IT8820412A0 - Sulfoamino derivati di condroitinsolfati, del dermatan solfato e dell'acido ialuronico e loro proprieta' farmacologiche. - Google Patents

Sulfoamino derivati di condroitinsolfati, del dermatan solfato e dell'acido ialuronico e loro proprieta' farmacologiche.

Info

Publication number
IT8820412A0
IT8820412A0 IT8820412A IT2041288A IT8820412A0 IT 8820412 A0 IT8820412 A0 IT 8820412A0 IT 8820412 A IT8820412 A IT 8820412A IT 2041288 A IT2041288 A IT 2041288A IT 8820412 A0 IT8820412 A0 IT 8820412A0
Authority
IT
Italy
Prior art keywords
sulfoamino
derivatives
hyaluronic acid
pharmacological properties
dermatan sulfate
Prior art date
Application number
IT8820412A
Other languages
English (en)
Other versions
IT1217458B (it
Inventor
Benito Casu
Giangiacomo Torri
Annamaria Naggi
Marisa Mantovani
Rodolfo Pescador
Roberto Porta
Giuseppe Prino
Original Assignee
Villa Guardia Como Crinos Ind
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Villa Guardia Como Crinos Ind filed Critical Villa Guardia Como Crinos Ind
Publication of IT8820412A0 publication Critical patent/IT8820412A0/it
Priority to IT20412/88A priority Critical patent/IT1217458B/it
Priority to ES89107615T priority patent/ES2057006T3/es
Priority to EP89107615A priority patent/EP0340628B1/en
Priority to AT89107615T priority patent/ATE109163T1/de
Priority to DE68917009T priority patent/DE68917009T2/de
Priority to PT90414A priority patent/PT90414B/pt
Priority to US07/346,502 priority patent/US5008253A/en
Priority to CA000598507A priority patent/CA1307525C/en
Priority to KR1019890005904A priority patent/KR900018129A/ko
Priority to JP1112324A priority patent/JPH01318002A/ja
Priority to AU33922/89A priority patent/AU618346B2/en
Application granted granted Critical
Publication of IT1217458B publication Critical patent/IT1217458B/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H5/00—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
    • C07H5/04—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium to nitrogen
    • C07H5/06—Aminosugars
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0069—Chondroitin-4-sulfate, i.e. chondroitin sulfate A; Dermatan sulfate, i.e. chondroitin sulfate B or beta-heparin; Chondroitin-6-sulfate, i.e. chondroitin sulfate C; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0072—Hyaluronic acid, i.e. HA or hyaluronan; Derivatives thereof, e.g. crosslinked hyaluronic acid (hylan) or hyaluronates

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Polymers & Plastics (AREA)
  • Materials Engineering (AREA)
  • Dermatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
IT20412/88A 1988-05-02 1988-05-02 Sulfoamino derivati di condroitin solfati,del dermatan solfato e dell' acido ialuronico e loro proprieta' farmacologiche IT1217458B (it)

Priority Applications (11)

Application Number Priority Date Filing Date Title
IT20412/88A IT1217458B (it) 1988-05-02 1988-05-02 Sulfoamino derivati di condroitin solfati,del dermatan solfato e dell' acido ialuronico e loro proprieta' farmacologiche
DE68917009T DE68917009T2 (de) 1988-05-02 1989-04-27 Sulfaminoderivate von Chondroitinsulfat, Dermatansulfat und Hyaluronsäure und ihre pharmakologischen Eigenschaften.
EP89107615A EP0340628B1 (en) 1988-05-02 1989-04-27 Sulfoamino derivatives of chondroitin sulfates, of dermaten sulfate and of hyaluronic acid and their pharmacological properties
AT89107615T ATE109163T1 (de) 1988-05-02 1989-04-27 Sulfaminoderivate von chondroitinsulfat, dermatansulfat und hyaluronsäure und ihre pharmakologischen eigenschaften.
ES89107615T ES2057006T3 (es) 1988-05-02 1989-04-27 Derivados sulfoamino de sulfatos de controitina, de sulfato de dermatano y de acido hialuronico y sus propiedades farmacologicas.
PT90414A PT90414B (pt) 1988-05-02 1989-04-28 Processo para a preparacao de derivados sulfaminados sinteticos de glicosaminoglicanos, nomeadamente, sulfatos de controitina, sulfato de dermatano e acido hialuronico e/ou suas misturas e de composicoes farmaceuticas que os contem
US07/346,502 US5008253A (en) 1988-05-02 1989-05-02 Sulfoamino derivatives of chondroitin sulfates of dermatan sulfate and of hyaluronic acid and their pharmacological properties
CA000598507A CA1307525C (en) 1988-05-02 1989-05-02 Sulfoamino derivatives of chondroitin sulfates, of dermatan sulfate and hyaluronic acid and their pharmacological properties
KR1019890005904A KR900018129A (ko) 1988-05-02 1989-05-02 콘드로이틴 황산염, 데르마탄황산염 및 히알루론산의 술포아미노 유도체와 그 약제학적 성질
JP1112324A JPH01318002A (ja) 1988-05-02 1989-05-02 コンドロイチン硫酸塩の、デルマタン硫酸塩の、およびヒアルロン酸のスルホアミノ誘導体類、並びにそれらの薬学的性質
AU33922/89A AU618346B2 (en) 1988-05-02 1989-05-02 Sulfoamino derivatives of chondroitin sulfates, of dermatan sulfate and of hyaluronic acid and their pharmacological properties

