ATE334194T1 - Homologe enzyme der humanen heparanase sowie alternative spleissformen davon - Google Patents

Homologe enzyme der humanen heparanase sowie alternative spleissformen davon

Info

Publication number
ATE334194T1
ATE334194T1 AT00985677T AT00985677T ATE334194T1 AT E334194 T1 ATE334194 T1 AT E334194T1 AT 00985677 T AT00985677 T AT 00985677T AT 00985677 T AT00985677 T AT 00985677T AT E334194 T1 ATE334194 T1 AT E334194T1
Authority
AT
Austria
Prior art keywords
homologue
enzymes
alternative splicing
human heparanase
splicing forms
Prior art date
Application number
AT00985677T
Other languages
English (en)
Inventor
Edward Alexander Mckenzie
Alasdair Craig Stamps
Jonathan Alexander Terrett
Kerry Louise Tyson
Original Assignee
Ucb Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9930392.7A external-priority patent/GB9930392D0/en
Priority claimed from GB0008713A external-priority patent/GB0008713D0/en
Application filed by Ucb Sa filed Critical Ucb Sa
Application granted granted Critical
Publication of ATE334194T1 publication Critical patent/ATE334194T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/01166—Heparanase (3.2.1.166)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/16—Emollients or protectives, e.g. against radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Molecular Biology (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Hematology (AREA)
  • Dermatology (AREA)
  • Emergency Medicine (AREA)
  • Communicable Diseases (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Cardiology (AREA)
  • Transplantation (AREA)
  • Obesity (AREA)
AT00985677T 1999-12-22 2000-12-21 Homologe enzyme der humanen heparanase sowie alternative spleissformen davon ATE334194T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9930392.7A GB9930392D0 (en) 1999-12-22 1999-12-22 Substances
GB0008713A GB0008713D0 (en) 2000-04-07 2000-04-07 Substances

Publications (1)

Publication Number Publication Date
ATE334194T1 true ATE334194T1 (de) 2006-08-15

Family

ID=26244068

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00985677T ATE334194T1 (de) 1999-12-22 2000-12-21 Homologe enzyme der humanen heparanase sowie alternative spleissformen davon

Country Status (11)

Country Link
US (2) US7273744B2 (de)
EP (1) EP1240313B1 (de)
JP (1) JP2003517835A (de)
AT (1) ATE334194T1 (de)
AU (1) AU2207801A (de)
CA (1) CA2393855A1 (de)
DE (1) DE60029624T2 (de)
DK (1) DK1240313T3 (de)
ES (1) ES2269211T3 (de)
IL (1) IL149889A0 (de)
WO (1) WO2001046392A2 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU5033101A (en) * 2000-02-24 2001-10-08 Bayer Aktiengesellschaft Regulation of human heparanase-like enzyme
GB0008912D0 (en) * 2000-04-11 2000-05-31 Janssen Pharmaceutica Nv Mammalian heparanase
US20020064853A1 (en) * 2000-04-20 2002-05-30 Heinrikson Robert Leroy Heparanase II, a novel human heparanase paralog
AU2001287610A1 (en) * 2000-07-12 2002-01-21 Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw A second human heparanase, and splice variants thereof, with a predominant expression in skeletal muscle, heart and pancreas
US20040132123A1 (en) * 2001-05-09 2004-07-08 Oron Yacoby-Zeevi Methods and kits utilizing heparanase as a diagnostic marker for haemostatic disorders
WO2006018319A1 (en) * 2004-08-18 2006-02-23 Bayer Cropscience Gmbh Plants with increased plastidic activity of r3 starch-phosphorylating enzyme
WO2007070463A2 (en) * 2005-12-12 2007-06-21 Riolan Technologies, Inc. Compositions, methods and kits for removing debris from an ocular area

