PT2336124E - Hidrato estável de um antagonista de receptor muscarínico - Google Patents
Hidrato estável de um antagonista de receptor muscarínico Download PDFInfo
- Publication number
- PT2336124E PT2336124E PT101777167T PT10177716T PT2336124E PT 2336124 E PT2336124 E PT 2336124E PT 101777167 T PT101777167 T PT 101777167T PT 10177716 T PT10177716 T PT 10177716T PT 2336124 E PT2336124 E PT 2336124E
- Authority
- PT
- Portugal
- Prior art keywords
- hydrate
- bladder
- dihydrobenzofuran
- pyrrolidinyl
- urinary
- Prior art date
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- 239000003149 muscarinic antagonist Substances 0.000 title claims description 6
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Classifications
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Urology & Nephrology (AREA)
- Pulmonology (AREA)
- Pain & Pain Management (AREA)
- Neurology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
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| GBGB0207104.1A GB0207104D0 (en) | 2002-03-26 | 2002-03-26 | Stable hydrate of a muscarinic receptor antagonist |
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| PT2336124E true PT2336124E (pt) | 2012-12-12 |
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| PT101777167T PT2336124E (pt) | 2002-03-26 | 2003-03-17 | Hidrato estável de um antagonista de receptor muscarínico |
| PT03744716T PT1490357E (pt) | 2002-03-26 | 2003-03-17 | Hidrato estável de um antagonista de receptor muscarínico |
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| PT03744716T PT1490357E (pt) | 2002-03-26 | 2003-03-17 | Hidrato estável de um antagonista de receptor muscarínico |
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|---|---|
| US (3) | US6930188B2 (enExample) |
| EP (2) | EP2336124B1 (enExample) |
| JP (2) | JP2005524678A (enExample) |
| KR (4) | KR101212908B1 (enExample) |
| CN (1) | CN100345840C (enExample) |
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| AT (1) | ATE495169T1 (enExample) |
| AU (1) | AU2003209921A1 (enExample) |
| BR (2) | BRPI0308706B8 (enExample) |
| CA (1) | CA2480287C (enExample) |
| CY (2) | CY1111200T1 (enExample) |
| DE (1) | DE60335711D1 (enExample) |
| DK (2) | DK1490357T3 (enExample) |
| ES (2) | ES2394067T3 (enExample) |
| GB (1) | GB0207104D0 (enExample) |
| PA (1) | PA8569701A1 (enExample) |
| PT (2) | PT2336124E (enExample) |
| SI (2) | SI1490357T1 (enExample) |
| SV (1) | SV2003001515A (enExample) |
| TW (1) | TW200306816A (enExample) |
| UY (1) | UY27735A1 (enExample) |
| WO (1) | WO2003080599A1 (enExample) |
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| GB0207104D0 (en) * | 2002-03-26 | 2002-05-08 | Pfizer Ltd | Stable hydrate of a muscarinic receptor antagonist |
| US7244765B2 (en) * | 2004-06-25 | 2007-07-17 | Cytokine Pharmasciences, Inc | Guanylhydrazone salts, compositions, processes of making and methods of using |
| US20060258712A1 (en) * | 2005-04-24 | 2006-11-16 | Wyeth | Methods for modulating bladder function |
| EP1891034A2 (en) * | 2005-12-27 | 2008-02-27 | Teva Pharmaceutical Fine Chemicals S.R.L. | Processes for preparing darifenacin hydrobromide |
