AU2014248007B2 - Methods and materials for assessing homologous recombination deficiency - Google Patents

Methods and materials for assessing homologous recombination deficiency Download PDF

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AU2014248007B2
AU2014248007B2 AU2014248007A AU2014248007A AU2014248007B2 AU 2014248007 B2 AU2014248007 B2 AU 2014248007B2 AU 2014248007 A AU2014248007 A AU 2014248007A AU 2014248007 A AU2014248007 A AU 2014248007A AU 2014248007 B2 AU2014248007 B2 AU 2014248007B2
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AU2014248007A1 (en
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Victor Abkevich
Alexander Gutin
Kirsten Timms
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Myriad Genetics Inc
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Assigned to MYRIAD GENETICS, INC. reassignment MYRIAD GENETICS, INC. Request for Assignment Assignors: ABKEVICH, VICTOR, GUTIN, ALEXANDER, MYRIAD GENETICS, INC., TIMMS, KIRSTEN
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    • C—CHEMISTRY; METALLURGY
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    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
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    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/6858—Allele-specific amplification
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • G16B20/20—Allele or variant detection, e.g. single nucleotide polymorphism [SNP] detection
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/154—Methylation markers
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    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations

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  • Chemical & Material Sciences (AREA)
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  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
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  • Genetics & Genomics (AREA)
  • Physics & Mathematics (AREA)
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  • General Engineering & Computer Science (AREA)
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  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pathology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Inorganic Chemistry (AREA)
  • Epidemiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Theoretical Computer Science (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Medical Informatics (AREA)
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AU2014248007A 2013-04-05 2014-04-04 Methods and materials for assessing homologous recombination deficiency Active AU2014248007B2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2020204028A AU2020204028B2 (en) 2013-04-05 2020-06-17 Methods and Materials for Assessing Homologous Recombination Deficiency
AU2022211880A AU2022211880B2 (en) 2013-04-05 2022-08-04 Methods and materials for assessing homologous recombination deficiency

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201361809105P 2013-04-05 2013-04-05
US61/809,105 2013-04-05
US201361913762P 2013-12-09 2013-12-09
US61/913,762 2013-12-09
PCT/US2014/033014 WO2014165785A2 (en) 2013-04-05 2014-04-04 Methods and materials for assessing homologous recombination deficiency

Related Child Applications (1)

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AU2020204028A Division AU2020204028B2 (en) 2013-04-05 2020-06-17 Methods and Materials for Assessing Homologous Recombination Deficiency

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AU2014248007A1 AU2014248007A1 (en) 2015-10-15
AU2014248007B2 true AU2014248007B2 (en) 2020-03-26

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AU2014248007A Active AU2014248007B2 (en) 2013-04-05 2014-04-04 Methods and materials for assessing homologous recombination deficiency
AU2020204028A Active AU2020204028B2 (en) 2013-04-05 2020-06-17 Methods and Materials for Assessing Homologous Recombination Deficiency
AU2022211880A Active AU2022211880B2 (en) 2013-04-05 2022-08-04 Methods and materials for assessing homologous recombination deficiency

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AU2020204028A Active AU2020204028B2 (en) 2013-04-05 2020-06-17 Methods and Materials for Assessing Homologous Recombination Deficiency
AU2022211880A Active AU2022211880B2 (en) 2013-04-05 2022-08-04 Methods and materials for assessing homologous recombination deficiency

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US (4) US20140363521A1 (enExample)
EP (2) EP2981624B1 (enExample)
JP (5) JP6625045B2 (enExample)
AU (3) AU2014248007B2 (enExample)
CA (1) CA2908745C (enExample)
DK (1) DK2981624T3 (enExample)
ES (1) ES2777228T3 (enExample)
PT (1) PT2981624T (enExample)
WO (1) WO2014165785A2 (enExample)

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CA2839210A1 (en) 2011-06-17 2012-12-20 Myriad Genetics, Inc. Methods and materials for assessing allelic imbalance
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CA2867434C (en) 2012-06-07 2021-10-12 Institut Curie Methods for detecting inactivation of the homologous recombination pathway (brca1/2) in human tumors
AU2014248007B2 (en) * 2013-04-05 2020-03-26 Myriad Genetics, Inc. Methods and materials for assessing homologous recombination deficiency
EP4023765A1 (en) 2013-12-09 2022-07-06 Institut Curie Methods for detecting inactivation of the homologous recombination pathway (brca1/2) in human tumors
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ES2800673T3 (es) 2014-08-15 2021-01-04 Myriad Genetics Inc Métodos y materiales para evaluar una deficiencia de recombinación homóloga
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JP7368483B2 (ja) 2019-02-12 2023-10-24 テンパス ラブズ，インコーポレイテッド 相同組換え欠損を推定するための統合された機械学習フレームワーク
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EP2981624A4 (en) 2016-11-30
JP2016523511A (ja) 2016-08-12
EP3693475A1 (en) 2020-08-12
NZ712663A (en) 2021-07-30
US20180030544A1 (en) 2018-02-01
AU2014248007A1 (en) 2015-10-15
EP2981624A2 (en) 2016-02-10
CA2908745A1 (en) 2014-10-09
DK2981624T3 (da) 2020-03-02
US20250223655A1 (en) 2025-07-10
EP2981624B1 (en) 2019-12-18
JP7641938B2 (ja) 2025-03-07
ES2777228T3 (es) 2020-08-04
WO2014165785A2 (en) 2014-10-09
JP6625045B2 (ja) 2019-12-25
JP2019165731A (ja) 2019-10-03
US20210310079A1 (en) 2021-10-07
AU2020204028A1 (en) 2020-07-09
JP2025090619A (ja) 2025-06-17
JP7522643B2 (ja) 2024-07-25
PT2981624T (pt) 2020-03-23
CA2908745C (en) 2023-03-14
JP2021036903A (ja) 2021-03-11
AU2020204028B2 (en) 2022-08-18
JP7522539B2 (ja) 2024-07-25
AU2022211880B2 (en) 2025-05-29
US20140363521A1 (en) 2014-12-11
AU2022211880A1 (en) 2022-09-01
JP2023012488A (ja) 2023-01-25

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