PT852491E - Utilizacao de heparinases para diminuir respostas inflamatorias - Google Patents
Utilizacao de heparinases para diminuir respostas inflamatoriasInfo
- Publication number
- PT852491E PT852491E PT96936052T PT96936052T PT852491E PT 852491 E PT852491 E PT 852491E PT 96936052 T PT96936052 T PT 96936052T PT 96936052 T PT96936052 T PT 96936052T PT 852491 E PT852491 E PT 852491E
- Authority
- PT
- Portugal
- Prior art keywords
- heparinase
- endothelium
- localized
- inflammatory responses
- heparin
- Prior art date
Links
- 230000002757 inflammatory effect Effects 0.000 title 1
- 108010022901 Heparin Lyase Proteins 0.000 abstract 7
- 229920002971 Heparan sulfate Polymers 0.000 abstract 4
- 210000003038 endothelium Anatomy 0.000 abstract 4
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 abstract 2
- 229960002897 heparin Drugs 0.000 abstract 2
- 210000000265 leukocyte Anatomy 0.000 abstract 2
- 102000019034 Chemokines Human genes 0.000 abstract 1
- 108010012236 Chemokines Proteins 0.000 abstract 1
- 206010015866 Extravasation Diseases 0.000 abstract 1
- 206010061218 Inflammation Diseases 0.000 abstract 1
- 238000009825 accumulation Methods 0.000 abstract 1
- 210000002469 basement membrane Anatomy 0.000 abstract 1
- 230000029087 digestion Effects 0.000 abstract 1
- 210000002889 endothelial cell Anatomy 0.000 abstract 1
- 230000036251 extravasation Effects 0.000 abstract 1
- 230000004054 inflammatory process Effects 0.000 abstract 1
- 230000028709 inflammatory response Effects 0.000 abstract 1
- 108020001756 ligand binding domains Proteins 0.000 abstract 1
- 238000005096 rolling process Methods 0.000 abstract 1
- 230000008685 targeting Effects 0.000 abstract 1
- 210000001519 tissue Anatomy 0.000 abstract 1
- 230000002792 vascular Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/51—Lyases (4)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/88—Lyases (4.)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S424/00—Drug, bio-affecting and body treating compositions
- Y10S424/81—Drug, bio-affecting and body treating compositions involving autoimmunity, allergy, immediate hypersensitivity, delayed hypersensitivity, immunosuppression, immunotolerance, or anergy
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US462295P | 1995-09-29 | 1995-09-29 | |
| US08/722,659 US20010006635A1 (en) | 1995-09-29 | 1996-09-27 | Use of heparinase to decrease inflammatory responses |
| PCT/US1996/015593 WO1997011684A1 (en) | 1995-09-29 | 1996-09-27 | Use of heparinases to decrease inflammatory responses |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT852491E true PT852491E (pt) | 2004-11-30 |
Family
ID=26673252
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT96936052T PT852491E (pt) | 1995-09-29 | 1996-09-27 | Utilizacao de heparinases para diminuir respostas inflamatorias |
Country Status (11)
| Country | Link |
|---|---|
| US (3) | US20010006635A1 (pt) |
| EP (2) | EP0852491B1 (pt) |
| JP (1) | JP3713276B2 (pt) |
| AT (1) | ATE273020T1 (pt) |
| AU (1) | AU703394B2 (pt) |
| CA (1) | CA2233343A1 (pt) |
| DE (1) | DE69633127T2 (pt) |
| DK (1) | DK0852491T3 (pt) |
| ES (1) | ES2227611T3 (pt) |
| PT (1) | PT852491E (pt) |
| WO (1) | WO1997011684A1 (pt) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6153187A (en) * | 1997-09-02 | 2000-11-28 | Insight Strategy & Marketing Ltd. | Use of glycosaminoglycans degrading enzymes for management of airway associated diseases |
| CA2242693C (en) * | 1997-09-04 | 2002-09-17 | Becton, Dickinson And Company | Additive formulation and method of use thereof |
