PT90805A - Processo para a preparacao de 1-indolilalquil-4-(piridinil substituido)-piperazinas e de composicoes farmaceuticas que as contem - Google Patents
Processo para a preparacao de 1-indolilalquil-4-(piridinil substituido)-piperazinas e de composicoes farmaceuticas que as contemInfo
- Publication number
- PT90805A PT90805A PT90805A PT9080589A PT90805A PT 90805 A PT90805 A PT 90805A PT 90805 A PT90805 A PT 90805A PT 9080589 A PT9080589 A PT 9080589A PT 90805 A PT90805 A PT 90805A
- Authority
- PT
- Portugal
- Prior art keywords
- hydrogen
- indolilalquil
- piperazines
- preparation
- pharmaceutical compositions
- Prior art date
Links
- FIULGFJIHJJXMT-UHFFFAOYSA-N [C]1[N]C=CC=C1 Chemical group [C]1[N]C=CC=C1 FIULGFJIHJJXMT-UHFFFAOYSA-N 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- 239000001257 hydrogen Substances 0.000 abstract 4
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 abstract 2
- 150000002431 hydrogen Chemical class 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 239000000935 antidepressant agent Substances 0.000 abstract 1
- 229940005513 antidepressants Drugs 0.000 abstract 1
- 239000004202 carbamide Substances 0.000 abstract 1
- 235000013877 carbamide Nutrition 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000000392 cycloalkenyl group Chemical group 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01M—PROCESSES OR MEANS, e.g. BATTERIES, FOR THE DIRECT CONVERSION OF CHEMICAL ENERGY INTO ELECTRICAL ENERGY
- H01M6/00—Primary cells; Manufacture thereof
- H01M6/04—Cells with aqueous electrolyte
- H01M6/06—Dry cells, i.e. cells wherein the electrolyte is rendered non-fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01M—PROCESSES OR MEANS, e.g. BATTERIES, FOR THE DIRECT CONVERSION OF CHEMICAL ENERGY INTO ELECTRICAL ENERGY
- H01M4/00—Electrodes
- H01M4/02—Electrodes composed of, or comprising, active material
- H01M4/62—Selection of inactive substances as ingredients for active masses, e.g. binders, fillers
- H01M4/621—Binders
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Electrochemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Psychiatry (AREA)
- Manufacturing & Machinery (AREA)
- Pain & Pain Management (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US20484588A | 1988-06-10 | 1988-06-10 | |
| US07/338,253 US4954502A (en) | 1988-06-10 | 1989-04-14 | 1-indolyalkyl-4-(substituted-pyridinyl)piperazines |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PT90805A true PT90805A (pt) | 1989-12-29 |
| PT90805B PT90805B (pt) | 1994-10-31 |
Family
ID=26899839
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT90805A PT90805B (pt) | 1988-06-10 | 1989-06-09 | Processo para a preparacao de 1-indolilalquil-4-(piridinil substituido)-piperazinas e de composicoes farmaceuticas que as contem |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US4954502A (pt) |
| EP (1) | EP0345808B1 (pt) |
| JP (1) | JP2786480B2 (pt) |
| KR (1) | KR0128210B1 (pt) |
| AT (1) | ATE116982T1 (pt) |
| AU (1) | AU624147B2 (pt) |
| CA (1) | CA1337421C (pt) |
| CY (1) | CY1846A (pt) |
| DE (1) | DE68920482T2 (pt) |
| DK (1) | DK283589A (pt) |
| ES (1) | ES2067500T3 (pt) |
| FI (1) | FI95698C (pt) |
| HK (1) | HK83295A (pt) |
| IE (1) | IE66569B1 (pt) |
| NO (1) | NO174296C (pt) |
| PT (1) | PT90805B (pt) |
| SG (1) | SG32583G (pt) |
