PT88425A - Dna sequences recombinant dna molecules and processes for producing soluble t4 proteins - Google Patents

Dna sequences recombinant dna molecules and processes for producing soluble t4 proteins

Info

Publication number
PT88425A
PT88425A PT88425A PT8842588A PT88425A PT 88425 A PT88425 A PT 88425A PT 88425 A PT88425 A PT 88425A PT 8842588 A PT8842588 A PT 8842588A PT 88425 A PT88425 A PT 88425A
Authority
PT
Portugal
Prior art keywords
proteins
processes
producing soluble
recombinant dna
dna sequences
Prior art date
Application number
PT88425A
Other languages
English (en)
Other versions
PT88425B (pt
Inventor
Richard A Fischer
Vicki L Sato
John M Maraganore
Theresa R Liu
Walter Gilbert
Richard A Flavell
Original Assignee
Biogen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biogen Inc filed Critical Biogen Inc
Publication of PT88425A publication Critical patent/PT88425A/pt
Publication of PT88425B publication Critical patent/PT88425B/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/12—Acyclic radicals, not substituted by cyclic structures attached to a nitrogen atom of the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70514—CD4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2812—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD4
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56983—Viruses
    • G01N33/56988—HIV or HTLV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/15011—Lentivirus, not HIV, e.g. FIV, SIV
    • C12N2740/15051—Methods of production or purification of viral material

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Virology (AREA)
  • Zoology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Urology & Nephrology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Hematology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cell Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physics & Mathematics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Physics & Mathematics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Transplantation (AREA)
  • AIDS & HIV (AREA)
  • Pathology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Analytical Chemistry (AREA)
PT88425A 1987-09-04 1988-09-05 Processo para a preparacao de proteinas t4 soluveis PT88425B (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US9432287A 1987-09-04 1987-09-04
US14164988A 1988-01-07 1988-01-07

Publications (2)

Publication Number Publication Date
PT88425A true PT88425A (pt) 1989-07-31
PT88425B PT88425B (pt) 1992-10-30

Family

ID=26788733

Family Applications (1)

Application Number Title Priority Date Filing Date
PT88425A PT88425B (pt) 1987-09-04 1988-09-05 Processo para a preparacao de proteinas t4 soluveis

Country Status (12)

