PT88070A - Processo para a preparacao de compostos antibioticos a base de cefalosporinas e de composicoes farmaceuticas que os contem - Google Patents

Processo para a preparacao de compostos antibioticos a base de cefalosporinas e de composicoes farmaceuticas que os contem

Info

Publication number
PT88070A
PT88070A PT88070A PT8807088A PT88070A PT 88070 A PT88070 A PT 88070A PT 88070 A PT88070 A PT 88070A PT 8807088 A PT8807088 A PT 8807088A PT 88070 A PT88070 A PT 88070A
Authority
PT
Portugal
Prior art keywords
het
ring
group
preparation
chem
Prior art date
Application number
PT88070A
Other languages
English (en)
Other versions
PT88070B (pt
Inventor
Frederick Henri Jung
David Huw Davies
Jean Claude Arnould
Dominique Boucherot
Colin John Strawson
Original Assignee
Ici Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ici Plc filed Critical Ici Plc
Publication of PT88070A publication Critical patent/PT88070A/pt
Publication of PT88070B publication Critical patent/PT88070B/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/38—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/38—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof
    • C07D501/46—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof with the 7-amino radical acylated by carboxylic acids containing hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/38—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof
    • C07D501/40—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof with the 7-amino radical acylated by an aliphatic carboxylic acid, which is substituted by hetero atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Revetment (AREA)
  • Pit Excavations, Shoring, Fill Or Stabilisation Of Slopes (AREA)
  • Threshing Machine Elements (AREA)
  • Pyrane Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
PT88070A 1987-07-23 1988-07-22 Processo para a preparacao de compostos antibioticos a base de cefalosporinas e de composicoes farmaceuticas que os contem PT88070B (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP87401718 1987-07-23

Publications (2)

Publication Number Publication Date
PT88070A true PT88070A (pt) 1989-06-30
PT88070B PT88070B (pt) 1995-03-01

Family

ID=8198237

Family Applications (1)

Application Number Title Priority Date Filing Date
PT88070A PT88070B (pt) 1987-07-23 1988-07-22 Processo para a preparacao de compostos antibioticos a base de cefalosporinas e de composicoes farmaceuticas que os contem

Country Status (16)

Country Link
US (1) US5019570A (pt)
EP (1) EP0304158B1 (pt)
JP (1) JPH0193592A (pt)
KR (1) KR890002186A (pt)
CN (1) CN1031378A (pt)
AT (1) ATE107651T1 (pt)
AU (1) AU1976288A (pt)
DE (1) DE3850321T2 (pt)
DK (1) DK414888A (pt)
FI (1) FI883439A (pt)
GB (1) GB8816519D0 (pt)
HU (1) HU201949B (pt)
NO (1) NO883275L (pt)
NZ (1) NZ225533A (pt)
PT (1) PT88070B (pt)
ZA (1) ZA885271B (pt)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5232918A (en) * 1987-07-23 1993-08-03 Imperial Chemical Industries Plc Cephalosporin derivatives
GB8811055D0 (en) * 1988-05-10 1988-06-15 Ici Plc Antibiotic compounds
EP0341990B1 (en) * 1988-05-10 1994-11-09 Imperial Chemical Industries Plc Cephalosporins, process for their preparation and pharmaceutical compositions
US5149803A (en) * 1988-05-10 1992-09-22 Imperial Chemical Industries Plc Intermediates for cephalosporin compounds
GB8811056D0 (en) * 1988-05-10 1988-06-15 Ici Plc Antibiotic compounds
US4904775A (en) * 1988-05-16 1990-02-27 E. R. Squibb & Sons, Inc. Heteroaroylhydrazide derivatives of monocyclic beta-lactam antibiotics
EP0366189A3 (en) * 1988-10-24 1992-01-02 Norwich Eaton Pharmaceuticals, Inc. Novel antimicrobial lactam-quinolones
CA2001203C (en) * 1988-10-24 2001-02-13 Thomas P. Demuth, Jr. Novel antimicrobial dithiocarbamoyl quinolones
EP0366193A3 (en) * 1988-10-24 1992-01-08 Norwich Eaton Pharmaceuticals, Inc. Novel antimicrobial quinolonyl lactams
US5273973A (en) * 1988-10-24 1993-12-28 Norwich Eaton Pharmaceuticals, Inc. Antimicrobial quinolonyl esters
US5180719A (en) * 1988-10-24 1993-01-19 Norwich Eaton Pharmaceuticals, Inc. Antimicrobial quinolonyl lactam esters
US5491139A (en) * 1988-10-24 1996-02-13 The Procter & Gamble Company Antimicrobial quinolonyl lactams
US5328908A (en) * 1988-10-24 1994-07-12 Procter & Gamble Pharmaceuticals, Inc. Antimicrobial quinolone thioureas
CA2024282A1 (en) * 1989-09-21 1991-03-22 Peter H. Ermann Heterocyclic hydrazide derivatives of monocyclic beta-lactam antibiotics
ES2147721T3 (es) * 1990-04-18 2000-10-01 Procter & Gamble Pharma Quinolonil lactamas antimicrobianas.
US5234920A (en) * 1990-08-23 1993-08-10 Bristol-Myers Squibb Company Antibiotic C-7 catechol-substituted cephalosporin compounds, compositions, and method of use thereof
ZA918014B (en) * 1990-11-05 1992-07-29 Squibb & Sons Inc Heteroaroyl derivatives of monocyclic beta-lactam antibiotics
US5250691A (en) * 1991-09-09 1993-10-05 E. R. Squibb & Sons, Inc. Heteroaryl derivatives of monocyclic beta-lactam antibiotics
AU7706394A (en) * 1994-02-25 1995-09-11 Arrieta Munguia, Judith Marcia Quinolonylcarboxamidocephalosporin derivatives and pharmaceutical compositions containing them
ATE303993T1 (de) * 1997-12-22 2005-09-15 Pharmacia & Upjohn Co Llc 4-hydroxychinolin-3-carboxamide und hydrazide als antivirale wirkstoffe
FI20001593A (fi) 2000-07-03 2002-01-04 Orion Yhtymo Oyj Comt-entsyymiõ inhiboivaa aktiivisuutta omaavia kumariinijohdannaisia
ZA200609259B (en) 2004-04-30 2008-07-30 Takeda Pharmaceutical Heterocyclic amide compound and use thereof as an mmp-13 inhibitor
FR2874922A1 (fr) * 2004-07-30 2006-03-10 Palumed Sa Molecules hybrides qa ou q est une aminoquinoleine et a est un residu antibiotique, leur synthese et leurs utilisations en tant qu'agent antibacterien
BRPI0514381A (pt) * 2004-07-30 2008-06-10 Palumed Sa compostos hìbridos de aminoquinolina-antibiótico, composições farmacêuticas, método de preparação e uso destes
FR2873695A1 (fr) * 2004-07-30 2006-02-03 Palumed Sa Molecules hybrides qa ou q est une aminoquinoleine et a est un antibiotique ou un inhibiteur de resistance), leur synthese et leurs utilisations en tant qu'agent antibacterien
US8324405B2 (en) 2008-02-05 2012-12-04 Fibrogen, Inc. Chromene derivatives and use thereof as HIF hydroxylase activity inhibitors
US8927591B2 (en) 2008-11-14 2015-01-06 Fibrogen, Inc. Thiochromene derivatives as HIF hydroxylase inhibitors
BR112012029139A2 (pt) * 2010-05-21 2019-09-24 Syngenta Participations Ag amidas como fungicidas
TWI547496B (zh) * 2011-10-04 2016-09-01 葛蘭素集團公司 抗菌化合物
UY35103A (es) 2012-10-29 2014-05-30 Glaxo Group Ltd Compuestos de cefem 2-sustituidos
UA117672C2 (uk) 2012-12-21 2018-09-10 ЯНССЕН САЙЄНСІЗ АЙРЛЕНД ЮСі Антибактеріальні сполуки

