PT80010B - Processo para a preparacao de 17-beta-carbamoil n-monossubstituido- ou 17-beta-acil-4-aza-5-alfa-androst-1-en-3-onas como inibidores de redutase 5-alfa - Google Patents

Processo para a preparacao de 17-beta-carbamoil n-monossubstituido- ou 17-beta-acil-4-aza-5-alfa-androst-1-en-3-onas como inibidores de redutase 5-alfa

Info

Publication number
PT80010B
PT80010B PT80010A PT8001085A PT80010B PT 80010 B PT80010 B PT 80010B PT 80010 A PT80010 A PT 80010A PT 8001085 A PT8001085 A PT 8001085A PT 80010 B PT80010 B PT 80010B
Authority
PT
Portugal
Prior art keywords
beta
alpha
monosubstituide
onas
androst
Prior art date
Application number
PT80010A
Other languages
English (en)
Portuguese (pt)
Other versions
PT80010A (en
Inventor
Gary H Rasmusson
Glenn F Reynolds
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27078980&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PT80010(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of PT80010A publication Critical patent/PT80010A/pt
Publication of PT80010B publication Critical patent/PT80010B/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C62/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C62/30—Unsaturated compounds
    • C07C62/38—Unsaturated compounds containing keto groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/18—Ring systems of four or more rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J73/00—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms
    • C07J73/001—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom
    • C07J73/005—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom by nitrogen as hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/06—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members
    • C07C2603/10—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings
    • C07C2603/12—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings only one five-membered ring
    • C07C2603/16—Benz[e]indenes; Hydrogenated benz[e]indenes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
PT80010A 1984-02-27 1985-02-26 Processo para a preparacao de 17-beta-carbamoil n-monossubstituido- ou 17-beta-acil-4-aza-5-alfa-androst-1-en-3-onas como inibidores de redutase 5-alfa PT80010B (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US58406184A 1984-02-27 1984-02-27
US58406284A 1984-02-27 1984-02-27

Publications (2)

Publication Number Publication Date
PT80010A PT80010A (en) 1985-03-01
PT80010B true PT80010B (pt) 1987-09-18

Family

ID=27078980

Family Applications (1)

Application Number Title Priority Date Filing Date
PT80010A PT80010B (pt) 1984-02-27 1985-02-26 Processo para a preparacao de 17-beta-carbamoil n-monossubstituido- ou 17-beta-acil-4-aza-5-alfa-androst-1-en-3-onas como inibidores de redutase 5-alfa

Country Status (16)

Country Link
EP (1) EP0155096B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
JP (1) JPH0193600A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
KR (1) KR900001206B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AU (4) AU584321B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CA (1) CA1314541C (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CY (1) CY1553A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DE (2) DE3584172D1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DK (1) DK166704B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
ES (1) ES8702430A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
GR (1) GR850483B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
HK (1) HK63090A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
IE (2) IE58058B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
IL (1) IL74365A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
NL (1) NL930005I2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
NZ (1) NZ211145A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
PT (1) PT80010B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)

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EP0285383B1 (en) * 1987-04-03 1994-03-16 Merck & Co. Inc. Treatment of prostatic carcinoma with 17beta-n-monosubstituted-carbamoyl-4-aza-5alpha-androst-1-en-3-ones
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US5084574A (en) * 1988-04-18 1992-01-28 Merck & Co., Inc. Dehydrogenation process
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CA2023157A1 (en) * 1989-08-21 1991-02-22 Gary H. Rasmusson 17 beta-acyl-4-aza-5 alpha-androst-1-ene-3-ones as 5 alpha-reductase inhibitors
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GB9002922D0 (en) * 1990-02-09 1990-04-04 Erba Carlo Spa 17 beta-substituted-4-aza-5 alpha-androstan-3-one derivatives and process for their preparation
US5162332A (en) * 1990-06-20 1992-11-10 Merck & Co., Inc. Selected 17 β-polyaroyl-4-aza-5 α-androst-1-en-3-ones as steroidal reductase inhibitors
EP0462664A3 (en) * 1990-06-20 1992-11-25 Merck & Co. Inc. Specific 17beta-thiobenzoyl-4-aza-5alpha-androst-1-en-3-ones as antiandrogenic agents
US5098908A (en) * 1990-06-20 1992-03-24 Merck & Co., Inc. 17β-hydroxybenzoyl-4-aza-5α-androst-1-en-3-ones as testosterone reductase inhibitors
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US5061803A (en) * 1990-09-24 1991-10-29 Merck & Co., Inc. Process for making 17-beta alkanoyl 3-oxo-4-aza-5-α-androst-1-enes
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US5547957A (en) 1993-10-15 1996-08-20 Merck & Co., Inc. Method of treating androgenic alopecia with 5-α reductase inhibitors
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CN1314241C (zh) * 2002-09-27 2007-05-02 华为技术有限公司 在城域网相同虚容器映射通道内传送不同用户数据的方法
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Also Published As

Publication number Publication date
AU626293B2 (en) 1992-07-30
DE3573429D1 (en) 1989-11-09
JPH0193600A (ja) 1989-04-12
ES8702430A1 (es) 1987-01-01
NL930005I2 (nl) 1993-09-16
IL74365A (en) 1990-07-26
NZ211145A (en) 1988-10-28
CA1314541C (en) 1993-03-16
IE850476L (en) 1985-08-27
KR850006185A (ko) 1985-10-02
PT80010A (en) 1985-03-01
AU584321B2 (en) 1989-05-25
DK85985D0 (da) 1985-02-26
GR850483B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1985-06-26
EP0155096A3 (en) 1986-07-02
HK63090A (en) 1990-08-17
KR900001206B1 (ko) 1990-02-28
AU3916785A (en) 1985-09-05
IL74365A0 (en) 1985-05-31
AU7083591A (en) 1991-07-11
CY1553A (en) 1991-03-22
EP0155096A2 (en) 1985-09-18
DE3584172D1 (de) 1991-10-24
DK166704B1 (da) 1993-06-28
AU651741B2 (en) 1994-07-28
IE58058B1 (en) 1993-06-16
JPH0541638B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1993-06-24
NL930005I1 (nl) 1993-04-01
ES540705A0 (es) 1987-01-01
DK85985A (da) 1985-10-22
EP0155096B1 (en) 1989-10-04
AU3313589A (en) 1989-08-10
AU2748192A (en) 1993-03-18
IE922862L (en) 1985-08-27

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