NO20004220L - Inhibitorer av fosfolipaseenzymer - Google Patents
Inhibitorer av fosfolipaseenzymerInfo
- Publication number
- NO20004220L NO20004220L NO20004220A NO20004220A NO20004220L NO 20004220 L NO20004220 L NO 20004220L NO 20004220 A NO20004220 A NO 20004220A NO 20004220 A NO20004220 A NO 20004220A NO 20004220 L NO20004220 L NO 20004220L
- Authority
- NO
- Norway
- Prior art keywords
- inhibitors
- phospholipase enzymes
- phospholipase
- enzymes
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/12—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US3006298A | 1998-02-25 | 1998-02-25 | |
| PCT/US1999/003899 WO1999043651A2 (en) | 1998-02-25 | 1999-02-24 | Inhibitors of phospholipase enzymes |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO20004220D0 NO20004220D0 (no) | 2000-08-23 |
| NO20004220L true NO20004220L (no) | 2000-10-05 |
Family
ID=21852314
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20004220A NO20004220L (no) | 1998-02-25 | 2000-08-23 | Inhibitorer av fosfolipaseenzymer |
Country Status (19)
| Country | Link |
|---|---|
| EP (1) | EP1056719A2 (no) |
| JP (1) | JP2002504539A (no) |
| KR (1) | KR20010041343A (no) |
| CN (1) | CN1299347A (no) |
| AU (1) | AU2782699A (no) |
| BG (1) | BG104780A (no) |
| BR (1) | BR9908280A (no) |
| CA (1) | CA2322161A1 (no) |
| EA (1) | EA200000868A1 (no) |
| EE (1) | EE200000486A (no) |
| HR (1) | HRP20000552A2 (no) |
| HU (1) | HUP0100757A3 (no) |
| ID (1) | ID27280A (no) |
| IL (1) | IL137718A0 (no) |
| NO (1) | NO20004220L (no) |
| PL (1) | PL342995A1 (no) |
| SK (1) | SK12742000A3 (no) |
| TR (1) | TR200002446T2 (no) |
| WO (1) | WO1999043651A2 (no) |
Families Citing this family (67)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000068223A1 (en) * | 1999-05-05 | 2000-11-16 | Aventis Pharma Limited | Ureas and their use as cell adhesion modulators |
| AU2001277056B2 (en) | 2000-07-25 | 2005-09-29 | Merck & Co., Inc. | N-substituted indoles useful in the treatment of diabetes |
| KR100854424B1 (ko) | 2001-01-29 | 2008-08-27 | 3-디멘져널 파마슈티칼즈 인코오포레이티드 | 치환된 인돌 및 인테그린 길항제로서의 이들의 용도 |
| US20030013656A1 (en) | 2001-05-03 | 2003-01-16 | Bing Wang | Pyruvate derivatives |
| US6608196B2 (en) | 2001-05-03 | 2003-08-19 | Galileo Pharmaceuticals, Inc. | Process for solid supported synthesis of pyruvate-derived compounds |
| TWI224101B (en) | 2001-06-20 | 2004-11-21 | Wyeth Corp | Substituted naphthyl indole derivatives as inhibitors of plasminogen activator inhibitor type-1 (PAI-1) |
| WO2003000253A1 (en) | 2001-06-20 | 2003-01-03 | Wyeth | Substituted indole acid derivatives as inhibitors of plasminogen activator inhibitor-1 (pai-1) |
| US7291639B2 (en) | 2001-06-20 | 2007-11-06 | Wyeth | Aryloxy-acetic acid compounds useful as inhibitors of plasminogen activator inhibitor-1 (PAI-1) |
| WO2003000668A1 (en) * | 2001-06-25 | 2003-01-03 | Nippon Soda Co., Ltd. | Oxa(thia)zolidine compounds, process for preparation thereof and anti-inflammatory agents |
| US6984735B2 (en) | 2001-12-03 | 2006-01-10 | Wyeth | Process for making an aldehyde |
| US7713964B2 (en) | 2001-12-03 | 2010-05-11 | Wyeth Llc | Methods for treating asthmatic conditions |
| US6797708B2 (en) | 2001-12-03 | 2004-09-28 | Wyeth | Inhibitors of cytosolic phospholipase A2 |
| EP1892239B1 (en) * | 2001-12-03 | 2013-02-20 | Wyeth LLC | Inhibitors of cytosolic phospholipase A2 |
