PT2723176T - Dipéptido química e metabolicamente estável que possui potente atividade bloqueadora do canal de sódio - Google Patents
Dipéptido química e metabolicamente estável que possui potente atividade bloqueadora do canal de sódioInfo
- Publication number
- PT2723176T PT2723176T PT128039245T PT12803924T PT2723176T PT 2723176 T PT2723176 T PT 2723176T PT 128039245 T PT128039245 T PT 128039245T PT 12803924 T PT12803924 T PT 12803924T PT 2723176 T PT2723176 T PT 2723176T
- Authority
- PT
- Portugal
- Prior art keywords
- chemically
- sodium channel
- channel blocker
- metabolically stable
- blocker activity
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D241/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with nitrogen atoms directly attached to ring carbon atoms
- C07D241/28—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with nitrogen atoms directly attached to ring carbon atoms in which said hetero-bound carbon atoms have double bonds to oxygen, sulfur or nitrogen atoms
- C07D241/30—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with nitrogen atoms directly attached to ring carbon atoms in which said hetero-bound carbon atoms have double bonds to oxygen, sulfur or nitrogen atoms in which said hetero-bound carbon atoms are part of a substructure —C(=X)—X—C(=X)—X— in which X is an oxygen or sulphur atom or an imino radical, e.g. imidoylguanidines
- C07D241/32—(Amino-pyrazinoyl) guanidines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Hematology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161501524P | 2011-06-27 | 2011-06-27 |
Publications (1)
Publication Number | Publication Date |
---|---|
PT2723176T true PT2723176T (pt) | 2017-07-18 |
Family
ID=47424521
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT128039245T PT2723176T (pt) | 2011-06-27 | 2012-06-27 | Dipéptido química e metabolicamente estável que possui potente atividade bloqueadora do canal de sódio |
Country Status (13)
Country | Link |
---|---|
US (4) | US9072738B2 (pt) |
EP (1) | EP2723176B1 (pt) |
CN (1) | CN103687488B (pt) |
BR (1) | BR112013032771B1 (pt) |
CA (1) | CA2839709C (pt) |
DK (1) | DK2723176T3 (pt) |
ES (1) | ES2633177T3 (pt) |
HR (1) | HRP20171044T1 (pt) |
HU (1) | HUE032851T2 (pt) |
PL (1) | PL2723176T3 (pt) |
PT (1) | PT2723176T (pt) |
SI (1) | SI2723176T1 (pt) |
WO (1) | WO2013003444A1 (pt) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6858615B2 (en) | 2002-02-19 | 2005-02-22 | Parion Sciences, Inc. | Phenyl guanidine sodium channel blockers |
EP2723176B1 (en) | 2011-06-27 | 2017-04-12 | Parion Sciences, Inc. | A chemically and metabolically stable dipeptide possessing potent sodium channel blocker activity |
AR086745A1 (es) | 2011-06-27 | 2014-01-22 | Parion Sciences Inc | 3,5-diamino-6-cloro-n-(n-(4-(4-(2-(hexil(2,3,4,5,6-pentahidroxihexil)amino)etoxi)fenil)butil)carbamimidoil)pirazina-2-carboxamida |
CN106279110B (zh) | 2011-11-02 | 2019-12-10 | 勃林格殷格翰国际有限公司 | 杂环化合物、含有所述化合物的药物及其用途和其制备方法 |
KR20140095057A (ko) | 2011-11-02 | 2014-07-31 | 베링거 인겔하임 인터내셔날 게엠베하 | 아실구아니딘 및 아실티오우레아의 신규한 제조방법 |
US8859559B2 (en) | 2011-12-20 | 2014-10-14 | Boehringer Ingelheim International Gmbh | Substituted pyrazines and their use in the treatment of disease |
WO2013174757A1 (en) | 2012-05-25 | 2013-11-28 | Boehringer Ingelheim International Gmbh | Tertiary amines, medicaments containing said amines, use thereof and processes for the preparation thereof |