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT20412/88A IT1217458B (it) 1988-05-02 1988-05-02 Sulfoamino derivati di condroitin solfati,del dermatan solfato e dell' acido ialuronico e loro proprieta' farmacologiche

Publications (2)

Publication Number Publication Date
IT8820412A0 true IT8820412A0 (it) 1988-05-02
IT1217458B IT1217458B (it) 1990-03-22

Family

ID=11166540

Family Applications (1)

Application Number Title Priority Date Filing Date
IT20412/88A IT1217458B (it) 1988-05-02 1988-05-02 Sulfoamino derivati di condroitin solfati,del dermatan solfato e dell' acido ialuronico e loro proprieta' farmacologiche

Country Status (11)

Country Link
US (1) US5008253A (it)
EP (1) EP0340628B1 (it)
JP (1) JPH01318002A (it)
KR (1) KR900018129A (it)
AT (1) ATE109163T1 (it)
AU (1) AU618346B2 (it)
CA (1) CA1307525C (it)
DE (1) DE68917009T2 (it)
ES (1) ES2057006T3 (it)
IT (1) IT1217458B (it)
PT (1) PT90414B (it)

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Publication number Priority date Publication date Assignee Title
GB8826448D0 (en) * 1988-11-11 1988-12-14 Thrombosis Res Inst Improvements in/relating to organic compounds
EP0421508B1 (en) * 1989-10-04 1993-12-15 Akzo Nobel N.V. Sulphated glycosaminoglycuronan with antithrombotic activity
FR2655267B1 (fr) * 1989-12-04 1992-04-03 Roussel Uclaf Nouveau derive sulfate du galactanne extrait de klebsiella, procede de preparation, application a titre de medicaments et compositions pharmaceutiques le renfermant.
AU7742591A (en) * 1990-04-06 1991-10-30 Washington University Anticoagulant oligosaccharides
FR2669932B1 (fr) * 1990-12-03 1994-07-01 Sanofi Sa Nouvel heparosane-n,o-sulfate, son procede de preparation et les compositions pharmaceutiques qui le contiennent.
US5629287A (en) * 1991-01-18 1997-05-13 University College London Depot formulations
US5610148A (en) * 1991-01-18 1997-03-11 University College London Macroscopically oriented cell adhesion protein for wound treatment
GB2286193A (en) * 1991-03-28 1995-08-09 Italfarmaco Spa Anticoagulants and processes for preparing such
US5605938A (en) * 1991-05-31 1997-02-25 Gliatech, Inc. Methods and compositions for inhibition of cell invasion and fibrosis using dextran sulfate
US5705178A (en) * 1991-05-31 1998-01-06 Gliatech, Inc. Methods and compositions based on inhibition of cell invasion and fibrosis by anionic polymers
US5234914A (en) * 1991-06-11 1993-08-10 Patent Biopharmaceutics, Inc. Methods of treating hemorrhoids and anorecial disease
ATE168497T1 (de) * 1993-01-21 1998-08-15 Mayo Foundation Mikropartikelschaltvorrichtung
US5753261A (en) * 1993-02-12 1998-05-19 Access Pharmaceuticals, Inc. Lipid-coated condensed-phase microparticle composition
US5820879A (en) * 1993-02-12 1998-10-13 Access Pharmaceuticals, Inc. Method of delivering a lipid-coated condensed-phase microparticle composition
US5654006A (en) * 1993-02-12 1997-08-05 Mayo Foundation For Medical Education And Research Condensed-phase microparticle composition and method
ITPD940054A1 (it) * 1994-03-23 1995-09-23 Fidia Advanced Biopolymers Srl Polisaccaridi solfatati
US5690961A (en) * 1994-12-22 1997-11-25 Hercules Incorporated Acidic polysaccharides crosslinked with polycarboxylic acids and their uses
IT1290814B1 (it) * 1997-03-24 1998-12-11 Istituto Scient Di Chimica E B Glicosaminoglicani aventi elevata attivita' antitrombotica
ES2189166T3 (es) 1997-04-04 2003-07-01 Fidia Advanced Biopolymers Srl Compuestos del acido hialuronico n-sulfatado, sus derivados y proceso para su preparacion.
DE19813234A1 (de) * 1998-03-26 1999-09-30 Knoell Hans Forschung Ev Verfahren zur Herstellung hochsulfatierter Hyaluronsäuren
US20080108110A1 (en) * 1998-04-02 2008-05-08 Deangelis Paul L Targeted glycosaminoglycan polymers by polymer grafting and methods of making and using same
US20030104601A1 (en) * 1999-04-01 2003-06-05 Deangelis Paul L. Chondroitin synthase gene and methods of making and using same
US20060188966A1 (en) * 1998-04-02 2006-08-24 Deangelis Paul L Natural, chimeric and hybrid glycosaminoglycan polymers and methods of making and using same
US7223571B2 (en) * 1998-04-02 2007-05-29 The Board Of Regents Of The Universtiy Of Oklahoma Targeted glycosaminoglycan polymers by polymer grafting and methods of making and using same
ATE302785T1 (de) 1998-04-30 2005-09-15 Maruha Corp Verbindungen, deren struktur derivate von glukuronsäure und glukosamin enthält, verfahren zu deren herstellung und deren verwendung
ITPD980169A1 (it) 1998-07-06 2000-01-06 Fidia Advanced Biopolymers Srl Ammidi dell'acido ialuronico e dei suoi derivati e processo per la loro preparazione.
US7642071B2 (en) 1999-04-01 2010-01-05 The Board Of Regents Of The University Of Oklahoma Methods of expressing gram-negative glycosaminoglycan synthase genes in gram-positive hosts
EP1292314A2 (en) * 2000-05-23 2003-03-19 The Trustees of Columbia University in the City of New York Method for treating respiratory disorders associated with pulmonary elastic fiber injury comprising the use of glycosaminoglycans
US20040161476A1 (en) * 2003-02-19 2004-08-19 Hahn Sungtack Samuel Cystitis treatment with high dose chondroitin sulfate
ITPD20050056A1 (it) 2005-03-02 2006-09-03 Fidia Farmaceutici Derivati ammidici del'acido ialuronico in osteoartrosi
BRPI0909849A2 (pt) 2008-04-04 2015-10-06 Univ Utah Res Found éteres semi-sintéticos de glicosaminoglicosanos e métodos para fazê-los e usá-los
IT1397247B1 (it) * 2009-05-14 2013-01-04 Fidia Farmaceutici Nuovi agenti regolatori dell'attivita' citochinica
US8546353B2 (en) * 2010-05-06 2013-10-01 Glykos Finland Oy Compounds and combinations
JP6062917B2 (ja) 2011-03-23 2017-01-18 ザ ユニバーシティ オブ ユタ リサーチ ファウンデイション 泌尿器科の炎症の治療及び予防の方法
CA2932532C (en) 2012-12-04 2021-06-22 Phosphorex, Inc. Microparticles and nanoparticles having negative surface charges
WO2016159296A1 (ja) * 2015-03-31 2016-10-06 生化学工業株式会社 グリコサミノグリカンの硫酸化方法
US11337994B2 (en) 2016-09-15 2022-05-24 University Of Utah Research Foundation In situ gelling compositions for the treatment or prevention of inflammation and tissue damage
CN111662394B (zh) * 2019-03-05 2022-11-04 中国医学科学院药物研究所 硫酸软骨素多糖半合成制备方法和应用