| US7605156B2 (en) | 2001-12-03 | 2009-10-20 | Wyeth | Methods for the use of inhibitors of cytosolic phospholipase A2 |
| US6635771B2 (en) | 2001-12-03 | 2003-10-21 | Wyeth | N-benzhydryl indole compounds |
| ATE384045T1 (de) * | 2001-12-03 | 2008-02-15 | Wyeth Corp | Inhibitoren von cytosolischen phospholipase a2 |
| US7101875B2 (en) | 2001-12-03 | 2006-09-05 | Wyeth | Methods for treating arthritic disorders |
| AUPS282602A0 (en) | 2002-06-07 | 2002-06-27 | Garvan Institute Of Medical Research | Method of inhibiting cell proliferation |
| WO2004019869A2 (en) | 2002-08-29 | 2004-03-11 | Merck & Co., Inc. | Indoles having anti-diabetic activity |
| KR20050057074A (ko) | 2002-08-29 | 2005-06-16 | 머크 앤드 캄파니 인코포레이티드 | 항당뇨 활성을 갖는 인돌 |
| KR20050072812A (ko) | 2002-11-07 | 2005-07-12 | 악조 노벨 엔.브이. | 안드로겐-수용체와 관련된 질병의 치료에 효과적인 인돌 |
| DK1569900T3 (da) | 2002-12-10 | 2006-10-23 | Wyeth Corp | Substituerede 3-carbonyl-1-yl-eddikesyrederivater som inhibitorer af plasminogenaktivator-inhibitor-1 (PAI-1) |
| JP2006510672A (ja) | 2002-12-10 | 2006-03-30 | ワイス | プラスミノーゲン活性化因子の阻害因子−１（ｐａｉ−１）の阻害剤としての置換インドールオキソ−アセチルアミノ酢酸誘導体 |
| CN1723198A (zh) | 2002-12-10 | 2006-01-18 | 惠氏公司 | 用作纤溶酶原激活物抑制剂－1(pai－1)的抑制剂的芳基、芳氧基和烷氧基取代的1h－吲哚－3－基乙醛酸衍生物 |
| CN1723197A (zh) | 2002-12-10 | 2006-01-18 | 惠氏公司 | 作为纤溶酶原激活物抑制剂－1(pai－1)的抑制剂的取代3－烷基和3－芳基烷基1h－吲哚－1－基乙酸衍生物 |
| UA80453C2 (en) | 2002-12-10 | 2007-09-25 | Derivatives of substituted dyhydropyranoindol-3,4-dion as inhibitors of plasminogen activator inhibitor-1 (pai-1) | |
| TW200510305A (en) * | 2003-07-25 | 2005-03-16 | Wyeth Corp | Process for the preparation of CPLA2 inhibitors |
| US7442805B2 (en) | 2003-09-25 | 2008-10-28 | Wyeth | Substituted sulfonamide-indoles |
| US7265148B2 (en) | 2003-09-25 | 2007-09-04 | Wyeth | Substituted pyrrole-indoles |
| US7582773B2 (en) | 2003-09-25 | 2009-09-01 | Wyeth | Substituted phenyl indoles |
| US7420083B2 (en) | 2003-09-25 | 2008-09-02 | Wyeth | Substituted aryloximes |
| US7446201B2 (en) | 2003-09-25 | 2008-11-04 | Wyeth | Substituted heteroaryl benzofuran acids |
| US7163954B2 (en) | 2003-09-25 | 2007-01-16 | Wyeth | Substituted naphthyl benzothiophene acids |
| US7268159B2 (en) | 2003-09-25 | 2007-09-11 | Wyeth | Substituted indoles |
| US7351726B2 (en) | 2003-09-25 | 2008-04-01 | Wyeth | Substituted oxadiazolidinediones |
| US7141592B2 (en) | 2003-09-25 | 2006-11-28 | Wyeth | Substituted oxadiazolidinediones |
| US7342039B2 (en) | 2003-09-25 | 2008-03-11 | Wyeth | Substituted indole oximes |
| US7332521B2 (en) | 2003-09-25 | 2008-02-19 | Wyeth | Substituted indoles |
| US7411083B2 (en) | 2003-09-25 | 2008-08-12 | Wyeth | Substituted acetic acid derivatives |
| GB0324763D0 (en) | 2003-10-23 | 2003-11-26 | Oxagen Ltd | Use of compounds in therapy |
| TW200602317A (en) | 2004-04-23 | 2006-01-16 | Akzo Nobel Nv | Novel androgens |
| EP1778632B1 (en) | 2004-06-18 | 2008-08-20 | Biolipox AB | Indoles useful in the treatment of inflammation |
| KR20070055563A (ko) | 2004-08-23 | 2007-05-30 | 와이어쓰 | 혈전증 및 심혈관 질병의 치료에 유용한 플라스미노겐활성화제 억제제 타입-1(ｐａｉ-1)의 조절제로서의옥사졸로-나프틸 산 |
| CN101048382B (zh) * | 2004-10-27 | 2010-05-05 | 霍夫曼-拉罗奇有限公司 | 新型吲哚或苯并咪唑衍生物 |
| JP2008527029A (ja) | 2005-01-19 | 2008-07-24 | バイオリポックス エービー | 炎症の治療に有用なインドール類 |
| US7777040B2 (en) | 2005-05-03 | 2010-08-17 | Cgi Pharmaceuticals, Inc. | Certain substituted ureas, as modulators of kinase activity |
