PT90414A - Processo para a preparacao de derivados sulfaminados sinteticos de glicosaminoglicanos, nomeadamente, sulfatos de controitina, sulfato de dermatano e acido hialuronico e/ou suas misturas e de composicoes farmaceuticas que os contem - Google Patents

Processo para a preparacao de derivados sulfaminados sinteticos de glicosaminoglicanos, nomeadamente, sulfatos de controitina, sulfato de dermatano e acido hialuronico e/ou suas misturas e de composicoes farmaceuticas que os contem

Info

Publication number
PT90414A
PT90414A PT90414A PT9041489A PT90414A PT 90414 A PT90414 A PT 90414A PT 90414 A PT90414 A PT 90414A PT 9041489 A PT9041489 A PT 9041489A PT 90414 A PT90414 A PT 90414A
Authority
PT
Portugal
Prior art keywords
derivatives
hyaluronic acid
sulfaminated
controitin
glycosaminoglycans
Prior art date
Application number
PT90414A
Other languages
English (en)
Other versions
PT90414B (pt
Inventor
Giangiacomo Torri
Annamaria Maggi
Original Assignee
Crinos Industria Farmaco
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Crinos Industria Farmaco filed Critical Crinos Industria Farmaco
Publication of PT90414A publication Critical patent/PT90414A/pt
Publication of PT90414B publication Critical patent/PT90414B/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H5/00—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
    • C07H5/04—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium to nitrogen
    • C07H5/06—Aminosugars
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0069—Chondroitin-4-sulfate, i.e. chondroitin sulfate A; Dermatan sulfate, i.e. chondroitin sulfate B or beta-heparin; Chondroitin-6-sulfate, i.e. chondroitin sulfate C; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0072—Hyaluronic acid, i.e. HA or hyaluronan; Derivatives thereof, e.g. crosslinked hyaluronic acid (hylan) or hyaluronates

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Materials Engineering (AREA)
  • Polymers & Plastics (AREA)
  • Dermatology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
PT90414A 1988-05-02 1989-04-28 Processo para a preparacao de derivados sulfaminados sinteticos de glicosaminoglicanos, nomeadamente, sulfatos de controitina, sulfato de dermatano e acido hialuronico e/ou suas misturas e de composicoes farmaceuticas que os contem PT90414B (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT20412/88A IT1217458B (it) 1988-05-02 1988-05-02 Sulfoamino derivati di condroitin solfati,del dermatan solfato e dell' acido ialuronico e loro proprieta' farmacologiche

Publications (2)

Publication Number Publication Date
PT90414A true PT90414A (pt) 1989-11-30
PT90414B PT90414B (pt) 1994-08-31

Family

ID=11166540

Family Applications (1)

Application Number Title Priority Date Filing Date
PT90414A PT90414B (pt) 1988-05-02 1989-04-28 Processo para a preparacao de derivados sulfaminados sinteticos de glicosaminoglicanos, nomeadamente, sulfatos de controitina, sulfato de dermatano e acido hialuronico e/ou suas misturas e de composicoes farmaceuticas que os contem

Country Status (11)

Country Link
US (1) US5008253A (pt)
EP (1) EP0340628B1 (pt)
JP (1) JPH01318002A (pt)
KR (1) KR900018129A (pt)
AT (1) ATE109163T1 (pt)
AU (1) AU618346B2 (pt)
CA (1) CA1307525C (pt)
DE (1) DE68917009T2 (pt)
ES (1) ES2057006T3 (pt)
IT (1) IT1217458B (pt)
PT (1) PT90414B (pt)

