PT2862860T - Compostos de 1,3-oxazolidina ou 1,3-oxazinano como antagonistas do recetor de orexina - Google Patents
Compostos de 1,3-oxazolidina ou 1,3-oxazinano como antagonistas do recetor de orexinaInfo
- Publication number
- PT2862860T PT2862860T PT138048764T PT13804876T PT2862860T PT 2862860 T PT2862860 T PT 2862860T PT 138048764 T PT138048764 T PT 138048764T PT 13804876 T PT13804876 T PT 13804876T PT 2862860 T PT2862860 T PT 2862860T
- Authority
- PT
- Portugal
- Prior art keywords
- oxazinane
- oxazolidine
- compounds
- receptor antagonists
- orexin receptor
- Prior art date
Links
- LQPOOAJESJYDLS-UHFFFAOYSA-N 1,3-oxazinane Chemical class C1CNCOC1 LQPOOAJESJYDLS-UHFFFAOYSA-N 0.000 title 1
- 229940123730 Orexin receptor antagonist Drugs 0.000 title 1
- WYNCHZVNFNFDNH-UHFFFAOYSA-N Oxazolidine Chemical compound C1COCN1 WYNCHZVNFNFDNH-UHFFFAOYSA-N 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5355—Non-condensed oxazines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P25/04—Centrally acting analgesics, e.g. opioids
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- A61P37/00—Drugs for immunological or allergic disorders
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Diabetes (AREA)
- Immunology (AREA)
- Obesity (AREA)
- Cardiology (AREA)
- Addiction (AREA)
- Heart & Thoracic Surgery (AREA)
- Psychology (AREA)
- Hematology (AREA)
- Anesthesiology (AREA)
- Rheumatology (AREA)
- Child & Adolescent Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Endocrinology (AREA)
- Nutrition Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2012135277 | 2012-06-15 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT2862860T true PT2862860T (pt) | 2017-03-13 |
Family
ID=49758285
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT138048764T PT2862860T (pt) | 2012-06-15 | 2013-06-13 | Compostos de 1,3-oxazolidina ou 1,3-oxazinano como antagonistas do recetor de orexina |
Country Status (31)
| Country | Link |
|---|---|
| US (1) | US9266870B2 (en:Method) |
| EP (1) | EP2862860B1 (en:Method) |
| JP (1) | JP5896319B2 (en:Method) |
| KR (1) | KR102098977B1 (en:Method) |
| CN (1) | CN104350053B (en:Method) |
| AU (1) | AU2013275210B2 (en:Method) |
| BR (1) | BR112014031360B1 (en:Method) |
| CA (1) | CA2876253C (en:Method) |
| CY (1) | CY1118848T1 (en:Method) |
| DK (1) | DK2862860T3 (en:Method) |
| ES (1) | ES2613663T3 (en:Method) |
| HR (1) | HRP20161797T1 (en:Method) |
| HU (1) | HUE031538T2 (en:Method) |
| IL (1) | IL236140A (en:Method) |
| IN (1) | IN2014DN10490A (en:Method) |
| LT (1) | LT2862860T (en:Method) |
| ME (1) | ME02606B (en:Method) |
| MX (1) | MX355660B (en:Method) |
| MY (1) | MY171464A (en:Method) |
| NZ (1) | NZ702647A (en:Method) |
| PH (1) | PH12014502750B1 (en:Method) |
| PL (1) | PL2862860T3 (en:Method) |
| PT (1) | PT2862860T (en:Method) |
| RS (1) | RS55675B1 (en:Method) |
| RU (1) | RU2639869C2 (en:Method) |
| SG (1) | SG11201408327XA (en:Method) |
| SI (1) | SI2862860T1 (en:Method) |
| SM (1) | SMT201700141T1 (en:Method) |
| TW (1) | TWI583683B (en:Method) |
| WO (1) | WO2013187467A1 (en:Method) |
| ZA (1) | ZA201409168B (en:Method) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ME02437B (me) | 2009-10-23 | 2016-09-20 | Janssen Pharmaceutica Nv | Disupstituirani oktahidropirolo[3,4-c]piroli kao modulatori oreksin receptora |
| JP2017024990A (ja) * | 2013-12-13 | 2017-02-02 | 大正製薬株式会社 | オキサゾリジン及びオキサジナン誘導体 |
| JP5907310B2 (ja) * | 2013-12-13 | 2016-04-26 | 大正製薬株式会社 | オキサジナン化合物の結晶形及びその製造方法 |
| CN104370755B (zh) * | 2014-08-18 | 2017-04-12 | 江西隆莱生物制药有限公司 | 一种光学活性的3‑氨基丁醇和3‑氨基丁酸的制备方法 |
| JP2018188364A (ja) * | 2015-10-02 | 2018-11-29 | 大正製薬株式会社 | 複素芳香環誘導体 |
| IL288321B2 (en) | 2016-03-10 | 2025-08-01 | Janssen Pharmaceutica Nv | Methods of treating depression using orexin-2 receptor antagonists |
| CN108129426B (zh) * | 2016-12-01 | 2021-06-29 | 中国科学院大连化学物理研究所 | 一种2,5-二氰基呋喃催化加氢合成2,5-二甲胺基呋喃的方法 |
| JOP20190156B1 (ar) * | 2016-12-23 | 2023-09-17 | Bayer Pharma AG | أميدات عطرية لحمض الكربوكسيليك بصفتها مضادات لمستقبلة البراديكينين b1 |
| JP7178002B2 (ja) * | 2017-07-13 | 2022-11-25 | 大正製薬株式会社 | （２ｓ）－２－［（１ｈ－ピラゾール－１－イル）メチル］－１，３－オキサジナン誘導体の製造方法 |