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL79255A0 (en) 1986-06-26 1986-09-30 Hadassah Med Org Composition for metastasis prevention
CA2176934A1 (en) 1993-11-17 1995-05-26 Ramnath Sasisekharan Method for inhibiting angiogenesis using heparinase
US20010006635A1 (en) 1995-09-29 2001-07-05 D. Clark Bennett Use of heparinase to decrease inflammatory responses
US5968822A (en) 1997-09-02 1999-10-19 Pecker; Iris Polynucleotide encoding a polypeptide having heparanase activity and expression of same in transduced cells
WO1999021975A1 (en) * 1997-10-28 1999-05-06 The Australian National University Isolated nucleic acid molecule encoding mammalian endoglucuronidase and uses therefor
GB9802725D0 (en) 1998-02-09 1998-04-08 Ciba Geigy Ag Organic compounds
WO1999043830A2 (en) 1998-02-24 1999-09-02 Pharmacia & Upjohn Company Human platelet heparanase polypeptides, polynucleotide molecules that encode them, and methods for the identification of compounds that alter heparanase activity
KR20020028906A (ko) * 1999-06-25 2002-04-17 추후보정 폴리누클레오티드 및 그에 의해 코딩된 헤파라나제와간접적으로 유사한 폴리펩티드
US7101706B1 (en) * 1999-06-25 2006-09-05 Insight Biopharmaceuticals Ltd. Polynucleotides and polypeptides encoded thereby distantly homologous to heparanase
US6872558B1 (en) * 1999-09-23 2005-03-29 Merck Patent Gmbh Heparanase-2 a member of the heparanase protein family
WO2001079253A1 (en) * 2000-04-18 2001-10-25 Human Genome Sciences, Inc. Extracellular matrix polynucleotides, polypeptides, and antibodies

Also Published As

Publication number Publication date
US20090246201A1 (en) 2009-10-01
EP1240313A2 (de) 2002-09-18
US20030083254A1 (en) 2003-05-01
EP1240313B1 (de) 2006-07-26
JP2003517835A (ja) 2003-06-03
WO2001046392A2 (en) 2001-06-28
ES2269211T3 (es) 2007-04-01
AU2207801A (en) 2001-07-03
CA2393855A1 (en) 2001-06-28
DE60029624D1 (de) 2006-09-07
DE60029624T2 (de) 2007-08-09
IL149889A0 (en) 2002-11-10
DK1240313T3 (da) 2006-11-27
WO2001046392A3 (en) 2001-12-06
US7273744B2 (en) 2007-09-25

Similar Documents

Publication Publication Date Title
NO20004219D0 (no) Inhibitorer av fosfolipaseenzymer
NO20004220L (no) Inhibitorer av fosfolipaseenzymer
NO20014535D0 (no) Inhibitorer av IMPDH-enzym
FI942624A0 (fi) Alfa-heteroaryylioksimetyyliketoneja interleukiini-1betaa muuttavan entsyymin inhibiittoreina
NO20015020D0 (no) Vandig fraksjonering av biomasse basert på ny karbohydrathydrolysekinetikk
NO20005100D0 (no) Genetisk modifiserte celler og fremgangsmÕter for ekspresjon av rekombinant heparanase og fremgangsmÕter for rensing av samme
DE69700624D1 (de) Enzymatische hydrolyse von cyclischen oligomeren
NO20005293L (no) Visse tiolininhibitorer av endotelinomdannende enzym
ES2162110T3 (es) Derivados de la quinolina antimalaria.
ATE334194T1 (de) Homologe enzyme der humanen heparanase sowie alternative spleissformen davon
PT1164996E (pt) Sistemas terapeuticos transdermicos com nicotina e adicao de cetonas monoterpenicas
NO965564D0 (no) Medisinsk anvendelse av bromelain
DE69828985D1 (de) Lichtgebender katheter sowie anwendungsverfahren
AU2001250193A1 (en) Novel pyridones and their use as modulators of serine hydrolase enzymes
NO963482D0 (no) Medisinsk anvendelse av bromelain
BG103859A (en) The use of 1-ar(alk)yl-imidazolin-2-on for the treatment of fear and stress conditions
ITRM990787A0 (it) Idrolisi stereospecifica di esteri otticamente attivi.
DE69713192D1 (de) Kombination von Enzymen
DE60002523D1 (de) Racemisierung von optisch aktiven Alkoxyaminen
NO994056D0 (no) Anvendelse av disintegrin metalloprotease samt mutanter og fragmenter derav
SE9603101D0 (sv) Medicinsk användning av enzym
DE3774947D1 (de) Alpha-acylamino-aminoalkyl-phosphonat-inhibitor des angiotensin umwandelnden enzyms.
FR2724931B1 (fr) Hydrolyse enzymatique des 4-methylthiobutyronitrile
AU2002212246A1 (en) Regulation of human serine palmitoyltransferase-like enzyme
FR2731438B1 (fr) Hydrolise enzymatique des 4-methylthiobutyronitriles

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties