AU2013258027B2 - 18F-labelled follate/antifolate analogues - Google Patents
18F-labelled follate/antifolate analogues Download PDFInfo
- Publication number
- AU2013258027B2 AU2013258027B2 AU2013258027A AU2013258027A AU2013258027B2 AU 2013258027 B2 AU2013258027 B2 AU 2013258027B2 AU 2013258027 A AU2013258027 A AU 2013258027A AU 2013258027 A AU2013258027 A AU 2013258027A AU 2013258027 B2 AU2013258027 B2 AU 2013258027B2
- Authority
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- Australia
- Prior art keywords
- folate
- independently
- acid
- alkyl
- aza
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 150000001875 compounds Chemical class 0.000 claims description 66
- 239000011724 folic acid Substances 0.000 claims description 64
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- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/041—Heterocyclic compounds
- A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
- A61K51/0459—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
- C07B59/002—Heterocyclic compounds
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D475/00—Heterocyclic compounds containing pteridine ring systems
- C07D475/02—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4
- C07D475/04—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4 with a nitrogen atom directly attached in position 2
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D475/00—Heterocyclic compounds containing pteridine ring systems
- C07D475/06—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4
- C07D475/08—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4 with a nitrogen atom directly attached in position 2
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- G—PHYSICS
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- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
- G01N33/60—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances involving radioactive labelled substances
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
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- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
Landscapes
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- Health & Medical Sciences (AREA)
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- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12167126 | 2012-05-08 | ||
| EP12167126.7 | 2012-05-08 | ||
| PCT/EP2013/059584 WO2013167653A1 (en) | 2012-05-08 | 2013-05-08 | 18f-labelled folate/antifolate analogues |
Publications (2)
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| CA3057042A1 (en) | 2017-03-20 | 2018-09-27 | Merck Patent Gmbh | Isomerically pure 18f-labelled tetrahydrofolates |
| EP3671511B1 (en) | 2018-12-19 | 2022-07-06 | Rohde & Schwarz GmbH & Co. KG | Communication system and method |
| DE102019110904B4 (de) * | 2019-04-26 | 2022-01-20 | Helmholtz-Zentrum Dresden - Rossendorf E. V. | N-(4-methoxy-7-morpholinobenzo[d]thiazol-2-yl)-acetamid-Derivate und deren Verwendung |
| WO2021257863A1 (en) | 2020-06-19 | 2021-12-23 | Incyte Corporation | Pyrrolotriazine compounds as jak2 v617f inhibitors |
| WO2021257857A1 (en) | 2020-06-19 | 2021-12-23 | Incyte Corporation | Naphthyridinone compounds as jak2 v617f inhibitors |
| US11767323B2 (en) | 2020-07-02 | 2023-09-26 | Incyte Corporation | Tricyclic pyridone compounds as JAK2 V617F inhibitors |
| WO2022006457A1 (en) | 2020-07-02 | 2022-01-06 | Incyte Corporation | Tricyclic urea compounds as jak2 v617f inhibitors |
| WO2022046989A1 (en) | 2020-08-27 | 2022-03-03 | Incyte Corporation | Tricyclic urea compounds as jak2 v617f inhibitors |
| US11919908B2 (en) | 2020-12-21 | 2024-03-05 | Incyte Corporation | Substituted pyrrolo[2,3-d]pyrimidine compounds as JAK2 V617F inhibitors |
| WO2022182839A1 (en) | 2021-02-25 | 2022-09-01 | Incyte Corporation | Spirocyclic lactams as jak2 v617f inhibitors |
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| RU2007128036A (ru) | 2004-12-23 | 2009-01-27 | Пердью Рисерч Фаундейшн (Us) | Способ получения изображения позитронно-эмиссионной томографией |
| JP4503039B2 (ja) | 2006-04-27 | 2010-07-14 | 三洋電機株式会社 | 回路装置 |
| EP2109466B1 (en) | 2007-02-07 | 2014-11-12 | Purdue Research Foundation | Positron emission tomography imaging method |
| CN101646639A (zh) | 2007-04-11 | 2010-02-10 | 默克阿泼洛发股份公司 | 18f-标记的叶酸 |
| AU2008237935B2 (en) | 2007-04-11 | 2014-03-27 | Merck & Cie | Folate-conjugates and corresponding metal-chelate complexes for use in diagnostic imaging and radiotherapy |
| AU2008237932C1 (en) | 2007-04-11 | 2014-04-24 | Merck & Cie | 18 F-labelled folates |
| PT2346870E (pt) | 2008-10-10 | 2015-10-21 | Merck & Cie | Folatos marcados com 18f como marcadores radioactivos de pet |
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| WO2008125617A2 (en) * | 2007-04-11 | 2008-10-23 | Merck Eprova Ag | 18f-labelled folates |
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| ROBERTS, E. C. ET AL., J. Med. Chem., 1972, Vol. 15 (12), pages 1310-1312 * |
Also Published As
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| PL2864329T3 (pl) | 2019-03-29 |
| JP6198814B2 (ja) | 2017-09-20 |
| TR201819802T4 (tr) | 2019-01-21 |
| CN104379585A (zh) | 2015-02-25 |
| IL235476A0 (en) | 2014-12-31 |
| AU2013258027A1 (en) | 2014-11-13 |
| CA2870124C (en) | 2021-02-16 |
| CN104379585B (zh) | 2018-07-06 |
| SG11201406481TA (en) | 2014-11-27 |
| KR20150010970A (ko) | 2015-01-29 |
| EP2864329B1 (en) | 2018-09-26 |
| PT2864329T (pt) | 2019-01-10 |
| WO2013167653A1 (en) | 2013-11-14 |
| EP2864329A1 (en) | 2015-04-29 |
| DK2864329T3 (en) | 2019-01-21 |
| CA2870124A1 (en) | 2013-11-14 |
| EA201401225A1 (ru) | 2015-04-30 |
| IL235476B (en) | 2019-09-26 |
| HK1202548A1 (en) | 2015-10-02 |
| US10357576B2 (en) | 2019-07-23 |
| ZA201407266B (en) | 2016-09-28 |
| ES2703627T3 (es) | 2019-03-11 |
| KR102116000B1 (ko) | 2020-05-29 |
| JP2015516405A (ja) | 2015-06-11 |
| US20150125390A1 (en) | 2015-05-07 |
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