| CN110967321A (zh) * | 2018-09-29 | 2020-04-07 | 泰州医药城国科化物生物医药科技有限公司 | 一种用于均一体系细胞荧光检测钙流方法 |
| CN115968403A (zh) | 2020-05-22 | 2023-04-14 | 纽卫制药有限公司 | 用于治疗脑白质营养不良的vlp |
| CN113336655A (zh) * | 2020-12-30 | 2021-09-03 | 江西迪赛诺制药有限公司 | 一种(r)-3-氨基丁醇的制备方法 |
| CN116925022B (zh) * | 2023-07-06 | 2025-08-01 | 江苏信和生物医药有限公司 | 一种(s)-5-烯丙基-2-氧杂双环[3.3.0]辛-8-烯的制备方法 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0115862D0 (en) * | 2001-06-28 | 2001-08-22 | Smithkline Beecham Plc | Compounds |
| US7169744B2 (en) * | 2002-06-06 | 2007-01-30 | Procter & Gamble Company | Organic catalyst with enhanced solubility |
| JP5205274B2 (ja) * | 2006-11-22 | 2013-06-05 | 日本農薬株式会社 | 新規なピラゾール誘導体、有害生物防除剤及びその使用方法 |
| WO2008108991A1 (en) * | 2007-03-02 | 2008-09-12 | Merck & Co., Inc. | Bipyridine carboxamide orexin receptor antagonists |
| CN101679366B (zh) * | 2007-05-23 | 2013-08-07 | 默沙东公司 | 吡啶基哌啶食欲素受体拮抗剂 |
| AU2008284268A1 (en) * | 2007-08-09 | 2009-02-12 | Merck & Co., Inc. | Pyridine carboxamide orexin receptor antagonists |
| WO2010038200A1 (en) * | 2008-10-01 | 2010-04-08 | Actelion Pharmaceuticals Ltd | Oxazolidine compounds as orexin receptor antagonists |
| WO2010044054A1 (en) * | 2008-10-14 | 2010-04-22 | Actelion Pharmaceuticals Ltd | Phenethylamide derivatives and their heterocyclic analogues |
| WO2010048013A1 (en) * | 2008-10-21 | 2010-04-29 | Merck Sharp & Dohme Corp. | 2,5-disubstituted morpholine orexin receptor antagonists |
| US8399494B2 (en) | 2008-10-30 | 2013-03-19 | Merck Sharp & Dohme Corp. | 2,5-disubstituted phenyl carboxamide orexin receptor antagonists |
| JP5635991B2 (ja) | 2008-10-30 | 2014-12-03 | メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． | イソニコチンアミドオレキシン受容体アンタゴニスト |
| TW201307320A (zh) * | 2010-12-17 | 2013-02-16 | 大正製藥股份有限公司 | 吡唑衍生物 |
| JPWO2012153729A1 (ja) | 2011-05-10 | 2014-07-31 | 大正製薬株式会社 | ヘテロ芳香環誘導体 |
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2013
- 2013-06-13 IN IN10490DEN2014 patent/IN2014DN10490A/en unknown
- 2013-06-13 DK DK13804876.4T patent/DK2862860T3/en active
- 2013-06-13 JP JP2014521401A patent/JP5896319B2/ja active Active
- 2013-06-13 CN CN201380031372.4A patent/CN104350053B/zh active Active
- 2013-06-13 ES ES13804876.4T patent/ES2613663T3/es active Active
- 2013-06-13 PL PL13804876T patent/PL2862860T3/pl unknown
- 2013-06-13 MX MX2014015077A patent/MX355660B/es active IP Right Grant
- 2013-06-13 PT PT138048764T patent/PT2862860T/pt unknown
- 2013-06-13 BR BR112014031360-1A patent/BR112014031360B1/pt active IP Right Grant
- 2013-06-13 ME MEP-2017-34A patent/ME02606B/me unknown
- 2013-06-13 HU HUE13804876A patent/HUE031538T2/en unknown
- 2013-06-13 RU RU2015101102A patent/RU2639869C2/ru active
- 2013-06-13 SM SM20170141T patent/SMT201700141T1/it unknown
- 2013-06-13 CA CA2876253A patent/CA2876253C/en active Active
- 2013-06-13 SI SI201330457A patent/SI2862860T1/sl unknown
- 2013-06-13 RS RS20170123A patent/RS55675B1/sr unknown
- 2013-06-13 EP EP13804876.4A patent/EP2862860B1/en active Active
- 2013-06-13 NZ NZ702647A patent/NZ702647A/en unknown
- 2013-06-13 MY MYPI2014703693A patent/MY171464A/en unknown
- 2013-06-13 SG SG11201408327XA patent/SG11201408327XA/en unknown
- 2013-06-13 US US14/407,353 patent/US9266870B2/en active Active
- 2013-06-13 WO PCT/JP2013/066322 patent/WO2013187467A1/ja not_active Ceased
- 2013-06-13 HR HRP20161797TT patent/HRP20161797T1/hr unknown
- 2013-06-13 LT LTEP13804876.4T patent/LT2862860T/lt unknown
- 2013-06-13 AU AU2013275210A patent/AU2013275210B2/en active Active
- 2013-06-13 KR KR1020147035124A patent/KR102098977B1/ko active Active
- 2013-06-14 TW TW102121127A patent/TWI583683B/zh active
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2014
- 2014-12-08 IL IL236140A patent/IL236140A/en active IP Right Grant
- 2014-12-09 PH PH12014502750A patent/PH12014502750B1/en unknown
- 2014-12-12 ZA ZA2014/09168A patent/ZA201409168B/en unknown
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2017
- 2017-03-08 CY CY20171100300T patent/CY1118848T1/el unknown
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