KR102116000B1 - 18f-표지된 폴레이트/안티폴레이트 유사체들 - Google Patents

18f-표지된 폴레이트/안티폴레이트 유사체들 Download PDF

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KR102116000B1
KR102116000B1 KR1020147033749A KR20147033749A KR102116000B1 KR 102116000 B1 KR102116000 B1 KR 102116000B1 KR 1020147033749 A KR1020147033749 A KR 1020147033749A KR 20147033749 A KR20147033749 A KR 20147033749A KR 102116000 B1 KR102116000 B1 KR 102116000B1
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folate
formula
compound
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KR20150010970A (ko
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로제르 쉬블리
루돌프 모세르
크리스티나 막달레나 뮐러
지몬 멘사 아메타메이
토마스 베첼
비올라 그로엔
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메르크 앤드 씨에
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D475/00—Heterocyclic compounds containing pteridine ring systems
    • C07D475/02—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4
    • C07D475/04—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4 with a nitrogen atom directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/002—Heterocyclic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0459—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D475/00—Heterocyclic compounds containing pteridine ring systems
    • C07D475/06—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4
    • C07D475/08—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4 with a nitrogen atom directly attached in position 2
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/60—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances involving radioactive labelled substances
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05—Isotopically modified compounds, e.g. labelled
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Optics & Photonics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Rheumatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
KR1020147033749A 2012-05-08 2013-05-08 18f-표지된 폴레이트/안티폴레이트 유사체들 Active KR102116000B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP12167126 2012-05-08
EP12167126.7 2012-05-08
PCT/EP2013/059584 WO2013167653A1 (en) 2012-05-08 2013-05-08 18f-labelled folate/antifolate analogues

Publications (2)

Publication Number Publication Date
KR20150010970A KR20150010970A (ko) 2015-01-29
KR102116000B1 true KR102116000B1 (ko) 2020-05-29

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KR1020147033749A Active KR102116000B1 (ko) 2012-05-08 2013-05-08 18f-표지된 폴레이트/안티폴레이트 유사체들

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Country Link
US (1) US10357576B2 (enExample)
EP (1) EP2864329B1 (enExample)
JP (1) JP6198814B2 (enExample)
KR (1) KR102116000B1 (enExample)
CN (1) CN104379585B (enExample)
AU (1) AU2013258027B2 (enExample)
CA (1) CA2870124C (enExample)
DK (1) DK2864329T3 (enExample)
EA (1) EA201401225A1 (enExample)
ES (1) ES2703627T3 (enExample)
IL (1) IL235476B (enExample)
PL (1) PL2864329T3 (enExample)
PT (1) PT2864329T (enExample)
SG (1) SG11201406481TA (enExample)
TR (1) TR201819802T4 (enExample)
WO (1) WO2013167653A1 (enExample)
ZA (1) ZA201407266B (enExample)

Families Citing this family (12)

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Publication number Priority date Publication date Assignee Title
KR101646577B1 (ko) * 2014-08-14 2016-08-09 원광대학교산학협력단 엽산수용체 표적용 화합물 또는 이의 약학적으로 허용가능한 염과, 이를 유효성분으로 포함하는 암 예방, 진단 또는 치료용 조성물
CA3057042A1 (en) 2017-03-20 2018-09-27 Merck Patent Gmbh Isomerically pure 18f-labelled tetrahydrofolates
EP3671511B1 (en) 2018-12-19 2022-07-06 Rohde & Schwarz GmbH & Co. KG Communication system and method
DE102019110904B4 (de) * 2019-04-26 2022-01-20 Helmholtz-Zentrum Dresden - Rossendorf E. V. N-(4-methoxy-7-morpholinobenzo[d]thiazol-2-yl)-acetamid-Derivate und deren Verwendung
WO2021257863A1 (en) 2020-06-19 2021-12-23 Incyte Corporation Pyrrolotriazine compounds as jak2 v617f inhibitors
WO2021257857A1 (en) 2020-06-19 2021-12-23 Incyte Corporation Naphthyridinone compounds as jak2 v617f inhibitors
US11767323B2 (en) 2020-07-02 2023-09-26 Incyte Corporation Tricyclic pyridone compounds as JAK2 V617F inhibitors
WO2022006457A1 (en) 2020-07-02 2022-01-06 Incyte Corporation Tricyclic urea compounds as jak2 v617f inhibitors
WO2022046989A1 (en) 2020-08-27 2022-03-03 Incyte Corporation Tricyclic urea compounds as jak2 v617f inhibitors
US11919908B2 (en) 2020-12-21 2024-03-05 Incyte Corporation Substituted pyrrolo[2,3-d]pyrimidine compounds as JAK2 V617F inhibitors
WO2022182839A1 (en) 2021-02-25 2022-09-01 Incyte Corporation Spirocyclic lactams as jak2 v617f inhibitors
JP2025509672A (ja) 2022-03-17 2025-04-11 インサイト・コーポレイション Ｊａｋ２ ｖ６１７ｆ阻害剤としての三環式尿素化合物

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008125617A2 (en) * 2007-04-11 2008-10-23 Merck Eprova Ag 18f-labelled folates

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2007128036A (ru) 2004-12-23 2009-01-27 Пердью Рисерч Фаундейшн (Us) Способ получения изображения позитронно-эмиссионной томографией
JP4503039B2 (ja) 2006-04-27 2010-07-14 三洋電機株式会社 回路装置
EP2109466B1 (en) 2007-02-07 2014-11-12 Purdue Research Foundation Positron emission tomography imaging method
CN101646639A (zh) 2007-04-11 2010-02-10 默克阿泼洛发股份公司 18f-标记的叶酸
AU2008237935B2 (en) 2007-04-11 2014-03-27 Merck & Cie Folate-conjugates and corresponding metal-chelate complexes for use in diagnostic imaging and radiotherapy
AU2008237932C1 (en) 2007-04-11 2014-04-24 Merck & Cie 18 F-labelled folates
PT2346870E (pt) 2008-10-10 2015-10-21 Merck & Cie Folatos marcados com 18f como marcadores radioactivos de pet

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008125617A2 (en) * 2007-04-11 2008-10-23 Merck Eprova Ag 18f-labelled folates

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Journal of Nuclear Medicine, 2012. 05. 01., vol. 53, supplement 1, 1645, 초록*

Also Published As

Publication number Publication date
PL2864329T3 (pl) 2019-03-29
JP6198814B2 (ja) 2017-09-20
TR201819802T4 (tr) 2019-01-21
CN104379585A (zh) 2015-02-25
IL235476A0 (en) 2014-12-31
AU2013258027A1 (en) 2014-11-13
CA2870124C (en) 2021-02-16
CN104379585B (zh) 2018-07-06
SG11201406481TA (en) 2014-11-27
KR20150010970A (ko) 2015-01-29
AU2013258027B2 (en) 2017-11-30
EP2864329B1 (en) 2018-09-26
PT2864329T (pt) 2019-01-10
WO2013167653A1 (en) 2013-11-14
EP2864329A1 (en) 2015-04-29
DK2864329T3 (en) 2019-01-21
CA2870124A1 (en) 2013-11-14
EA201401225A1 (ru) 2015-04-30
IL235476B (en) 2019-09-26
HK1202548A1 (en) 2015-10-02
US10357576B2 (en) 2019-07-23
ZA201407266B (en) 2016-09-28
ES2703627T3 (es) 2019-03-11
JP2015516405A (ja) 2015-06-11
US20150125390A1 (en) 2015-05-07

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