PT3305790T - Método para preparação de um derivado de imidazol e seu intermediário e forma cristalina - Google Patents
Método para preparação de um derivado de imidazol e seu intermediário e forma cristalinaInfo
- Publication number
- PT3305790T PT3305790T PT168068062T PT16806806T PT3305790T PT 3305790 T PT3305790 T PT 3305790T PT 168068062 T PT168068062 T PT 168068062T PT 16806806 T PT16806806 T PT 16806806T PT 3305790 T PT3305790 T PT 3305790T
- Authority
- PT
- Portugal
- Prior art keywords
- crystal form
- imidazole derivative
- preparing imidazole
- preparing
- derivative
- Prior art date
Links
- 239000013078 crystal Substances 0.000 title 1
- 150000002460 imidazoles Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D9/00—Crystallisation
- B01D9/0004—Crystallisation cooling by heat exchange
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D9/00—Crystallisation
- B01D9/005—Selection of auxiliary, e.g. for control of crystallisation nuclei, of crystal growth, of adherence to walls; Arrangements for introduction thereof
- B01D9/0054—Use of anti-solvent
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B41/00—Formation or introduction of functional groups containing oxygen
- C07B41/06—Formation or introduction of functional groups containing oxygen of carbonyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B43/00—Formation or introduction of functional groups containing nitrogen
- C07B43/04—Formation or introduction of functional groups containing nitrogen of amino groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/96—Spiro-condensed ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Crystallography & Structural Chemistry (AREA)
- Communicable Diseases (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Virology (AREA)
- Epidemiology (AREA)
- Physics & Mathematics (AREA)
- Thermal Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510309106 | 2015-06-08 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT3305790T true PT3305790T (pt) | 2020-10-19 |
Family
ID=57502897
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT168068062T PT3305790T (pt) | 2015-06-08 | 2016-06-07 | Método para preparação de um derivado de imidazol e seu intermediário e forma cristalina |
Country Status (8)
| Country | Link |
|---|---|
| US (3) | US10227309B2 (pt) |
| EP (1) | EP3305790B1 (pt) |
| JP (1) | JP6548751B2 (pt) |
| CN (1) | CN107709328B (pt) |
| ES (1) | ES2821649T3 (pt) |
| PT (1) | PT3305790T (pt) |
| TW (1) | TWI695005B (pt) |
| WO (1) | WO2016197908A1 (pt) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2016197908A1 (zh) | 2015-06-08 | 2016-12-15 | 南京明德新药研发股份有限公司 | 咪唑衍生物及其中间体的制备方法和晶型 |
| CN112057453B (zh) * | 2019-08-26 | 2022-06-28 | 中检科医药科技(北京)集团有限公司 | Enc002及其类似物在治疗或预防肠道病毒感染中的应用 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4175289A (en) | 1978-06-05 | 1979-11-20 | International Business Machines Corporation | Serrated Y-bar magnetic bubble switch |
| US4324794A (en) | 1980-08-26 | 1982-04-13 | Research Triangle Institute | Inhibition of respiratory syncytial virus-induced cell fusion by amidino compounds |
