PT4003532T - Formas cristalinas de 7-cloro-2-(4-(3-metoxiazetidina-1- il)ciclohexil)-2,4-dimetil-n-((6-metil-4-(metiltio)-2-oxo- 1,2-di-hidropiridin-3-il)metil)benzo[d][1,3]dioxol-5- carboxamida - Google Patents
Formas cristalinas de 7-cloro-2-(4-(3-metoxiazetidina-1- il)ciclohexil)-2,4-dimetil-n-((6-metil-4-(metiltio)-2-oxo- 1,2-di-hidropiridin-3-il)metil)benzo[d][1,3]dioxol-5- carboxamidaInfo
- Publication number
- PT4003532T PT4003532T PT207544826T PT20754482T PT4003532T PT 4003532 T PT4003532 T PT 4003532T PT 207544826 T PT207544826 T PT 207544826T PT 20754482 T PT20754482 T PT 20754482T PT 4003532 T PT4003532 T PT 4003532T
- Authority
- PT
- Portugal
- Prior art keywords
- methyl
- methoxyazetidin
- dihydropyridin
- dioxole
- methylthio
- Prior art date
Links
- HUSYTLMIRXITQS-UHFFFAOYSA-N 1,3-benzodioxole-5-carboxamide Chemical compound NC(=O)C1=CC=C2OCOC2=C1 HUSYTLMIRXITQS-UHFFFAOYSA-N 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/443—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962878012P | 2019-07-24 | 2019-07-24 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT4003532T true PT4003532T (pt) | 2024-12-02 |
Family
ID=72047059
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT207544826T PT4003532T (pt) | 2019-07-24 | 2020-07-23 | Formas cristalinas de 7-cloro-2-(4-(3-metoxiazetidina-1- il)ciclohexil)-2,4-dimetil-n-((6-metil-4-(metiltio)-2-oxo- 1,2-di-hidropiridin-3-il)metil)benzo[d][1,3]dioxol-5- carboxamida |
Country Status (29)
| Country | Link |
|---|---|
| US (1) | US20220251073A1 (pt) |
| EP (2) | EP4442261A3 (pt) |
| JP (2) | JP7603653B2 (pt) |
| KR (1) | KR20220041129A (pt) |
| CN (2) | CN118852139A (pt) |
| AU (1) | AU2020316073A1 (pt) |
| BR (1) | BR112022001161A2 (pt) |
| CA (1) | CA3148447A1 (pt) |
| CL (1) | CL2022000175A1 (pt) |
| CO (1) | CO2022001482A2 (pt) |
| DK (1) | DK4003532T3 (pt) |
| ES (1) | ES2997972T3 (pt) |
| FI (1) | FI4003532T3 (pt) |
| HR (1) | HRP20241443T1 (pt) |
| HU (1) | HUE069127T2 (pt) |
| IL (1) | IL289972A (pt) |
| LT (1) | LT4003532T (pt) |
| MA (1) | MA56661B1 (pt) |
| MD (1) | MD4003532T2 (pt) |
| MX (2) | MX2022000931A (pt) |
| MY (1) | MY207951A (pt) |
| PE (1) | PE20220562A1 (pt) |
| PH (1) | PH12022550188A1 (pt) |
| PL (1) | PL4003532T3 (pt) |
| PT (1) | PT4003532T (pt) |
| RS (1) | RS66244B1 (pt) |
| SI (1) | SI4003532T1 (pt) |
| SM (1) | SMT202400485T1 (pt) |
| WO (1) | WO2021016414A1 (pt) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11919912B2 (en) | 2018-05-21 | 2024-03-05 | Constellation Pharmaceuticals, Inc. | Modulators of methyl modifying enzymes, compositions and uses thereof |
| WO2023135564A1 (ko) * | 2022-01-14 | 2023-07-20 | 동화약품주식회사 | 1,3-벤조다이옥솔 유도체 화합물 및 이를 포함하는 약학적 조성물 |
| KR20250023483A (ko) | 2022-06-13 | 2025-02-18 | 트리라인 바이오사이언시스, 인크. | 퀴놀론 bcl6 이작용성 분해제 |
| AU2023295387A1 (en) | 2022-06-13 | 2025-01-09 | Treeline Biosciences, Inc. | 1,8-naphthyridin-2-one heterobifunctional bcl6 degraders |
| IL318346A (en) | 2022-07-15 | 2025-03-01 | Constellation Pharmaceuticals Inc | EZH2 inhibition therapies for cancer with ARID1A-rich interacting domain-containing protein mutation |
| CN115403040B (zh) * | 2022-08-11 | 2023-08-01 | 中国地质大学（北京） | 一种可通过光辐射调控导热系数的偶氮苯聚合物表面修饰的金刚石纳米粒子及其制备方法 |
| CA3264686A1 (en) | 2022-08-17 | 2024-02-22 | Incyte Corp | Therapy including an anti-CD19 antibody and EZ2 modulators |
