PT3081569T - Derivado de imidazole utilizado como agente antiviral e sua utilização na preparação do medicamento - Google Patents
Derivado de imidazole utilizado como agente antiviral e sua utilização na preparação do medicamentoInfo
- Publication number
- PT3081569T PT3081569T PT148703812T PT14870381T PT3081569T PT 3081569 T PT3081569 T PT 3081569T PT 148703812 T PT148703812 T PT 148703812T PT 14870381 T PT14870381 T PT 14870381T PT 3081569 T PT3081569 T PT 3081569T
- Authority
- PT
- Portugal
- Prior art keywords
- medicament
- preparation
- antiviral agent
- derivative used
- imidazole derivative
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/18—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/20—Spiro-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Virology (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Communicable Diseases (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201310661317.5A CN104693211A (zh) | 2013-12-10 | 2013-12-10 | 作为抗病毒剂的咪唑衍生物及其制药用途 |
CN201410028072 | 2014-01-22 | ||
CN201410191550 | 2014-05-07 |
Publications (1)
Publication Number | Publication Date |
---|---|
PT3081569T true PT3081569T (pt) | 2019-12-30 |
Family
ID=53370603
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT148703812T PT3081569T (pt) | 2013-12-10 | 2014-11-11 | Derivado de imidazole utilizado como agente antiviral e sua utilização na preparação do medicamento |
Country Status (8)
Country | Link |
---|---|
US (2) | US9850251B2 (pt) |
EP (1) | EP3081569B1 (pt) |
JP (1) | JP6118470B2 (pt) |
CN (1) | CN105793265B (pt) |
ES (1) | ES2757570T3 (pt) |
HK (1) | HK1223607A1 (pt) |
PT (1) | PT3081569T (pt) |
WO (1) | WO2015085844A1 (pt) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2015148926A (ru) * | 2013-05-14 | 2017-06-15 | Ф. Хоффманн-Ля Рош Аг | Аза-оксо-индолы для лечения и профилактики респираторно-синцитиальной вирусной инфекции |
CA2914541A1 (en) * | 2013-08-15 | 2015-02-19 | F. Hoffmann-La Roche Ag | Novel aza-oxo-indoles for the treatment and prophylaxis of respiratory syncytial virus infection |
WO2015085844A1 (zh) | 2013-12-10 | 2015-06-18 | 南京明德新药研发股份有限公司 | 作为抗病毒剂的咪唑衍生物及其制药用途 |
PT3305790T (pt) * | 2015-06-08 | 2020-10-19 | Shangdong Danhong Pharmaceutical Co Ltd | Método para preparação de um derivado de imidazol e seu intermediário e forma cristalina |
JP6990657B2 (ja) * | 2016-02-08 | 2022-01-13 | エフ・ホフマン-ラ・ロシュ・アクチェンゲゼルシャフト | Ddr1阻害剤としてのスピロインドリノン |
SI3494110T1 (sl) * | 2016-08-04 | 2021-12-31 | ReViral Limited | Derivati pirimidina in njihova uporaba v zdravljenju ali preprečevanju okužbe z respiratornim sincicijskim virusom |
CN109476677B (zh) * | 2016-08-08 | 2024-06-07 | 辉诺生物医药科技(杭州)有限公司 | 抗hcmv病毒化合物 |
WO2018038667A1 (en) * | 2016-08-25 | 2018-03-01 | Medivir Ab | Respiratory syncytial virus inhibitors |
WO2018038668A1 (en) * | 2016-08-25 | 2018-03-01 | Medivir Ab | Respiratory syncytial virus inhibitors |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4324794A (en) | 1980-08-26 | 1982-04-13 | Research Triangle Institute | Inhibition of respiratory syncytial virus-induced cell fusion by amidino compounds |
NO155805C (no) | 1981-02-06 | 1987-06-10 | Ucb Sa | Analogifremgangsmaate for fremstilling av terapeutisk virksomme 2-(4-(difenylmethyl)-1-piperazinyl)-eddiksyrer og deres amider og ikke-toksiske salter. |
US5256668A (en) | 1993-03-17 | 1993-10-26 | American Home Products Corporation | Aminopyrimidine derivatives as antiviral agents for respiratory syncytial virus |
ZA971185B (en) | 1996-02-13 | 1998-08-12 | American Cyanamid Co | Triazine containing compounds useful as antiviral agents |
WO1999038508A1 (en) | 1998-01-29 | 1999-08-05 | Viropharma Incorporated | Compounds, compositions and methods for treating or preventing pneumovirus infection and associated diseases |
EP1098644A1 (en) | 1998-07-20 | 2001-05-16 | Bristol-Myers Squibb Company | Substituted benzimidazole antiviral agents |
US6774134B2 (en) | 2000-12-20 | 2004-08-10 | Bristol-Myers Squibb Company | Heterocyclic substituted 2-methyl-benzimidazole antiviral agents |
WO2010103306A1 (en) | 2009-03-10 | 2010-09-16 | Astrazeneca Uk Limited | Benzimidazole derivatives and their use as antivaral agents |
TWI527814B (zh) | 2010-12-16 | 2016-04-01 | 健生科學愛爾蘭無限公司 | 作為呼吸道融合病毒抗病毒劑之氮雜苯并咪唑類 |
GB201119538D0 (en) | 2011-11-10 | 2011-12-21 | Viral Ltd | Pharmaceutical compounds |
MX363717B (es) | 2012-10-16 | 2019-03-29 | Janssen Sciences Ireland Uc | Compuestos antiviricos para el virus sincitial respiratorio. |
WO2015085844A1 (zh) | 2013-12-10 | 2015-06-18 | 南京明德新药研发股份有限公司 | 作为抗病毒剂的咪唑衍生物及其制药用途 |
CN104693211A (zh) | 2013-12-10 | 2015-06-10 | 南京明德新药研发股份有限公司 | 作为抗病毒剂的咪唑衍生物及其制药用途 |
-
2014
- 2014-11-11 WO PCT/CN2014/090771 patent/WO2015085844A1/zh active Application Filing
- 2014-11-11 ES ES14870381T patent/ES2757570T3/es active Active
- 2014-11-11 US US15/103,189 patent/US9850251B2/en active Active
- 2014-11-11 PT PT148703812T patent/PT3081569T/pt unknown
- 2014-11-11 EP EP14870381.2A patent/EP3081569B1/en active Active
- 2014-11-11 JP JP2016539200A patent/JP6118470B2/ja active Active
- 2014-11-11 CN CN201480061605.XA patent/CN105793265B/zh active Active
-
2016
- 2016-09-07 HK HK16110640.5A patent/HK1223607A1/zh unknown
-
2017
- 2017-09-19 US US15/708,906 patent/US10030029B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
EP3081569A4 (en) | 2016-10-26 |
HK1223607A1 (zh) | 2017-08-04 |
JP6118470B2 (ja) | 2017-04-19 |
US20160318943A1 (en) | 2016-11-03 |
CN105793265A (zh) | 2016-07-20 |
WO2015085844A1 (zh) | 2015-06-18 |
US20180009820A1 (en) | 2018-01-11 |
EP3081569A1 (en) | 2016-10-19 |
CN105793265B (zh) | 2018-02-13 |
US10030029B2 (en) | 2018-07-24 |
JP2017502951A (ja) | 2017-01-26 |
US9850251B2 (en) | 2017-12-26 |
ES2757570T3 (es) | 2020-04-29 |
EP3081569B1 (en) | 2019-09-18 |
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