Families Citing this family (51)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5120843A (en) * | 1987-04-27 | 1992-06-09 | Upjohn | Pharmaceutically active amines |
| US4975445A (en) * | 1989-12-06 | 1990-12-04 | Warner-Lambert Company | Substituted cyclohexenes as central nervous system agents |
| DE69028552T2 (de) * | 1989-12-28 | 1997-03-06 | The Upjohn Co., Kalamazoo, Mich. | Diaromatische substituierte verbindungen gegen den aids-virus |
| US5563142A (en) * | 1989-12-28 | 1996-10-08 | The Upjohn Company | Diaromatic substituted compounds as anti-HIV-1 agents |
| US5077293A (en) * | 1990-06-29 | 1991-12-31 | Bristol-Myers Squibb Co. | 1-indolyalkyl-4-(alkoxypyrimidinyl)piperazines |
| CA2043709C (en) * | 1990-06-29 | 2002-01-22 | David W. Smith | Antimigraine alkoxypyrimidine derivatives |
| US5270312A (en) * | 1990-11-05 | 1993-12-14 | Warner-Lambert Company | Substituted piperazines as central nervous system agents |
| US5124332A (en) * | 1991-01-28 | 1992-06-23 | Warner-Lambert Company | Substituted indoles as central nervous system agents |
| US5177088A (en) * | 1991-04-17 | 1993-01-05 | Hoechst-Roussel Pharmaceuticals Incorporated | Substituted 3-(pyridinylamino)-indoles |
| US5328920A (en) * | 1991-04-17 | 1994-07-12 | Hoechst-Roussel Pharmaceuticals Incorporated | Substituted (pyridinylamino)-indoles |
| US5599930A (en) * | 1991-07-03 | 1997-02-04 | The Upjohn Company | Substituted indoles as anti-AIDS pharmaceuticals |
| US5206393A (en) * | 1991-09-30 | 1993-04-27 | Union Carbide Chemicals & Plastics Technology Corporation | Oxa-bicyclic polyfunctional compounds and preparation thereof |
| US5145973A (en) * | 1991-09-30 | 1992-09-08 | Union Carbide Chemicals & Plastics Technology Corporation | Oxa-Bicyclic polyfunctional compounds and preparation thereof |
| US5314896A (en) * | 1991-11-20 | 1994-05-24 | Warner-Lambert Company | 1,3-substituted cycloalkenes and cycloalkanes as central nervous system agents |
| CA2084531A1 (en) * | 1991-12-19 | 1993-06-20 | David W. Smith | Antimigraine 4-pyrimidinyl and pyridinyl derivatives of indol-3yl-alkyl piperazines |
| CA2091204C (en) * | 1992-03-11 | 1997-04-08 | Ronald J. Mattson | Antiischemic-piperazinyl and piperidinyl-cyclohexanes |
| EP0675109A1 (en) * | 1992-12-21 | 1995-10-04 | Taisho Pharmaceutical Co. Ltd | N-substituted indole derivative |
| CA2130078A1 (en) * | 1993-09-16 | 1995-03-17 | Jonas A. Gylys | Antimigraine cyclobutenedione derivatives of indolylalkyl-pyridinyl and pyrimidinylpiperazines |
| US5391570A (en) * | 1993-10-14 | 1995-02-21 | Bristol-Myers Squibb | Aminomethyl-benzodioxane and benzopyran serotonergic agents |
| US5468768A (en) * | 1994-01-06 | 1995-11-21 | Bristol-Myers Squibb Company | Antimigraine derivatives of indolylcycloalkanylamines |
| US5468767A (en) * | 1994-01-06 | 1995-11-21 | Bristol-Myers Squibb Company | Antidepressant 3-(aminocycloalkenyl)-indole-5-nitrile derivatives |
| GB9423682D0 (en) * | 1994-11-23 | 1995-01-11 | Merck Sharp & Dohme | Therapeutic agents |
| US5618816A (en) * | 1995-03-02 | 1997-04-08 | Bristol-Myers Squibb Company | Antimigraine 1,2,5-thiadiazole derivatives of indolylalkyl-pyridnyl and pyrimidinylpiperazines |
| JPH09124643A (ja) * | 1995-08-14 | 1997-05-13 | Bristol Myers Squibb Co | 抗うつ作用を有する１−アリールアルキル−４−（アルコキシピリジニル）−又は４−（アルコキシピリミジニル）ピペラジン誘導体 |
