PT2944688T - Utilização de células estaminais estromais derivadas de tecido adiposo para o tratamento de fístulas - Google Patents

Utilização de células estaminais estromais derivadas de tecido adiposo para o tratamento de fístulas

Info

Publication number
PT2944688T
PT2944688T PT151585718T PT15158571T PT2944688T PT 2944688 T PT2944688 T PT 2944688T PT 151585718 T PT151585718 T PT 151585718T PT 15158571 T PT15158571 T PT 15158571T PT 2944688 T PT2944688 T PT 2944688T
Authority
PT
Portugal
Prior art keywords
stem cells
adipose tissue
derived stromal
stromal stem
treating fistula
Prior art date
Application number
PT151585718T
Other languages
English (en)
Portuguese (pt)
Inventor
Gema Fernandez Miguel Maria
Angel Gonzalez De La Pena Manuel
Ana Garcia Castro Rosa
Garcia Arranz Mariano
Garcia Olmo Damian
Original Assignee
Univ Madrid Autonoma
Tigenix S A U
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37116048&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PT2944688(T) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Univ Madrid Autonoma, Tigenix S A U filed Critical Univ Madrid Autonoma
Publication of PT2944688T publication Critical patent/PT2944688T/pt

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    • A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
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    • A61L27/3895—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells using specific culture conditions, e.g. stimulating differentiation of stem cells, pulsatile flow conditions
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PT151585718T 2005-06-24 2006-05-16 Utilização de células estaminais estromais derivadas de tecido adiposo para o tratamento de fístulas PT2944688T (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US11/167,061 US20060045872A1 (en) 2004-08-25 2005-06-24 Use of adipose tissue-derived stromal stem cells in treating fistula

Publications (1)

Publication Number Publication Date
PT2944688T true PT2944688T (pt) 2018-01-19

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Family Applications (3)

Application Number Title Priority Date Filing Date
PT17150455T PT3176255T (pt) 2005-06-24 2006-05-16 Utilização de células estaminais estromais derivadas de tecido adiposo para o tratamento de fístulas
PT101792125T PT2292737E (pt) 2005-06-24 2006-05-16 Utilização de células estaminais estromais derivadas de tecido adiposo para o tratamento de fístulas
PT151585718T PT2944688T (pt) 2005-06-24 2006-05-16 Utilização de células estaminais estromais derivadas de tecido adiposo para o tratamento de fístulas

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PT17150455T PT3176255T (pt) 2005-06-24 2006-05-16 Utilização de células estaminais estromais derivadas de tecido adiposo para o tratamento de fístulas
PT101792125T PT2292737E (pt) 2005-06-24 2006-05-16 Utilização de células estaminais estromais derivadas de tecido adiposo para o tratamento de fístulas

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US (10) US20060045872A1 (OSRAM)
EP (7) EP2292737B2 (OSRAM)
JP (5) JP2008546397A (OSRAM)
KR (1) KR20080036588A (OSRAM)
CN (2) CN103143055A (OSRAM)
AU (1) AU2006261383B2 (OSRAM)
BR (1) BRPI0613811B8 (OSRAM)
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CY (3) CY1116764T1 (OSRAM)
DK (4) DK3176254T3 (OSRAM)
ES (6) ES2696535T3 (OSRAM)
HU (3) HUE036590T2 (OSRAM)
IL (1) IL188378A (OSRAM)
LT (3) LT2944688T (OSRAM)
LU (1) LUC00085I2 (OSRAM)
NL (1) NL300953I2 (OSRAM)
NZ (2) NZ594848A (OSRAM)
PL (3) PL2944688T3 (OSRAM)
PT (3) PT3176255T (OSRAM)
RU (3) RU2435846C2 (OSRAM)
SG (1) SG166770A1 (OSRAM)
SI (3) SI2944688T1 (OSRAM)
WO (1) WO2006136244A2 (OSRAM)

Families Citing this family (56)