US8980898B2 (en) | 2012-05-29 | 2015-03-17 | Parion Sciences, Inc. | Dendrimer like amino amides possessing sodium channel blocker activity for the treatment of dry eye and other mucosal diseases |
WO2014044849A1 (en) | 2012-09-24 | 2014-03-27 | Boehringer Ingelheim International Gmbh | Heterocyclic compounds, medicaments containing said compounds, use thereof and processes for the preparation thereof |
RU2671976C2 (ru) | 2012-12-17 | 2018-11-08 | Пэрион Сайенсиз, Инк. | Соединения 3,5-диамино-6-хлор-n-(n-(4-фенилбутил)карбамимидоил)пиразин-2-карбоксамида |
CN108484513A (zh) | 2012-12-17 | 2018-09-04 | 帕里昂科学公司 | 可用于治疗由黏膜水化不足造成的疾病的氯-吡嗪甲酰胺衍生物 |
JP6596421B2 (ja) | 2013-08-23 | 2019-10-23 | パリオン・サイエンシィズ・インコーポレーテッド | ジチオール粘液溶解薬 |
US9102633B2 (en) | 2013-12-13 | 2015-08-11 | Parion Sciences, Inc. | Arylalkyl- and aryloxyalkyl-substituted epithelial sodium channel blocking compounds |
US20150376145A1 (en) | 2014-06-30 | 2015-12-31 | Parion Sciences, Inc. | Stable sodium channel blockers |
CN107614480B (zh) | 2015-01-30 | 2020-09-15 | 帕里昂科学公司 | 新型单硫醇粘液溶解剂 |
CA2984424A1 (en) | 2015-04-30 | 2016-11-03 | Parion Sciences, Inc. | Novel prodrugs of dithiol mucolytic agents |
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JPS6034925B2 (ja) | 1979-07-31 | 1985-08-12 | 帝人株式会社 | 持続性鼻腔用製剤およびその製造法 |
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JPS6032714A (ja) | 1983-08-01 | 1985-02-19 | Teijin Ltd | 鼻腔粘膜に適用するための安定化された粉末状薬学的組成物 |
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US5292498A (en) | 1991-06-19 | 1994-03-08 | The University Of North Carolina At Chapel Hill | Method of treating lung disease with uridine triphosphates |
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US5785049A (en) | 1994-09-21 | 1998-07-28 | Inhale Therapeutic Systems | Method and apparatus for dispersion of dry powder medicaments |
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US5656256A (en) | 1994-12-14 | 1997-08-12 | The University Of North Carolina At Chapel Hill | Methods of treating lung disease by an aerosol containing benzamil or phenamil |
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US6858615B2 (en) | 2002-02-19 | 2005-02-22 | Parion Sciences, Inc. | Phenyl guanidine sodium channel blockers |
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KR20070052317A (ko) | 2004-08-18 | 2007-05-21 | 마이클 알 존슨. | 환형 아미드 및 에스테르 피라지노일구아니딘 나트륨 채널차단제 |
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CA2653773A1 (en) | 2006-06-09 | 2007-12-21 | Parion Sciences, Inc. | Cyclic substituted pyrazinoylguanidine sodium channel blockers possessing beta agonist activity |
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DK2035004T3 (en) | 2006-06-09 | 2013-01-02 | Parion Sciences Inc | Phenylsubstituerede pyrazinoylguanidin-natriumkanalblokkere med beta-agonistaktivitet |
US8058278B2 (en) | 2006-09-07 | 2011-11-15 | Parion Sciences, Inc. | Methods of enhancing mucosal hydration and mucosal clearance by treatment with sodium channel blockers and osmolytes |
AR062742A1 (es) | 2006-09-07 | 2008-12-03 | Johnson Michael R | Hidratacion de la mucosa y depuracion de la mucosa aumentadas por tratamiento con bloquadores de canales de sodio y osmolitos |