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GB8826448D0 (en) * 1988-11-11 1988-12-14 Thrombosis Res Inst Improvements in/relating to organic compounds
DK0421508T3 (da) * 1989-10-04 1994-04-11 Akzo Nobel Nv Sulfateret glycosaminoglycuronan med antithrombotisk aktivitet
FR2655267B1 (fr) * 1989-12-04 1992-04-03 Roussel Uclaf Nouveau derive sulfate du galactanne extrait de klebsiella, procede de preparation, application a titre de medicaments et compositions pharmaceutiques le renfermant.
WO1991015217A1 (en) * 1990-04-06 1991-10-17 Washington University Anticoagulant oligosaccharides
FR2669932B1 (fr) * 1990-12-03 1994-07-01 Sanofi Sa Nouvel heparosane-n,o-sulfate, son procede de preparation et les compositions pharmaceutiques qui le contiennent.
US5629287A (en) * 1991-01-18 1997-05-13 University College London Depot formulations
US5610148A (en) * 1991-01-18 1997-03-11 University College London Macroscopically oriented cell adhesion protein for wound treatment
GB2286193A (en) * 1991-03-28 1995-08-09 Italfarmaco Spa Anticoagulants and processes for preparing such
US5605938A (en) * 1991-05-31 1997-02-25 Gliatech, Inc. Methods and compositions for inhibition of cell invasion and fibrosis using dextran sulfate
US5705178A (en) * 1991-05-31 1998-01-06 Gliatech, Inc. Methods and compositions based on inhibition of cell invasion and fibrosis by anionic polymers
US5234914A (en) * 1991-06-11 1993-08-10 Patent Biopharmaceutics, Inc. Methods of treating hemorrhoids and anorecial disease
WO1994017538A2 (en) * 1993-01-21 1994-08-04 Mayo Foundation For Medical Education And Research Microparticle switching devices
US5654006A (en) * 1993-02-12 1997-08-05 Mayo Foundation For Medical Education And Research Condensed-phase microparticle composition and method
US5753261A (en) * 1993-02-12 1998-05-19 Access Pharmaceuticals, Inc. Lipid-coated condensed-phase microparticle composition
US5820879A (en) * 1993-02-12 1998-10-13 Access Pharmaceuticals, Inc. Method of delivering a lipid-coated condensed-phase microparticle composition
ITPD940054A1 (it) * 1994-03-23 1995-09-23 Fidia Advanced Biopolymers Srl Polisaccaridi solfatati
US5690961A (en) * 1994-12-22 1997-11-25 Hercules Incorporated Acidic polysaccharides crosslinked with polycarboxylic acids and their uses
IT1290814B1 (it) * 1997-03-24 1998-12-11 Istituto Scient Di Chimica E B Glicosaminoglicani aventi elevata attivita' antitrombotica
ATE229038T1 (de) 1997-04-04 2002-12-15 Fidia Advanced Biopolymers Srl N-sulfatierte hyaluronsäureverbindungen, ihre derivate und verfahren zu ihrer herstellung
DE19813234A1 (de) * 1998-03-26 1999-09-30 Knoell Hans Forschung Ev Verfahren zur Herstellung hochsulfatierter Hyaluronsäuren
US20030104601A1 (en) * 1999-04-01 2003-06-05 Deangelis Paul L. Chondroitin synthase gene and methods of making and using same
US7223571B2 (en) * 1998-04-02 2007-05-29 The Board Of Regents Of The Universtiy Of Oklahoma Targeted glycosaminoglycan polymers by polymer grafting and methods of making and using same
US20080108110A1 (en) * 1998-04-02 2008-05-08 Deangelis Paul L Targeted glycosaminoglycan polymers by polymer grafting and methods of making and using same
US20060188966A1 (en) * 1998-04-02 2006-08-24 Deangelis Paul L Natural, chimeric and hybrid glycosaminoglycan polymers and methods of making and using same
KR100530196B1 (ko) 1998-04-30 2005-11-22 마루하 가부시키가이샤 구조내 글루쿠론산 유도체 및 글루코사민 유도체를 갖는화합물, 그의 제법 및 그의 용도
US20020086852A1 (en) * 1998-05-14 2002-07-04 Cantor Jerome O. Method for treating respiratory disorders associated with pulmonary elastic fiber injury
ITPD980169A1 (it) 1998-07-06 2000-01-06 Fidia Advanced Biopolymers Srl Ammidi dell'acido ialuronico e dei suoi derivati e processo per la loro preparazione.
US7642071B2 (en) 1999-04-01 2010-01-05 The Board Of Regents Of The University Of Oklahoma Methods of expressing gram-negative glycosaminoglycan synthase genes in gram-positive hosts
US20040161476A1 (en) * 2003-02-19 2004-08-19 Hahn Sungtack Samuel Cystitis treatment with high dose chondroitin sulfate
ITPD20050056A1 (it) 2005-03-02 2006-09-03 Fidia Farmaceutici Derivati ammidici del'acido ialuronico in osteoartrosi
BRPI0909849A2 (pt) 2008-04-04 2015-10-06 Univ Utah Res Found éteres semi-sintéticos de glicosaminoglicosanos e métodos para fazê-los e usá-los
IT1397247B1 (it) * 2009-05-14 2013-01-04 Fidia Farmaceutici Nuovi agenti regolatori dell'attivita' citochinica
US8546353B2 (en) * 2010-05-06 2013-10-01 Glykos Finland Oy Compounds and combinations
US9522162B2 (en) 2011-03-23 2016-12-20 University Of Utah Research Foundation Methods for treating or preventing urological inflammation
EP2928500B1 (en) 2012-12-04 2019-03-06 Phosphorex Inc. Microparticles and nanoparticles having negative surface charges
JP6063103B1 (ja) * 2015-03-31 2017-01-18 生化学工業株式会社 グリコサミノグリカンの硫酸化方法
WO2018053111A1 (en) 2016-09-15 2018-03-22 University Of Utah Research Foundation In situ gelling compositions for the treatment or prevention of inflammation and tissue damage
CN111228653A (zh) 2018-11-13 2020-06-05 格莱科米拉治疗公司 用电离辐射加强癌症治疗的方法
CN111662394B (zh) * 2019-03-05 2022-11-04 中国医学科学院药物研究所 硫酸软骨素多糖半合成制备方法和应用

