PT708099E - Novos compostos amidas triciclicas processo para a sua preparacao e as composicoes farmaceuticas que os contem - Google Patents

Novos compostos amidas triciclicas processo para a sua preparacao e as composicoes farmaceuticas que os contem

Info

Publication number
PT708099E
PT708099E PT95402331T PT95402331T PT708099E PT 708099 E PT708099 E PT 708099E PT 95402331 T PT95402331 T PT 95402331T PT 95402331 T PT95402331 T PT 95402331T PT 708099 E PT708099 E PT 708099E
Authority
PT
Portugal
Prior art keywords
alkyl
cycloalkyl
new
substd
alkoxy
Prior art date
Application number
PT95402331T
Other languages
English (en)
Inventor
Daniel Lesieur
Pierre Renard
Philippe Delagrange
Patrick Depreux
Hamid Ait Mansour
Veronique Leclerk
Original Assignee
Servier Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Servier Lab filed Critical Servier Lab
Publication of PT708099E publication Critical patent/PT708099E/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/92—Naphthofurans; Hydrogenated naphthofurans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/12—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by halogen atoms or by nitro or nitroso groups
    • C07C233/13—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by halogen atoms or by nitro or nitroso groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C07C233/17—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/20—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a carbon atom of an acyclic unsaturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/57—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C233/60—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/78—Ring systems having three or more relevant rings
    • C07D311/92—Naphthopyrans; Hydrogenated naphthopyrans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/04—Systems containing only non-condensed rings with a four-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Transplantation (AREA)
  • Child & Adolescent Psychology (AREA)
  • Endocrinology (AREA)
  • Anesthesiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Furan Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Indole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
PT95402331T 1994-10-21 1995-10-19 Novos compostos amidas triciclicas processo para a sua preparacao e as composicoes farmaceuticas que os contem PT708099E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9412581A FR2725985B1 (fr) 1994-10-21 1994-10-21 Nouveaux composes tricycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Publications (1)

Publication Number Publication Date
PT708099E true PT708099E (pt) 2002-05-31

Family

ID=9468074

Family Applications (1)

Application Number Title Priority Date Filing Date
PT95402331T PT708099E (pt) 1994-10-21 1995-10-19 Novos compostos amidas triciclicas processo para a sua preparacao e as composicoes farmaceuticas que os contem

Country Status (17)