| AT403803B (de) * | 1996-04-19 | 1998-05-25 | Sanochemia Ltd | Neue benzazepinderivate, diese enthaltende arzneimittel und verwendung derselben zum herstellen von arzneimitteln |
| WO1998031679A1 (en) * | 1997-01-21 | 1998-07-23 | Yoshitomi Pharmaceutical Industries, Ltd. | Thiophene compounds and medicinal use thereof |
| US6150533A (en) * | 1998-04-08 | 2000-11-21 | American Home Products Corp. | N-aryloxyethyl-indoly-alkylamines for the treatment of depression |
| ATE227718T1 (de) * | 1998-04-08 | 2002-11-15 | Wyeth Corp | N-aryloxyethyl-indolyl-alkylamine zur behandlung von depressionen |
| TW520367B (en) * | 1998-04-29 | 2003-02-11 | Wyeth Corp | Indolyl derivatives as serotonergic agents |
| FR2786769B1 (fr) * | 1998-12-04 | 2002-10-25 | Synthelabo | Derives de 2,5-diazabicyclo[2.2.1]heptane, leur preparation et leur application en therapeutique |
| US6313126B1 (en) * | 1999-01-07 | 2001-11-06 | American Home Products Corp | Arylpiperazinyl-cyclohexyl indole derivatives for the treatment of depression |
| ES2219302T3 (es) * | 1999-01-07 | 2004-12-01 | Wyeth | Derivados de arilpiperazinil-ciclohexilindol para el tratamiento de la depresion. |
| CA2360683A1 (en) * | 1999-01-28 | 2000-08-03 | Joseph P. Yevich | Antidepressant heterocyclic compounds |
| US7265115B2 (en) | 1999-01-29 | 2007-09-04 | Abbott Laboratories | Diazabicyclic CNS active agents |
| MXPA02004554A (es) * | 1999-11-08 | 2004-09-10 | Wyeth Corp | N-aril-(homopiperazinil)-ciclohexil aminas como transportadores de 5-ht. |
| NZ516302A (en) | 2000-03-31 | 2004-02-27 | Sanochemia Pharmazeutika Ag | Novel derivatives and analogues of galanthamin |
| US6809105B2 (en) | 2000-04-27 | 2004-10-26 | Abbott Laboratories | Diazabicyclic central nervous system active agents |
| CA2354606C (en) * | 2000-08-03 | 2005-12-06 | Pfizer Products Inc. | Azabicycloalkane derivatives and therapeutic uses thereof |
| CA2448729A1 (en) * | 2000-11-20 | 2002-05-23 | Biovitrum Ab | Piperazinyl and piperidyl substituted heterocyclic compounds |
| SE0004245D0 (sv) | 2000-11-20 | 2000-11-20 | Pharmacia Ab | Novel compounds and their use |
| WO2004083235A2 (en) * | 2003-03-19 | 2004-09-30 | Exelixis Inc. | Tie-2 modulators and methods of use |
| WO2006072608A2 (en) * | 2005-01-03 | 2006-07-13 | Universitá Degli Studi Di Siena | Aryl piperazine derivatives for the treatment of neuropsychiatric disorders |
| US20080103312A1 (en) * | 2006-08-29 | 2008-05-01 | Kansal Vinod K | Processes for the synthesis of 5-phenyl-1-trityl-1H-tetrazole |
| JP2011517440A (ja) * | 2008-03-14 | 2011-06-09 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング | 中枢神経系障害を処置するためのアザインドール化合物 |
| CN104163813B (zh) * | 2013-05-16 | 2017-02-01 | 广东东阳光药业有限公司 | 取代的吲哚化合物及其使用方法和用途 |
| WO2015014256A1 (en) * | 2013-07-29 | 2015-02-05 | Sunshine Lake Pharma Co., Ltd. | Substituted heteroaryl compounds and methods of use thereof |
| EP3083589B1 (en) * | 2013-12-20 | 2019-12-18 | Sunshine Lake Pharma Co., Ltd. | Substituted piperazine compounds and methods of use thereof |
| CN104725363B (zh) * | 2013-12-20 | 2019-03-01 | 广东东阳光药业有限公司 | 取代的哌嗪化合物及其使用方法和用途 |
| US10316025B2 (en) | 2015-06-03 | 2019-06-11 | Sunshine Lake Pharma Co., Ltd. | Substituted piperazine compounds and methods of use and use thereof |
| CN106795143B (zh) * | 2015-08-13 | 2019-05-24 | 广东东阳光药业有限公司 | 取代的吲哚化合物及其使用方法和用途 |