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5718689A (en) * 1980-07-08 1982-01-30 Eisai Co Ltd 7alpha-methoxycephem derivative
NZ198350A (en) * 1980-09-25 1985-02-28 Toyama Chemical Co Ltd Cephalosporins and intermediates;pharmaceutical compositions
JPS57165389A (en) * 1981-04-02 1982-10-12 Eisai Co Ltd Novel penicillin and cephalosporin compound
GB8413152D0 (en) * 1983-06-03 1984-06-27 Ici Pharma Cephalosporin derivatives
US4552891A (en) * 1983-09-13 1985-11-12 Eli Lilly And Company Benzothiophene derivatives
JPS6064986A (ja) * 1983-09-20 1985-04-13 Toyama Chem Co Ltd セファロスポリン類の製造法
FI851934L (fi) * 1984-05-30 1985-12-01 Ici Plc Kefalosporinderivat.
EP0182210B1 (en) * 1984-11-12 1991-02-27 Banyu Pharmaceutical Co., Ltd. Cephalosporin derivatives
EP0187456A1 (en) * 1984-11-29 1986-07-16 Ici Pharma Cephalosporin derivatives
DE3585434D1 (de) * 1984-12-27 1992-04-02 Banyu Pharma Co Ltd Cephalosporinverbindungen.
JPS6251688A (ja) * 1985-08-30 1987-03-06 Taito Pfizer Kk 新規なセフアロスポリン化合物
JPS62209082A (ja) * 1986-03-11 1987-09-14 Banyu Pharmaceut Co Ltd セフアロスポリン誘導体
EP0238060B1 (en) * 1986-03-19 1992-01-08 Banyu Pharmaceutical Co., Ltd. Cephalosporin derivatives, processes for their preparation and antibacterial agents
DE3750411T2 (de) * 1986-04-14 1995-03-16 Banyu Pharma Co Ltd Cephalosporinderivate, Verfahren zu ihrer Herstellung und antibakterielle Präparate.
EP0265185A3 (en) * 1986-10-21 1990-03-28 Beecham Group Plc Cephalosporins, processes for their preparation and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
FI883439A0 (fi) 1988-07-20
PT88070B (pt) 1995-03-01
JPH0193592A (ja) 1989-04-12
DE3850321T2 (de) 1994-10-06
US5019570A (en) 1991-05-28
HUT47942A (en) 1989-04-28
FI883439A (fi) 1989-01-24
AU1976288A (en) 1989-01-27
NZ225533A (en) 1990-12-21
CN1031378A (zh) 1989-03-01
HU201949B (en) 1991-01-28
ATE107651T1 (de) 1994-07-15
EP0304158A1 (en) 1989-02-22
NO883275L (no) 1989-01-24
ZA885271B (en) 1989-03-29
EP0304158B1 (en) 1994-06-22
NO883275D0 (no) 1988-07-22
DE3850321D1 (de) 1994-07-28
KR890002186A (ko) 1989-04-08
DK414888D0 (da) 1988-07-22
DK414888A (da) 1989-01-24
GB8816519D0 (en) 1988-08-17

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Legal Events

Date Code Title Description
FG3A Patent granted, date of granting

Effective date: 19940808

MM3A Annulment or lapse

Free format text: LAPSE DUE TO NON-PAYMENT OF FEES

Effective date: 19960229