Country Link
US (1) US5843986A (pt)
EP (1) EP0708099B1 (pt)
JP (1) JP2999143B2 (pt)
CN (2) CN1053662C (pt)
AT (1) ATE209641T1 (pt)
AU (1) AU688586B2 (pt)
CA (1) CA2160961C (pt)
DE (1) DE69524186T2 (pt)
DK (1) DK0708099T3 (pt)
ES (1) ES2169113T3 (pt)
FI (1) FI118565B (pt)
FR (1) FR2725985B1 (pt)
HK (1) HK1029116A1 (pt)
NO (1) NO314262B1 (pt)
NZ (1) NZ280298A (pt)
PT (1) PT708099E (pt)
ZA (1) ZA958894B (pt)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5998461A (en) * 1994-10-21 1999-12-07 Adir Et Compagnie Tricyclic amide compounds
US6071946A (en) * 1994-10-21 2000-06-06 Adir Et Compagnie Tricyclic urea compounds
FR2739379B1 (fr) * 1995-09-29 1997-10-24 Adir Nouveaux composes amines de 5,6,7,8-tetrahydronaphto(2,3-b) furane et d'indano(5,6-b)furane, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent
EP1199304A1 (en) * 1997-03-05 2002-04-24 Takeda Chemical Industries, Ltd. Bicyclic compounds and pharmaceutical composition containing tricyclic compound for treating or preventing sleep disorders
US6034239A (en) * 1996-03-08 2000-03-07 Takeda Chemical Industries, Ltd. Tricyclic compounds, their production and use
KR100494214B1 (ko) * 1996-03-08 2005-11-25 다케다 야쿠힌 고교 가부시키가이샤 삼환화합물,그의제조방법및용도
BR9713690B1 (pt) * 1996-12-10 2009-08-11 agentes melatoninérgicos benzodioxola, benzofurano, diidrobenzofurano e benzodioxano.
FR2763335B1 (fr) * 1997-05-16 2000-11-24 Adir Nouveaux composes heterocycliques substitues, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR2773798B1 (fr) * 1998-01-16 2001-02-02 Adir Nouveaux composes tricycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
EP1082115A4 (en) 1998-06-05 2002-10-24 Bristol Myers Squibb Co MELATONERGICS BASED ON HETEROCYCLIC CIS DERIVATIVES OF CYCLOPROPANE
DK1189900T3 (da) 1999-06-30 2004-04-26 Bristol Myers Squibb Co Heterocykliske aminopyrrolidinderivater som melatonerge lægemidler
AU6595000A (en) 1999-08-20 2001-03-19 Takeda Chemical Industries Ltd. Dihydrobenzofuran derivatives, process for the preparation thereof and agents
FR2805993B1 (fr) * 2000-03-08 2004-01-16 Adir Utilisation de ligands melatoninergiques pour l'obtention de compositions pharmaceutiques destinees a la prevention ou au traitement du developpement de la tolerance aux composes nitres
US7012090B1 (en) 2000-03-17 2006-03-14 Alcon, Inc. Pyranoindoles for treating glaucoma
TWI402261B (zh) * 2006-06-19 2013-07-21 Takeda Pharmaceutical 三環化合物及其醫藥組成物
MX2009006078A (es) 2006-12-08 2009-09-18 Takeda Pharmaceutical Compuesto triciclico y su uso medico.
GB201002372D0 (en) 2010-02-12 2010-03-31 Element Six Production Pty Ltd A superhard multiphase material and method of using same
CN107325011A (zh) * 2016-04-30 2017-11-07 陕西合成药业股份有限公司 一种褪黑激素类化合物及其制备方法和用途
KR20240035395A (ko) 2021-06-14 2024-03-15 스코르피온 테라퓨틱스, 인코퍼레이티드 암 치료에 사용할 수 있는 요소 유도체

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2613364B1 (fr) * 1987-04-01 1989-06-09 Adir Nouvelles amines tricycliques derivees du tetrahydro-5, 6, 7, 8 naphto (2, 3b) dihydro-2, 3 furanne, et du tetrahydro-6, 7, 8, 9 5h-benzocyclohepta (2, 3b) dihydro-2, 3 furanne, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent
FR2613365B1 (fr) * 1987-04-01 1989-07-28 Adir Nouveaux derives de l'amino tetrahydro-5, 6, 7, 8 naphto (2, 3b) furanne, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent
FR2658818B1 (fr) * 1990-02-27 1993-12-31 Adir Cie Nouveaux derives a structure naphtalenique, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
FR2680507B1 (fr) * 1991-08-23 1993-10-08 Adir Cie Nouvelles naphtylethylurees et naphtylethylthiourees, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
FR2689124A1 (fr) * 1992-03-27 1993-10-01 Adir Nouvelles naphtylalkylamines, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent.
GB9407919D0 (en) * 1994-04-21 1994-06-15 Glaxo Group Ltd Chemical compounds

