AU2001250193A1 - Novel pyridones and their use as modulators of serine hydrolase enzymes - Google Patents

Novel pyridones and their use as modulators of serine hydrolase enzymes

Info

Publication number
AU2001250193A1
AU2001250193A1 AU2001250193A AU5019301A AU2001250193A1 AU 2001250193 A1 AU2001250193 A1 AU 2001250193A1 AU 2001250193 A AU2001250193 A AU 2001250193A AU 5019301 A AU5019301 A AU 5019301A AU 2001250193 A1 AU2001250193 A1 AU 2001250193A1
Authority
AU
Australia
Prior art keywords
modulators
serine hydrolase
hydrolase enzymes
pyridones
novel
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001250193A
Inventor
Sultan Darvesh
David Magee
Earl Martin
Zdenek Valenta
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dalhousie University
Original Assignee
Dalhousie University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dalhousie University filed Critical Dalhousie University
Publication of AU2001250193A1 publication Critical patent/AU2001250193A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/64—One oxygen atom attached in position 2 or 6
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
AU2001250193A 2000-04-10 2001-04-09 Novel pyridones and their use as modulators of serine hydrolase enzymes Abandoned AU2001250193A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/545,994 US6436972B1 (en) 2000-04-10 2000-04-10 Pyridones and their use as modulators of serine hydrolase enzymes
US09545994 2000-04-10
PCT/CA2001/000476 WO2001077078A1 (en) 2000-04-10 2001-04-09 Novel pyridones and their use as modulators of serine hydrolase enzymes

Publications (1)

Publication Number Publication Date
AU2001250193A1 true AU2001250193A1 (en) 2001-10-23

Family

ID=24178400

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001250193A Abandoned AU2001250193A1 (en) 2000-04-10 2001-04-09 Novel pyridones and their use as modulators of serine hydrolase enzymes

Country Status (3)

Country Link
US (2) US6436972B1 (en)
AU (1) AU2001250193A1 (en)
WO (1) WO2001077078A1 (en)

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US7329388B2 (en) * 1999-11-08 2008-02-12 Princeton Biochemicals, Inc. Electrophoresis apparatus having staggered passage configuration
US20040014744A1 (en) * 2002-04-05 2004-01-22 Fortuna Haviv Substituted pyridines having antiangiogenic activity
US7607093B2 (en) * 2003-04-04 2009-10-20 Agilent Technologies, Inc. Displaying network segment decode information in diagrammatic form
JP4029802B2 (en) * 2003-08-28 2008-01-09 セイコーエプソン株式会社 Electro-optical device drive circuit, electro-optical device, and electronic apparatus
EP1694650A1 (en) 2003-12-15 2006-08-30 Laboratoire Theramex 1-n-phenyl-amino-1h-imidazole derivatives and pharmaceutical compositions containing them
TW200806284A (en) * 2006-03-31 2008-02-01 Alcon Mfg Ltd Prenyltransferase inhibitors for ocular hypertension control and the treatment of glaucoma
NZ591824A (en) * 2008-08-29 2013-07-26 Treventis Corp Butyrylcholinesterase ligands as diagnostic tools and treatment for deseases of the nervous system
JP5592388B2 (en) 2008-10-31 2014-09-17 メルク・シャープ・アンド・ドーム・コーポレーション Technical field of P2X3 receptor antagonist for the treatment of pain
CN109641884B (en) 2016-08-18 2024-01-02 维达克制药有限公司 Piperazine derivatives, pharmaceutical compositions thereof, and methods of use thereof