| AU2759199A (en) | 1998-02-24 | 1999-09-15 | Pharmacia & Upjohn Company | Human platelet heparanase polypeptides, polynucleotide molecules that encode them, and methods for the identification of compounds that alter heparanase activity |
| US7056504B1 (en) | 1998-08-27 | 2006-06-06 | Massachusetts Institute Of Technology | Rationally designed heparinases derived from heparinase I and II |
| EP1026250A1 (en) * | 1998-12-02 | 2000-08-09 | Aventis Behring GmbH | DNA-constructs of blood clotting factors and P-selectin |
| EP1010762A1 (en) * | 1998-12-02 | 2000-06-21 | Aventis Behring Gesellschaft mit beschränkter Haftung | DNA constructs of blood clotting factors and P-Selectin |
| IL149889A0 (en) | 1999-12-22 | 2002-11-10 | Oxford Glycosciences Uk Ltd | Heparanase-like proteins and nucleotides encoding them |
| AU4351201A (en) * | 2000-03-08 | 2001-09-17 | Massachusetts Inst Technology | Heparinase iii and uses thereof |
| AU2440802A (en) | 2000-10-18 | 2002-04-29 | Massachusetts Inst Technology | Methods and products related to pulmonary delivery of polysaccharides |
| US7629309B2 (en) | 2002-05-29 | 2009-12-08 | Zystor Therapeutics, Inc. | Targeted therapeutic proteins |
| US20040005309A1 (en) * | 2002-05-29 | 2004-01-08 | Symbiontics, Inc. | Targeted therapeutic proteins |
| WO2002087510A2 (en) * | 2001-04-30 | 2002-11-07 | Symbiontics, Inc. | Subcellular targeting of therapeutic proteins |
| US7560424B2 (en) | 2001-04-30 | 2009-07-14 | Zystor Therapeutics, Inc. | Targeted therapeutic proteins |
| US20030072761A1 (en) * | 2001-10-16 | 2003-04-17 | Lebowitz Jonathan | Methods and compositions for targeting proteins across the blood brain barrier |
| CA2556161A1 (en) * | 2004-01-30 | 2005-08-18 | Emory University | Heparan-sulfate proteoglycan degrading enzymes for promotion of nerve regeneration |
| US20050244400A1 (en) * | 2004-02-10 | 2005-11-03 | Zystor Therapeutics, Inc. | Acid alpha-glucosidase and fragments thereof |
| CN1312183C (zh) * | 2004-05-19 | 2007-04-25 | 清华大学 | 一种肝素酶i融合蛋白及其编码基因与表达方法 |
| CN100344769C (zh) * | 2005-08-04 | 2007-10-24 | 清华大学 | 一种制备低分子量肝素的方法 |
| US7767420B2 (en) * | 2005-11-03 | 2010-08-03 | Momenta Pharmaceuticals, Inc. | Heparan sulfate glycosaminoglycan lyase and uses thereof |
| US7691613B2 (en) | 2006-11-03 | 2010-04-06 | Momenta Pharmaceuticals, Inc. | Glycosaminoglycan lyase IV and uses thereof |
| US7691612B2 (en) | 2005-11-03 | 2010-04-06 | Momenta Pharmaceuticals, Inc. | Heparan sulfate glycosaminoglycan lyase and uses thereof |
| AU2007322123A1 (en) * | 2006-11-13 | 2008-05-29 | Biomarin Pharmaceutical Inc. | Methods for treating Pompe disease |
| EP3187508A1 (en) * | 2008-05-07 | 2017-07-05 | BioMarin Pharmaceutical Inc. | Lysosomal targeting peptides and uses thereof |
| WO2010148253A2 (en) | 2009-06-17 | 2010-12-23 | Zystor Therapeutics, Inc. | Formulations for lysosomal enzymes |
| BR112015020477B1 (pt) * | 2013-02-28 | 2019-10-29 | Kao Corp | processo, uso e kit para alisamento semipermanente dos cabelos |
| US11903963B2 (en) | 2017-03-10 | 2024-02-20 | The University Of North Carolina At Chapel Hill | Short-acting heparin-based anticoagulant compounds and methods |
| WO2019090203A1 (en) | 2017-11-03 | 2019-05-09 | The University Of North Carolina At Chapel Hill | Sulfated oligosaccharides having anti-inflammatory activity |
| CN112437667A (zh) | 2018-06-20 | 2021-03-02 | 北卡罗来纳大学查珀尔希尔分校 | 细胞保护方法和组合物 |
| CN114980904A (zh) * | 2019-11-13 | 2022-08-30 | 北卡罗来纳大学查珀尔希尔分校 | 硫酸乙酰肝素(hs)低聚糖在肝缺血再灌注损伤中的影响 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB941664A (en) * | 1959-02-19 | 1963-11-13 | Henry Thompson Stanton Jr | Buccal or sublingual tablet containing carbohydra e enzyme for controlling inflammation |