| NO155805C (no) | 1981-02-06 | 1987-06-10 | Ucb Sa | Analogifremgangsmaate for fremstilling av terapeutisk virksomme 2-(4-(difenylmethyl)-1-piperazinyl)-eddiksyrer og deres amider og ikke-toksiske salter. |
| US5256668A (en) | 1993-03-17 | 1993-10-26 | American Home Products Corporation | Aminopyrimidine derivatives as antiviral agents for respiratory syncytial virus |
| ZA971185B (en) | 1996-02-13 | 1998-08-12 | American Cyanamid Co | Triazine containing compounds useful as antiviral agents |
| CN1289248A (zh) | 1998-01-29 | 2001-03-28 | 维洛药品公司 | 治疗或预防肺病毒感染及有关疾病的化合物、组合物和方法 |
| JP2002521334A (ja) | 1998-07-20 | 2002-07-16 | ブリストルーマイヤーズ スクイブ カンパニー | 置換ベンズイミダゾール抗ウィルス剤 |
| US20100278835A1 (en) | 2009-03-10 | 2010-11-04 | Astrazeneca Uk Limited | Novel compounds 660 |
| US9090629B2 (en) | 2010-11-03 | 2015-07-28 | Immunogen, Inc. | Cytotoxic agents comprising new ansamitocin derivatives |
| TWI527814B (zh) * | 2010-12-16 | 2016-04-01 | 健生科學愛爾蘭無限公司 | 作為呼吸道融合病毒抗病毒劑之氮雜苯并咪唑類 |
| GB201119538D0 (en) | 2011-11-10 | 2011-12-21 | Viral Ltd | Pharmaceutical compounds |
| AU2013334001B2 (en) * | 2012-10-16 | 2017-07-20 | Janssen Sciences Ireland Uc | RSV antiviral compounds |
| CN103319599B (zh) | 2013-05-27 | 2015-02-18 | 上海交联药物研发有限公司 | 一种抗人ErbB2抗体—美登木素偶联物及其应用 |
| US9850251B2 (en) * | 2013-12-10 | 2017-12-26 | Shandong Danhong Pharmaceutical Co., Ltd. | Imidazole derivative used as antiviral agent and use therof in preparation of medicament |
| TWI671299B (zh) * | 2014-04-14 | 2019-09-11 | 愛爾蘭商健生科學愛爾蘭無限公司 | 作為ｒｓｖ抗病毒化合物之螺脲化合物 |
| GB201417707D0 (en) * | 2014-10-07 | 2014-11-19 | Viral Ltd | Pharmaceutical compounds |
| WO2016197908A1 (zh) * | 2015-06-08 | 2016-12-15 | 南京明德新药研发股份有限公司 | 咪唑衍生物及其中间体的制备方法和晶型 |
-
2016
- 2016-06-07 WO PCT/CN2016/085104 patent/WO2016197908A1/zh not_active Ceased
- 2016-06-07 CN CN201680031461.2A patent/CN107709328B/zh active Active
- 2016-06-07 EP EP16806806.2A patent/EP3305790B1/en active Active
- 2016-06-07 JP JP2017564539A patent/JP6548751B2/ja active Active
- 2016-06-07 ES ES16806806T patent/ES2821649T3/es active Active
- 2016-06-07 US US15/580,167 patent/US10227309B2/en active Active
- 2016-06-07 PT PT168068062T patent/PT3305790T/pt unknown
- 2016-06-08 TW TW105118076A patent/TWI695005B/zh active
-
2019
- 2019-01-08 US US16/242,753 patent/US10633347B2/en active Active
-
2020
- 2020-03-20 US US16/824,877 patent/US10858322B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| US10227309B2 (en) | 2019-03-12 |
| US20200223802A1 (en) | 2020-07-16 |
| JP6548751B2 (ja) | 2019-07-24 |
| US20180141915A1 (en) | 2018-05-24 |
| US10858322B2 (en) | 2020-12-08 |
| HK1244807A1 (zh) | 2018-08-17 |
| TW201704238A (zh) | 2017-02-01 |
| US10633347B2 (en) | 2020-04-28 |
| EP3305790B1 (en) | 2020-08-05 |
| EP3305790A4 (en) | 2018-10-03 |
| EP3305790A1 (en) | 2018-04-11 |
| WO2016197908A1 (zh) | 2016-12-15 |
| US20190218189A1 (en) | 2019-07-18 |
| CN107709328B (zh) | 2021-03-05 |
| CN107709328A (zh) | 2018-02-16 |
| TWI695005B (zh) | 2020-06-01 |
| ES2821649T3 (es) | 2021-04-27 |
| JP2018517719A (ja) | 2018-07-05 |
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