PT2864329T - Análogos de folato/antifolato marcados com 18f - Google Patents
Análogos de folato/antifolato marcados com 18fInfo
- Publication number
- PT2864329T PT2864329T PT13721738T PT13721738T PT2864329T PT 2864329 T PT2864329 T PT 2864329T PT 13721738 T PT13721738 T PT 13721738T PT 13721738 T PT13721738 T PT 13721738T PT 2864329 T PT2864329 T PT 2864329T
- Authority
- PT
- Portugal
- Prior art keywords
- antifolate
- analogues
- folate
- labelled
- labelled folate
- Prior art date
Links
- 150000002224 folic acids Chemical class 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/041—Heterocyclic compounds
- A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
- A61K51/0459—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
- C07B59/002—Heterocyclic compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D475/00—Heterocyclic compounds containing pteridine ring systems
- C07D475/02—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4
- C07D475/04—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4 with a nitrogen atom directly attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D475/00—Heterocyclic compounds containing pteridine ring systems
- C07D475/06—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4
- C07D475/08—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4 with a nitrogen atom directly attached in position 2
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
- G01N33/60—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances involving radioactive labelled substances
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/05—Isotopically modified compounds, e.g. labelled
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Physics & Mathematics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Epidemiology (AREA)
- Optics & Photonics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Microbiology (AREA)
- Pathology (AREA)
- Food Science & Technology (AREA)
- Biotechnology (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Rheumatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12167126 | 2012-05-08 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT2864329T true PT2864329T (pt) | 2019-01-10 |
Family
ID=48407549
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT13721738T PT2864329T (pt) | 2012-05-08 | 2013-05-08 | Análogos de folato/antifolato marcados com 18f |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US10357576B2 (enExample) |
| EP (1) | EP2864329B1 (enExample) |
| JP (1) | JP6198814B2 (enExample) |
| KR (1) | KR102116000B1 (enExample) |
| CN (1) | CN104379585B (enExample) |
| AU (1) | AU2013258027B2 (enExample) |
| CA (1) | CA2870124C (enExample) |
| DK (1) | DK2864329T3 (enExample) |
| EA (1) | EA201401225A1 (enExample) |
| ES (1) | ES2703627T3 (enExample) |
| IL (1) | IL235476B (enExample) |
| PL (1) | PL2864329T3 (enExample) |
| PT (1) | PT2864329T (enExample) |
| SG (1) | SG11201406481TA (enExample) |
| TR (1) | TR201819802T4 (enExample) |
| WO (1) | WO2013167653A1 (enExample) |
| ZA (1) | ZA201407266B (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101646577B1 (ko) * | 2014-08-14 | 2016-08-09 | 원광대학교산학협력단 | 엽산수용체 표적용 화합물 또는 이의 약학적으로 허용가능한 염과, 이를 유효성분으로 포함하는 암 예방, 진단 또는 치료용 조성물 |
| CA3057042A1 (en) | 2017-03-20 | 2018-09-27 | Merck Patent Gmbh | Isomerically pure 18f-labelled tetrahydrofolates |
| EP3671511B1 (en) | 2018-12-19 | 2022-07-06 | Rohde & Schwarz GmbH & Co. KG | Communication system and method |
| DE102019110904B4 (de) * | 2019-04-26 | 2022-01-20 | Helmholtz-Zentrum Dresden - Rossendorf E. V. | N-(4-methoxy-7-morpholinobenzo[d]thiazol-2-yl)-acetamid-Derivate und deren Verwendung |
| WO2021257863A1 (en) | 2020-06-19 | 2021-12-23 | Incyte Corporation | Pyrrolotriazine compounds as jak2 v617f inhibitors |
