PT76745B - Process for the preparation of imidazo-<1,2-c>pyrazolio-<3,4-e>-pyrimidines with antipsychotic effect and pharmaceutical compositions therewith - Google Patents

Process for the preparation of imidazo-<1,2-c>pyrazolio-<3,4-e>-pyrimidines with antipsychotic effect and pharmaceutical compositions therewith

Info

Publication number
PT76745B
PT76745B PT76745A PT7674583A PT76745B PT 76745 B PT76745 B PT 76745B PT 76745 A PT76745 A PT 76745A PT 7674583 A PT7674583 A PT 7674583A PT 76745 B PT76745 B PT 76745B
Authority
PT
Portugal
Prior art keywords
pyrazolio
pyrimidines
imidazo
preparation
pharmaceutical compositions
Prior art date
Application number
PT76745A
Other languages
English (en)
Portuguese (pt)
Other versions
PT76745A (en
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Publication of PT76745A publication Critical patent/PT76745A/pt
Publication of PT76745B publication Critical patent/PT76745B/pt

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D231/00Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/38Nitrogen atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D231/00Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D231/00Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/16Halogen atoms or nitro radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D231/00Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/38Nitrogen atoms
    • C07D231/40Acylated on said nitrogen atom
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
PT76745A 1982-05-24 1983-05-23 Process for the preparation of imidazo-<1,2-c>pyrazolio-<3,4-e>-pyrimidines with antipsychotic effect and pharmaceutical compositions therewith PT76745B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/381,484 US4469868A (en) 1982-05-24 1982-05-24 Alkylimidazo[1,2-c]pyrazolo[3,4-e]pyrimidines

Publications (2)

Publication Number Publication Date
PT76745A PT76745A (en) 1983-06-01
PT76745B true PT76745B (en) 1986-04-21

Family

ID=23505215

Family Applications (1)

Application Number Title Priority Date Filing Date
PT76745A PT76745B (en) 1982-05-24 1983-05-23 Process for the preparation of imidazo-<1,2-c>pyrazolio-<3,4-e>-pyrimidines with antipsychotic effect and pharmaceutical compositions therewith

Country Status (22)