| EP4598527A1 (en) | 2022-10-06 | 2025-08-13 | Constellation Pharmaceuticals, Inc. | Ezh2 inhibition therapies for the treatment of brca1-associated protein (bap1) mutated cancers |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SMT201900451T1 (it) * | 2012-01-25 | 2019-11-13 | Vertex Pharma | Formulazioni di acido 3-(6-(1-(2,2-difluorobenzo[d][1,3]diossol-5-il) ciclopropancarbossammido)-3-metilpiridin-2-il)benzoico |
| MA38341B1 (fr) * | 2013-02-11 | 2018-11-30 | Constellation Pharmaceuticals Inc | Modulateurs d'enzymes de modification par méthylation, compositions et utilisations associées |
| LT3121175T (lt) * | 2014-03-17 | 2020-03-10 | Daiichi Sankyo Company, Limited | 1,3-benzodioksazolo dariniai, kaip ezh1 ir (arba) ezh2 inhibitoriai |
| US10577350B2 (en) * | 2015-08-28 | 2020-03-03 | Constellation Pharmaceuticals, Inc. | Crystalline forms of (R)-N-((4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-1-(1-(1-(2,2,2-trifluoroethyl)piperidin-4-yl)ethyl)-1H-indole-3-carboxamide |
| CN110191722B (zh) * | 2017-01-19 | 2022-03-01 | 第一三共株式会社 | 用于治疗htlv-1相关性脊髓病的药物组合物 |
| CN119954787A (zh) * | 2018-04-18 | 2025-05-09 | 星座制药公司 | 甲基修饰酶的调节剂、其组合物和用途 |
| US11919912B2 (en) * | 2018-05-21 | 2024-03-05 | Constellation Pharmaceuticals, Inc. | Modulators of methyl modifying enzymes, compositions and uses thereof |
-
2020
- 2020-07-23 PT PT207544826T patent/PT4003532T/pt unknown
- 2020-07-23 DK DK20754482.6T patent/DK4003532T3/da active
- 2020-07-23 ES ES20754482T patent/ES2997972T3/es active Active
- 2020-07-23 MX MX2022000931A patent/MX2022000931A/es unknown
- 2020-07-23 SM SM20240485T patent/SMT202400485T1/it unknown
- 2020-07-23 MY MYPI2022000428A patent/MY207951A/en unknown
- 2020-07-23 JP JP2022504532A patent/JP7603653B2/ja active Active
- 2020-07-23 CN CN202410901775.XA patent/CN118852139A/zh active Pending
- 2020-07-23 SI SI202030528T patent/SI4003532T1/sl unknown
- 2020-07-23 EP EP24182094.3A patent/EP4442261A3/en active Pending
- 2020-07-23 KR KR1020227005690A patent/KR20220041129A/ko active Pending
- 2020-07-23 FI FIEP20754482.6T patent/FI4003532T3/fi active
- 2020-07-23 PL PL20754482.6T patent/PL4003532T3/pl unknown
- 2020-07-23 HU HUE20754482A patent/HUE069127T2/hu unknown
- 2020-07-23 LT LTEPPCT/US2020/043178T patent/LT4003532T/lt unknown
- 2020-07-23 CA CA3148447A patent/CA3148447A1/en active Pending
- 2020-07-23 RS RS20241327A patent/RS66244B1/sr unknown
- 2020-07-23 AU AU2020316073A patent/AU2020316073A1/en active Pending
- 2020-07-23 EP EP20754482.6A patent/EP4003532B1/en active Active
- 2020-07-23 PH PH1/2022/550188A patent/PH12022550188A1/en unknown
- 2020-07-23 WO PCT/US2020/043178 patent/WO2021016414A1/en not_active Ceased
- 2020-07-23 PE PE2022000116A patent/PE20220562A1/es unknown
- 2020-07-23 US US17/628,947 patent/US20220251073A1/en active Pending
- 2020-07-23 BR BR112022001161A patent/BR112022001161A2/pt unknown
- 2020-07-23 HR HRP20241443TT patent/HRP20241443T1/hr unknown
- 2020-07-23 MA MA56661A patent/MA56661B1/fr unknown
- 2020-07-23 MD MDE20220601T patent/MD4003532T2/ro unknown
- 2020-07-23 CN CN202080066219.5A patent/CN114450279B/zh active Active
-
2022
- 2022-01-19 IL IL289972A patent/IL289972A/en unknown
- 2022-01-21 MX MX2025004573A patent/MX2025004573A/es unknown
- 2022-01-24 CL CL2022000175A patent/CL2022000175A1/es unknown
- 2022-02-15 CO CONC2022/0001482A patent/CO2022001482A2/es unknown
-
2024
- 2024-12-09 JP JP2024214565A patent/JP7692524B2/ja active Active
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