IL62841A0 - 1,4-dihydropyridine derivatives,their production and pharmaceutical compositions containing them - Google Patents

1,4-dihydropyridine derivatives,their production and pharmaceutical compositions containing them

Info

Publication number
IL62841A0
IL62841A0 IL62841A IL6284181A IL62841A0 IL 62841 A0 IL62841 A0 IL 62841A0 IL 62841 A IL62841 A IL 62841A IL 6284181 A IL6284181 A IL 6284181A IL 62841 A0 IL62841 A0 IL 62841A0
Authority
IL
Israel
Prior art keywords
production
pharmaceutical compositions
compositions containing
exception
carbon atoms
Prior art date
Application number
IL62841A
Other versions
IL62841A (en
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of IL62841A0 publication Critical patent/IL62841A0/en
Publication of IL62841A publication Critical patent/IL62841A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

1. Compound of the general formula I see diagramm : EP0039863,P18,F1 in which R represents a phenyl radical which optionally contains 1 or 2 identical or different substituents from the group comprising nitro, chlorine, cyano or trifluoromethyl, with the exception of a phenyl radical which is at the same time ortho- and metadichlorosubstituted, when R**2 denotes methyl and R**4 denotes alkyl with 2-3 carbon atoms, R**1 represents a saturated hydrocarbon radical with up to 6 carbon atons which is optionally interrupted by an oxygen atom, R**2 and R**4 are always different and each represents hydrogen, alkyl with 1 to 4 carbon atoms or cyclohexylmethyl, with the exception of the compound diethyl-2-methyl-6-propyl-4-(3-nitrophenyl)-1,4- dihydropyridine-3,5-carboxylate.
IL62841A 1980-05-13 1981-05-11 1,4-dihydropyridine derivatives,their production and pharmaceutical compositions containing them IL62841A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19803018259 DE3018259A1 (en) 1980-05-13 1980-05-13 1,4-DIHYDROPYRIDINE WITH DIFFERENT SUBSTITUENTS IN 2- AND 6-POSITIONS, METHODS FOR THEIR PRODUCTION AND THEIR USE IN MEDICINAL PRODUCTS

Publications (2)

Publication Number Publication Date
IL62841A0 true IL62841A0 (en) 1981-07-31
IL62841A IL62841A (en) 1984-11-30

Family

ID=6102290

Family Applications (1)

Application Number Title Priority Date Filing Date
IL62841A IL62841A (en) 1980-05-13 1981-05-11 1,4-dihydropyridine derivatives,their production and pharmaceutical compositions containing them

Country Status (17)

Country Link
EP (1) EP0039863B1 (en)
JP (1) JPS577468A (en)
AT (1) ATE5718T1 (en)
AU (1) AU541935B2 (en)
CA (2) CA1175438A (en)
DE (2) DE3018259A1 (en)
DK (1) DK210281A (en)
ES (2) ES8300093A1 (en)
FI (1) FI811437L (en)
GR (1) GR74910B (en)
HU (1) HU184434B (en)
IE (1) IE51267B1 (en)
IL (1) IL62841A (en)
NO (1) NO811424L (en)
PH (1) PH18747A (en)
PT (1) PT72964B (en)
ZA (1) ZA813141B (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3207982A1 (en) * 1982-03-05 1983-09-08 Bayer Ag, 5090 Leverkusen NEW 1,4-DIHYDROPYRIDINE, METHOD FOR THE PRODUCTION AND USE THEREOF IN MEDICINAL PRODUCTS
DE3208628A1 (en) * 1982-03-10 1983-09-22 Bayer Ag, 5090 Leverkusen NEW COMPOUNDS, METHOD FOR THEIR PRODUCTION AND THEIR USE AS MEDICINAL PRODUCTS
US4414213A (en) * 1982-03-22 1983-11-08 Mead Johnson & Company Dihydropyridyl cyclic imidate esters and their pharmaceutical use
JPS58208271A (en) * 1982-04-30 1983-12-03 Kyowa Hakko Kogyo Co Ltd 1,4-dihydropyridine derivative
JPS6094963A (en) * 1983-10-31 1985-05-28 Teijin Ltd 1,4-dihydropyridine-3,5-dicarboxylic acid diester derivative and production thereof
NZ212895A (en) * 1984-08-22 1988-07-28 Glaxo Spa 1,4-dihydropyridine derivatives and pharmaceutical compositions
DE3447169A1 (en) * 1984-12-22 1986-07-03 Bayer Ag, 5090 Leverkusen OPTICALLY ACTIVE NITRODIHYDROPYRIDINE, METHOD FOR THE PRODUCTION AND THEIR USE IN MEDICINAL PRODUCTS
JPS625958A (en) * 1985-07-03 1987-01-12 Suntory Ltd 1,4-dihydropyridine derivative, production thereof and remedy for circulatory disease
US4761420A (en) * 1986-06-13 1988-08-02 Laboratoires Syntex S.A. Antihypertensive dihydropyridine derivatives
WO1988005043A1 (en) * 1986-12-24 1988-07-14 Boehringer Biochemia Robin S.P.A. New aralkyl-1,4-dihydropyridines, a method for their preparation and pharmaceutical compositions containing them
US5158963A (en) * 1989-08-02 1992-10-27 Kaken Pharmaceutical Co., Ltd. 1-4-dihydropyridine derivative, process for preparing the same and pharmaceutical composition containing the same
EP0461264A4 (en) * 1989-12-29 1992-02-19 Kaken Pharmaceutical Co., Ltd. Ethynylphenyl derivative, production thereof, and remedy for diseases of circulatory organs containing the same as active ingredient
ATE234286T1 (en) * 1993-12-10 2003-03-15 Bayer Ag PHENYL-SUBSTITUTED 1,4-DIHYDROPYRIDINES WITH CEREBRAL ACTIVITY