US8288391B2 (en) | 2007-04-03 | 2012-10-16 | Parion Sciences, Inc. | Pyrazinoylguanidine compounds for use as taste modulators |
WO2008124496A1 (en) | 2007-04-03 | 2008-10-16 | Parion Sciences, Inc. | Method of treating acid-sensing ion channel mediated pain, cough, and central nervous system disorders |
EP2211956A4 (en) | 2007-10-10 | 2014-07-09 | Parion Sciences Inc | DISPOSAL OF OSMOLYTES WITH A NOSE CANNULA |
EP2257296B1 (en) | 2008-02-26 | 2014-05-07 | Parion Sciences, Inc. | Poly aromatic sodium channel blockers |
US20100074881A1 (en) | 2008-07-11 | 2010-03-25 | Parion Sciences, Inc. | Multiple nebulizer systems |
AR086745A1 (es) | 2011-06-27 | 2014-01-22 | Parion Sciences Inc | 3,5-diamino-6-cloro-n-(n-(4-(4-(2-(hexil(2,3,4,5,6-pentahidroxihexil)amino)etoxi)fenil)butil)carbamimidoil)pirazina-2-carboxamida |
EP2723176B1 (en) | 2011-06-27 | 2017-04-12 | Parion Sciences, Inc. | A chemically and metabolically stable dipeptide possessing potent sodium channel blocker activity |
US8980898B2 (en) | 2012-05-29 | 2015-03-17 | Parion Sciences, Inc. | Dendrimer like amino amides possessing sodium channel blocker activity for the treatment of dry eye and other mucosal diseases |
RU2671976C2 (ru) | 2012-12-17 | 2018-11-08 | Пэрион Сайенсиз, Инк. | Соединения 3,5-диамино-6-хлор-n-(n-(4-фенилбутил)карбамимидоил)пиразин-2-карбоксамида |
CN108484513A (zh) | 2012-12-17 | 2018-09-04 | 帕里昂科学公司 | 可用于治疗由黏膜水化不足造成的疾病的氯-吡嗪甲酰胺衍生物 |
-
2012
- 2012-06-27 EP EP12803924.5A patent/EP2723176B1/en active Active
- 2012-06-27 CN CN201280031699.7A patent/CN103687488B/zh not_active Expired - Fee Related
- 2012-06-27 WO PCT/US2012/044372 patent/WO2013003444A1/en active Application Filing
- 2012-06-27 DK DK12803924.5T patent/DK2723176T3/en active
- 2012-06-27 PL PL12803924T patent/PL2723176T3/pl unknown
- 2012-06-27 ES ES12803924.5T patent/ES2633177T3/es active Active
- 2012-06-27 CA CA2839709A patent/CA2839709C/en active Active
- 2012-06-27 BR BR112013032771-5A patent/BR112013032771B1/pt active IP Right Grant
- 2012-06-27 SI SI201231012T patent/SI2723176T1/sl unknown
- 2012-06-27 US US14/129,734 patent/US9072738B2/en active Active
- 2012-06-27 HU HUE12803924A patent/HUE032851T2/en unknown
- 2012-06-27 PT PT128039245T patent/PT2723176T/pt unknown
-
2015
- 2015-01-12 US US14/594,744 patent/US9655896B2/en active Active
-
2017
- 2017-04-12 US US15/485,361 patent/US20170281620A1/en not_active Abandoned
- 2017-07-10 HR HRP20171044TT patent/HRP20171044T1/hr unknown
- 2017-12-15 US US15/843,404 patent/US10159672B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
HRP20171044T1 (hr) | 2017-10-06 |
WO2013003444A1 (en) | 2013-01-03 |
HUE032851T2 (en) | 2017-11-28 |
US20180104241A1 (en) | 2018-04-19 |
US9072738B2 (en) | 2015-07-07 |
BR112013032771B1 (pt) | 2021-01-12 |
CN103687488A (zh) | 2014-03-26 |
US20170281620A1 (en) | 2017-10-05 |
EP2723176A4 (en) | 2014-11-12 |
PL2723176T3 (pl) | 2018-01-31 |
SI2723176T1 (sl) | 2017-09-29 |
EP2723176A1 (en) | 2014-04-30 |
US20150290189A1 (en) | 2015-10-15 |
CA2839709C (en) | 2020-01-14 |
BR112013032771A2 (pt) | 2016-08-16 |
US9655896B2 (en) | 2017-05-23 |
DK2723176T3 (en) | 2017-07-31 |
ES2633177T3 (es) | 2017-09-19 |
US10159672B2 (en) | 2018-12-25 |
CN103687488B (zh) | 2015-06-10 |
CA2839709A1 (en) | 2013-01-03 |
US20140142118A1 (en) | 2014-05-22 |
EP2723176B1 (en) | 2017-04-12 |
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