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Publication number Priority date Publication date Assignee Title
US8455458B2 (en) 2002-10-16 2013-06-04 Arthrodynamic Technologies, Animal Health Division, Inc. Composition and method for treating connective tissue damage
US7803787B2 (en) * 2002-10-16 2010-09-28 Arthrodynamic Technologies, Animal Health Division, Inc. Composition and method for treating connective tissue damage by transmucosal administration
US20060045872A1 (en) * 2004-08-25 2006-03-02 Universidad Autonoma De Madrid Ciudad Universitaria de Cantoblanco Use of adipose tissue-derived stromal stem cells in treating fistula
JP2008541238A (ja) 2005-05-05 2008-11-20 アーキペラゴ ホールディングス インコーポレイテッド 値段が付けられていない注文のオークション及び転送
US20070027543A1 (en) * 2005-08-01 2007-02-01 Gimble Jeffrey M Use of adipose tissue-derived stromal cells in spinal fusion
DK1926813T4 (da) 2005-09-23 2019-08-19 Tigenix S A U Cellepopulationer med immunregulatorisk aktivitet, fremgangsmåde til isolering og anvendelser
US20100322906A1 (en) * 2005-10-05 2010-12-23 Osaka University Method for Obtaining Pancreatic Endocrine Cells From Adipose Tissue-Origin Cells
WO2007064819A2 (en) * 2005-12-02 2007-06-07 Cook Incorporated Devices, systems, and methods for occluding a defect
US20090209031A1 (en) * 2006-01-26 2009-08-20 Tyco Healthcare Group Lp Medical device package
EP1984488B1 (en) * 2006-01-30 2017-12-27 University Of Virginia Patent Foundation Methods of preparing and characterizing mesenchymal stem cell aggregates and uses thereof
US20070224173A1 (en) * 2006-03-21 2007-09-27 Koullick Edouard A Nonexpansion Protocol for Autologous Cell-Based Therapies
US8021882B2 (en) 2006-08-24 2011-09-20 Johnstone Brian H Production of neural protective and regenerative factors from stem cells and treatment of nervous system conditions therewith
US8835170B2 (en) * 2006-10-06 2014-09-16 University Of Virginia Patent Foundation Methods and compositions useful for diabetic wound healing
KR20080103637A (ko) * 2007-05-25 2008-11-28 주식회사 알앤엘바이오 지방유래 줄기세포를 함유하는 사지말단부 허혈성 질환의세포치료용 조성물
US9186375B2 (en) 2007-06-21 2015-11-17 Arthrodynamic Technologies, Animal Health Division, Inc. Glycosaminoglycan compositions in combination with stem cells
AU2014227541B2 (en) * 2007-09-19 2015-10-01 Pluristem Ltd. Methods of Treating Inflammatory Colon Diseases
BRPI0909541A2 (pt) * 2008-05-27 2016-10-11 Pluristem Ltd ''método para tratamento de doenças inflamatórias do cólon''
US9144584B2 (en) * 2008-06-11 2015-09-29 Cell4Vet Corporation Adipose tissue-derived stem cells for veterinary use
KR101712560B1 (ko) * 2008-06-24 2017-03-06 바이오엑티브 써지컬, 아이엔씨. 줄기 세포 또는 기타 생활성 물질이 혼입된 수술용 봉합사
US20100098739A1 (en) * 2008-10-20 2010-04-22 University Of Virginia Patent Foundation Compositions and methods for modular soft tissue repair
US20100112696A1 (en) * 2008-11-03 2010-05-06 Baxter International Inc. Apparatus And Methods For Processing Tissue To Release Cells
US8309343B2 (en) * 2008-12-01 2012-11-13 Baxter International Inc. Apparatus and method for processing biological material
US20120020937A1 (en) * 2009-04-28 2012-01-26 Anterogen Co., Ltd. Autologous and allogenic adipose-derived stromal stem cell composition for treating fistulas
US10130736B1 (en) 2010-05-14 2018-11-20 Musculoskeletal Transplant Foundation Tissue-derived tissuegenic implants, and methods of fabricating and using same
US9352003B1 (en) 2010-05-14 2016-05-31 Musculoskeletal Transplant Foundation Tissue-derived tissuegenic implants, and methods of fabricating and using same
US8883210B1 (en) 2010-05-14 2014-11-11 Musculoskeletal Transplant Foundation Tissue-derived tissuegenic implants, and methods of fabricating and using same
US9669200B2 (en) 2010-08-06 2017-06-06 Boston Scientific Scimed, Inc. Systems and methods for the treatment of pelvic disorders including magnetic particulates
