FI811437L - 1,4-DIHYDROPYRIDINER MED OLIKA SUBSTITUENTER I 2- OCH 6-POSITION FOERFARANDE FOER DERAS FRAMSTAELLNING OCH ANVAENDNING SOM LAEKEMEDEL - Google Patents

1,4-DIHYDROPYRIDINER MED OLIKA SUBSTITUENTER I 2- OCH 6-POSITION FOERFARANDE FOER DERAS FRAMSTAELLNING OCH ANVAENDNING SOM LAEKEMEDEL

Info

Publication number
FI811437L
FI811437L FI811437A FI811437A FI811437L FI 811437 L FI811437 L FI 811437L FI 811437 A FI811437 A FI 811437A FI 811437 A FI811437 A FI 811437A FI 811437 L FI811437 L FI 811437L
Authority
FI
Finland
Prior art keywords
och
substituenter
dihydropyridiner
foerfarande foer
deras framstaellning
Prior art date
Application number
FI811437A
Other languages
Finnish (fi)
Inventor
Egbert Wehinger
Horst Meyer
Friedrich Bossert
Stanislav Kazda
Kurt Stoepel
Robertson Towart
Wulf Vater
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of FI811437L publication Critical patent/FI811437L/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Psychiatry (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

1. Compound of the general formula I see diagramm : EP0039863,P18,F1 in which R represents a phenyl radical which optionally contains 1 or 2 identical or different substituents from the group comprising nitro, chlorine, cyano or trifluoromethyl, with the exception of a phenyl radical which is at the same time ortho- and metadichlorosubstituted, when R**2 denotes methyl and R**4 denotes alkyl with 2-3 carbon atoms, R**1 represents a saturated hydrocarbon radical with up to 6 carbon atons which is optionally interrupted by an oxygen atom, R**2 and R**4 are always different and each represents hydrogen, alkyl with 1 to 4 carbon atoms or cyclohexylmethyl, with the exception of the compound diethyl-2-methyl-6-propyl-4-(3-nitrophenyl)-1,4- dihydropyridine-3,5-carboxylate.
FI811437A 1980-05-13 1981-05-11 1,4-DIHYDROPYRIDINER MED OLIKA SUBSTITUENTER I 2- OCH 6-POSITION FOERFARANDE FOER DERAS FRAMSTAELLNING OCH ANVAENDNING SOM LAEKEMEDEL FI811437L (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19803018259 DE3018259A1 (en) 1980-05-13 1980-05-13 1,4-DIHYDROPYRIDINE WITH DIFFERENT SUBSTITUENTS IN 2- AND 6-POSITIONS, METHODS FOR THEIR PRODUCTION AND THEIR USE IN MEDICINAL PRODUCTS

Publications (1)

Publication Number Publication Date
FI811437L true FI811437L (en) 1981-11-14

Family

ID=6102290

Family Applications (1)

Application Number Title Priority Date Filing Date
FI811437A FI811437L (en) 1980-05-13 1981-05-11 1,4-DIHYDROPYRIDINER MED OLIKA SUBSTITUENTER I 2- OCH 6-POSITION FOERFARANDE FOER DERAS FRAMSTAELLNING OCH ANVAENDNING SOM LAEKEMEDEL

Country Status (17)

