PT816358E - Amidas de acido 4-amino-2-ureido-pirimidina-5-carboxilico, processos para a sua preparacao, medicamentos contendo estes compostos e sua utilizacao - Google Patents
Amidas de acido 4-amino-2-ureido-pirimidina-5-carboxilico, processos para a sua preparacao, medicamentos contendo estes compostos e sua utilizacaoInfo
- Publication number
- PT816358E PT816358E PT97109547T PT97109547T PT816358E PT 816358 E PT816358 E PT 816358E PT 97109547 T PT97109547 T PT 97109547T PT 97109547 T PT97109547 T PT 97109547T PT 816358 E PT816358 E PT 816358E
- Authority
- PT
- Portugal
- Prior art keywords
- amino
- ureido
- amendments
- pyrimidine
- compounds
- Prior art date
Links
- CANCNNXFBGDUHY-UHFFFAOYSA-N 4-amino-2-(carbamoylamino)pyrimidine-5-carboxylic acid Chemical compound NC(=O)NC1=NC=C(C(O)=O)C(N)=N1 CANCNNXFBGDUHY-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- 238000002360 preparation method Methods 0.000 title 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000004414 alkyl thio group Chemical group 0.000 abstract 2
- NKTWBSSRNCDNCD-UHFFFAOYSA-N 4-amino-2-(2-oxoimidazolidin-1-yl)pyrimidine-5-carboxamide Chemical class N1=C(N)C(C(=O)N)=CN=C1N1C(=O)NCC1 NKTWBSSRNCDNCD-UHFFFAOYSA-N 0.000 abstract 1
- 125000005530 alkylenedioxy group Chemical group 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicinal Preparation (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19625089A DE19625089A1 (de) | 1996-06-24 | 1996-06-24 | 4-Amino-2-ureido-pyrimidin-5-carbonsäureamide, Verfahren zu deren Herstellung, diese Verbindungen enthaltende Arzneimittel und deren Verwendung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT816358E true PT816358E (pt) | 2005-01-31 |
Family
ID=7797762
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT97109547T PT816358E (pt) | 1996-06-24 | 1997-06-12 | Amidas de acido 4-amino-2-ureido-pirimidina-5-carboxilico, processos para a sua preparacao, medicamentos contendo estes compostos e sua utilizacao |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US5939424A (enExample) |
| EP (1) | EP0816358B1 (enExample) |
| JP (1) | JP4101906B2 (enExample) |
| AT (1) | ATE281452T1 (enExample) |
| CA (1) | CA2208630C (enExample) |
| DE (2) | DE19625089A1 (enExample) |
| DK (1) | DK0816358T3 (enExample) |
| ES (1) | ES2230575T3 (enExample) |
| MX (1) | MX9704704A (enExample) |
| NO (1) | NO312414B1 (enExample) |
| PT (1) | PT816358E (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19625088A1 (de) * | 1996-06-24 | 1998-01-02 | Hoechst Ag | 4-Amino-2-ureido-pyrimidin-5-carbonsäureamide, Verfahren zu deren Herstellung, diese Verbindungen enthaltende Arzneimittel und deren Verwendung |
| US6887712B1 (en) * | 1998-11-09 | 2005-05-03 | Atherogenics, Inc. | Methods and compositions to lower plasma cholesterol levels |
| EP1223170B1 (en) | 1999-10-12 | 2005-12-28 | Takeda Pharmaceutical Company Limited | Pyrimidine-5-carboxamide compounds, process for producing the same and use thereof |
| US7176310B1 (en) | 2002-04-09 | 2007-02-13 | Ucb Sa | Pyrimidinecarboxamide derivatives and their use as anti-inflammatory agents |
