PT3572410T - Análogos dioxolano de uridina para o tratamento de cancro - Google Patents

Análogos dioxolano de uridina para o tratamento de cancro

Info

Publication number
PT3572410T
PT3572410T PT191778240T PT19177824T PT3572410T PT 3572410 T PT3572410 T PT 3572410T PT 191778240 T PT191778240 T PT 191778240T PT 19177824 T PT19177824 T PT 19177824T PT 3572410 T PT3572410 T PT 3572410T
Authority
PT
Portugal
Prior art keywords
dioxolan
uridine
analogs
cancer
treatment
Prior art date
Application number
PT191778240T
Other languages
English (en)
Portuguese (pt)
Original Assignee
Medivir Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medivir Ab filed Critical Medivir Ab
Publication of PT3572410T publication Critical patent/PT3572410T/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65586—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system at least one of the hetero rings does not contain nitrogen as ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/665—Phosphorus compounds having oxygen as a ring hetero atom, e.g. fosfomycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/22—Amides of acids of phosphorus
    • C07F9/24—Esteramides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
PT191778240T 2014-08-25 2015-08-24 Análogos dioxolano de uridina para o tratamento de cancro PT3572410T (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE1450983 2014-08-25
SE1550858 2015-06-22

Publications (1)

Publication Number Publication Date
PT3572410T true PT3572410T (pt) 2022-09-15

Family

ID=54014804

Family Applications (2)

Application Number Title Priority Date Filing Date
PT191778240T PT3572410T (pt) 2014-08-25 2015-08-24 Análogos dioxolano de uridina para o tratamento de cancro
PT157568882T PT3186244T (pt) 2014-08-25 2015-08-24 Análogos dioxolano de uridina para o tratamento de cancro

Family Applications After (1)

Application Number Title Priority Date Filing Date
PT157568882T PT3186244T (pt) 2014-08-25 2015-08-24 Análogos dioxolano de uridina para o tratamento de cancro

Country Status (24)