WO2012048099A2 (en) 2010-10-08 2012-04-12 Osiris Therapeutics, Inc. Nanoparticle-loaded cells
US9180172B2 (en) 2010-12-15 2015-11-10 Ams Research Corporation Treatment of Peyronies disease
US8979797B2 (en) 2010-12-16 2015-03-17 Ams Research Corporation High pressure delivery system and method for treating pelvic disorder using large molecule therapeutics
US20140154274A1 (en) 2011-01-12 2014-06-05 Tigenix Nv Methods and compositions for use in intralymphatic cellular therapies
JP2014508527A (ja) 2011-03-11 2014-04-10 ティゲニクス、エセ、ア、ウ 免疫調節活性を有する細胞集団、単離方法および使用
US8834928B1 (en) 2011-05-16 2014-09-16 Musculoskeletal Transplant Foundation Tissue-derived tissugenic implants, and methods of fabricating and using same
CL2011001904A1 (es) * 2011-08-08 2012-03-09 Univ Pontificia Catolica Chile Formulacion farmaceutica que comprende celulas madres mesenquimales vivas suspendidas en un vehiculo farmaceuticamente aceptable, sistema de aplicacion topica en aerosol que las comprende; y su uso para tratar heridas.
US20130072903A1 (en) * 2011-09-20 2013-03-21 John Chapman Adipose Tissue Graft for Wound Healing
GB201202319D0 (en) * 2012-02-10 2012-03-28 Orbsen Therapeutics Ltd Stromal stem cells
US20140024011A1 (en) * 2012-07-23 2014-01-23 AdiCyte, Inc. Method for Preparing Adipose Tissue
EP2908871B1 (en) * 2012-10-18 2018-08-08 Mayo Foundation For Medical Education And Research Techniques for treatment of abscesses
WO2014186854A1 (pt) * 2013-05-24 2014-11-27 Universidade Estadual De Campinas - Unicamp Processo de obtenção de fio de sutura enriquecido com celulas-tronco, fios obtidos, kit de sutura e seus usos
EP3027235A1 (en) 2013-07-30 2016-06-08 Musculoskeletal Transplant Foundation Acellular soft tissue-derived matrices and methods for preparing same
WO2016086147A1 (en) * 2014-11-26 2016-06-02 Millennium Pharmaceuticals, Inc. Vedolizumab for the treatment of fistulizing crohn's disease
RU2588835C1 (ru) * 2014-11-27 2016-07-10 Олег Германович Макеев Способ терапии повреждений кожи и биотрансплантат для его осуществления
CA2986702C (en) 2015-05-21 2023-04-04 David Wang Modified demineralized cortical bone fibers
US10912864B2 (en) 2015-07-24 2021-02-09 Musculoskeletal Transplant Foundation Acellular soft tissue-derived matrices and methods for preparing same
US11052175B2 (en) 2015-08-19 2021-07-06 Musculoskeletal Transplant Foundation Cartilage-derived implants and methods of making and using same
PL3365432T3 (pl) 2015-10-23 2020-09-21 Rigshospitalet Terapia komórkami macierzystymi oparta na komórkach macierzystych pozyskiwanych z tkanki tłuszczowej
GB201604304D0 (en) * 2016-03-14 2016-04-27 Tigenix S A U Adipose tissue-derived stromal stem cells for use in treating refractory complex perianal fistulas in crohn's disease
EP3484485A1 (en) * 2016-07-12 2019-05-22 Centre National De La Recherche Scientifique Compositions useful for mucosal healing
IT201700043316A1 (it) * 2017-04-20 2018-10-20 Lipogems Int S P A Drug delivery system
JP6999918B2 (ja) * 2017-08-21 2022-02-04 学校法人慶應義塾 血小板表面抗原と間葉系細胞表面抗原を共発現する血小板様細胞を含む創傷治癒促進剤
WO2019102268A1 (en) 2017-11-22 2019-05-31 Mesoblast International Sarl Cellular compositions and methods of treatment i
US11116737B1 (en) 2020-04-10 2021-09-14 University Of Georgia Research Foundation, Inc. Methods of using probenecid for treatment of coronavirus infections
CN111840645B (zh) * 2020-07-29 2022-04-01 沈阳细胞治疗工程技术研发中心有限公司 一种瘘洞修补制剂及其制备方法
US20240042100A1 (en) * 2020-12-24 2024-02-08 Rokit Healthcare Inc. Method of manufacturing a tissue regeneration patch
CN114949361A (zh) * 2021-12-31 2022-08-30 浙江金时代生物技术有限公司 一种用于子宫内膜修复的聚乳酸-羟基乙酸共聚物支架与人脐带间充质干细胞复合物的制备方法
WO2024227193A2 (en) * 2023-04-28 2024-10-31 Angiocrine Bioscience, Inc. Endothelial cells for treatment of gastrointestinal fistula

