PT2981624T - Métodos para avaliar deficiência na recombinação homóloga e prever resposta a tratamento para cancro - Google Patents

Métodos para avaliar deficiência na recombinação homóloga e prever resposta a tratamento para cancro

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Publication number
PT2981624T
PT2981624T PT147794036T PT14779403T PT2981624T PT 2981624 T PT2981624 T PT 2981624T PT 147794036 T PT147794036 T PT 147794036T PT 14779403 T PT14779403 T PT 14779403T PT 2981624 T PT2981624 T PT 2981624T
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PT
Portugal
Prior art keywords
assessing
materials
methods
homologous recombination
recombination deficiency
Prior art date
Application number
PT147794036T
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English (en)
Portuguese (pt)
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Myriad Genetics Inc
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=51659359&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PT2981624(T) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Myriad Genetics Inc filed Critical Myriad Genetics Inc
Publication of PT2981624T publication Critical patent/PT2981624T/pt

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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00Medicinal preparations containing inorganic active ingredients
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813Hybridisation assays
    • C12Q1/6827Hybridisation assays for detection of mutation or polymorphism
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    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844Nucleic acid amplification reactions
    • C12Q1/6858Allele-specific amplification
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • G16B20/20Allele or variant detection, e.g. single nucleotide polymorphism [SNP] detection
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    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/106Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
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    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/154Methylation markers
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    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/156Polymorphic or mutational markers
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Analytical Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pathology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Inorganic Chemistry (AREA)
  • Epidemiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Theoretical Computer Science (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Medical Informatics (AREA)
  • Evolutionary Biology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
PT147794036T 2013-04-05 2014-04-04 Métodos para avaliar deficiência na recombinação homóloga e prever resposta a tratamento para cancro PT2981624T (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361809105P 2013-04-05 2013-04-05
US201361913762P 2013-12-09 2013-12-09

Publications (1)

Publication Number Publication Date
PT2981624T true PT2981624T (pt) 2020-03-23

Family

ID=51659359

Family Applications (1)

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PT147794036T PT2981624T (pt) 2013-04-05 2014-04-04 Métodos para avaliar deficiência na recombinação homóloga e prever resposta a tratamento para cancro

Country Status (9)

