KR880005458A - 생체내 세포추적 - Google Patents

생체내 세포추적 Download PDF

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KR880005458A
KR880005458A KR870012050A KR870012050A KR880005458A KR 880005458 A KR880005458 A KR 880005458A KR 870012050 A KR870012050 A KR 870012050A KR 870012050 A KR870012050 A KR 870012050A KR 880005458 A KR880005458 A KR 880005458A
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cyanine dye
cells
labeled
platelets
red blood
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KR870012050A
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KR100298682B1 (ko
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칼 호랜 폴
엘렌 슬레작 슈
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스투어트 알.수터
스미스 클라인 베크만 코퍼레이션
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0032—Methine dyes, e.g. cyanine dyes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
    • A61K49/0058—Antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0063—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres
    • A61K49/0069—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres the agent being in a particular physical galenical form
    • A61K49/0097—Cells, viruses, ghosts, red blood cells, viral vectors, used for imaging or diagnosis in vivo

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pathology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Virology (AREA)
  • Hematology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Eye Examination Apparatus (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Exhaust Gas Treatment By Means Of Catalyst (AREA)
  • Treating Waste Gases (AREA)

Abstract

내용 없음

Description

생체내 세포추적
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (40)

  1. 사전에 피검물에 투여한 시아닌 염료-표시된 세포의 위치를 결정하는 것으로 구성되는 피검물에서 생체내의 세포를 추적하는 방법.
  2. 시아닌 염료-표시된 세포들이 종양 세포를 찾으므로서 초기 또는 전이성 종양세포를 탐지하는 제1항의 방법.
  3. 시아닌 염료-표시된 세포가 임파구나 자연소멸성 세포인 제2항의 방법.
  4. 임파구나 자연소멸 세포가 대상체에 투여전에 활성을 띄는 제3항의 방법.
  5. 종양세포를 찾는 시아닌 염료-표시된 세포들이 단구인 제2항의 방법.
  6. 종양세포를 찾는 세포들이 단구에 결합된 단일클론 항체에 특유한 종양을 갖는 단 핵세포여서 종양세포인식을 유지하도록 하는 제2항의 방법.
  7. 종양세포를 찾는 시아닌 염료-표시된 세포가 혈소판인 제2항의 방법.
  8. 종양세포를 찾는 시아닌 염료-표시된 세포가 호중구인 제2항의 방법.
  9. 시아닌 염료가 DiSC 14(5)이거나 DiOC 14(3)인 제1항의 방법.
  10. 시아닌 염료가 감마 방사체와 연결되어 있는 제9항의 방법.
  11. 시아닌 염료가 핵자기 공명 소식자와 연결되어 있는 제9항의 방법.
  12. 시아닌 염료-표시된 세포들이 특별히 피검물을 감염시키는 유기체와 상호 작용하므로서 감염부위를 결정하는 제1항의 방법.
  13. 유기체가 박테리아나 균류인 제12항의 방법.
  14. 시아닌 염료-표시된 세포들이 호중구인 제13항의 방법.
  15. 시아닌 염료-표시된 세포가 적혈구인 제1항의 방법.
  16. 망막증이나 혈관 변성을 탐지하기 위해서 대상물의 망막을 시아닌 염료로 표시된 적혈구의 존재에 관하여 시험하는 제15항의 방법.
  17. 시아닌 염료로-표시된 적혈구가 혈관을 통하여 흐르는 속도를 측정하는 제15항의 방법.
  18. 시아닌 염료의 자극파장이 인간의 가시 스펙트럼 밖에 있는 제15항의 방법.
  19. 시아닌 염료로-표시된 세포가 혈소판인 제1항의 방법.
  20. 시아닌 염료로-표시된 혈소판의 집합을 망막혈관에서 탐지하는 제19항의 방법.
  21. 시아닌 염료-표시된 세포가 단구, 호중구, 임파구, 또는 혈소판인 제1항의 방법.
  22. 시아닌 염료를 감마 방사체로 연결시킨 제21항의 방법.
  23. 시아닌 염료가 핵자가 공명 소식자를 가지는 제1항의 방법.
  24. 시아닌 염료로 표시된 세포들이 대상체에서 살아지는 속도를 측정하는 것으로 구성되는 생체내에서 세포수명을 결정하는 방법.
  25. 시아닌 염료-표시된 세포들이 적혈구인 제24항의 방법.
  26. 적혈구에 대한 출혈과 면역 반응간을 구별하기 위하여 시아닌 염료로 표시한 적혈구의 제거속도를 헤마토그리트관 변화와 비교하는 제25항의 방법.
  27. 전체 혈액 용적을 고정된 수의 완전하게 표시된 세포를 주사하고 평형을 유지시킨 후 희석 인자를 측정하는 제25항의 방법.
  28. 시아닌 염료-표시된 혈구를 대상체의 세포를 표시하여 제조하는 제25항의 방법.
  29. 시아닌 염료-표시된 적혈구를 임의 공여체 O형 적혈구를 표시하여 제조하는 제25항의 방법.
  30. 시아닌 염료-표시된 세포가 혈소판인 제24항의 방법.
  31. 시아닌 염료-표시한 혈소판의 소멸 속도를 총혈소판 계산과 비교하여 출혈이나 감소된 혈소판 생성 및 혈소판에 대한 면역 반응간을 구별하는 제30항의 방법.
  32. 시아닌 염료가 DiSC 14(5)이거나 DiOC 14(3)인 제24항의 방법.
  33. 시아닌 염료-표시된 혈소판의 수명을 아테롬성 동맥경화증의 측정으로 결정하는 제30항의 방법.
  34. 시아닌 염료-표시된 호중구를 사용하여 감염위치를 탐지하는 제22항의 방법.
  35. 시아닌 염료-표시한 혈소판을 안내로 미세 색전성을 탐지하기 위해서 측정하는 제32항의 방법.
  36. 동맥협착을 결정하기 위해서 영상 방법과 함께 시아닌 염료-표시한 세포를 사용하는 제22항의 방법.
  37. 시아닌 염료-표시한 세포를 관절염의 기를 결정하는데 사용하는 제24항의 방법.
  38. 시아닌 염료-표시한 세포를 관절염의 기를 결정하는데 사용하는 제22항의 방법.
  39. 시아닌 염료-표시된 세포를 이식 세포나 기간거부를 감지하는데 사용하는 제22항의 방법.
  40. 시아닌 염료-표시할 세포를 얻어서 그 세포를 시아닌 염료로 표시하고 시아닌 염료-표시한 세포를 대상체에 투여하여 시아닌 염료-표시세포를 탐지하는 것으로 이루어지는 대상체내의 생체내에서 세포를 추적하는 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019870012050A 1986-10-31 1987-10-30 시아닌염료-표시된세포의생체내세포추적용또는생체내세포의수명측정용용도 KR100298682B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/925,445 US4762701A (en) 1986-10-31 1986-10-31 In vivo cellular tracking
US925445 1993-07-13