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GB838709A (en) * 1955-09-22 1960-06-22 Upjohn Co Improvements in or relating to aminoalcohol-n-sulphonic acid compounds
US3405120A (en) * 1966-01-27 1968-10-08 Green Cross Corp Low molecular chondroitin sulfate and method for manufacturing the same
FR2504535B1 (fr) * 1981-04-28 1987-08-14 Choay Sa Disaccharides derives d'un acide uronique et d'une glucosamine et compositions pharmaceutiques les contenant pour le controle de la coagulation sanguine
US4818816A (en) * 1981-04-28 1989-04-04 Choay, S.A. Process for the organic synthesis of oligosaccharides and derivatives thereof
EP0838709A3 (de) * 1996-09-30 1999-07-28 Siemens Aktiengesellschaft Anordnung zur Erzeugung einer Umsetzung zwischen Lichtstrahlen kleineren Strahlquerschnitts und einem Lichtstrahl grösseren Strahlquerschnitts

Also Published As

Publication number Publication date
CA1307525C (en) 1992-09-15
US5008253A (en) 1991-04-16
EP0340628A3 (en) 1990-01-24
JPH01318002A (ja) 1989-12-22
KR900018129A (ko) 1990-12-20
EP0340628B1 (en) 1994-07-27
IT1217458B (it) 1990-03-22
ATE109163T1 (de) 1994-08-15
EP0340628A2 (en) 1989-11-08
IT8820412A0 (it) 1988-05-02
AU618346B2 (en) 1991-12-19
AU3392289A (en) 1989-11-02
DE68917009D1 (de) 1994-09-01
PT90414B (pt) 1994-08-31
ES2057006T3 (es) 1994-10-16
DE68917009T2 (de) 1994-11-10

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Legal Events

Date Code Title Description
FG3A Patent granted, date of granting

Effective date: 19940201

MM3A Annulment or lapse

Free format text: LAPSE DUE TO NON-PAYMENT OF FEES

Effective date: 19970831