PT3013836T - Preparação de reagentes de grignard utilizando um leito fluidizado - Google Patents

Preparação de reagentes de grignard utilizando um leito fluidizado

Info

Publication number
PT3013836T
PT3013836T PT14733203T PT14733203T PT3013836T PT 3013836 T PT3013836 T PT 3013836T PT 14733203 T PT14733203 T PT 14733203T PT 14733203 T PT14733203 T PT 14733203T PT 3013836 T PT3013836 T PT 3013836T
Authority
PT
Portugal
Prior art keywords
preparation
fluidized bed
grignard reagents
grignard
reagents
Prior art date
Application number
PT14733203T
Other languages
English (en)
Inventor
Wilhelmus Elisabeth Ghislain Reintjens Rafael
Poechlauer Peter
Thathagar Mehul
goldbach Michel
Original Assignee
Patheon Austria Gmbh & Co Kg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Patheon Austria Gmbh & Co Kg filed Critical Patheon Austria Gmbh & Co Kg
Publication of PT3013836T publication Critical patent/PT3013836T/pt

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F3/00Compounds containing elements of Groups 2 or 12 of the Periodic Table
    • C07F3/02Magnesium compounds
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/36Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring increasing the number of carbon atoms by reactions with formation of hydroxy groups, which may occur via intermediates being derivatives of hydroxy, e.g. O-metal
    • C07C29/38Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring increasing the number of carbon atoms by reactions with formation of hydroxy groups, which may occur via intermediates being derivatives of hydroxy, e.g. O-metal by reaction with aldehydes or ketones
    • C07C29/40Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring increasing the number of carbon atoms by reactions with formation of hydroxy groups, which may occur via intermediates being derivatives of hydroxy, e.g. O-metal by reaction with aldehydes or ketones with compounds containing carbon-to-metal bonds
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00Preparation of carboxylic acid esters
    • C07C67/30Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D257/00Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
    • C07F15/0006Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
    • C07F15/0046Ruthenium compounds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
PT14733203T 2013-06-27 2014-06-27 Preparação de reagentes de grignard utilizando um leito fluidizado PT3013836T (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP13173979 2013-06-27

Publications (1)

Publication Number Publication Date
PT3013836T true PT3013836T (pt) 2018-10-23

Family

ID=48699609

Family Applications (1)

Application Number Title Priority Date Filing Date
PT14733203T PT3013836T (pt) 2013-06-27 2014-06-27 Preparação de reagentes de grignard utilizando um leito fluidizado

Country Status (10)

Country Link
US (1) US9550797B2 (pt)
EP (1) EP3013836B1 (pt)
JP (2) JP6521463B2 (pt)
CN (1) CN105377858B (pt)
AU (1) AU2014300955B2 (pt)
BR (1) BR112015032514B1 (pt)
CA (1) CA2914899C (pt)
ES (1) ES2683245T3 (pt)
PT (1) PT3013836T (pt)
WO (1) WO2014207206A1 (pt)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106279216A (zh) * 2016-04-06 2017-01-04 海正化工南通股份有限公司 一种邻氯苄基氯化镁的合成办法
DE102016206211B4 (de) * 2016-04-13 2018-12-27 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Kontinuierliches Verfahren zur Herstellung von Grignard-Addukten und Vorrichtung zu dessen Durchführung
US20230050880A1 (en) * 2020-01-27 2023-02-16 Tokuyama Corporation Method for producing halogenated hydrocarbon magnesium compound and methods for producing tertiary alcohol compound and organosilicon compound
CN112724164B (zh) * 2021-01-05 2023-07-04 兰州康鹏威耳化工有限公司 一种格氏试剂的连续制备方法
JP7404606B2 (ja) * 2021-03-19 2023-12-26 国立大学法人北海道大学 有機金属求核剤の製造方法、及び有機金属求核剤を用いる反応方法
US20240181422A1 (en) * 2021-04-22 2024-06-06 Tokuyama Corporation Method for producing organic compound, and device for producing organic compound
WO2023152332A1 (en) 2022-02-10 2023-08-17 Chemium Sprl Method for the production of organometallic compounds
CN116178400B (zh) * 2023-04-28 2023-12-05 研峰科技(北京)股份有限公司 格氏试剂烯丙基溴化镁制备工艺

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2464685A (en) * 1946-12-02 1949-03-15 Diamond Alkali Co Continuous grignard method
DE1293767B (de) * 1967-08-26 1969-04-30 Basf Ag Verfahren zur Herstellung von Grignard-Verbindungen
US3911037A (en) * 1973-11-21 1975-10-07 Nalco Chemical Co Continuous Grignard reactors
US4105703A (en) * 1975-06-06 1978-08-08 Oxon Italia S.P.A. Continuous process for the production of cyclohexyl magnesium halides
JPS5818323A (ja) * 1981-07-27 1983-02-02 Sumitomo Chem Co Ltd アルコ−ル類の製造方法
JPS62227498A (ja) * 1986-03-31 1987-10-06 Kurita Water Ind Ltd 流動床式嫌気性処理装置
DE4027608A1 (de) * 1990-08-31 1992-03-05 Bayer Ag Verfahren zur herstellung von 1-chlor-2-(1-chlor-cyclopropyl)-3-(2-chlor-phenyl)-propan-2-ol und/oder 2-(1-chlor-cyclopropyl)-2-(2-chlor-benzyl)-oxiran
MY119161A (en) * 1994-04-18 2005-04-30 Novartis Ag Delta-amino-gamma-hydroxy-omega-aryl-alkanoic acid amides with enzyme especially renin inhibiting activities
EP0729931B1 (en) * 1995-03-03 1998-08-19 Dow Corning Corporation Process for the preparation of 1,5-hexadiene
US6124500A (en) * 1998-03-09 2000-09-26 Rohm And Haas Company Process for synthesizing benzoic acids
JP2000229982A (ja) * 1998-12-07 2000-08-22 Mitsubishi Chemicals Corp ビニルフェニルマグネシウムハライド類の連続的製造方法
WO2001009079A1 (de) * 1999-07-29 2001-02-08 Speedel Pharma Ag 2-alkyl-5-halogen-pent-4-encarbonsäuren und deren herstellung
EP1289641A2 (en) * 2000-05-12 2003-03-12 Upfront Chromatography A/S A bed adsorption system
JP4774775B2 (ja) * 2005-03-23 2011-09-14 日亜化学工業株式会社 トリアルキルガリウムの製造方法
CN102603775B (zh) * 2012-01-20 2015-08-05 上海海嘉诺医药发展股份有限公司 一种连续制备格氏试剂的装置及使用该装置进行格氏试剂连续制备的方法
US9090537B2 (en) * 2012-02-17 2015-07-28 Mylan Laboratories Limited Process for the preparation of aliskiren

Also Published As

Publication number Publication date
CA2914899A1 (en) 2014-12-31
EP3013836A1 (en) 2016-05-04
EP3013836B1 (en) 2018-06-20
US9550797B2 (en) 2017-01-24
WO2014207206A1 (en) 2014-12-31
JP2016525504A (ja) 2016-08-25
JP6521463B2 (ja) 2019-05-29
BR112015032514B1 (pt) 2021-01-26
CA2914899C (en) 2022-08-30
CN105377858A (zh) 2016-03-02
CN105377858B (zh) 2017-11-21
AU2014300955B2 (en) 2019-08-22
US20160137669A1 (en) 2016-05-19
AU2014300955A1 (en) 2016-02-18
JP2019055987A (ja) 2019-04-11
BR112015032514A2 (pt) 2017-07-25
ES2683245T3 (es) 2018-09-25

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