Country Link
US (7) US10144750B2 (OSRAM)
EP (2) EP3186244B1 (OSRAM)
JP (2) JP6663424B2 (OSRAM)
KR (2) KR102398714B1 (OSRAM)
CN (4) CN107074826B (OSRAM)
AU (2) AU2015308988C1 (OSRAM)
BR (1) BR112017003898B1 (OSRAM)
CA (2) CA3128645C (OSRAM)
CY (1) CY1122945T1 (OSRAM)
DK (2) DK3186244T3 (OSRAM)
EA (2) EA033300B1 (OSRAM)
ES (2) ES2927212T3 (OSRAM)
HR (1) HRP20201023T1 (OSRAM)
HU (2) HUE050705T2 (OSRAM)
IL (2) IL250344B (OSRAM)
MX (1) MX369649B (OSRAM)
MY (2) MY188089A (OSRAM)
NZ (2) NZ762628A (OSRAM)
PH (2) PH12017500184A1 (OSRAM)
PL (2) PL3186244T3 (OSRAM)
PT (2) PT3572410T (OSRAM)
SG (3) SG10202001117YA (OSRAM)
WO (1) WO2016030335A1 (OSRAM)
ZA (1) ZA201802864B (OSRAM)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3186244B1 (en) * 2014-08-25 2020-04-22 Medivir Aktiebolag Dioxolane analogues of uridine for the treatment of cancer
CN106543220A (zh) * 2015-09-16 2017-03-29 博瑞生物医药（苏州）股份有限公司 氨基磷酸酯化合物及其制备方法和晶体
MA43405B1 (fr) 2015-12-11 2021-11-30 NuCana plc Syntheses diastereoselectives de dérivés phosphates et du promedicament de gemcitabine nuc-1031
RU2018134336A (ru) * 2016-03-02 2020-04-02 Медивир Актиеболаг Комбинированная терапия сорафенибом или регорафенибом и фосфорамидатным пролекарством троксацитабина
CN106432328B (zh) * 2016-09-14 2019-03-22 江苏福瑞生物医药有限公司 一种索非布韦中间体的制备方法
AU2017361855A1 (en) * 2016-11-18 2019-05-30 Neurovive Pharmaceutical Ab Liver prodrugs of mitochondrial proton ionophores
GB201709471D0 (en) 2017-06-14 2017-07-26 Nucana Biomed Ltd Diastereoselective synthesis of hosphate derivatives
WO2019245444A1 (en) 2018-06-21 2019-12-26 Medivir Ab Base-modified cytidine nucleotides for leukemia therapy
JP7337539B2 (ja) * 2018-06-21 2023-09-04 メディヴィル・アクチエボラーグ 白血病療法のための塩基修飾シチジンヌクレオチド
KR20210130768A (ko) 2019-02-18 2021-11-01 메디비르 아베 경구 투여된 디옥솔란 뉴클레오타이드와 항-pd1 또는 항-pdl1 단일클론 항체를 함께 사용하여 간암을 치료하는 방법
CN110964057B (zh) * 2019-12-25 2022-05-06 东南大学 一种利用微流体反应装置制备索非布韦中间体的方法
CN113402546A (zh) * 2020-03-17 2021-09-17 浙江四维医药科技有限公司 一种瑞德西韦磷酸中间体尾链动态动力学拆分方法
KR20230003522A (ko) * 2020-04-15 2023-01-06 메디비르 아베 간암에 대한 miv-818/렌바티닙 병용 요법
CN113754692B (zh) * 2020-06-03 2022-06-10 上海交通大学 瑞德西韦中间体(s,s)-氨基磷酸酯的不对称催化合成方法
CN114685558A (zh) * 2020-12-28 2022-07-01 尚科生物医药（上海）有限公司 一种瑞德西韦中间体的制备方法
CN114249764A (zh) * 2021-11-10 2022-03-29 宁波大学 一种磷酰胺酯类前药的中间体及其制备方法与应用
WO2025155547A1 (en) * 2024-01-17 2025-07-24 University Of Georgia Research Foundation, Inc. An efficient synthesis of beta-l-5-[(e)-2-bromovinyl)-1-((2s,4s)-2-(hydroxymethyl)-1,3-(dioxolane-4-yl) uracil)] (l-bhdu) via chiral pure l-dioxolane

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5444063A (en) * 1990-12-05 1995-08-22 Emory University Enantiomerically pure β-D-dioxolane nucleosides with selective anti-Hepatitis B virus activity
US6022876A (en) 1996-11-15 2000-02-08 Yale University L-β-dioxolane uridine analogs and methods for treating and preventing Epstein-Barr virus infections
US20030013660A1 (en) * 2000-10-13 2003-01-16 Shire Biochem Inc. Dioxolane analogs for improved inter-cellular delivery
GB0317009D0 (en) * 2003-07-21 2003-08-27 Univ Cardiff Chemical compounds
WO2007106450A2 (en) * 2006-03-10 2007-09-20 University Of Georgia Research Foundation, Inc. Diketo acids with nucleobase scaffolds: anti-hiv replication inhibitors targeted at hiv integrase in combination therapy
CN101534835B (zh) * 2006-09-01 2012-05-30 佐治亚大学研究基金会 用于癌症的L-OddC的前药
PL216525B1 (pl) * 2006-10-17 2014-04-30 Ct Badań Molekularnych I Makromolekularnych Polskiej Akademii Nauk 5'-O-[(N-acylo)amidoditiofosforano] nukleozydy oraz sposób wytwarzania 5'-O-[(N-acylo)amidofosforano]-,5'-O-[(N-acylo)amidotiofosforano]-, 5'-O-[(N-acylo)amidoditiofosforano]nukleozydów
US20130143835A1 (en) * 2011-12-05 2013-06-06 Medivir Ab HCV Polymerase Inhibitors
RU2016125213A (ru) * 2013-11-27 2017-12-29 АЙДЕНИКС ФАРМАСЬЮТИКАЛЗ ЭлЭлСи Нуклеотиды для лечения рака печени
EP3186244B1 (en) * 2014-08-25 2020-04-22 Medivir Aktiebolag Dioxolane analogues of uridine for the treatment of cancer