| WO2021257857A1 (en) | 2020-06-19 | 2021-12-23 | Incyte Corporation | Naphthyridinone compounds as jak2 v617f inhibitors |
| US11767323B2 (en) | 2020-07-02 | 2023-09-26 | Incyte Corporation | Tricyclic pyridone compounds as JAK2 V617F inhibitors |
| WO2022006457A1 (en) | 2020-07-02 | 2022-01-06 | Incyte Corporation | Tricyclic urea compounds as jak2 v617f inhibitors |
| WO2022046989A1 (en) | 2020-08-27 | 2022-03-03 | Incyte Corporation | Tricyclic urea compounds as jak2 v617f inhibitors |
| US11919908B2 (en) | 2020-12-21 | 2024-03-05 | Incyte Corporation | Substituted pyrrolo[2,3-d]pyrimidine compounds as JAK2 V617F inhibitors |
| WO2022182839A1 (en) | 2021-02-25 | 2022-09-01 | Incyte Corporation | Spirocyclic lactams as jak2 v617f inhibitors |
| JP2025509672A (ja) | 2022-03-17 | 2025-04-11 | インサイト・コーポレイション | Ｊａｋ２ ｖ６１７ｆ阻害剤としての三環式尿素化合物 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2007128036A (ru) | 2004-12-23 | 2009-01-27 | Пердью Рисерч Фаундейшн (Us) | Способ получения изображения позитронно-эмиссионной томографией |
| JP4503039B2 (ja) | 2006-04-27 | 2010-07-14 | 三洋電機株式会社 | 回路装置 |
| EP2109466B1 (en) | 2007-02-07 | 2014-11-12 | Purdue Research Foundation | Positron emission tomography imaging method |
| CN101646639A (zh) | 2007-04-11 | 2010-02-10 | 默克阿泼洛发股份公司 | 18f-标记的叶酸 |
| AU2008237935B2 (en) | 2007-04-11 | 2014-03-27 | Merck & Cie | Folate-conjugates and corresponding metal-chelate complexes for use in diagnostic imaging and radiotherapy |
| CN104447750A (zh) | 2007-04-11 | 2015-03-25 | 默克和西伊公司 | 18f-标记的叶酸酯 |
| AU2008237932C1 (en) | 2007-04-11 | 2014-04-24 | Merck & Cie | 18 F-labelled folates |
| PT2346870E (pt) | 2008-10-10 | 2015-10-21 | Merck & Cie | Folatos marcados com 18f como marcadores radioactivos de pet |
-
2013
- 2013-05-08 CN CN201380024067.2A patent/CN104379585B/zh active Active
- 2013-05-08 PL PL13721738T patent/PL2864329T3/pl unknown
- 2013-05-08 KR KR1020147033749A patent/KR102116000B1/ko active Active
- 2013-05-08 WO PCT/EP2013/059584 patent/WO2013167653A1/en not_active Ceased
- 2013-05-08 US US14/399,688 patent/US10357576B2/en active Active
- 2013-05-08 EP EP13721738.6A patent/EP2864329B1/en active Active
- 2013-05-08 JP JP2015510812A patent/JP6198814B2/ja active Active
- 2013-05-08 ES ES13721738T patent/ES2703627T3/es active Active
- 2013-05-08 AU AU2013258027A patent/AU2013258027B2/en active Active
- 2013-05-08 PT PT13721738T patent/PT2864329T/pt unknown
- 2013-05-08 SG SG11201406481TA patent/SG11201406481TA/en unknown
- 2013-05-08 DK DK13721738.6T patent/DK2864329T3/en active
- 2013-05-08 CA CA2870124A patent/CA2870124C/en active Active
- 2013-05-08 TR TR2018/19802T patent/TR201819802T4/tr unknown
- 2013-05-08 EA EA201401225A patent/EA201401225A1/ru unknown
-
2014
- 2014-10-07 ZA ZA2014/07266A patent/ZA201407266B/en unknown
- 2014-11-03 IL IL235476A patent/IL235476B/en active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| PL2864329T3 (pl) | 2019-03-29 |
| JP6198814B2 (ja) | 2017-09-20 |
| TR201819802T4 (tr) | 2019-01-21 |
| CN104379585A (zh) | 2015-02-25 |
| IL235476A0 (en) | 2014-12-31 |
| AU2013258027A1 (en) | 2014-11-13 |
| CA2870124C (en) | 2021-02-16 |
| CN104379585B (zh) | 2018-07-06 |
| SG11201406481TA (en) | 2014-11-27 |
| KR20150010970A (ko) | 2015-01-29 |
| AU2013258027B2 (en) | 2017-11-30 |
| EP2864329B1 (en) | 2018-09-26 |
| WO2013167653A1 (en) | 2013-11-14 |
| EP2864329A1 (en) | 2015-04-29 |
| DK2864329T3 (en) | 2019-01-21 |
| CA2870124A1 (en) | 2013-11-14 |
| EA201401225A1 (ru) | 2015-04-30 |
| IL235476B (en) | 2019-09-26 |
| HK1202548A1 (en) | 2015-10-02 |
| US10357576B2 (en) | 2019-07-23 |
| ZA201407266B (en) | 2016-09-28 |
| ES2703627T3 (es) | 2019-03-11 |
| KR102116000B1 (ko) | 2020-05-29 |
| JP2015516405A (ja) | 2015-06-11 |
| US20150125390A1 (en) | 2015-05-07 |
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