Country Link
EP (1) EP0347435A4 (pt)
JP (1) JPH02501192A (pt)
KR (1) KR890701605A (pt)
DK (1) DK216589A (pt)
ES (1) ES2013346A6 (pt)
GR (1) GR1000489B (pt)
IL (1) IL87647A0 (pt)
NO (1) NO891818L (pt)
NZ (1) NZ226040A (pt)
OA (1) OA09625A (pt)
PT (1) PT88425B (pt)
WO (1) WO1989001940A1 (pt)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5958678A (en) * 1986-08-21 1999-09-28 The Trustees Of Columbia University In The City Of New York DNA encoding the T cell surface protein T4 and use of fragments of T4 in the treatment of AIDS
EP0280710B1 (en) 1986-08-21 1996-03-20 The Trustees Of Columbia University In The City Of New York Dna encoding the t cell surface protein t4 and use of fragments of t4 in the treatment of aids
US5336603A (en) * 1987-10-02 1994-08-09 Genentech, Inc. CD4 adheson variants
US6710169B2 (en) 1987-10-02 2004-03-23 Genentech, Inc. Adheson variants
ZA887365B (en) * 1987-10-02 1990-05-30 Genentech Inc Adheson variants
US6004781A (en) * 1988-01-22 1999-12-21 The General Hospital Corporation Nucleic acid encoding Ig-CD4 fusion proteins
ZA89430B (en) * 1988-01-22 1989-10-25 Gen Hospital Corp Cloned genes encoding ig-cd4 fusion proteins and the use thereof
AU3006789A (en) * 1988-02-24 1989-08-24 Smithkline Beckman Corporation Expression of hiv binding proteins
EP0346091A3 (en) * 1988-06-10 1990-09-12 Dana Farber Cancer Institute Method of diagnosis for naturally occurring antibodies to cd4
AU4660789A (en) * 1988-11-23 1990-06-12 Genentech Inc. Polypeptide derivatives
AU5437190A (en) * 1989-04-05 1990-11-05 Upjohn Company, The Soluble cd4 produced in (e. coli)
EP0408372A1 (en) * 1989-07-13 1991-01-16 Smithkline Beecham Corporation Anti-viral therapy
KR927003613A (ko) * 1989-08-23 1992-12-18 더 제너랄 호스피탈 코오퍼레이숀 비-인체 영장동물의 cd4폴리텝타이드, 글리코실화할 수 있는 인체 cd4분자, 그것의 단편, 그것의 융합 단백질, 유전자 서열 및 그것의 용도
US5180820A (en) * 1989-08-30 1993-01-19 Barde Yves Alain Brain-derived neurotrophic factor
JPH0725794B2 (ja) * 1990-03-23 1995-03-22 呉羽化学工業株式会社 新規なペプチド
CA2062758A1 (en) * 1990-05-25 1991-11-26 Richard A. Fisher Immunotherapeutic compositions for treating and preventing aids, arc and hiv infection
DE69126301T2 (de) * 1990-11-27 1998-01-02 Biogen, Inc., Cambridge, Mass. Hiv-induzierte synzytien blockierender anti-cd-4-antikörper
AU1438592A (en) * 1991-02-08 1992-09-07 Progenics Pharmaceuticals, Inc. Cd4-gamma1 and cd4-igg1 chimeras
US7070991B2 (en) 1991-02-08 2006-07-04 Progenics Pharmaceuticals, Inc. Cells expressing a CD4-IgG2 chimeric heterotetramer
ES2237727T3 (es) 1991-02-08 2005-08-01 Progenics Pharmaceuticals, Inc. Quimeras de gamma2-cd4 y igg2-cd4.
US5389529A (en) * 1991-06-12 1995-02-14 Regeneron Pharmaceuticals, Inc. Modified lamβ signal sequence and processes for producing recombinant neurotrophins
GB9219562D0 (en) 1992-03-11 1992-10-28 Prendergast Kennet F Anti-viral peptides
JPH10509031A (ja) * 1994-11-04 1998-09-08 アイデックス・ラボラトリーズ・インコーポレーテッド 試料中の標的微生物の検出用培地
US5635363A (en) * 1995-02-28 1997-06-03 The Board Of Trustees Of The Leland Stanford Junior University Compositions and methods for the detection, quantitation and purification of antigen-specific T cells
US6251939B1 (en) 1995-06-07 2001-06-26 Promega Biosciences, Inc. Carbamate-based cationic lipids
CA2358385C (en) 1998-12-31 2013-08-06 Chiron Corporation Polynucleotides encoding antigenic hiv type c polypeptides, polypeptides and uses thereof
JP2002533124A (ja) 1998-12-31 2002-10-08 カイロン コーポレイション Ｈｉｖポリペプチドの改善された発現およびウイルス様粒子の生成
US7935805B1 (en) 1998-12-31 2011-05-03 Novartis Vaccines & Diagnostics, Inc Polynucleotides encoding antigenic HIV Type C polypeptides, polypeptides and uses thereof
US20030194800A1 (en) 2001-08-31 2003-10-16 Megede Jan Zur Polynucleotides encoding antigenic HIV type B polypeptides, polypeptides and uses thereof
PT1141315E (pt) 1998-12-31 2008-05-05 Novartis Vaccines & Diagnostic Polipéptidos do envelope (env) de hiv modificados
EP1411770A4 (en) 2001-07-05 2006-05-10 Chiron Corp POLYNUCLEOTIDES CODING FOR ANTIGENIC C-TYPE HIV POLYPEPTIDES, POLYPEPTIDES AND THEIR USE
US20030170614A1 (en) 2001-08-31 2003-09-11 Megede Jan Zur Polynucleotides encoding antigenic HIV type B polypeptides, polypeptides and uses thereof
CN113209124B (zh) * 2021-02-24 2022-04-15 四川大学 Dna四面体在制备预防和治疗1型糖尿病的药物中的用途