Country Link
US (4) US20140363521A1 (enExample)
EP (2) EP2981624B1 (enExample)
JP (5) JP6625045B2 (enExample)
AU (3) AU2014248007B2 (enExample)
CA (1) CA2908745C (enExample)
DK (1) DK2981624T3 (enExample)
ES (1) ES2777228T3 (enExample)
PT (1) PT2981624T (enExample)
WO (1) WO2014165785A2 (enExample)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2704303T3 (es) 2010-08-24 2019-03-15 Dana Farber Cancer Inst Inc Procedimientos para la predicción de una respuesta contra el cáncer
KR20190002733A (ko) 2010-12-30 2019-01-08 파운데이션 메디신 인코포레이티드 종양 샘플의 다유전자 분석의 최적화
CA2839210A1 (en) 2011-06-17 2012-12-20 Myriad Genetics, Inc. Methods and materials for assessing allelic imbalance
EP3660161B1 (en) 2011-12-21 2024-07-31 Myriad Genetics, Inc. Methods and materials for assessing loss of heterozygosity
EP3415915B1 (en) 2012-02-23 2024-10-23 Children's Medical Center Corporation Methods for predicting response to parp inhibitors
CA2867434C (en) 2012-06-07 2021-10-12 Institut Curie Methods for detecting inactivation of the homologous recombination pathway (brca1/2) in human tumors
AU2014248007B2 (en) * 2013-04-05 2020-03-26 Myriad Genetics, Inc. Methods and materials for assessing homologous recombination deficiency
EP4023765A1 (en) 2013-12-09 2022-07-06 Institut Curie Methods for detecting inactivation of the homologous recombination pathway (brca1/2) in human tumors
EP3108246B1 (en) 2014-02-21 2019-10-09 Epic Sciences, Inc. Methods for analyzing rare circulating cells
ES2800673T3 (es) 2014-08-15 2021-01-04 Myriad Genetics Inc Métodos y materiales para evaluar una deficiencia de recombinación homóloga
ES2989276T3 (es) * 2014-12-05 2024-11-25 Found Medicine Inc Análisis multigénico de muestras tumorales
US20160160294A1 (en) * 2014-12-08 2016-06-09 Tesaro Methods and materials for predicting response to niraparib
US20180148792A1 (en) 2015-05-19 2018-05-31 T.S. Sridhar Method for Identification of a Deficient BRCA1 Function
AU2016348401A1 (en) * 2015-11-03 2018-05-24 Epic Sciences, Inc. Single cell genomic profiling of circulating tumor cells (CTCs) in metastatic disease to characterize disease heterogeneity
WO2017106365A1 (en) * 2015-12-14 2017-06-22 Myriad Genetics, Inc. Methods for measuring mutation load
WO2017191074A1 (en) * 2016-05-01 2017-11-09 Genome Research Limited Method of characterising a dna sample
EP3400311A4 (en) * 2016-01-06 2019-07-03 Epic Sciences, Inc. GENOMIC INDIVIDUAL CELL PROFILING OF CIRCULATING TUMOR CELLS (CTCS) IN METASTASIC DISEASE TO CHARACTERIZE THE DISEASE HETEROGENICITY
WO2017165270A1 (en) * 2016-03-21 2017-09-28 Myriad Genetics, Inc. Homologous recombination deficiency to predict neoadjuvant chemotherapy necessity in bladder cancer
WO2017178509A1 (en) 2016-04-12 2017-10-19 Xentech Methods for predicting sensibility to treatment with parp inhibitors in cancerous patients
GB2555765A (en) 2016-05-01 2018-05-16 Genome Res Ltd Method of detecting a mutational signature in a sample
WO2017191076A1 (en) 2016-05-01 2017-11-09 Genome Research Limited Method of characterising a dna sample
EP3478286B1 (en) * 2016-06-29 2024-01-03 Tesaro, Inc. Methods of treating ovarian cancer
EP3802923A4 (en) 2018-06-11 2022-03-16 Foundation Medicine, Inc. COMPOSITIONS AND METHODS FOR ASSESSING GENOMIC ALTERATIONS
WO2020137076A1 (ja) * 2018-12-28 2020-07-02 国立大学法人 東京大学 Parp阻害剤に対する癌の感受性の予測方法および相同組換修復不全を有する癌の検出方法
JP7368483B2 (ja) 2019-02-12 2023-10-24 テンパス ラブズ,インコーポレイテッド 相同組換え欠損を推定するための統合された機械学習フレームワーク
ES2989374T3 (es) 2019-12-10 2024-11-26 Tempus Ai Inc Sistemas y procedimientos para predecir el estado de deficiencia de recombinación homóloga de una muestra
JP2023506084A (ja) * 2019-12-16 2023-02-14 アジレント・テクノロジーズ・インク ゲノム瘢痕アッセイ及び関連する方法
EP3945525A1 (en) 2020-07-27 2022-02-02 Sophia Genetics S.A. Methods for identifying chromosomal spatial instability such as homologous repair deficiency in low coverage next-generation sequencing data
CN111883211B (zh) * 2020-08-07 2021-04-23 张哲� 一种表征hrd同源重组修复缺陷的基因瘢痕及鉴定方法
US11718869B2 (en) * 2020-08-12 2023-08-08 Zhenyue Biotechnology Jiangsu Co., Ltd. Method and kit for determining genome instability based on next generation sequencing (NGS)
CN112410423B (zh) * 2020-11-03 2021-08-13 南京世和基因生物技术股份有限公司 同源重组缺失的标志物、检测方法以及检测系统
EP4274908A1 (en) * 2021-01-10 2023-11-15 Act Genomics (IP) Limited Homologous recombination deficiency determining method and kit thereof
BE1029144B1 (fr) 2021-02-25 2022-09-20 Oncodna Méthode de caracterisation d'une tumeur à l'aide d'un séquençage ciblé
CN112820351A (zh) * 2021-03-01 2021-05-18 江苏医联生物科技有限公司 检测肿瘤患者的突变和hrd评分指导用药的方法
WO2022272310A1 (en) * 2021-06-25 2022-12-29 Foundation Medicine, Inc. System and method of classifying homologous repair deficiency
EP4444914A1 (en) * 2021-12-08 2024-10-16 Myriad Genetics, Inc. Methods and materials for assessing homologous recombination deficiency in breast cancer subtypes
KR102523938B1 (ko) * 2022-02-04 2023-04-19 가톨릭대학교 산학협력단 상동 재조합 결핍증 예측 모델의 모델링 방법
EP4605937A1 (en) 2022-10-19 2025-08-27 Vib Vzw Method of determining loss of heterozygosity status of a tumor
WO2025078387A1 (en) 2023-10-10 2025-04-17 Vib Vzw Method of detecting loss of heterozygosity status of a tumor
WO2025078404A1 (en) 2023-10-10 2025-04-17 Vib Vzw Methods of determining response of a tumor to dna-damaging agents or to agents inhibiting or impairing dna repair

