PT4140297T - Ratinhos tendo uma cadeia leve lambda de imunoglobulina manipulada e seus usos - Google Patents

Ratinhos tendo uma cadeia leve lambda de imunoglobulina manipulada e seus usos

Info

Publication number
PT4140297T
PT4140297T PT221886278T PT22188627T PT4140297T PT 4140297 T PT4140297 T PT 4140297T PT 221886278 T PT221886278 T PT 221886278T PT 22188627 T PT22188627 T PT 22188627T PT 4140297 T PT4140297 T PT 4140297T
Authority
PT
Portugal
Prior art keywords
light chain
human animals
lambda light
engineered immunoglobulin
immunoglobulin lambda
Prior art date
Application number
PT221886278T
Other languages
English (en)
Portuguese (pt)
Original Assignee
Regeneron Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Regeneron Pharma filed Critical Regeneron Pharma
Publication of PT4140297T publication Critical patent/PT4140297T/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0278—Knock-in vertebrates, e.g. humanised vertebrates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/461—Igs containing Ig-regions, -domains or -residues form different species
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/461—Igs containing Ig-regions, -domains or -residues form different species
    • C07K16/462—Igs containing a variable region (Fv) from one specie and a constant region (Fc) from another
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0603—Embryonic cells ; Embryoid bodies
    • C12N5/0606—Pluripotent embryonic cells, e.g. embryonic stem cells [ES]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1241—Nucleotidyltransferases (2.7.7)
    • C12N9/1264—DNA nucleotidylexotransferase (2.7.7.31), i.e. terminal nucleotidyl transferase
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2207/00—Modified animals
    • A01K2207/15—Humanized animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A01K2217/052—Animals comprising random inserted nucleic acids (transgenic) inducing gain of function
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/072—Animals genetically altered by homologous recombination maintaining or altering function, i.e. knock in
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/15—Animals comprising multiple alterations of the genome, by transgenesis or homologous recombination, e.g. obtained by cross-breeding
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/01—Animal expressing industrially exogenous proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/515—Complete light chain, i.e. VL + CL

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Environmental Sciences (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Animal Husbandry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Developmental Biology & Embryology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Reproductive Health (AREA)
  • Cell Biology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
PT221886278T 2017-12-05 2018-12-04 Ratinhos tendo uma cadeia leve lambda de imunoglobulina manipulada e seus usos PT4140297T (pt)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201762594946P 2017-12-05 2017-12-05
US201762594944P 2017-12-05 2017-12-05
US201762609241P 2017-12-21 2017-12-21
US201762609251P 2017-12-21 2017-12-21

Publications (1)

Publication Number Publication Date
PT4140297T true PT4140297T (pt) 2025-07-09

Family

ID=64734263

Family Applications (2)

Application Number Title Priority Date Filing Date
PT188219455T PT3720279T (pt) 2017-12-05 2018-12-04 Ratinhos tendo uma cadeia leve lambda de imunoglobulina manipulada e seus usos
PT221886278T PT4140297T (pt) 2017-12-05 2018-12-04 Ratinhos tendo uma cadeia leve lambda de imunoglobulina manipulada e seus usos

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PT188219455T PT3720279T (pt) 2017-12-05 2018-12-04 Ratinhos tendo uma cadeia leve lambda de imunoglobulina manipulada e seus usos

Country Status (24)

Country Link
US (3) US20210345591A1 (enExample)
EP (3) EP4596688A3 (enExample)
JP (2) JP7430636B2 (enExample)
KR (2) KR102760506B1 (enExample)
CN (2) CN116058333A (enExample)
AU (2) AU2018381316B2 (enExample)
BR (1) BR112020011184A2 (enExample)
CA (1) CA3084049A1 (enExample)
DK (2) DK4140297T3 (enExample)
ES (2) ES2928995T3 (enExample)
FI (1) FI4140297T3 (enExample)
HR (2) HRP20250920T1 (enExample)
HU (2) HUE060608T2 (enExample)
IL (2) IL318197A (enExample)
LT (2) LT3720279T (enExample)
MX (2) MX2020005830A (enExample)
PL (2) PL3720279T3 (enExample)
PT (2) PT3720279T (enExample)
RS (2) RS63772B1 (enExample)
SG (1) SG11202003044SA (enExample)
SI (2) SI4140297T1 (enExample)
SM (2) SMT202500277T1 (enExample)
TW (2) TWI827567B (enExample)
WO (1) WO2019113065A1 (enExample)

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IL318469A (en) 2018-06-14 2025-03-01 Regeneron Pharma Non-human animals capable of reorganizing transgenic DH-DH, and their uses
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Also Published As

Publication number Publication date
WO2019113065A1 (en) 2019-06-13
IL274797B2 (en) 2025-06-01
EP4140297A1 (en) 2023-03-01
KR20200093570A (ko) 2020-08-05
AU2025204547A1 (en) 2025-07-10
MX2024004496A (es) 2024-05-08
PL4140297T3 (pl) 2025-08-25
SMT202500277T1 (it) 2025-09-12
RS67058B1 (sr) 2025-08-29
CN111432635B (zh) 2022-10-21
CN111432635A (zh) 2020-07-17
CA3084049A1 (en) 2019-06-13
CN116058333A (zh) 2023-05-05
PT3720279T (pt) 2022-10-06
EP4596688A2 (en) 2025-08-06
LT4140297T (lt) 2025-07-25
JP7430636B2 (ja) 2024-02-13
TW202438676A (zh) 2024-10-01
IL318197A (en) 2025-03-01
EP4596688A3 (en) 2025-11-12
DK3720279T3 (da) 2022-10-24
SI4140297T1 (sl) 2025-08-29
US20190223418A1 (en) 2019-07-25
HRP20250920T1 (hr) 2025-09-26
BR112020011184A2 (pt) 2020-11-17
US12356967B2 (en) 2025-07-15
TWI827567B (zh) 2024-01-01
ES2928995T3 (es) 2022-11-24
IL274797A (en) 2020-07-30
JP7765514B2 (ja) 2025-11-06
KR20250022220A (ko) 2025-02-14
AU2018381316B2 (en) 2025-06-26
SI3720279T1 (sl) 2022-11-30
IL274797B1 (en) 2025-02-01
SG11202003044SA (en) 2020-04-29
LT3720279T (lt) 2022-10-25
KR102760506B1 (ko) 2025-02-04
US11051498B2 (en) 2021-07-06
JP2024036440A (ja) 2024-03-15
HRP20221459T1 (hr) 2023-01-20
EP3720279B1 (en) 2022-09-21
RU2020118699A (ru) 2022-01-10
EP4140297B1 (en) 2025-05-21
AU2018381316A1 (en) 2020-04-23
DK4140297T3 (da) 2025-06-23
MX2020005830A (es) 2020-08-20
EP3720279A1 (en) 2020-10-14
HUE060608T2 (hu) 2023-03-28
PL3720279T3 (pl) 2023-01-16
US20210345591A1 (en) 2021-11-11
FI4140297T3 (fi) 2025-07-10
US20210292439A1 (en) 2021-09-23
RU2020118699A3 (enExample) 2022-04-07
SMT202200448T1 (it) 2023-01-13
RS63772B1 (sr) 2022-12-30
ES3035461T3 (en) 2025-09-03
JP2021505141A (ja) 2021-02-18
TW201938019A (zh) 2019-10-01
HUE071852T2 (hu) 2025-09-28

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