PT72964B - Process for the preparation of 1,4-dihydropyridines having different substituents in the positions 2 and 6 with effect on the blood vessels - Google Patents

Process for the preparation of 1,4-dihydropyridines having different substituents in the positions 2 and 6 with effect on the blood vessels

Info

Publication number
PT72964B
PT72964B PT72964A PT7296481A PT72964B PT 72964 B PT72964 B PT 72964B PT 72964 A PT72964 A PT 72964A PT 7296481 A PT7296481 A PT 7296481A PT 72964 B PT72964 B PT 72964B
Authority
PT
Portugal
Prior art keywords
different substituents
dihydropyridines
positions
preparation
effect
Prior art date
Application number
PT72964A
Other languages
English (en)
Other versions
PT72964A (en
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of PT72964A publication Critical patent/PT72964A/pt
Publication of PT72964B publication Critical patent/PT72964B/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Psychiatry (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
PT72964A 1980-05-13 1981-05-04 Process for the preparation of 1,4-dihydropyridines having different substituents in the positions 2 and 6 with effect on the blood vessels PT72964B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19803018259 DE3018259A1 (de) 1980-05-13 1980-05-13 1,4-dihydropyridine mit unterschiedlichen substituenten in 2- und 6-position, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln

Publications (2)

Publication Number Publication Date
PT72964A PT72964A (en) 1981-06-01
PT72964B true PT72964B (en) 1982-06-25

Family

ID=6102290

Family Applications (1)

Application Number Title Priority Date Filing Date
PT72964A PT72964B (en) 1980-05-13 1981-05-04 Process for the preparation of 1,4-dihydropyridines having different substituents in the positions 2 and 6 with effect on the blood vessels

Country Status (17)

Country Link
EP (1) EP0039863B1 (pt)
JP (1) JPS577468A (pt)
AT (1) ATE5718T1 (pt)
AU (1) AU541935B2 (pt)
CA (2) CA1175438A (pt)
DE (2) DE3018259A1 (pt)
DK (1) DK210281A (pt)
ES (2) ES8300093A1 (pt)
FI (1) FI811437L (pt)
GR (1) GR74910B (pt)
HU (1) HU184434B (pt)
IE (1) IE51267B1 (pt)
IL (1) IL62841A (pt)
NO (1) NO811424L (pt)
PH (1) PH18747A (pt)
PT (1) PT72964B (pt)
ZA (1) ZA813141B (pt)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3207982A1 (de) * 1982-03-05 1983-09-08 Bayer Ag, 5090 Leverkusen Neue 1,4-dihydropyridine, verfahren zu ihrer herstellung und ihrer verwendung in arzneimitteln
DE3208628A1 (de) * 1982-03-10 1983-09-22 Bayer Ag, 5090 Leverkusen Neue verbindungen, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
US4414213A (en) * 1982-03-22 1983-11-08 Mead Johnson & Company Dihydropyridyl cyclic imidate esters and their pharmaceutical use
JPS58208271A (ja) * 1982-04-30 1983-12-03 Kyowa Hakko Kogyo Co Ltd １，４−ジヒドロピリジン誘導体
JPS6094963A (ja) * 1983-10-31 1985-05-28 Teijin Ltd １，４−ジヒドロピリジン−３，５−ジカルボン酸ジエステル誘導体及びその製造法
NZ212895A (en) * 1984-08-22 1988-07-28 Glaxo Spa 1,4-dihydropyridine derivatives and pharmaceutical compositions
DE3447169A1 (de) * 1984-12-22 1986-07-03 Bayer Ag, 5090 Leverkusen Optisch aktive nitrodihydropyridine, verfahren zur herstellung und ihre verwendung in arzneimitteln
JPS625958A (ja) * 1985-07-03 1987-01-12 Suntory Ltd １，４−ジヒドロピリジン誘導体、その製造法および循環系疾患治療剤
US4761420A (en) * 1986-06-13 1988-08-02 Laboratoires Syntex S.A. Antihypertensive dihydropyridine derivatives
WO1988005043A1 (en) * 1986-12-24 1988-07-14 Boehringer Biochemia Robin S.P.A. New aralkyl-1,4-dihydropyridines, a method for their preparation and pharmaceutical compositions containing them
US5158963A (en) * 1989-08-02 1992-10-27 Kaken Pharmaceutical Co., Ltd. 1-4-dihydropyridine derivative, process for preparing the same and pharmaceutical composition containing the same
CA2048668A1 (en) * 1989-12-29 1991-06-30 Michio Nakanishi Ethynylphenyl derivative, process for preparing the same and medicament for circulatory disease containing the same as an effective ingredient
PT657432E (pt) * 1993-12-10 2003-07-31 Bayer Ag 1,4-di-hidropiridinas fenil-substituidas com actividade cerebral

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1792764C3 (de) * 1967-03-20 1981-04-23 Bayer Ag, 5090 Leverkusen Coronarmittel
GB1430961A (en) * 1972-01-22 1976-04-07 Yamanouchi Pharma Co Ltd 1-substituted-1,4-dihyddrypyridine derivatives
DE2508181A1 (de) * 1975-02-26 1976-09-09 Bayer Ag 1,4-dihydropyridincarbonsaeurearal- kylester, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
GB1591089A (en) * 1976-12-17 1981-06-10 Fujisawa Pharmaceutical Co 1,4-dihydropyridine derivatives and process for preparation thereof
SE7910521L (sv) * 1979-12-20 1981-06-21 Haessle Ab Nya 2-metyl-6-substituerade-4-(2,3-disubstituerad fenyl)-1,4-dihydropyridin-3,5-diestrar med hypotesiva egenskaper, samt forfarande for deras framstellning, och farmaceutiska beredningar innehallande desamma

Also Published As

Publication number Publication date
IE811061L (en) 1981-11-13
NO811424L (no) 1981-11-16
IL62841A0 (en) 1981-07-31
IE51267B1 (en) 1986-11-26
DE3018259A1 (de) 1981-11-19
PT72964A (en) 1981-06-01
AU541935B2 (en) 1985-01-31
ES502132A0 (es) 1982-10-01
HU184434B (en) 1984-08-28
ES8300093A1 (es) 1982-10-01
AU7047381A (en) 1981-11-19
DK210281A (da) 1981-11-14
ES512592A0 (es) 1983-02-16
PH18747A (en) 1985-09-19
ATE5718T1 (de) 1984-01-15
EP0039863B1 (de) 1983-12-28
CA1185182A (en) 1985-04-09
GR74910B (pt) 1984-07-12
CA1175438A (en) 1984-10-02
ES8304082A1 (es) 1983-02-16
ZA813141B (en) 1982-04-28
DE3161760D1 (en) 1984-02-02
FI811437L (fi) 1981-11-14
JPS577468A (en) 1982-01-14
IL62841A (en) 1984-11-30
EP0039863A1 (de) 1981-11-18

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