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KR880005458A true KR880005458A (ko) 1988-06-29
KR100298682B1 KR100298682B1 (ko) 2001-11-22

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US (1) US4762701A (ko)
EP (1) EP0266195B1 (ko)
JP (1) JP2872243B2 (ko)
KR (1) KR100298682B1 (ko)
AT (1) ATE125710T1 (ko)
AU (1) AU607165B2 (ko)
CA (1) CA1294545C (ko)
DE (1) DE3751434T2 (ko)
DK (1) DK167957B1 (ko)
ES (1) ES2076929T3 (ko)
IE (1) IE70749B1 (ko)
IL (1) IL84294A (ko)
PH (1) PH24539A (ko)
PT (1) PT86030B (ko)
ZA (1) ZA878116B (ko)

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DK167957B1 (da) 1994-01-10
IE872871L (en) 1988-04-30
IL84294A0 (en) 1988-03-31
PT86030A (en) 1987-11-01
JPS63126833A (ja) 1988-05-30
PT86030B (pt) 1990-08-31
IL84294A (en) 1992-03-29
KR100298682B1 (ko) 2001-11-22
CA1294545C (en) 1992-01-21
DE3751434D1 (de) 1995-09-07
IE70749B1 (en) 1996-12-30
EP0266195A1 (en) 1988-05-04
EP0266195B1 (en) 1995-08-02
PH24539A (en) 1990-08-03
DK570487A (da) 1988-05-01
AU8040187A (en) 1988-05-05
JP2872243B2 (ja) 1999-03-17
AU607165B2 (en) 1991-02-28
DE3751434T2 (de) 1996-05-15
DK167850B1 (da) 1993-12-27
ATE125710T1 (de) 1995-08-15
ZA878116B (en) 1988-08-31
DK570487D0 (da) 1987-10-30
US4762701A (en) 1988-08-09
ES2076929T3 (es) 1995-11-16

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