| EP2109601A2 (en) * | 2007-01-05 | 2009-10-21 | Dr. Reddy's Laboratories Ltd. | Preparation of darifenacin and its salts |
| RU2452728C2 (ru) * | 2007-02-23 | 2012-06-10 | Тереванс, Инк. | Четвертичные аммониевые дифенилметилсоединения, применимые в качестве антагонистов мускариновых рецепторов |
| US20090005309A1 (en) * | 2007-05-18 | 2009-01-01 | Auspex Pharmaceuticals, Inc. | Substituted piperidines |
| US20100204296A1 (en) * | 2007-06-08 | 2010-08-12 | Actavis Group Ptc Ehf | Novel Polymorphs of Darifenacin Free Base and its Hydrobromide Salt |
| WO2009006413A1 (en) * | 2007-06-30 | 2009-01-08 | Auspex Pharmaceuticals, Inc. | Substituted pyrrolidines |
| AR068322A1 (es) * | 2007-07-13 | 2009-11-11 | Medichem Sa | Forma amorfa de hidrobromuro de darifenacina y procedimientos para su preparacion |
| CZ300895B6 (cs) | 2008-01-28 | 2009-09-02 | Zentiva, A. S. | Zpusob prípravy Darifenacinu |
| WO2009125426A2 (en) * | 2008-02-08 | 2009-10-15 | Neuland Laboratories Ltd | NOVEL PROCESS FOR THE PREPARATION OF (3SM-[2-(2 J-DIHYDRO-5- BENZOFURANYLϊETHYL]-α.α -DIPHENYL-3-PYRROLIDINEACETAMIDE HYDROBROMIDE |
| EP2261205A4 (en) | 2008-04-02 | 2012-06-06 | Kaneka Corp | PROCESS FOR PRODUCING (S) -3- (1-CYANO-1,1-DIPHENYLMETHYL) -PYRROLIDINE |
| US20110144354A1 (en) * | 2008-09-22 | 2011-06-16 | Watson Pharma Private Limited | Process for Preparation of Darifenacin and Intermediates Used in the Process |
| EP2236509A1 (en) | 2009-04-01 | 2010-10-06 | Ragactives, S.L. | Method for obtaining 1,3-difunctionalized pyrrolidine derivatives |
| WO2011070419A1 (en) | 2009-12-10 | 2011-06-16 | Aurobindo Pharma Limited | An improved process for the preparation of darifenacin hydrobromide |
| JP6440625B2 (ja) | 2012-11-14 | 2018-12-19 | ザ・ジョンズ・ホプキンス・ユニバーシティー | 精神分裂病を処置するための方法および組成物 |
| WO2017106175A2 (en) * | 2015-12-14 | 2017-06-22 | Ironwood Pharmaceuticals, Inc. | USE OF sGC STIMULATORS FOR THE TREATMENT OF GASTROINTESTINAL SPHINCTER DYSFUNCTION |
| CN109641822B (zh) * | 2016-08-12 | 2022-03-11 | 拜耳作物科学股份公司 | 制备取代苯乙烯衍生物的方法 |
| CN111278503B (zh) * | 2017-09-12 | 2023-12-05 | Lts勒曼治疗系统股份公司 | 离子电渗微针装置 |
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| US5233053A (en) * | 1989-03-17 | 1993-08-03 | Pfizer Inc. | Pyrrolidine derivatives |
| GB8906166D0 (en) * | 1989-03-17 | 1989-05-04 | Pfizer Ltd | Therapeutic agents |
| US5376645A (en) | 1990-01-23 | 1994-12-27 | University Of Kansas | Derivatives of cyclodextrins exhibiting enhanced aqueous solubility and the use thereof |
| KR0166088B1 (ko) | 1990-01-23 | 1999-01-15 | . | 수용해도가 증가된 시클로덱스트린 유도체 및 이의 용도 |
| GB9400600D0 (en) | 1994-01-14 | 1994-03-09 | Pfizer Ltd | Treatment of motion seckness |
| GB9518953D0 (en) * | 1995-09-15 | 1995-11-15 | Pfizer Ltd | Pharmaceutical formulations |
| GB9612710D0 (en) * | 1996-06-18 | 1996-08-21 | Pfizer Ltd | Method of treatment |
| JP2001502302A (ja) * | 1996-09-19 | 2001-02-20 | アメリカン・ホーム・プロダクツ・コーポレイション | 尿失禁を治療する方法 |
| GB9711643D0 (en) | 1997-06-05 | 1997-07-30 | Janssen Pharmaceutica Nv | Glass thermoplastic systems |