Country Link
US (1) US4469868A (en, 2012)
EP (1) EP0095289B1 (en, 2012)
JP (1) JPS58210087A (en, 2012)
KR (1) KR870000931B1 (en, 2012)
AR (1) AR240941A1 (en, 2012)
AT (1) ATE24510T1 (en, 2012)
AU (1) AU553708B2 (en, 2012)
CA (1) CA1210393A (en, 2012)
DE (1) DE3368635D1 (en, 2012)
DK (1) DK161968C (en, 2012)
ES (4) ES8407051A1 (en, 2012)
FI (1) FI74012C (en, 2012)
GR (1) GR79262B (en, 2012)
HK (1) HK102989A (en, 2012)
HU (1) HU187913B (en, 2012)
IE (1) IE55111B1 (en, 2012)
IL (1) IL68360A0 (en, 2012)
NO (1) NO160444C (en, 2012)
NZ (1) NZ204321A (en, 2012)
PH (1) PH18454A (en, 2012)
PT (1) PT76745B (en, 2012)
ZA (1) ZA832637B (en, 2012)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1988000192A1 (en) * 1986-06-26 1988-01-14 Warner-Lambert Company 5-SUBSTITUTED PYRAZOLO[4,3-d]PYRIMIDIN-7-ONES
CN101107250A (zh) * 2004-11-23 2008-01-16 雷迪美国治疗股份有限公司 新颖的二环杂环化合物、它们的制备方法及含有它们的组合物
JP5084725B2 (ja) 2005-06-06 2012-11-28 武田薬品工業株式会社 有機化合物
WO2008070095A1 (en) 2006-12-05 2008-06-12 Intra-Cellular Therapies, Inc. Novel uses
CN102238872A (zh) 2008-12-06 2011-11-09 细胞内治疗公司 有机化合物
EP2434895A4 (en) 2009-05-13 2013-08-07 Intra Cellular Therapies Inc ORGANIC CONNECTIONS
EP2576551A4 (en) 2010-05-31 2014-04-16 Intra Cellular Therapies Inc ORGANIC CONNECTIONS
TW201206937A (en) 2010-05-31 2012-02-16 Intra Cellular Therapies Inc Organic compounds
AU2012244550C1 (en) * 2011-04-21 2017-06-22 Origenis Gmbh Pyrazolo [4, 3-d] pyrimidines useful as kinase inhibitors
US9637491B2 (en) 2012-10-19 2017-05-02 Origenis Gmbh Pyrazolo[4,3-D]pyrimidines as kinase inhibitors
US9801882B2 (en) 2013-02-17 2017-10-31 Intra-Cellular Therapies, Inc. Phosphodiesterase-1 inhibitors and their use in treatment of cardiovascular diseases
ES2717688T3 (es) 2013-03-15 2019-06-24 Intra Cellular Therapies Inc Inhibidores de la PDE1 para uso en el tratamiento y/o prevención de lesiones de SNC, y enfermedades, trastornos o lesiones de SNP
WO2014151409A1 (en) 2013-03-15 2014-09-25 Intra-Cellular Therapies, Inc. Organic compounds
US9884872B2 (en) 2014-06-20 2018-02-06 Intra-Cellular Therapies, Inc. Organic compounds
US10285992B2 (en) 2014-08-07 2019-05-14 Intra-Cellular Therapies, Inc. Combinations of PDE1 inhibitors and NEP inhibitors and associated methods
ES2745819T3 (es) 2014-08-07 2020-03-03 Intra Cellular Therapies Inc Derivados de imidazo[1,2-a]-pirazolo[4,3-e]-pirimidin-4-ona con actividad inhibidora de la PDE1
MX385382B (es) 2014-09-17 2025-03-18 Intra Cellular Therapies Inc Compuestos y metodos.
US10682354B2 (en) 2016-03-28 2020-06-16 Intra-Cellular Therapies, Inc. Compositions and methods
JP7134168B6 (ja) 2016-09-12 2024-02-02 イントラ-セルラー・セラピーズ・インコーポレイテッド 新規使用
US11839614B2 (en) 2018-01-31 2023-12-12 Intra-Cellular Therapies, Inc. Methods for treating or mitigating cardiotoxicity characterized by inhibition of adenosine A2 signaling and/or adenosine A2 receptor expression
EP4413980A3 (en) 2019-09-03 2024-10-30 Intra-Cellular Therapies, Inc. Novel compounds
US12364695B2 (en) 2020-06-02 2025-07-22 Intra-Cellular Therapies, Inc. Methods of treating inflammatory disease