Family Cites Families (78)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4298002A (en) 1979-09-10 1981-11-03 National Patent Development Corporation Porous hydrophilic materials, chambers therefrom, and devices comprising such chambers and biologically active tissue and methods of preparation
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US5143842A (en) 1988-11-01 1992-09-01 The University Of Colorado Foundation, Inc. Media for normal human muscle satellite cells
US5145770A (en) 1990-06-04 1992-09-08 Biosurface Technology, Inc. Cryopreservation of cultured epithelial sheets
US5149543A (en) 1990-10-05 1992-09-22 Massachusetts Institute Of Technology Ionically cross-linked polymeric microcapsules
US5733542A (en) 1990-11-16 1998-03-31 Haynesworth; Stephen E. Enhancing bone marrow engraftment using MSCS
US5486359A (en) 1990-11-16 1996-01-23 Osiris Therapeutics, Inc. Human mesenchymal stem cells
US6010696A (en) * 1990-11-16 2000-01-04 Osiris Therapeutics, Inc. Enhancing hematopoietic progenitor cell engraftment using mesenchymal stem cells
BR9307217A (pt) 1992-10-10 1999-03-30 Hemscheidt Fahrwerktech Gmbh Sistema de suspenção hidropneumático
JPH09502421A (ja) 1992-12-02 1997-03-11 シエル・インターナシヨナル・リサーチ・マートシヤツピイ・ベー・ブイ アゾキシシアノベンゼン誘導体
US5709854A (en) * 1993-04-30 1998-01-20 Massachusetts Institute Of Technology Tissue formation by injecting a cell-polymeric solution that gels in vivo
US5578475A (en) 1993-07-12 1996-11-26 Life Technologies, Inc. Composition and methods for transfecting eukaryotic cells
US6174333B1 (en) 1994-06-06 2001-01-16 Osiris Therapeutics, Inc. Biomatrix for soft tissue regeneration using mesenchymal stem cells
AU686823B2 (en) 1994-06-06 1998-02-12 Case Western Reserve University Biomatrix for tissue regeneration
US5976567A (en) 1995-06-07 1999-11-02 Inex Pharmaceuticals Corp. Lipid-nucleic acid particles prepared via a hydrophobic lipid-nucleic acid complex intermediate and use for gene transfer
US6051429A (en) 1995-06-07 2000-04-18 Life Technologies, Inc. Peptide-enhanced cationic lipid transfections
WO1997006241A1 (en) 1995-08-04 1997-02-20 The General Hospital Corporation Transgenic swine and swine cells having human hla genes
US5744335A (en) 1995-09-19 1998-04-28 Mirus Corporation Process of transfecting a cell with a polynucleotide mixed with an amphipathic compound and a DNA-binding protein
US5705308A (en) 1996-09-30 1998-01-06 Eastman Kodak Company Infrared-sensitive, negative-working diazonaphthoquinone imaging composition and element
US6541028B1 (en) * 1997-01-17 2003-04-01 Celadon Science, Llc Methods for promoting healing of corneal resurfacing wounds
ATE478135T1 (de) 1997-12-02 2010-09-15 Artecel Sciences Inc Differenzierung in osteoblasten der fettgewebe- stromalen zellen und ihre verwendungen
EP1058555B1 (en) 1998-02-04 2004-04-28 The General Hospital Corporation Costimulatory blockade and mixed chimerism in allotransplantation
US6368636B1 (en) 1998-03-18 2002-04-09 Osiris Therapeutics, Inc. Mesenchymal stem cells for prevention and treatment of immune responses in transplantation
US9585916B2 (en) 1999-03-26 2017-03-07 Northern Therapeutics Inc. Cell based therapy for the pulmonary system
CA2326838C (en) 1998-04-03 2008-12-23 Osiris Therapeutics, Inc. Mesenchymal stem cells as immunosuppressants
US6546105B1 (en) 1998-10-30 2003-04-08 Matsushita Electric Industrial Co., Ltd. Sound image localization device and sound image localization method