| US4179337A (en) | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
| IL85145A (en) * | 1987-01-23 | 1994-08-26 | Univ Australian | Anti-metastatic pharmacological or veterinary preparations containing modified herpin with reduced anticoagulant activity |
| US5169772A (en) * | 1988-06-06 | 1992-12-08 | Massachusetts Institute Of Technology | Large scale method for purification of high purity heparinase from flavobacterium heparinum |
| EP0487627B1 (en) | 1989-08-23 | 1998-06-10 | Hadassah Medical Organization | Wound healing preparations containing heparanase |
| US5099855A (en) | 1989-11-09 | 1992-03-31 | State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University | Methods of and apparatus for monitoring respiration and conductive gel used therewith |
| AU8631991A (en) * | 1990-08-27 | 1992-03-17 | Cetus Corporation | Cd18 peptide medicaments for the treatment of disease |
| US5270197A (en) | 1990-12-20 | 1993-12-14 | The Children's Medical Center Corporation | Cells expressing a substantial number of surface high affinity HBGF receptors but relatively few low affinity HBGF binding sites and system for assaying binding to HBGF receptor |
| US5714376A (en) | 1991-10-23 | 1998-02-03 | Massachusetts Institute Of Technology | Heparinase gene from flavobacterium heparinum |
| DK75593D0 (pt) | 1993-06-25 | 1993-06-25 | Novo Nordisk As | |
| EP0726773A1 (en) * | 1993-11-17 | 1996-08-21 | Massachusetts Institute Of Technology | Method for inhibiting angiogenesis using heparinase |
| US5997863A (en) * | 1994-07-08 | 1999-12-07 | Ibex Technologies R And D, Inc. | Attenuation of wound healing processes |
-
1996
- 1996-09-27 AT AT96936052T patent/ATE273020T1/de not_active IP Right Cessation
- 1996-09-27 ES ES96936052T patent/ES2227611T3/es not_active Expired - Lifetime
- 1996-09-27 US US08/722,659 patent/US20010006635A1/en not_active Abandoned
- 1996-09-27 EP EP96936052A patent/EP0852491B1/en not_active Expired - Lifetime
- 1996-09-27 DK DK96936052T patent/DK0852491T3/da active
- 1996-09-27 EP EP04076600A patent/EP1552846A3/en not_active Withdrawn
- 1996-09-27 CA CA002233343A patent/CA2233343A1/en not_active Abandoned
- 1996-09-27 JP JP51372397A patent/JP3713276B2/ja not_active Expired - Fee Related
- 1996-09-27 WO PCT/US1996/015593 patent/WO1997011684A1/en active IP Right Grant
- 1996-09-27 PT PT96936052T patent/PT852491E/pt unknown
- 1996-09-27 DE DE69633127T patent/DE69633127T2/de not_active Expired - Fee Related
- 1996-09-27 AU AU73791/96A patent/AU703394B2/en not_active Ceased
-
2005
- 2005-05-02 US US11/118,477 patent/US20050191288A1/en not_active Abandoned
-
2006
- 2006-02-22 US US11/357,967 patent/US7264799B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US20050191288A1 (en) | 2005-09-01 |
| US20010006635A1 (en) | 2001-07-05 |
| EP1552846A2 (en) | 2005-07-13 |
| DK0852491T3 (da) | 2004-12-20 |
| US20060140928A1 (en) | 2006-06-29 |
| DE69633127T2 (de) | 2005-08-04 |
| JPH11512721A (ja) | 1999-11-02 |
| AU703394B2 (en) | 1999-03-25 |
| EP0852491B1 (en) | 2004-08-11 |
| EP1552846A3 (en) | 2008-05-07 |
| DE69633127D1 (de) | 2004-09-16 |
| EP0852491A1 (en) | 1998-07-15 |
| US7264799B2 (en) | 2007-09-04 |
| AU7379196A (en) | 1997-04-17 |
| EP0852491A4 (en) | 2002-08-07 |
| ES2227611T3 (es) | 2005-04-01 |
| WO1997011684A1 (en) | 1997-04-03 |
| ATE273020T1 (de) | 2004-08-15 |
| JP3713276B2 (ja) | 2005-11-09 |
| CA2233343A1 (en) | 1997-04-03 |
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