PT2723176T - Dipéptido química e metabolicamente estável que possui potente atividade bloqueadora do canal de sódio - Google Patents

Dipéptido química e metabolicamente estável que possui potente atividade bloqueadora do canal de sódio

Info

Publication number
PT2723176T
PT2723176T PT128039245T PT12803924T PT2723176T PT 2723176 T PT2723176 T PT 2723176T PT 128039245 T PT128039245 T PT 128039245T PT 12803924 T PT12803924 T PT 12803924T PT 2723176 T PT2723176 T PT 2723176T
Authority
PT
Portugal
Prior art keywords
chemically
sodium channel
channel blocker
metabolically stable
blocker activity
Prior art date
Application number
PT128039245T
Other languages
English (en)
Inventor
Ross Johnson Michael
Original Assignee
Parion Sciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Parion Sciences Inc filed Critical Parion Sciences Inc
Publication of PT2723176T publication Critical patent/PT2723176T/pt

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965Non-condensed pyrazines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D241/00Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/24Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D241/26Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with nitrogen atoms directly attached to ring carbon atoms
    • C07D241/28Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with nitrogen atoms directly attached to ring carbon atoms in which said hetero-bound carbon atoms have double bonds to oxygen, sulfur or nitrogen atoms
    • C07D241/30Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with nitrogen atoms directly attached to ring carbon atoms in which said hetero-bound carbon atoms have double bonds to oxygen, sulfur or nitrogen atoms in which said hetero-bound carbon atoms are part of a substructure —C(=X)—X—C(=X)—X— in which X is an oxygen or sulphur atom or an imino radical, e.g. imidoylguanidines
    • C07D241/32(Amino-pyrazinoyl) guanidines
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06Dipeptides
    • C07K5/06008Dipeptides with the first amino acid being neutral
    • C07K5/06078Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
PT128039245T 2011-06-27 2012-06-27 Dipéptido química e metabolicamente estável que possui potente atividade bloqueadora do canal de sódio PT2723176T (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201161501524P 2011-06-27 2011-06-27

Publications (1)

Publication Number Publication Date
PT2723176T true PT2723176T (pt) 2017-07-18

Family

ID=47424521

Family Applications (1)

Application Number Title Priority Date Filing Date
PT128039245T PT2723176T (pt) 2011-06-27 2012-06-27 Dipéptido química e metabolicamente estável que possui potente atividade bloqueadora do canal de sódio

Country Status (13)

Country Link
US (4) US9072738B2 (pt)
EP (1) EP2723176B1 (pt)
CN (1) CN103687488B (pt)
BR (1) BR112013032771B1 (pt)
CA (1) CA2839709C (pt)
DK (1) DK2723176T3 (pt)
ES (1) ES2633177T3 (pt)
HR (1) HRP20171044T1 (pt)
HU (1) HUE032851T2 (pt)
PL (1) PL2723176T3 (pt)
PT (1) PT2723176T (pt)
SI (1) SI2723176T1 (pt)
WO (1) WO2013003444A1 (pt)

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EP2723176B1 (en) 2011-06-27 2017-04-12 Parion Sciences, Inc. A chemically and metabolically stable dipeptide possessing potent sodium channel blocker activity
AR086745A1 (es) 2011-06-27 2014-01-22 Parion Sciences Inc 3,5-diamino-6-cloro-n-(n-(4-(4-(2-(hexil(2,3,4,5,6-pentahidroxihexil)amino)etoxi)fenil)butil)carbamimidoil)pirazina-2-carboxamida
CN106279110B (zh) 2011-11-02 2019-12-10 勃林格殷格翰国际有限公司 杂环化合物、含有所述化合物的药物及其用途和其制备方法
KR20140095057A (ko) 2011-11-02 2014-07-31 베링거 인겔하임 인터내셔날 게엠베하 아실구아니딘 및 아실티오우레아의 신규한 제조방법
US8859559B2 (en) 2011-12-20 2014-10-14 Boehringer Ingelheim International Gmbh Substituted pyrazines and their use in the treatment of disease
WO2013174757A1 (en) 2012-05-25 2013-11-28 Boehringer Ingelheim International Gmbh Tertiary amines, medicaments containing said amines, use thereof and processes for the preparation thereof
US8980898B2 (en) 2012-05-29 2015-03-17 Parion Sciences, Inc. Dendrimer like amino amides possessing sodium channel blocker activity for the treatment of dry eye and other mucosal diseases
WO2014044849A1 (en) 2012-09-24 2014-03-27 Boehringer Ingelheim International Gmbh Heterocyclic compounds, medicaments containing said compounds, use thereof and processes for the preparation thereof
RU2671976C2 (ru) 2012-12-17 2018-11-08 Пэрион Сайенсиз, Инк. Соединения 3,5-диамино-6-хлор-n-(n-(4-фенилбутил)карбамимидоил)пиразин-2-карбоксамида
CN108484513A (zh) 2012-12-17 2018-09-04 帕里昂科学公司 可用于治疗由黏膜水化不足造成的疾病的氯-吡嗪甲酰胺衍生物
JP6596421B2 (ja) 2013-08-23 2019-10-23 パリオン・サイエンシィズ・インコーポレーテッド ジチオール粘液溶解薬
US9102633B2 (en) 2013-12-13 2015-08-11 Parion Sciences, Inc. Arylalkyl- and aryloxyalkyl-substituted epithelial sodium channel blocking compounds
US20150376145A1 (en) 2014-06-30 2015-12-31 Parion Sciences, Inc. Stable sodium channel blockers
CN107614480B (zh) 2015-01-30 2020-09-15 帕里昂科学公司 新型单硫醇粘液溶解剂
CA2984424A1 (en) 2015-04-30 2016-11-03 Parion Sciences, Inc. Novel prodrugs of dithiol mucolytic agents

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US8980898B2 (en) 2012-05-29 2015-03-17 Parion Sciences, Inc. Dendrimer like amino amides possessing sodium channel blocker activity for the treatment of dry eye and other mucosal diseases
RU2671976C2 (ru) 2012-12-17 2018-11-08 Пэрион Сайенсиз, Инк. Соединения 3,5-диамино-6-хлор-n-(n-(4-фенилбутил)карбамимидоил)пиразин-2-карбоксамида
CN108484513A (zh) 2012-12-17 2018-09-04 帕里昂科学公司 可用于治疗由黏膜水化不足造成的疾病的氯-吡嗪甲酰胺衍生物

Also Published As

Publication number Publication date
HRP20171044T1 (hr) 2017-10-06
WO2013003444A1 (en) 2013-01-03
HUE032851T2 (en) 2017-11-28
US20180104241A1 (en) 2018-04-19
US9072738B2 (en) 2015-07-07
BR112013032771B1 (pt) 2021-01-12
CN103687488A (zh) 2014-03-26
US20170281620A1 (en) 2017-10-05
EP2723176A4 (en) 2014-11-12
PL2723176T3 (pl) 2018-01-31
SI2723176T1 (sl) 2017-09-29
EP2723176A1 (en) 2014-04-30
US20150290189A1 (en) 2015-10-15
CA2839709C (en) 2020-01-14
BR112013032771A2 (pt) 2016-08-16
US9655896B2 (en) 2017-05-23
DK2723176T3 (en) 2017-07-31
ES2633177T3 (es) 2017-09-19
US10159672B2 (en) 2018-12-25
CN103687488B (zh) 2015-06-10
CA2839709A1 (en) 2013-01-03
US20140142118A1 (en) 2014-05-22
EP2723176B1 (en) 2017-04-12

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