Also Published As

Publication number Publication date
AU2018201980B2 (en) 2019-05-16
AU2015308988A1 (en) 2017-02-23
US10822360B2 (en) 2020-11-03
US10144750B2 (en) 2018-12-04
CA2956251A1 (en) 2016-03-03
JP2020090535A (ja) 2020-06-11
US10654877B2 (en) 2020-05-19
US20190389890A1 (en) 2019-12-26
SG11201701172SA (en) 2017-03-30
CY1122945T1 (el) 2021-10-29
IL250344A0 (en) 2017-03-30
AU2015308988C1 (en) 2018-09-06
DK3186244T3 (da) 2020-07-13
JP2017526677A (ja) 2017-09-14
EP3186244B1 (en) 2020-04-22
CA3128645A1 (en) 2016-03-03
MY198325A (en) 2023-08-24
CN107074826B (zh) 2020-05-22
PL3572410T3 (pl) 2022-10-03
IL266766B (en) 2020-05-31
ES2796089T3 (es) 2020-11-25
EA033300B1 (ru) 2019-09-30
JP6663424B2 (ja) 2020-03-11
KR102396905B1 (ko) 2022-05-13
EP3572410B1 (en) 2022-07-20
BR112017003898A2 (pt) 2017-12-05
KR20170046736A (ko) 2017-05-02
EA201890648A3 (ru) 2019-02-28
IL250344B (en) 2020-01-30
US20170267705A1 (en) 2017-09-21
US20210054008A1 (en) 2021-02-25
CA2956251C (en) 2022-10-25
PH12019501919A1 (en) 2020-09-14
SG10201911558UA (en) 2020-01-30
EA201890648A2 (ru) 2018-08-31
US20230382931A1 (en) 2023-11-30
HUE059640T2 (hu) 2022-12-28
SG10202001117YA (en) 2020-04-29
KR20200035482A (ko) 2020-04-03
KR102398714B1 (ko) 2022-05-17
CN107074826A (zh) 2017-08-18
CN110790789B (zh) 2023-05-12
PL3186244T3 (pl) 2020-11-16
PH12017500184B1 (en) 2017-06-28
US20200239502A1 (en) 2020-07-30
WO2016030335A1 (en) 2016-03-03
CN110804072A (zh) 2020-02-18
DK3572410T3 (da) 2022-08-29
US20190100541A1 (en) 2019-04-04
MX2017002328A (es) 2017-05-22
EA031106B1 (ru) 2018-11-30
AU2018201980A1 (en) 2018-04-12
BR112017003898B1 (pt) 2022-10-18
CA3128645C (en) 2023-06-27
US10336780B2 (en) 2019-07-02
HRP20201023T1 (hr) 2020-10-16
US20230117570A1 (en) 2023-04-20
ES2927212T3 (es) 2022-11-03
CN111269264A (zh) 2020-06-12
EA201790328A1 (ru) 2017-08-31
PT3186244T (pt) 2020-05-29
NZ762628A (en) 2023-04-28
US11447511B2 (en) 2022-09-20
EP3572410A1 (en) 2019-11-27
PH12017500184A1 (en) 2017-06-28
AU2015308988B2 (en) 2018-04-26
EP3186244A1 (en) 2017-07-05
JP6905609B2 (ja) 2021-07-21
CN110790789A (zh) 2020-02-14
CN110804072B (zh) 2023-05-12
MY188089A (en) 2021-11-17
NZ729118A (en) 2022-02-25
IL266766A (en) 2019-07-31
ZA201802864B (en) 2019-07-31
HUE050705T2 (hu) 2020-12-28
MX369649B (es) 2019-11-15

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