US20050153442A1 (en) 1999-03-10 2005-07-14 Adam Katz Adipose-derived stem cells and lattices
US6777231B1 (en) 1999-03-10 2004-08-17 The Regents Of The University Of California Adipose-derived stem cells and lattices
US20030082152A1 (en) 1999-03-10 2003-05-01 Hedrick Marc H. Adipose-derived stem cells and lattices
IL145002A0 (en) * 1999-03-10 2002-06-30 Univ Pittsburgh Adipose-derived stem cells and lattices
WO2000073418A2 (en) * 1999-05-28 2000-12-07 Pacgen Technologies Llc A method of using autologous fibroblasts to promote healing of wounds and fistulas
US7670628B2 (en) 1999-07-07 2010-03-02 Angioblast Systems, Inc. Mesenchymal precursor cell
US7078232B2 (en) * 1999-08-19 2006-07-18 Artecel, Inc. Adipose tissue-derived adult stem or stromal cells for the repair of articular cartilage fractures and uses thereof
US6555374B1 (en) 1999-08-19 2003-04-29 Artecel Sciences, Inc. Multiple mesodermal lineage differentiation potentials for adipose tissue-derived stromal cells and uses thereof
AU778929B2 (en) 1999-12-06 2004-12-23 General Hospital Corporation, The Pancreatic stem cells and their use in transplantation
WO2002067867A2 (en) 2001-02-23 2002-09-06 The University Of Pittsburgh Rapid preparation of stem cell matrices for use in tissue and organ treatment and repair
US20030054331A1 (en) 2001-09-14 2003-03-20 Stemsource, Inc. Preservation of non embryonic cells from non hematopoietic tissues
KR20050044395A (ko) 2001-11-09 2005-05-12 아르테셀 사이언스, 인크. 배아 및 성체 줄기 세포를 유지시키기 위해 스트로마세포를 이용하는 방법 및 조성물
WO2003047530A2 (en) * 2001-12-04 2003-06-12 Woolverton Christopher J Storage-stable fibrin sealant
US7771716B2 (en) 2001-12-07 2010-08-10 Cytori Therapeutics, Inc. Methods of using regenerative cells in the treatment of musculoskeletal disorders
WO2003070922A1 (en) * 2002-02-19 2003-08-28 Medipost Co., Ltd. Isolation and culture-expansion methods of mesenchymal stem/progenitor cells from umbilical cord blood, and differentiation method of umbilical cord blood-derived mesenchymal stem/progenitor cells into various mesenchymal tissues
CN100579577C (zh) 2002-03-15 2010-01-13 退伍军人事务研发服务部 使用细胞脱唾液酸决定簇和糖缀合物将细胞靶向组织和器官的方法和组合物
WO2003106493A1 (en) * 2002-06-14 2003-12-24 Dyax Corporation Protein analysis
US7749710B2 (en) 2002-06-14 2010-07-06 Xintela Ab Marker for stem cells and its use
US20040101959A1 (en) * 2002-11-21 2004-05-27 Olga Marko Treatment of tissue with undifferentiated mesenchymal cells
JP2004190976A (ja) * 2002-12-12 2004-07-08 Sony Corp 熱輸送装置及び電子デバイス
NZ566132A (en) * 2003-02-13 2009-09-25 Anthrogenesis Corp Use of umbilical cord blood to treat inflammation, ParkinsonÆs disease or diabetes
AU2004227342B2 (en) 2003-04-01 2011-01-20 United States Of America Department Of Veteran's Affairs Stem-cell, precursor cell, or target cell-based treatment of multi-organ failure and renal dysfunction
ES2265199B1 (es) 2003-06-12 2008-02-01 Cellerix, S.L. Celulas madre adultas multipotentes procedentes de condrocitos desdiferenciados y sus aplicaciones.
AU2004252571C1 (en) 2003-06-27 2012-03-01 Ethicon, Incorporated Postpartum-derived cells for use in treatment of disease of the heart and circulatory system
US7645229B2 (en) * 2003-09-26 2010-01-12 Armstrong David N Instrument and method for endoscopic visualization and treatment of anorectal fistula