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1792764C3 (en) * 1967-03-20 1981-04-23 Bayer Ag, 5090 Leverkusen Coronary drugs
GB1430961A (en) * 1972-01-22 1976-04-07 Yamanouchi Pharma Co Ltd 1-substituted-1,4-dihyddrypyridine derivatives
DE2508181A1 (en) * 1975-02-26 1976-09-09 Bayer Ag 1,4-DIHYDROPYRIDINCARBONIC ACID ARAL KYLESTER, METHOD FOR MANUFACTURING AND USING THEY AS A MEDICINAL PRODUCT
GB1591089A (en) * 1976-12-17 1981-06-10 Fujisawa Pharmaceutical Co 1,4-dihydropyridine derivatives and process for preparation thereof
SE7910521L (en) * 1979-12-20 1981-06-21 Haessle Ab NEW 2-METHYL-6-SUBSTITUTED-4- (2,3-DISUBSTITUTED PHENYL) -1,4-DIHYDROPYRIDINE-3,5-DIESTERS WITH HYPOTHESIVE PROPERTIES, AND PROCEDURES FOR THEIR PREPARATION AND PHARMACEUTICAL PREPARATION

Also Published As

Publication number Publication date
ES502132A0 (en) 1982-10-01
IL62841A (en) 1984-11-30
ATE5718T1 (en) 1984-01-15
ES8300093A1 (en) 1982-10-01
PT72964A (en) 1981-06-01
AU541935B2 (en) 1985-01-31
DE3018259A1 (en) 1981-11-19
CA1185182A (en) 1985-04-09
DK210281A (en) 1981-11-14
EP0039863A1 (en) 1981-11-18
PT72964B (en) 1982-06-25
CA1175438A (en) 1984-10-02
EP0039863B1 (en) 1983-12-28
ZA813141B (en) 1982-04-28
GR74910B (en) 1984-07-12
FI811437L (en) 1981-11-14
JPS577468A (en) 1982-01-14
NO811424L (en) 1981-11-16
AU7047381A (en) 1981-11-19
ES512592A0 (en) 1983-02-16
DE3161760D1 (en) 1984-02-02
ES8304082A1 (en) 1983-02-16
IE811061L (en) 1981-11-13
PH18747A (en) 1985-09-19
IE51267B1 (en) 1986-11-26
HU184434B (en) 1984-08-28

Similar Documents

Publication Publication Date Title
GB1500581A (en) Substituted amides and their use as fungicides
ATE126219T1 (en) BENZIMIDAZOLE DERIVATIVES, METHOD FOR THE PRODUCTION AND USE THEREOF.
IL62841A (en) 1,4-dihydropyridine derivatives,their production and pharmaceutical compositions containing them
MY100115A (en) Nitrogen containing heterocyclic compounds, and their production and use.
EP0151006A3 (en) Dihydropyridine compounds, their production, pharmaceutical compositions containing them, and methods of producing these compositions
MD422C2 (en) Azole derivatives and intermediate compositions for preparation thereof
DE3174132D1 (en) New ethenylimidazole derivatives, processes for their preparation and pharmaceutical compositions containing them; intermediates, useful in their preparation and a process for the preparation thereof
NZ189091A (en) Prostaglandin derivatives
GB1430926A (en) 2-amino-3,4-dihydropyridines their production and their medicinal use
GB1509864A (en) Pyridine-4-carboxylic acid hydrazides and pyridine-4-carboxylic acid hydrazones for combatting microorganisms and for regulating plant growth
DE69001852T3 (en) Manufacture of derivatives of glutaric acid.
GB1299053A (en) Substituted 6-nitroaniline derivatives, processes for their preparation, and their use as herbicidal agents
DE68926016D1 (en) Halogeno-4-methylpyrazoles and process for their preparation
ATE50569T1 (en) ALPHA-ALLYLATED ARYLALKYLTRIAZOLES, PROCESS FOR THEIR PRODUCTION AND THEIR USE AS FUNGICIDES.
DK362479A (en) PROCEDURE FOR MANUFACTURING THIOETHERS
TH2282EX (en) Phenylsulfonylguanidine with a new class of substitutes for the control of weeds and trail mixtures.
MY104164A (en) Heterocyclic compounds.
ES481620A1 (en) Procedure for preparing 1-hydroxymethyl-1-oxoprostan derivatives of series e, a and f. (Machine-translation by Google Translate, not legally binding)
TH3183EX (en) Allofannate derivatives
TH5961EX (en) Diphenyl ether type weed killer
TH1768EX (en) 2- Substitutech Phenyl-4,5,6,7-tetrahydro-2H-Indasol, and the production of these compounds And utilization