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
YU33730B (en) 1967-04-18 1978-02-28 Farmaceutici Italia Process for preparing a novel antibiotic substance and salts thereof
GB1432562A (en) 1972-04-10 1976-04-22 Rustenburg Platinum Mines Ltd Platinum co-ordination compounds
GB1432563A (en) 1972-04-10 1976-04-22 Rustenburg Platinum Mines Ltd Platinum- co-ordination compounds
ES444380A1 (es) 1976-01-16 1977-06-16 Gosalvez Mario Un procedimiento para preparar derivados metalicos antraci- clinicos.
US4950738A (en) 1984-09-13 1990-08-21 Cytogen Corporation Amine derivatives of anthracycline antibiotics
US5977082A (en) 1985-08-02 1999-11-02 Pharmacia & Upjohn Company Injectable ready-to-use solutions containing an antitumor anthracycline glycoside
US5177075A (en) 1988-08-19 1993-01-05 Warner-Lambert Company Substituted dihydroisoquinolinones and related compounds as potentiators of the lethal effects of radiation and certain chemotherapeutic agents; selected compounds, analogs and process
US5295944A (en) 1991-05-14 1994-03-22 Dana-Farber Cancer Institute Method for treating a tumor with ionizing radiation
MX9206577A (es) 1991-11-15 1993-05-01 Smithkline Beecham Corp COMPOSICIóN FARMACEUTICA PARA INHIBIR EL CRECIMIENTO DE CELULAS TUMORALES
GB9806324D0 (en) 1998-03-24 1998-05-20 Pharmacia & Upjohn Spa Antitumour synergetic composition
ATE478664T1 (de) 2000-12-01 2010-09-15 Eisai Inc Azaphenanthridone-derivate und deren verwendung als parp-inhibitoren
GB0121285D0 (en) 2001-09-03 2001-10-24 Cancer Res Ventures Ltd Anti-cancer combinations
US7754684B2 (en) 2003-06-11 2010-07-13 Access Pharmaceuticals, Inc. Macromolecular platinum chelates
DE04777189T1 (de) 2003-07-02 2011-04-07 Solux Corporation, San Diego Thermisch stabiles kristallines epirubicin-hydrochlorid und herstellungsverfahren dafür
ATE454893T1 (de) 2003-07-25 2010-01-15 Cancer Rec Tech Ltd Tricyclische parp-hemmer
DE602004015811D1 (de) 2003-08-13 2008-09-25 Univ South Florida Verfahren zur inhibierung der proliferation von tumorzellen, bei dem platinkomplexe eingesetzt werden
MX2007015852A (es) 2005-06-30 2008-02-22 Bionumerik Pharmaceuticals Inc Analogos de platino con ligandos de monoazol.
KR100925337B1 (ko) * 2009-05-25 2009-11-09 주식회사 마크로젠 염색체 수 이상 검출을 통한 유방암 약물 반응성 예측
WO2011160063A2 (en) 2010-06-18 2011-12-22 Myriad Genetics, Inc. Methods and materials for assessing loss of heterozygosity
ES2704303T3 (es) 2010-08-24 2019-03-15 Dana Farber Cancer Inst Inc Procedimientos para la predicción de una respuesta contra el cáncer
EP3415915B1 (en) * 2012-02-23 2024-10-23 Children's Medical Center Corporation Methods for predicting response to parp inhibitors
AU2014248007B2 (en) * 2013-04-05 2020-03-26 Myriad Genetics, Inc. Methods and materials for assessing homologous recombination deficiency

Also Published As

Publication number Publication date
EP2981624A4 (en) 2016-11-30
JP2016523511A (ja) 2016-08-12
EP3693475A1 (en) 2020-08-12
NZ712663A (en) 2021-07-30
US20180030544A1 (en) 2018-02-01
AU2014248007A1 (en) 2015-10-15
EP2981624A2 (en) 2016-02-10
CA2908745A1 (en) 2014-10-09
DK2981624T3 (da) 2020-03-02
US20250223655A1 (en) 2025-07-10
EP2981624B1 (en) 2019-12-18
JP7641938B2 (ja) 2025-03-07
ES2777228T3 (es) 2020-08-04
WO2014165785A2 (en) 2014-10-09
JP6625045B2 (ja) 2019-12-25
JP2019165731A (ja) 2019-10-03
US20210310079A1 (en) 2021-10-07
AU2020204028A1 (en) 2020-07-09
AU2014248007B2 (en) 2020-03-26
JP2025090619A (ja) 2025-06-17
JP7522643B2 (ja) 2024-07-25
CA2908745C (en) 2023-03-14
JP2021036903A (ja) 2021-03-11
AU2020204028B2 (en) 2022-08-18
JP7522539B2 (ja) 2024-07-25
AU2022211880B2 (en) 2025-05-29
US20140363521A1 (en) 2014-12-11
AU2022211880A1 (en) 2022-09-01
JP2023012488A (ja) 2023-01-25

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