| GT200600228A (es) * | 2005-05-27 | 2006-12-26 | Inhibidores de la fosfolipasa a2 citosolica | |
| BRPI0614340A2 (pt) | 2005-08-17 | 2011-04-12 | Wyeth Corp | indóis substituìdos e métodos de seu uso |
| GB2431927B (en) | 2005-11-04 | 2010-03-17 | Amira Pharmaceuticals Inc | 5-Lipoxygenase-activating protein (FLAP) inhibitors |
| WO2009093029A1 (en) | 2008-01-22 | 2009-07-30 | Oxagen Limited | Compounds having crth2 antagonist activity |
| AR072297A1 (es) | 2008-06-27 | 2010-08-18 | Novartis Ag | Derivados de indol-2-il-piridin-3-ilo, composicion farmaceutica que los comprende y su uso en medicamentos para el tratamiento de enfermedades mediadas por la sintasa aldosterona. |
| EP2845856A1 (en) | 2009-06-29 | 2015-03-11 | Incyte Corporation | Pyrimidinones as PI3K inhibitors |
| US8759359B2 (en) | 2009-12-18 | 2014-06-24 | Incyte Corporation | Substituted heteroaryl fused derivatives as PI3K inhibitors |
| AR081823A1 (es) | 2010-04-14 | 2012-10-24 | Incyte Corp | DERIVADOS FUSIONADOS COMO INHIBIDORES DE PI3Kd |
| US9062055B2 (en) | 2010-06-21 | 2015-06-23 | Incyte Corporation | Fused pyrrole derivatives as PI3K inhibitors |
| EP3660016A1 (en) | 2010-12-20 | 2020-06-03 | Incyte Holdings Corporation | N-(1-(substituted-phenyl)ethyl)-9h-purin-6-amines as pi3k inhibitors |
| WO2012125629A1 (en) | 2011-03-14 | 2012-09-20 | Incyte Corporation | Substituted diamino-pyrimidine and diamino-pyridine derivatives as pi3k inhibitors |
| WO2012135009A1 (en) | 2011-03-25 | 2012-10-04 | Incyte Corporation | Pyrimidine-4,6-diamine derivatives as pi3k inhibitors |
| SG11201400232WA (en) | 2011-09-02 | 2014-03-28 | Incyte Corp | Heterocyclylamines as pi3k inhibitors |
| AR090548A1 (es) | 2012-04-02 | 2014-11-19 | Incyte Corp | Azaheterociclobencilaminas biciclicas como inhibidores de pi3k |
| NZ703129A (en) | 2012-07-17 | 2017-06-30 | Glaxosmithkline Intellectual Property (No 2) Ltd | Indolecarbonitriles as selective androgen receptor modulators |
| GB201322273D0 (en) | 2013-12-17 | 2014-01-29 | Atopix Therapeutics Ltd | Process |
| WO2015191677A1 (en) | 2014-06-11 | 2015-12-17 | Incyte Corporation | Bicyclic heteroarylaminoalkyl phenyl derivatives as pi3k inhibitors |
| EP3262046B1 (en) | 2015-02-27 | 2020-11-04 | Incyte Corporation | Salts of pi3k inhibitor and processes for their preparation |
| US9988401B2 (en) | 2015-05-11 | 2018-06-05 | Incyte Corporation | Crystalline forms of a PI3K inhibitor |
| US9732097B2 (en) | 2015-05-11 | 2017-08-15 | Incyte Corporation | Process for the synthesis of a phosphoinositide 3-kinase inhibitor |
| WO2020073011A1 (en) | 2018-10-05 | 2020-04-09 | Annapurna Bio, Inc. | Compounds and compositions for treating conditions associated with apj receptor activity |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE314373B (no) * | 1966-04-12 | 1969-09-08 | Sumitomo Chemical Co | |
| FR1492929A (fr) * | 1966-05-11 | 1967-08-25 | Roussel Uclaf | Nouveaux 1-(omega-carboxyalcoyl) indoles substitués et procédé de préparation |
| US3505354A (en) * | 1967-05-18 | 1970-04-07 | Geigy Chem Corp | 2-methyl-3-p-halobenzoylindole-n-aliphatic acids |
| DE1816335A1 (de) * | 1968-12-21 | 1970-07-09 | Thiemann Gmbh Chem Pharm Fabri | Verfahren zur Herstellung von [2-Methyl-5-alkoxy-3-acyl-indol-1]-essigsaeuren und deren Estern |