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GB838709A (en) * 1955-09-22 1960-06-22 Upjohn Co Improvements in or relating to aminoalcohol-n-sulphonic acid compounds
US3405120A (en) * 1966-01-27 1968-10-08 Green Cross Corp Low molecular chondroitin sulfate and method for manufacturing the same
US4818816A (en) * 1981-04-28 1989-04-04 Choay, S.A. Process for the organic synthesis of oligosaccharides and derivatives thereof
FR2504535B1 (fr) * 1981-04-28 1987-08-14 Choay Sa Disaccharides derives d'un acide uronique et d'une glucosamine et compositions pharmaceutiques les contenant pour le controle de la coagulation sanguine
EP0838709A3 (de) * 1996-09-30 1999-07-28 Siemens Aktiengesellschaft Anordnung zur Erzeugung einer Umsetzung zwischen Lichtstrahlen kleineren Strahlquerschnitts und einem Lichtstrahl grösseren Strahlquerschnitts

Also Published As

Publication number Publication date
AU3392289A (en) 1989-11-02
ATE109163T1 (de) 1994-08-15
DE68917009D1 (de) 1994-09-01
US5008253A (en) 1991-04-16
ES2057006T3 (es) 1994-10-16
PT90414A (pt) 1989-11-30
JPH01318002A (ja) 1989-12-22
IT1217458B (it) 1990-03-22
PT90414B (pt) 1994-08-31
EP0340628A3 (en) 1990-01-24
DE68917009T2 (de) 1994-11-10
KR900018129A (ko) 1990-12-20
AU618346B2 (en) 1991-12-19
EP0340628A2 (en) 1989-11-08
CA1307525C (en) 1992-09-15
EP0340628B1 (en) 1994-07-27

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Legal Events

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TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19960509