| EP1737414A2 (en) * | 2004-01-23 | 2007-01-03 | Amgen Inc. | Vanilloid receptor ligands and their use in treatments of inflammatory and neuropatic pain |
| JP2011057661A (ja) * | 2009-08-14 | 2011-03-24 | Bayer Cropscience Ag | 殺虫性カルボキサミド類 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2853220A1 (de) * | 1978-12-09 | 1980-07-03 | Hoechst Ag | Neue amino-pyrimidin-carbanilide, verfahren zu ihrer herstellung, diese verbindungen enthaltende arzneimittel und ihre verwendung |
| DE3522940A1 (de) * | 1985-06-27 | 1987-01-08 | Hoechst Ag | 4-amino-2-(imidazolidin-2-on-1-yl)-pyrimidin-5-carbonsaeure-(n-(3-trifluormethyl-phenyl)-amide) zur antithrombotischen prophylaxe und behandlung sowie ihre verwendung zur herstellung von antithrombotisch wirksamen arzneimitteln |
| EP0577877B1 (en) * | 1991-09-04 | 1995-10-18 | Sumitomo Electric Industries, Ltd. | Adjusting shim |
| EP0557877B1 (de) * | 1992-02-22 | 1997-09-24 | Hoechst Aktiengesellschaft | Lösliche Salze von 4-Amino-2-(4,4-dimethyl-imidazolidin-2-on-1-yl)-pyrimidin-5 -carbonsäure- N-methyl-N-(3-trifluormethyl-phenyl)- amid, Verfahren zu ihrer Herstellung, ihre Verwendung als Arzneimittel und Ausgangsprodukte |
| DK0557879T3 (da) * | 1992-02-22 | 1997-06-16 | Hoechst Ag | 4-amino-2-ureido-pyrimidin-5-carboxylsyreamider, fremgangsmåde til deres fremstilling, lægemidler med indhold af disse forbindelser og deres anvendelse |
| DE19625088A1 (de) * | 1996-06-24 | 1998-01-02 | Hoechst Ag | 4-Amino-2-ureido-pyrimidin-5-carbonsäureamide, Verfahren zu deren Herstellung, diese Verbindungen enthaltende Arzneimittel und deren Verwendung |
-
1996
- 1996-06-24 DE DE19625089A patent/DE19625089A1/de not_active Withdrawn
-
1997
- 1997-06-04 US US08/868,991 patent/US5939424A/en not_active Expired - Lifetime
- 1997-06-12 EP EP97109547A patent/EP0816358B1/de not_active Expired - Lifetime
- 1997-06-12 PT PT97109547T patent/PT816358E/pt unknown
- 1997-06-12 DE DE59712053T patent/DE59712053D1/de not_active Expired - Lifetime
- 1997-06-12 ES ES97109547T patent/ES2230575T3/es not_active Expired - Lifetime
- 1997-06-12 DK DK97109547T patent/DK0816358T3/da active
- 1997-06-12 AT AT97109547T patent/ATE281452T1/de active
- 1997-06-23 MX MX9704704A patent/MX9704704A/es active IP Right Grant
- 1997-06-23 NO NO19972943A patent/NO312414B1/no not_active IP Right Cessation
- 1997-06-23 JP JP16581597A patent/JP4101906B2/ja not_active Expired - Fee Related
- 1997-06-23 CA CA002208630A patent/CA2208630C/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| NO972943D0 (no) | 1997-06-23 |
| ES2230575T3 (es) | 2005-05-01 |
| CA2208630C (en) | 2006-07-11 |
| US5939424A (en) | 1999-08-17 |
| EP0816358A1 (de) | 1998-01-07 |
| EP0816358B1 (de) | 2004-11-03 |
| NO312414B1 (no) | 2002-05-06 |
| DK0816358T3 (da) | 2005-03-07 |
| DE19625089A1 (de) | 1998-01-02 |
| JPH1072463A (ja) | 1998-03-17 |
| MX9704704A (es) | 1997-12-31 |
| ATE281452T1 (de) | 2004-11-15 |
| NO972943L (no) | 1997-12-29 |
| JP4101906B2 (ja) | 2008-06-18 |
| DE59712053D1 (de) | 2004-12-09 |
| CA2208630A1 (en) | 1997-12-24 |
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