| US4894386A (en) * | 1987-04-15 | 1990-01-16 | Ici Americas Inc. | Aliphatic carboxamides |
| ES2045420T3 (es) * | 1988-04-13 | 1994-01-16 | Ici America Inc | Amidas ciclicas. |
| US5420289A (en) * | 1989-10-27 | 1995-05-30 | American Home Products Corporation | Substituted indole-, indene-, pyranoindole- and tetrahydrocarbazole-alkanoic acid derivatives as inhibitors of PLA2 and lipoxygenase |
| US5290798A (en) * | 1991-09-30 | 1994-03-01 | Merck Frosst Canada, Inc. | (hetero-arylmethoxy)indoles as inhibitors of leukotriene biosynthesis |
| EP0640080B1 (en) * | 1992-05-13 | 1997-10-22 | Syntex (U.S.A.) Inc. | Substituted indoles as angiotensin ii antagonists |
| IL109311A0 (en) * | 1993-04-16 | 1994-07-31 | Lilly Co Eli | 1H-indole-3-acetamide sPla2 inhibitors |
| DE4338770A1 (de) * | 1993-11-12 | 1995-05-18 | Matthias Dr Lehr | Indol-2-alkansäuren und ihre Derivate als Hemmstoffe der Phospholipase A¶2¶ |
| ATE255090T1 (de) * | 1996-08-01 | 2003-12-15 | Merckle Gmbh | Acylpyrroldicarbonsäuren und acylindoldicarbonsäuren sowie ihre derivate als hemmstoffe der cytosolischen phospholipase a2 |
| WO1998008818A1 (en) * | 1996-08-26 | 1998-03-05 | Genetics Institute, Inc. | Inhibitors of phospholipase enzymes |
-
1999
- 1999-02-24 CN CN99805385A patent/CN1299347A/zh active Pending
- 1999-02-24 EA EA200000868A patent/EA200000868A1/ru unknown
- 1999-02-24 HU HU0100757A patent/HUP0100757A3/hu unknown
- 1999-02-24 TR TR2000/02446T patent/TR200002446T2/xx unknown
- 1999-02-24 AU AU27826/99A patent/AU2782699A/en not_active Abandoned
- 1999-02-24 WO PCT/US1999/003899 patent/WO1999043651A2/en not_active Application Discontinuation
- 1999-02-24 IL IL13771899A patent/IL137718A0/xx unknown
- 1999-02-24 SK SK1274-2000A patent/SK12742000A3/sk unknown
- 1999-02-24 KR KR1020007009456A patent/KR20010041343A/ko not_active Application Discontinuation
- 1999-02-24 BR BR9908280-2A patent/BR9908280A/pt not_active IP Right Cessation
- 1999-02-24 EE EEP200000486A patent/EE200000486A/xx unknown
- 1999-02-24 ID IDW20001594A patent/ID27280A/id unknown
- 1999-02-24 EP EP99908379A patent/EP1056719A2/en not_active Withdrawn
- 1999-02-24 PL PL99342995A patent/PL342995A1/xx unknown
- 1999-02-24 JP JP2000533409A patent/JP2002504539A/ja not_active Withdrawn
- 1999-02-24 CA CA002322161A patent/CA2322161A1/en not_active Abandoned
-
2000
- 2000-08-23 NO NO20004220A patent/NO20004220L/no unknown
- 2000-08-24 HR HR20000552A patent/HRP20000552A2/hr not_active Application Discontinuation
- 2000-09-19 BG BG104780A patent/BG104780A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP1056719A2 (en) | 2000-12-06 |
| CN1299347A (zh) | 2001-06-13 |
| EA200000868A1 (ru) | 2001-04-23 |
| KR20010041343A (ko) | 2001-05-15 |
| HUP0100757A3 (en) | 2001-11-28 |
| HRP20000552A2 (en) | 2001-04-30 |
| IL137718A0 (en) | 2001-10-31 |
| ID27280A (id) | 2001-03-22 |
| JP2002504539A (ja) | 2002-02-12 |
| EE200000486A (et) | 2002-02-15 |
| TR200002446T2 (tr) | 2000-12-21 |
| SK12742000A3 (sk) | 2001-05-10 |
| BG104780A (en) | 2001-10-31 |
| WO1999043651A3 (en) | 1999-12-16 |
| BR9908280A (pt) | 2000-10-31 |
| HUP0100757A1 (hu) | 2001-08-28 |
| NO20004220D0 (no) | 2000-08-23 |
| WO1999043651A2 (en) | 1999-09-02 |
| PL342995A1 (en) | 2001-07-16 |
| CA2322161A1 (en) | 1999-09-02 |
| AU2782699A (en) | 1999-09-15 |
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