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH422807A (de) * 1963-08-16 1966-10-31 Wander Ag Dr A Verfahren zur Herstellung von Imidazo- und Pyrimidochinazolinen
US3313815A (en) * 1964-05-04 1967-04-11 Sterling Drug Inc 8-chloropyrazolo-[1, 5-c]quinazoline derivatives and methods of preparing same
US3309369A (en) * 1966-04-11 1967-03-14 Wander Ag Dr A Imidazo- and pyrimido-quinazolines
US3594379A (en) * 1968-09-16 1971-07-20 Sandoz Ag 2,3-dihydroimidazo(1,2-c)quinazolines
DE2058501A1 (de) * 1970-11-27 1972-05-31 Bayer Ag Verfahren zur Herstellung von neuen N-verbrueckten bicyclischen Heteroaromaten
GB1347493A (en) * 1971-02-11 1974-02-27 Aspro Nicholas Ltd Benzazine derivatives
US3984556A (en) * 1973-01-19 1976-10-05 Sandoz, Inc. Alkyl-substituted-tricyclic quinazolinones for lowering blood pressure
JPS516993A (en) * 1974-07-05 1976-01-20 Dainippon Pharmaceutical Co Adeninjudotaino seiho
JPS5398997A (en) * 1977-02-09 1978-08-29 Sumitomo Chem Co Ltd Fused pyridine derivertives and process for their preparation
US4206123A (en) * 1977-10-31 1980-06-03 Mccall John M Isothiochroman
US4247553A (en) * 1977-10-31 1981-01-27 The Upjohn Company Methods of treating psychosis
US4250181A (en) * 1977-10-31 1981-02-10 The Upjohn Company Methods of treating psychosis
US4192803A (en) * 1978-09-15 1980-03-11 American Cyanamid Company 5H-Pyrrolo[2,1-c][1,4]benzodiazepine derivatives
CA1141384A (en) * 1978-11-01 1983-02-15 Morton Harfenist Pharmaceutical heterocyclic comounds, preparation, use and intermediates therefor and their preparations
CH643263A5 (de) * 1979-05-11 1984-05-30 Sandoz Ag Benzodiazepine, ihre herstellung und verwendung.
HU178523B (en) * 1979-05-18 1982-05-28 Egyt Gyogyszervegyeszeti Gyar Process for preparing new pyrazolo-quinazoline derivatives
US4230707A (en) * 1979-08-27 1980-10-28 Warner-Lambert Company Oxo-pyrido[1,2-a]thienopyrimidine compounds and methods for their production
US4358456A (en) * 1980-05-03 1982-11-09 John Wyeth & Brother Limited Antipsychotic piperidinomethyl-indole derivatives
US4396770A (en) * 1982-04-09 1983-08-02 Hoechst-Roussel Pharmaceuticals Inc. 1-[3-(6-Fluoro-1,2-benzisoxazol-3-yl)propyl]-4-hydroxy-4-phenylpiperidines
US4352811A (en) * 1981-11-12 1982-10-05 Hoechst-Roussel Pharmaceuticals Inc. 3-(1-Substituted-4-piperidyl)-1,2-benzisoxazoles
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Also Published As

Publication number Publication date
AU553708B2 (en) 1986-07-24
ES8506019A1 (es) 1985-06-16
ES522617A0 (es) 1984-09-01
ZA832637B (en) 1984-01-25
GR79262B (en, 2012) 1984-10-22
FI831742A0 (fi) 1983-05-18
IE55111B1 (en) 1990-06-06
PT76745A (en) 1983-06-01
IE830822L (en) 1983-11-24
PH18454A (en) 1985-07-18
JPS58210087A (ja) 1983-12-07
FI831742L (fi) 1983-11-25
EP0095289A3 (en) 1984-09-05
IL68360A (en) 1986-10-31
NO831792L (no) 1983-11-25
US4469868A (en) 1984-09-04
AU1342783A (en) 1983-12-01
HU187913B (en) 1986-03-28
DK161968B (da) 1991-09-02
ES529372A0 (es) 1985-06-16
ES529373A0 (es) 1985-06-16
KR840004756A (ko) 1984-10-24
EP0095289A2 (en) 1983-11-30
NZ204321A (en) 1986-06-11
FI74012B (fi) 1987-08-31
ES529371A0 (es) 1985-07-01
ES8506004A1 (es) 1985-06-16
KR870000931B1 (ko) 1987-05-11
AR240941A2 (es) 1991-03-27
AR240941A1 (es) 1991-03-27
DK227183A (da) 1983-11-25
JPH0320395B2 (en, 2012) 1991-03-19
ATE24510T1 (de) 1987-01-15
NO160444C (no) 1989-04-19
ES8506315A1 (es) 1985-07-01
EP0095289B1 (en) 1986-12-30
NO160444B (no) 1989-01-09
CA1210393A (en) 1986-08-26
ES8407051A1 (es) 1984-09-01
IL68360A0 (en) 1986-10-31
FI74012C (fi) 1987-12-10
DE3368635D1 (en) 1987-02-05
DK227183D0 (da) 1983-05-20
DK161968C (da) 1992-02-03
HK102989A (en) 1990-01-05

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