5 (OSRAM) | 1992-06-15 |
| BE1005589A3 (fr) | 1993-11-16 |
| KR0169982B1 (ko) | 1999-02-01 |
| HU910511D0 (en) | 1991-09-30 |
| ITMI910381A0 (it) | 1991-02-14 |
| PT96789A (pt) | 1991-10-31 |
| AT402152B (de) | 1997-02-25 |
| EG19540A (en) | 1995-08-30 |
| ITMI910381A1 (it) | 1992-08-14 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| BB1A | Laying open of patent application |
Effective date: 19910702 |
|
| FG3A | Patent granted, date of granting |
Effective date: 19980520 |
|
| MM3A | Annulment or lapse |
Free format text: LAPSE DUE TO NON-PAYMENT OF FEES Effective date: 20001130 |