| ES2974248T3 (es) | 2017-09-29 | 2024-06-26 | Sunshine Lake Pharma Co Ltd | Compuesto de pirimidin-piperazina sustituido y uso del mismo |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB944443A (pt) * | 1959-09-25 | 1900-01-01 | ||
| US3468882A (en) | 1966-10-07 | 1969-09-23 | Sterling Drug Inc | Phenylhydrazone derivatives as intermediates for preparing indoles |
| GB1189064A (en) * | 1967-05-01 | 1970-04-22 | Sterling Drug Inc | Indole Derivatives |
| US3472855A (en) * | 1967-05-29 | 1969-10-14 | Sterling Drug Inc | 1-((benz(g)-indolyl)-lower-alkyl)-4-substituted-piperazines |
| US4302589A (en) * | 1980-05-08 | 1981-11-24 | American Cyanamid Company | Cis-mono and disubstituted-2-methyl-3-[(piperazinyl) and (piperidino)ethyl]indolines, intermediates for their preparation and methods of preparation |
-
1989
- 1989-04-14 US US07/338,253 patent/US4954502A/en not_active Expired - Lifetime
- 1989-05-30 CA CA000601179A patent/CA1337421C/en not_active Expired - Lifetime
- 1989-06-07 FI FI892787A patent/FI95698C/fi active IP Right Grant
- 1989-06-09 DK DK283589A patent/DK283589A/da not_active Application Discontinuation
- 1989-06-09 AU AU36282/89A patent/AU624147B2/en not_active Expired
- 1989-06-09 AT AT89110485T patent/ATE116982T1/de not_active IP Right Cessation
- 1989-06-09 JP JP1148200A patent/JP2786480B2/ja not_active Expired - Lifetime
- 1989-06-09 DE DE68920482T patent/DE68920482T2/de not_active Expired - Lifetime
- 1989-06-09 SG SG1995907465A patent/SG32583G/en unknown
- 1989-06-09 ES ES89110485T patent/ES2067500T3/es not_active Expired - Lifetime
- 1989-06-09 PT PT90805A patent/PT90805B/pt not_active IP Right Cessation
- 1989-06-09 NO NO892381A patent/NO174296C/no not_active IP Right Cessation
- 1989-06-09 EP EP89110485A patent/EP0345808B1/en not_active Expired - Lifetime
- 1989-06-10 KR KR1019890008025A patent/KR0128210B1/ko not_active Expired - Fee Related
- 1989-06-12 IE IE186189A patent/IE66569B1/en not_active IP Right Cessation
-
1995
- 1995-05-25 HK HK83295A patent/HK83295A/en not_active IP Right Cessation
-
1996
- 1996-03-08 CY CY184696A patent/CY1846A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IE66569B1 (en) | 1996-01-24 |
| FI892787L (fi) | 1989-12-11 |
| NO174296B (no) | 1994-01-03 |
| EP0345808A1 (en) | 1989-12-13 |
| US4954502A (en) | 1990-09-04 |
| EP0345808B1 (en) | 1995-01-11 |
| FI892787A0 (fi) | 1989-06-07 |
| NO174296C (no) | 1994-04-13 |
| FI95698C (fi) | 1996-03-11 |
| AU3628289A (en) | 1989-12-14 |
| JP2786480B2 (ja) | 1998-08-13 |
| AU624147B2 (en) | 1992-06-04 |
| CA1337421C (en) | 1995-10-24 |
| DK283589D0 (da) | 1989-06-09 |
| ES2067500T3 (es) | 1995-04-01 |
| NO892381D0 (no) | 1989-06-09 |
| SG32583G (en) | 1995-09-01 |
| JPH0285277A (ja) | 1990-03-26 |
| FI95698B (fi) | 1995-11-30 |
| DE68920482D1 (de) | 1995-02-23 |
| IE891861L (en) | 1989-12-10 |
| HK83295A (en) | 1995-06-01 |
| DE68920482T2 (de) | 1995-06-01 |
| KR0128210B1 (ko) | 1998-04-02 |
| ATE116982T1 (de) | 1995-01-15 |
| NO892381L (no) | 1989-12-11 |
| CY1846A (en) | 1996-03-08 |
| PT90805B (pt) | 1994-10-31 |
| KR910000708A (ko) | 1991-01-30 |
| DK283589A (da) | 1989-12-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG3A | Patent granted, date of granting |
Effective date: 19940420 |
|
| MM4A | Annulment/lapse due to non-payment of fees, searched and examined patent |
Free format text: MAXIMUM VALIDITY LIMIT REACHED Effective date: 20090609 |