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0280710B1 (en) * 1986-08-21 1996-03-20 The Trustees Of Columbia University In The City Of New York Dna encoding the t cell surface protein t4 and use of fragments of t4 in the treatment of aids
IL83687A (en) * 1987-08-30 1995-03-30 Yeda Res & Dev Pharmaceutical compositions comprising molecular decays and their use in the manufacture of said compositions
NZ226414A (en) * 1987-10-02 1992-07-28 Genentech Inc Cd4 peptide adhesion variants and their preparation and use

Also Published As

Publication number Publication date
JPH02501192A (ja) 1990-04-26
EP0347435A4 (en) 1991-11-21
KR890701605A (ko) 1989-12-21
AU626007B2 (en) 1992-07-23
GR880100579A (en) 1989-06-22
WO1989001940A1 (en) 1989-03-09
PT88425B (pt) 1992-10-30
IL87647A0 (en) 1989-02-28
ES2013346A6 (es) 1990-05-01
DK216589A (da) 1989-07-04
OA09625A (en) 1993-04-30
DK216589D0 (da) 1989-05-03
NO891818L (no) 1989-07-03
GR1000489B (el) 1992-07-30
AU2482988A (en) 1989-03-31
NO891818D0 (no) 1989-05-02
EP0347435A1 (en) 1989-12-27
NZ226040A (en) 1992-02-25

Similar Documents

Publication Publication Date Title
PT88425A (pt) Dna sequences recombinant dna molecules and processes for producing soluble t4 proteins
DK166087D0 (da) Proteiner og fremgangsmaade til fremstilling deraf
DE69331507D1 (de) Verfahren zur Reinigung von menschlichem, rekombinantem Serumalbumin
DE69532492D1 (de) Verfahren zur Reinigung von rekombinantem menschlichem Serumalbumin
DE68922427D1 (de) Verfahren zur Zurückgewinnung von sauerstoffreichem Gas.
ZA81103B (en) Dna sequences ,recombinant dna molecules dna molecules and processes for producing human interferon -like polypeptides
CY1346A (en) Dna sequences,recombinant dna molecules and processes for producing human interferon-like polypeptides
MA21169A1 (fr) Acides desoxyribonucleiques et procede de preparation des proteines qui en derivant.
DE68919246D1 (de) Verfahren zur Herstellung von Aminosäuren.
DE69005959D1 (de) Verfahren zur Reinigung von menschlichem Serum-Albumin.
ZA86217B (en) Dna sequences,recombinant dna molecules and processes for producing human lipocortin-like polypeptides
DK275788A (da) Fibrinolytiske proteiner
PT88912A (pt) Processo de engenharia genetica para a preparacao da proteina anticoagulante pp4
DE69010155D1 (de) Verfahren zur Trennung von Aminosäuren.
DK203087D0 (da) Proteiner og fremgangsmaade til fremstilling deraf
DE3852293D1 (de) Verfahren und struktur zur justierung von reflektorflächen.
NO905561D0 (no) Proteiner og nukleinsyrer.
PT87207A (pt) Process for preparing recombinant htlv-iii proteins and uses thereof
DE3767764D1 (de) Verfahren zur herstellung von n-acryloyl-alpha-aminosaeuren.
DE3884324D1 (de) Verfahren zur Herstellung von menschlichen pro-apolipoprotein-A-I-ähnlichen Proteinen.
DE3769749D1 (de) Verfahren zur gewinnung von gereinigten aminosaeuren.
DE68917769D1 (de) Verfahren zur Raffination der Aminosäuren.
DE59004279D1 (de) Verfahren zur C-terminalen Modifizierung von Proteinen.
DE3884261D1 (de) Verfahren zur Herstellung von Fremdproteinen in Streptomyceten.
PT88363A (pt) Geerate zur ausgleichung stoerender felder

Legal Events

Date Code Title Description
FG3A Patent granted, date of granting

Effective date: 19920410

MM3A Annulment or lapse

Free format text: LAPSE DUE TO NON-PAYMENT OF FEES

Effective date: 19931031