Also Published As

Publication number Publication date
CN1263095A (zh) 2000-08-16
FR2725985B1 (fr) 1996-11-15
ZA958894B (en) 1996-05-14
ES2169113T3 (es) 2002-07-01
FI118565B (fi) 2007-12-31
FI955023A0 (fi) 1995-10-20
DE69524186D1 (de) 2002-01-10
CN1137889C (zh) 2004-02-11
HK1029116A1 (en) 2001-03-23
FI955023A (fi) 1996-04-22
CA2160961C (fr) 2001-07-17
AU3437795A (en) 1996-05-02
AU688586B2 (en) 1998-03-12
CN1130184A (zh) 1996-09-04
ATE209641T1 (de) 2001-12-15
NO954149L (no) 1996-04-22
CN1053662C (zh) 2000-06-21
DK0708099T3 (da) 2002-02-11
JP2999143B2 (ja) 2000-01-17
CA2160961A1 (fr) 1996-04-22
EP0708099B1 (fr) 2001-11-28
FR2725985A1 (fr) 1996-04-26
US5843986A (en) 1998-12-01
NO314262B1 (no) 2003-02-24
EP0708099A1 (fr) 1996-04-24
JPH08239377A (ja) 1996-09-17
NO954149D0 (no) 1995-10-18
NZ280298A (en) 1996-10-28
DE69524186T2 (de) 2002-07-04

Similar Documents

Publication Publication Date Title
PT708099E (pt) Novos compostos amidas triciclicas processo para a sua preparacao e as composicoes farmaceuticas que os contem
PT98641A (pt) Processo para a preparacao de 2-amino-1,2,3,4-tetrahidronaftlalenos 3-aminocromanos substituidos no anel
PT919541E (pt) Novos compostos naftalenicos processo para a sua preparacao e as composicoes farmaceuticas que os contem
ES2143154T3 (es) Compuestos alcoxi-arilos con afinidad para los receptores melatoninergicos, sus procedimientos de preparacion, y las composiciones farmaceuticas que los contienen.
ES2157404T3 (es) Nuevos compuestos alquil-heterociclicos, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen.
ES2098023T3 (es) Compuestos de estructura guanidinica y composiciones farmaceuticas que los contienen.
PT93218A (pt) Processo para a preparacao de 2-amino-1,2,3,4-tetra-idronaftalenos e 3-aminocromanos substituidos no anel
PT96226A (pt) Processo para a preparacao de derivados morfolinilicos de doxorubicina e de composicoes farmaceuticas que os contem
MX9200206A (es) 1,2,3,4- TETRAHIDROCICLOPENT (b) INDOLES SUSBSTITUIDOS, 1,2,3,3a-4,8a- HEXAHIDROCICLOPENT (b) INDOLES Y COMPUESTOS RELACIONADOS, COMPUESTOS INTERMEDIOS Y UN PROCEDIMIENTO PARA LA PREPARACIONDE LOS MISMOS Y SU USO COMO MEDICAMENTOS.
DE69425970D1 (de) Benzol-derivate, verwendbar für ischämische erkrankungen
DE69424524D1 (de) Neue cephem-derivate
ATE135694T1 (de) Alkylthiopoly(ethylimidazolium)verbindungen, verfahren zur herstellung und deren verwendung als biozidemittel
MX9200651A (es) Nuevas feniletanolamino y feniletanolaminometil-tetralinas, proceso para su preparacion y composiciones farmaceuticas que las contienen
FI832560A0 (fi) Foerfarande foer framstaellning av nya benzotiopyranopyridinoner och deras salter
ES2118592T3 (es) Procedimiento para la preparacion de hidroxi-7 taxanos.
ES2128572T3 (es) Utilizacion de los derivados de cefem como agentes antimetastaticos.
EA199900836A1 (ru) Противосудорожные производные изохинолилбензамида
CA2027542A1 (en) Uv-absorbing cyclic enaminoketones
PT90831A (pt) Processo para a preparacao de eteres da 2-amino-7-hidroxitetralina
ATE52501T1 (de) Cyclohexan-1,3-dionderivate, diese enthaltende zusammensetzungen, verfahren zu deren herstellung und deren verwendung als herbizide und pflanzenwachstumsregulatoren.
SE8401064D0 (sv) Neue isoxazole und verfahren zu ihrer herstellung
RU93058583A (ru) Новые амидоалкил и имидоалкил-пиперазины, способ их получения, фармацевтическая композиция, способ лечения