| GB0207104D0 (en) * | 2002-03-26 | 2002-05-08 | Pfizer Ltd | Stable hydrate of a muscarinic receptor antagonist |
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2002
- 2002-03-26 GB GBGB0207104.1A patent/GB0207104D0/en not_active Ceased
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2003
- 2003-03-17 WO PCT/IB2003/001043 patent/WO2003080599A1/en not_active Ceased
- 2003-03-17 CN CNB038070847A patent/CN100345840C/zh not_active Expired - Lifetime
- 2003-03-17 KR KR1020117027931A patent/KR101212908B1/ko not_active Expired - Lifetime
- 2003-03-17 JP JP2003578353A patent/JP2005524678A/ja not_active Withdrawn
- 2003-03-17 AT AT03744716T patent/ATE495169T1/de active
- 2003-03-17 ES ES10177716T patent/ES2394067T3/es not_active Expired - Lifetime
- 2003-03-17 EP EP10177716A patent/EP2336124B1/en not_active Expired - Lifetime
- 2003-03-17 KR KR1020047015243A patent/KR101026283B1/ko not_active Expired - Lifetime
- 2003-03-17 AU AU2003209921A patent/AU2003209921A1/en not_active Abandoned
- 2003-03-17 PT PT101777167T patent/PT2336124E/pt unknown
- 2003-03-17 ES ES03744716T patent/ES2358644T3/es not_active Expired - Lifetime
- 2003-03-17 DK DK03744716.6T patent/DK1490357T3/da active
- 2003-03-17 SI SI200331973T patent/SI1490357T1/sl unknown
- 2003-03-17 PT PT03744716T patent/PT1490357E/pt unknown
- 2003-03-17 KR KR1020127018787A patent/KR20120098888A/ko not_active Ceased
- 2003-03-17 BR BRPI0308706A patent/BRPI0308706B8/pt not_active IP Right Cessation
- 2003-03-17 KR KR1020107018853A patent/KR20100101182A/ko not_active Ceased
- 2003-03-17 DE DE60335711T patent/DE60335711D1/de not_active Expired - Lifetime
- 2003-03-17 CA CA2480287A patent/CA2480287C/en not_active Expired - Lifetime
- 2003-03-17 SI SI200332215T patent/SI2336124T1/sl unknown
- 2003-03-17 EP EP03744716A patent/EP1490357B1/en not_active Expired - Lifetime
- 2003-03-17 BR BR122018000397A patent/BR122018000397B8/pt not_active IP Right Cessation
- 2003-03-17 DK DK10177716.7T patent/DK2336124T3/da active
- 2003-03-20 PA PA20038569701A patent/PA8569701A1/es unknown
- 2003-03-24 AR ARP030101017A patent/AR042608A1/es unknown
- 2003-03-25 SV SV2003001515A patent/SV2003001515A/es not_active Application Discontinuation
- 2003-03-25 TW TW092106635A patent/TW200306816A/zh unknown
- 2003-03-25 US US10/396,887 patent/US6930188B2/en not_active Expired - Lifetime
- 2003-03-25 UY UY27735A patent/UY27735A1/es not_active Application Discontinuation
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2005
- 2005-07-13 US US11/180,433 patent/US20050245597A1/en not_active Abandoned
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2008
- 2008-03-17 US US12/049,660 patent/US7696357B2/en not_active Expired - Lifetime
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2010
- 2010-06-02 JP JP2010126865A patent/JP2010195828A/ja active Pending
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2011
- 2011-02-22 CY CY20111100213T patent/CY1111200T1/el unknown
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2012
- 2012-11-29 CY CY20121101165T patent/CY1113433T1/el unknown
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