Country Link
EP (1) EP0039863B1 (en)
JP (1) JPS577468A (en)
AT (1) ATE5718T1 (en)
AU (1) AU541935B2 (en)
CA (2) CA1175438A (en)
DE (2) DE3018259A1 (en)
DK (1) DK210281A (en)
ES (2) ES8300093A1 (en)
FI (1) FI811437L (en)
GR (1) GR74910B (en)
HU (1) HU184434B (en)
IE (1) IE51267B1 (en)
IL (1) IL62841A (en)
NO (1) NO811424L (en)
PH (1) PH18747A (en)
PT (1) PT72964B (en)
ZA (1) ZA813141B (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3207982A1 (en) * 1982-03-05 1983-09-08 Bayer Ag, 5090 Leverkusen NEW 1,4-DIHYDROPYRIDINE, METHOD FOR THE PRODUCTION AND USE THEREOF IN MEDICINAL PRODUCTS
DE3208628A1 (en) * 1982-03-10 1983-09-22 Bayer Ag, 5090 Leverkusen NEW COMPOUNDS, METHOD FOR THEIR PRODUCTION AND THEIR USE AS MEDICINAL PRODUCTS
US4414213A (en) * 1982-03-22 1983-11-08 Mead Johnson & Company Dihydropyridyl cyclic imidate esters and their pharmaceutical use
JPS58208271A (en) * 1982-04-30 1983-12-03 Kyowa Hakko Kogyo Co Ltd 1,4-dihydropyridine derivative
JPS6094963A (en) * 1983-10-31 1985-05-28 Teijin Ltd 1,4-dihydropyridine-3,5-dicarboxylic acid diester derivative and production thereof
NZ212895A (en) * 1984-08-22 1988-07-28 Glaxo Spa 1,4-dihydropyridine derivatives and pharmaceutical compositions
DE3447169A1 (en) * 1984-12-22 1986-07-03 Bayer Ag, 5090 Leverkusen OPTICALLY ACTIVE NITRODIHYDROPYRIDINE, METHOD FOR THE PRODUCTION AND THEIR USE IN MEDICINAL PRODUCTS
JPS625958A (en) * 1985-07-03 1987-01-12 Suntory Ltd 1,4-dihydropyridine derivative, production thereof and remedy for circulatory disease
US4761420A (en) * 1986-06-13 1988-08-02 Laboratoires Syntex S.A. Antihypertensive dihydropyridine derivatives
AU1153088A (en) * 1986-12-24 1988-07-27 Boehringer Biochemia Robin S.P.A New aralkyl-1,4-dihydropyridines, a method for their preparation and pharmaceutical compositions containing them
US5158963A (en) * 1989-08-02 1992-10-27 Kaken Pharmaceutical Co., Ltd. 1-4-dihydropyridine derivative, process for preparing the same and pharmaceutical composition containing the same
CA2048668A1 (en) * 1989-12-29 1991-06-30 Michio Nakanishi Ethynylphenyl derivative, process for preparing the same and medicament for circulatory disease containing the same as an effective ingredient
EP0657432B1 (en) * 1993-12-10 2003-03-12 Bayer Ag Phenyl-substituted 1,4-dihydropyridines with cerebral activity

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1792764C3 (en) * 1967-03-20 1981-04-23 Bayer Ag, 5090 Leverkusen Coronary drugs
GB1430961A (en) * 1972-01-22 1976-04-07 Yamanouchi Pharma Co Ltd 1-substituted-1,4-dihyddrypyridine derivatives
DE2508181A1 (en) * 1975-02-26 1976-09-09 Bayer Ag 1,4-DIHYDROPYRIDINCARBONIC ACID ARAL KYLESTER, METHOD FOR MANUFACTURING AND USING THEY AS A MEDICINAL PRODUCT
GB1591089A (en) * 1976-12-17 1981-06-10 Fujisawa Pharmaceutical Co 1,4-dihydropyridine derivatives and process for preparation thereof
SE7910521L (en) * 1979-12-20 1981-06-21 Haessle Ab NEW 2-METHYL-6-SUBSTITUTED-4- (2,3-DISUBSTITUTED PHENYL) -1,4-DIHYDROPYRIDINE-3,5-DIESTERS WITH HYPOTHESIVE PROPERTIES, AND PROCEDURES FOR THEIR PREPARATION AND PHARMACEUTICAL PREPARATION

Also Published As

Publication number Publication date
CA1185182A (en) 1985-04-09
PT72964B (en) 1982-06-25
AU7047381A (en) 1981-11-19
NO811424L (en) 1981-11-16
AU541935B2 (en) 1985-01-31
DE3018259A1 (en) 1981-11-19
HU184434B (en) 1984-08-28
IE811061L (en) 1981-11-13
ATE5718T1 (en) 1984-01-15
ES502132A0 (en) 1982-10-01
EP0039863A1 (en) 1981-11-18
CA1175438A (en) 1984-10-02
IL62841A0 (en) 1981-07-31
ES8304082A1 (en) 1983-02-16
PT72964A (en) 1981-06-01
ES512592A0 (en) 1983-02-16
ZA813141B (en) 1982-04-28
DK210281A (en) 1981-11-14
PH18747A (en) 1985-09-19
EP0039863B1 (en) 1983-12-28
ES8300093A1 (en) 1982-10-01
JPS577468A (en) 1982-01-14
IL62841A (en) 1984-11-30
GR74910B (en) 1984-07-12
DE3161760D1 (en) 1984-02-02
IE51267B1 (en) 1986-11-26

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Owner name: BAYER AKTIENGESELLSCHAFT