PT3083605T - Compostos fluorofenil pirazole - Google Patents

Compostos fluorofenil pirazole

Info

Publication number
PT3083605T
PT3083605T PT148279094T PT14827909T PT3083605T PT 3083605 T PT3083605 T PT 3083605T PT 148279094 T PT148279094 T PT 148279094T PT 14827909 T PT14827909 T PT 14827909T PT 3083605 T PT3083605 T PT 3083605T
Authority
PT
Portugal
Prior art keywords
fluorophenyl
pyrazol compounds
pyrazol
compounds
fluorophenyl pyrazol
Prior art date
Application number
PT148279094T
Other languages
English (en)
Inventor
Kun-Chin Liu Kevin
Wu Liang
Xie Yinong
Zhou Guoqiang
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of PT3083605T publication Critical patent/PT3083605T/pt

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D231/00Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/18One oxygen or sulfur atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4151,2-Diazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4151,2-Diazoles
    • A61K31/41521,2-Diazoles having oxo groups directly attached to the heterocyclic ring, e.g. antipyrine, phenylbutazone, sulfinpyrazone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/04Anorexiants; Antiobesity agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D231/00Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/18One oxygen or sulfur atom
    • C07D231/20One oxygen atom attached in position 3 or 5
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
PT148279094T 2013-12-19 2014-12-11 Compostos fluorofenil pirazole PT3083605T (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/CN2013/089987 WO2015089800A1 (en) 2013-12-19 2013-12-19 Fluorophenyl pyrazol compounds

Publications (1)

Publication Number Publication Date
PT3083605T true PT3083605T (pt) 2018-03-01

Family

ID=52355187

Family Applications (1)

Application Number Title Priority Date Filing Date
PT148279094T PT3083605T (pt) 2013-12-19 2014-12-11 Compostos fluorofenil pirazole

Country Status (23)

Country Link
US (1) US9499490B2 (pt)
EP (1) EP3083605B1 (pt)
JP (1) JP6190067B2 (pt)
KR (1) KR101827660B1 (pt)
CN (1) CN105814039B (pt)
AU (1) AU2014366436B2 (pt)
BR (1) BR112016011778A8 (pt)
CA (1) CA2929563C (pt)
DK (1) DK3083605T3 (pt)
EA (1) EA029058B1 (pt)
ES (1) ES2664418T3 (pt)
HR (1) HRP20180618T1 (pt)
HU (1) HUE039102T2 (pt)
LT (1) LT3083605T (pt)
MX (1) MX2016007985A (pt)
NO (1) NO3083605T3 (pt)
PL (1) PL3083605T3 (pt)
PT (1) PT3083605T (pt)
RS (1) RS57071B1 (pt)
SA (1) SA516371323B1 (pt)
SI (1) SI3083605T1 (pt)
TR (1) TR201802981T4 (pt)
WO (2) WO2015089800A1 (pt)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI582083B (zh) 2014-10-07 2017-05-11 美國禮來大藥廠 胺基吡啶基氧基吡唑化合物
ES2968785T3 (es) * 2014-10-31 2024-05-14 Hoffmann La Roche Nuevos compuestos de piridiniloxi- y feniloxipirazolilo
WO2016131198A1 (en) 2015-02-18 2016-08-25 Eli Lilly And Company Pyrazole compounds
WO2016201662A1 (en) * 2015-06-18 2016-12-22 Eli Lilly And Company Fluoropyridyl pyrazol compounds
CN109096194B (zh) * 2018-10-09 2022-02-08 湖南师范大学 一种双胍衍生物、药物组合物、制备方法和用途

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1223932A4 (en) * 1999-10-01 2003-01-15 Smithkline Beecham Corp COMPOUNDS AND METHODS
WO2002000651A2 (en) 2000-06-27 2002-01-03 Bristol-Myers Squibb Pharma Company Factor xa inhibitors
EP1379241A1 (en) * 2001-03-29 2004-01-14 SmithKline Beecham Corporation Compounds and methods
WO2003031434A1 (en) * 2001-10-12 2003-04-17 Smith Kline Beecham Corporation Compounds and methods
AU2002359694A1 (en) * 2001-12-14 2003-06-30 Smithkline Beecham Corporation Compounds and methods
JP4498133B2 (ja) 2002-07-02 2010-07-07 シェーリング コーポレイション 新規神経ペプチドyy5レセプターアンタゴニスト
US7253204B2 (en) 2004-03-26 2007-08-07 Methylgene Inc. Inhibitors of histone deacetylase
DE102004049078A1 (de) * 2004-10-08 2006-04-13 Merck Patent Gmbh Phenylpyrazole
WO2010065879A2 (en) * 2008-12-04 2010-06-10 Zafgen Corporation Methods of treating an overweight or obese subject
TW201245155A (en) 2010-09-01 2012-11-16 Du Pont Fungicidal pyrazoles
WO2012090219A2 (en) * 2010-12-31 2012-07-05 Jubilant Biosys Ltd. Thiazole compounds useful as acetyl-coa carboxylase (acc) inhibitors
JP2014518853A (ja) * 2011-04-28 2014-08-07 ブリストル−マイヤーズ スクイブ カンパニー 新規な二環式窒素含有ヘテロアリールtgr5受容体調節因子
TWI582083B (zh) 2014-10-07 2017-05-11 美國禮來大藥廠 胺基吡啶基氧基吡唑化合物

Also Published As

Publication number Publication date
AU2014366436A1 (en) 2016-05-19
SI3083605T1 (en) 2018-04-30
DK3083605T3 (en) 2018-03-12
LT3083605T (lt) 2018-04-10
HRP20180618T1 (hr) 2018-07-13
ES2664418T3 (es) 2018-04-19
US9499490B2 (en) 2016-11-22
KR20160075827A (ko) 2016-06-29
EP3083605B1 (en) 2018-02-21
BR112016011778A2 (pt) 2017-08-08
EA029058B1 (ru) 2018-02-28
PL3083605T3 (pl) 2018-07-31
JP6190067B2 (ja) 2017-08-30
EA201690924A1 (ru) 2016-09-30
WO2015089800A1 (en) 2015-06-25
HUE039102T2 (hu) 2018-12-28
CA2929563A1 (en) 2015-06-25
JP2016540801A (ja) 2016-12-28
CN105814039B (zh) 2018-07-17
CA2929563C (en) 2018-05-15
AU2014366436B2 (en) 2017-08-24
MX2016007985A (es) 2016-09-09
US20160289195A1 (en) 2016-10-06
RS57071B1 (sr) 2018-06-29
SA516371323B1 (ar) 2018-04-24
NO3083605T3 (pt) 2018-07-21
WO2015094913A1 (en) 2015-06-25
TR201802981T4 (tr) 2018-03-21
EP3083605A1 (en) 2016-10-26
CN105814039A (zh) 2016-07-27
BR112016011778A8 (pt) 2018-01-30
KR101827660B1 (ko) 2018-02-08

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