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US3644626A (en) 1969-11-25 1972-02-22 Merck & Co Inc Novel pyridones in compositions and methods for treating inflammation pain and fever
US3655897A (en) 1971-01-25 1972-04-11 Merck & Co Inc Anti-inflammatory agents
US3897556A (en) 1972-10-20 1975-07-29 Sankyo Co Substitute pyridinol-containing compositions and methods for the treatment of coccidiosis
US3839346A (en) 1972-12-18 1974-10-01 Affiliated Med Res N-substituted pyridone and general method for preparing pyridones
US3897356A (en) 1973-02-28 1975-07-29 Scott Paper Co Windshield wipers containing nonionic surfactant
JPS5270014A (en) 1975-12-05 1977-06-10 Senju Pharma Co Stabilization of pyrido*3*22a*phenoxadine compounds
US4465686A (en) * 1981-09-08 1984-08-14 Sterling Drug Inc. 5-(Hydroxy- and/or amino-phenyl)-6-(lower-alkyl)-2-(1H)-pyridinones, their cardiotonic use and preparation
EP0089765A3 (en) 1982-03-17 1984-05-23 Smith Kline & French Laboratories Limited Pyridine derivatives
US4657919A (en) * 1984-08-03 1987-04-14 E. I. Du Pont De Nemours & Co. Pyridone esters as inotropic agents
CA1275097A (en) 1984-10-02 1990-10-09 Fujio Nohara Pyridyloxy derivatives
US4689325A (en) 1985-12-23 1987-08-25 Abbott Laboratories Isoxazolo-pyrido-phenoxazine and isothiazolo-pyrido-phenoxazine derivatives
GB8603475D0 (en) 1986-02-12 1986-03-19 Glaxo Group Ltd Chemical compounds
US5106979A (en) 1989-02-21 1992-04-21 University Of Pittsburgh Method for the synthesis of huperzine A and analogs thereof and compounds useful therein
US4929731A (en) 1989-02-21 1990-05-29 University Of Pittsburgh Method for the synthesis of huperzine A and analogs thereof and compounds useful therein
ZA913760B (en) 1990-05-24 1992-02-26 Sumitomo Chemical Co Pyridine derivatives,their production processes and their compounds for control of insect pests
AU641769B2 (en) * 1990-06-18 1993-09-30 Merck & Co., Inc. Inhibitors of HIV reverse transcriptase
JP2700943B2 (en) 1990-07-06 1998-01-21 高砂香料工業株式会社 Optically active 2-morpholino-2- (1-naphthylmethyl) -4-oxobutyric acid 2'-hydroxy-1,1'-binaphthalen-2-yl and process for producing the same
TW202434B (en) 1991-04-04 1993-03-21 Ciba Geigy Ag
US5104880A (en) 1991-05-01 1992-04-14 Mayo Foundation For Medical Education And Research Huperzine a analogs as acetylcholinesterase inhibitors
DE4127404A1 (en) 1991-08-19 1993-02-25 Thomae Gmbh Dr K CYCLIC IMINODERIVATES, MEDICAMENTS CONTAINING SUCH COMPOUNDS AND METHOD FOR THE PRODUCTION THEREOF
US5852041A (en) 1993-04-07 1998-12-22 Sibia Neurosciences, Inc. Substituted pyridines useful as modulators of acethylcholine receptors
DE4430091A1 (en) * 1994-08-25 1996-02-29 Bayer Ag Use of N-substituted phenothiazines
US5547960A (en) 1994-09-07 1996-08-20 Mayo Foundation For Medical Education And Research C-10 analogs of huperzine a
CN1125725A (en) 1994-12-28 1996-07-03 中国科学院上海药物研究所 First-kind "Haikelin" alkali derivant and its usage
US5789426A (en) * 1995-01-20 1998-08-04 Cornell Research Foundation, Inc. Method for the treatment of fibroproliferative disorders by application of inhibitors of protein hydroxylation
CZ20003978A3 (en) * 1998-04-27 2001-09-12 Centre National De La Recherche Scientifique Derivatives of 3-(amino- or aminoalkyl)pyridinone and use thereof
US6586475B1 (en) * 1998-11-20 2003-07-01 Takeda Chemical Industries, Ltd. β-amyloid protein production/secretion inhibitors
GB0002100D0 (en) 2000-01-28 2000-03-22 Novartis Ag Organic compounds

Also Published As

Publication number Publication date
US6436972B1 (en) 2002-08-20
US20020049330A1 (en) 2002-04-25
US6544986B2 (en) 2003-04-08
WO2001077078A1 (en) 2001-10-18

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