JP4749331B2 (ja) 2003-10-07 2011-08-17 株式会社バイオマスター 脂肪由来前駆細胞の細胞分化
ATE493492T1 (de) 2003-11-04 2011-01-15 Biomaster Inc Verfahren und system zur herstellung von stammzellen aus fettgewebe
EP1699523A4 (en) 2003-12-24 2008-05-21 Univ Columbia GENERATION OF A BIOLOGICAL ATRIOVENTRICULAR BYPASS FOR COMPENSATING AN ATRIOVENTRICULAR BLOCK
US20080095749A1 (en) 2004-03-22 2008-04-24 Sudeepta Aggarwal Mesenchymal stem cells and uses therefor
EP2298862B1 (en) 2004-03-22 2017-08-30 Mesoblast International Sàrl Mesenchymal stem cells and uses therefor
RU2252252C1 (ru) 2004-04-09 2005-05-20 Тепляшин Александр Сергеевич Способ выделения мезенхимальных стволовых клеток
ES2264862B8 (es) 2004-08-25 2017-01-20 Cellerix, S.L. Biomaterial para sutura.
ES2313805B1 (es) * 2004-10-04 2009-12-23 Cellerix, S.L. Identificacion y aislamiento de celulas multipotentes de tejido mesenquimal no osteocondral.
US20060045872A1 (en) * 2004-08-25 2006-03-02 Universidad Autonoma De Madrid Ciudad Universitaria de Cantoblanco Use of adipose tissue-derived stromal stem cells in treating fistula
US7732126B2 (en) 2004-09-03 2010-06-08 University Of Maryland, Baltimore Integrin CD18 is a novel stromal stem cell marker and functions to promote osteogenesis
US20060286089A1 (en) 2005-04-08 2006-12-21 Xcyte Therapies, Inc. Compositions and methods for the treatment of burns and sepsis
DK1926813T4 (da) 2005-09-23 2019-08-19 Tigenix S A U Cellepopulationer med immunregulatorisk aktivitet, fremgangsmåde til isolering og anvendelser
EP1795588A1 (en) 2005-12-07 2007-06-13 Cellerix, S.L. Use of adipose tissue derived mesenchymal stem cells for the treatment of graft versus host disease
US20120269774A1 (en) 2006-09-21 2012-10-25 Medistem Laboratories, Inc Allogeneic stem cell transplants in non-conditioned recipients
EP2191835A4 (en) 2007-09-07 2011-12-14 Japan Chem Res THERAPEUTIC AND PROPHYLACTIC AGENTS FOR ARTHRITIS
KR20100075924A (ko) 2007-09-19 2010-07-05 플루리스템 리미티드 지방 또는 태반 조직 유래의 부착 세포 및 이의 치료 용도
CN101835889B (zh) 2007-10-17 2013-07-17 特克赛尔公司 Tr1细胞、间充质干细胞和其用途
GB0814249D0 (en) 2008-08-04 2008-09-10 Cellerix Sa Uses of mesenchymal stem cells
ES2345867B1 (es) 2009-04-03 2011-07-28 Fundacion Instituto Mediterraneo Para La Biotecnologia Y La Investigacion Sanitaria (Imabis) Celulas madre multipotentes derivadas de estroma de mesenterio.
US20120020937A1 (en) 2009-04-28 2012-01-26 Anterogen Co., Ltd. Autologous and allogenic adipose-derived stromal stem cell composition for treating fistulas
US8679834B2 (en) 2009-07-09 2014-03-25 TiGenix S.A.U Methods and compositions for use in cellular therapies
US20140154274A1 (en) 2011-01-12 2014-06-05 Tigenix Nv Methods and compositions for use in intralymphatic cellular therapies
JP2014508527A (ja) 2011-03-11 2014-04-10 ティゲニクス、エセ、ア、ウ 免疫調節活性を有する細胞集団、単離方法および使用
US20140134140A1 (en) 2012-11-09 2014-05-15 Case Western Reserve University Mesenchymal stem cell compositions for the treatment of microbial infections
HUE046531T2 (hu) 2013-03-15 2020-03-30 Tigenix S A U Limfocita biomarkerek sejtterápiára adott klinikai válasz meghatározására
JP6412933B2 (ja) 2013-06-25 2018-10-24 ティジェニクス エス．エー．ユー． 免疫調節活性を有する細胞集団、その調製方法および使用
GB201604304D0 (en) * 2016-03-14 2016-04-27 Tigenix S A U Adipose tissue-derived stromal stem cells for use in treating refractory complex perianal fistulas in crohn's disease

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