PT86030A - In vivo cellular tracking - Google Patents

In vivo cellular tracking

Info

Publication number
PT86030A
PT86030A PT86030A PT8603087A PT86030A PT 86030 A PT86030 A PT 86030A PT 86030 A PT86030 A PT 86030A PT 8603087 A PT8603087 A PT 8603087A PT 86030 A PT86030 A PT 86030A
Authority
PT
Portugal
Prior art keywords
cells
vivo
lifetimes
sites
cyanine dyes
Prior art date
Application number
PT86030A
Other languages
English (en)
Other versions
PT86030B (pt
Inventor
Paul Karl Horan
Sue Ellen Slezak
Original Assignee
Smithkline Beckman Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beckman Corp filed Critical Smithkline Beckman Corp
Publication of PT86030A publication Critical patent/PT86030A/pt
Publication of PT86030B publication Critical patent/PT86030B/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0032—Methine dyes, e.g. cyanine dyes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
    • A61K49/0058—Antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0063—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres
    • A61K49/0069—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres the agent being in a particular physical galenical form
    • A61K49/0097—Cells, viruses, ghosts, red blood cells, viral vectors, used for imaging or diagnosis in vivo

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pathology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)
  • Eye Examination Apparatus (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Exhaust Gas Treatment By Means Of Catalyst (AREA)
  • Treating Waste Gases (AREA)
PT86030A 1986-10-31 1987-10-29 Metodo para a deteccao celular in vivo PT86030B (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/925,445 US4762701A (en) 1986-10-31 1986-10-31 In vivo cellular tracking

Publications (2)

Publication Number Publication Date
PT86030A true PT86030A (en) 1987-11-01
PT86030B PT86030B (pt) 1990-08-31

Family

ID=25451745

Family Applications (1)

Application Number Title Priority Date Filing Date
PT86030A PT86030B (pt) 1986-10-31 1987-10-29 Metodo para a deteccao celular in vivo

Country Status (15)

Country Link
US (1) US4762701A (pt)
EP (1) EP0266195B1 (pt)
JP (1) JP2872243B2 (pt)
KR (1) KR100298682B1 (pt)
AT (1) ATE125710T1 (pt)
AU (1) AU607165B2 (pt)
CA (1) CA1294545C (pt)
DE (1) DE3751434T2 (pt)
DK (1) DK167957B1 (pt)
ES (1) ES2076929T3 (pt)
IE (1) IE70749B1 (pt)
IL (1) IL84294A (pt)
PH (1) PH24539A (pt)
PT (1) PT86030B (pt)
ZA (1) ZA878116B (pt)

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CA2124329C (en) * 1991-11-27 2008-11-18 Gregory A. Kopia Compounds, compositions and methods for binding bio-affecting substances to surface membranes of bio-particles
US5437274A (en) * 1993-02-25 1995-08-01 Gholam A. Peyman Method of visualizing submicron-size vesicles and particles in blood circulation
AU6365894A (en) * 1993-03-16 1994-10-11 Alliance Pharmaceutical Corporation Fluorocarbon compositions containing a visible or fluorescent label
US5650135A (en) * 1994-07-01 1997-07-22 The Board Of Trustees Of The Leland Stanford Junior University Non-invasive localization of a light-emitting conjugate in a mammal
US6649143B1 (en) 1994-07-01 2003-11-18 The Board Of Trustees Of The Leland Stanford Junior University Non-invasive localization of a light-emitting conjugate in a mammal
US7255851B2 (en) * 1994-07-01 2007-08-14 The Board Of Trustees Of The Leland Stanford Junior University Non-invasive localization of a light-emitting conjugate in a mammal
DE19500665A1 (de) * 1995-01-12 1996-07-18 Axel Prof Dr Haase Verfahren zur ortsauflösenden Abbildung eines Bereiches eines biologischen Objektes mit Hilfe elektromagnetischer Strahlen unter Applikation von Kontrastmittel
CN1093768C (zh) * 1995-01-30 2002-11-06 第一化学药品株式会社 诊断用标记物
DE19539409C2 (de) * 1995-10-11 1999-02-18 Diagnostikforschung Inst Kontrastmittel für die Nahinfrarot-Diagnostik
US6004536A (en) * 1995-11-14 1999-12-21 Molecular Probes, Inc. Lipophilic cyanine dyes with enchanced aqueous solubilty
US5804389A (en) * 1995-12-29 1998-09-08 Phanos Technologies, Inc. Method for detecting abnormal epithelial cell shedding
DE19603033A1 (de) 1996-01-19 1997-07-24 Schering Ag Perfluoralkylhaltige Metallkomplexe, Verfahren zu deren Herstellung und ihre Verwendung in der NMR-Diagnostik
US8349602B1 (en) 1996-04-19 2013-01-08 Xenogen Corporation Biodetectors targeted to specific ligands
US5723104A (en) * 1996-05-13 1998-03-03 Fung; Ella Y. Monocyclic functional dyes for contrast enhancement in optical imaging
US5672333A (en) * 1996-05-13 1997-09-30 Mallinckrodt Medical, Inc. Delta1,6 bicyclo 4,4,0! functional dyes for contrast enhancement in optical imaging
US5989835A (en) * 1997-02-27 1999-11-23 Cellomics, Inc. System for cell-based screening
US6008010A (en) * 1996-11-01 1999-12-28 University Of Pittsburgh Method and apparatus for holding cells
KR100502440B1 (ko) * 1997-02-04 2005-07-20 파노스 테크놀로지즈 인코포레이티드 비정상적 상피세포의 박리를 측정하는 방법
US6727071B1 (en) 1997-02-27 2004-04-27 Cellomics, Inc. System for cell-based screening
CA2282658C (en) 1997-02-27 2003-02-25 Cellomics, Inc. A system for cell-based screening
US7117098B1 (en) 1997-02-27 2006-10-03 Cellomics, Inc. Machine-readable storage medium for analyzing distribution of macromolecules between the cell membrane and the cell cytoplasm
US5976502A (en) * 1997-10-21 1999-11-02 Gholam A. Peyman Method of visualizing particles and blood cells containing a fluorescent lipophilic dye in the retina and choroid of the eye
US7294755B1 (en) 1997-11-14 2007-11-13 Cedars-Sinai Medical Center Genetic modification of male germ cells for generation of transgenic species and genetic therapies
EP1030929B1 (en) * 1997-11-14 2009-03-18 Cedars-Sinai Medical Center Transfection and transfer of non-human male germ cells for generation of transgenic non-human mammals
US6734338B1 (en) 1997-11-14 2004-05-11 Cedars-Sinai Medical Center Transfection, storage and transfer of male germ cells for generation of transgenic species and genetic therapies
US6986993B1 (en) 1999-08-05 2006-01-17 Cellomics, Inc. System for cell-based screening
US6944493B2 (en) * 1999-09-10 2005-09-13 Akora, Inc. Indocyanine green (ICG) compositions and related methods of use
US6351663B1 (en) 1999-09-10 2002-02-26 Akorn, Inc. Methods for diagnosing and treating conditions associated with abnormal vasculature using fluorescent dye angiography and dye-enhanced photocoagulation
US6443976B1 (en) 1999-11-30 2002-09-03 Akorn, Inc. Methods for treating conditions and illnesses associated with abnormal vasculature
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US20070212338A1 (en) * 2000-01-11 2007-09-13 Greenville Hospital System Hybrid cells
AU783931B2 (en) 2000-01-11 2005-12-22 Greenville Hospital System Hybrid cells obtainable from antigen presenting cells
US20090087450A1 (en) * 2000-01-11 2009-04-02 Greenville Hospital System Combination therapy of hybrid cells with BCG injection for treating Cancer Patients
US20030223935A1 (en) * 2001-03-05 2003-12-04 Gray Brian D. Fluorescent membrane intercalating probes and methods for their use
DE60138531D1 (de) * 2000-03-03 2009-06-10 Phanos Tech Inc Fluoreszierende im membran interkalierende proben und verfahren zu deren verwendung
US6689391B2 (en) 2001-03-30 2004-02-10 Council Of Scientific & Industrial Research Natural non-polar fluorescent dye from a non-bioluminescent marine invertebrate, compositions containing the said dye and its uses
AU2002303234A1 (en) * 2001-04-02 2002-10-15 Cytoprint, Inc. Methods and apparatus for discovering, identifying and comparing biological activity mechanisms
JP2006519032A (ja) * 2002-12-02 2006-08-24 エダ リサーチ アンド ディベロップメント カンパニー リミティド 光学的な画像化による動脈硬化症の特徴付け
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US7776529B2 (en) 2003-12-05 2010-08-17 Life Technologies Corporation Methine-substituted cyanine dye compounds
JP2008508888A (ja) * 2004-08-05 2008-03-27 ザ ボード オブ トラスティーズ オブ ザ リーランド スタンフォード ジュニア ユニバーシティ 細胞活性化のための方法および組成物
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EP1885718B1 (en) 2005-05-11 2017-03-15 Life Technologies Corporation Fluorescent chemical compounds having high selectivity for double stranded dna, and methods for their use
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US3673410A (en) * 1969-06-25 1972-06-27 John H Waite Method of examination of cell samples using a radioactively tagged dye
US4343782A (en) * 1978-04-20 1982-08-10 Shapiro Howard M Cytological assay procedure
US4424201A (en) * 1978-11-28 1984-01-03 Rockefeller University Employment of a mereyanine dye for the detection of malignant leukocytic cells
US4311688A (en) * 1979-10-29 1982-01-19 Serono Laboratories Inc. Composition and method for cancer detection in humans
US4401647A (en) * 1980-03-03 1983-08-30 The Regents Of The University Of Ca Radiolabeled neoglycopeptides

Also Published As

Publication number Publication date
IL84294A0 (en) 1988-03-31
IE872871L (en) 1988-04-30
AU607165B2 (en) 1991-02-28
ZA878116B (en) 1988-08-31
DK570487A (da) 1988-05-01
DK167850B1 (da) 1993-12-27
KR100298682B1 (ko) 2001-11-22
DK167957B1 (da) 1994-01-10
JPS63126833A (ja) 1988-05-30
US4762701A (en) 1988-08-09
EP0266195A1 (en) 1988-05-04
IL84294A (en) 1992-03-29
CA1294545C (en) 1992-01-21
PT86030B (pt) 1990-08-31
DE3751434D1 (de) 1995-09-07
DK570487D0 (da) 1987-10-30
IE70749B1 (en) 1996-12-30
ATE125710T1 (de) 1995-08-15
DE3751434T2 (de) 1996-05-15
PH24539A (en) 1990-08-03
AU8040187A (en) 1988-05-05
KR880005458A (ko) 1988-06-29
ES2076929T3 (es) 1995-11-16
JP2872243B2 (ja) 1999-03-17
EP0266195B1 (en) 1995-08-02

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Effective date: 19930831