PT2300609E - Novos compostos imunoadjuvantes à base de flagelina e suas utilizações - Google Patents

Novos compostos imunoadjuvantes à base de flagelina e suas utilizações Download PDF

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Publication number
PT2300609E
PT2300609E PT97692545T PT09769254T PT2300609E PT 2300609 E PT2300609 E PT 2300609E PT 97692545 T PT97692545 T PT 97692545T PT 09769254 T PT09769254 T PT 09769254T PT 2300609 E PT2300609 E PT 2300609E
Authority
PT
Portugal
Prior art keywords
flagellin
based compounds
novel immunoadjuvant
immunoadjuvant
novel
Prior art date
Application number
PT97692545T
Other languages
English (en)
Inventor
Jean-Claude Sirard
Original Assignee
Inst Nat Sante Rech Med
Pasteur Institut
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Inst Nat Sante Rech Med, Pasteur Institut filed Critical Inst Nat Sante Rech Med
Publication of PT2300609E publication Critical patent/PT2300609E/pt

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
    • C07K14/255—Salmonella (G)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A61K2039/541—Mucosal route
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55516—Proteins; Peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Engineering & Computer Science (AREA)
  • Virology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Communicable Diseases (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
PT97692545T 2008-06-25 2009-06-23 Novos compostos imunoadjuvantes à base de flagelina e suas utilizações PT2300609E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP08305327 2008-06-25

Publications (1)

Publication Number Publication Date
PT2300609E true PT2300609E (pt) 2014-02-17

Family

ID=39967832

Family Applications (1)

Application Number Title Priority Date Filing Date
PT97692545T PT2300609E (pt) 2008-06-25 2009-06-23 Novos compostos imunoadjuvantes à base de flagelina e suas utilizações

Country Status (20)

Country Link
US (2) US9527891B2 (pt)
EP (2) EP2300609B1 (pt)
JP (2) JP5756750B2 (pt)
KR (1) KR101684447B1 (pt)
CN (2) CN102203252B (pt)
AU (1) AU2009264257B2 (pt)
BR (1) BRPI0914691A2 (pt)
CA (1) CA2728038A1 (pt)
CY (1) CY1114820T1 (pt)
DK (1) DK2300609T3 (pt)
EA (1) EA019138B1 (pt)
ES (1) ES2445798T3 (pt)
HR (1) HRP20140109T1 (pt)
IL (1) IL209781A (pt)
MX (1) MX2010014575A (pt)
PL (1) PL2300609T3 (pt)
PT (1) PT2300609E (pt)
RS (1) RS53158B (pt)
SI (1) SI2300609T1 (pt)
WO (1) WO2009156405A1 (pt)

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SI2300609T1 (sl) * 2008-06-25 2014-04-30 Inserm Institut National De La Sante Et De La Recherche Medicale Nove imunoadjuvantne spojine na osnovi flagelina in njihova uporaba
EP2536425B1 (en) 2010-02-18 2019-06-19 Icahn School of Medicine at Mount Sinai Vaccines for use in the prophylaxis and treatment of influenza virus disease
CA2792537A1 (en) 2010-03-30 2011-10-06 Mount Sinai School Of Medicine Influenza virus vaccines and uses thereof
GB201009273D0 (en) 2010-06-03 2010-07-21 Glaxosmithkline Biolog Sa Novel vaccine
EP2585094B1 (en) 2010-06-25 2018-08-01 INSERM - Institut National de la Santé et de la Recherche Médicale Flagellin polypeptide as tlr5 agonist for use in the treatment of respiratory tract infections
EP2758075B1 (en) 2011-09-20 2023-05-03 Icahn School of Medicine at Mount Sinai Influenza virus vaccines and uses thereof
EP2744549A1 (en) * 2011-10-04 2014-06-25 Koninklijke Philips N.V. Forehead gas supply assembly for a patient interface system
GB201119999D0 (en) * 2011-11-20 2012-01-04 Glaxosmithkline Biolog Sa Vaccine
GB201120000D0 (en) * 2011-11-20 2012-01-04 Glaxosmithkline Biolog Sa Vaccine
WO2013177440A2 (en) * 2012-05-23 2013-11-28 The Board Of Trustees Of The Leland Stanford Junior University Ordered flagellin array as an immunostimulant
RU2510281C2 (ru) * 2012-06-22 2014-03-27 Общество с ограниченной ответственностью "Эпитоп" (ООО "Эпитоп") ВАКЦИНА ПРОТИВ ПНЕВМОНИИ, ВЫЗЫВАЕМОЙ Streptococcus pneumoniae, НА ОСНОВЕ ГИБРИДНОГО БЕЛКА
JP2016508133A (ja) 2012-12-18 2016-03-17 アイカーン スクール オブ メディシン アット マウント サイナイ インフルエンザウイルスワクチン及びその使用
CN103055311B (zh) * 2012-12-28 2014-05-21 中山大学 一种传染性喉气管炎粘膜疫苗及其制备方法和应用
US9908930B2 (en) 2013-03-14 2018-03-06 Icahn School Of Medicine At Mount Sinai Antibodies against influenza virus hemagglutinin and uses thereof
WO2015011254A1 (en) * 2013-07-26 2015-01-29 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and pharmaceutical compositions for the treatment of bacterial infections
WO2015130584A2 (en) 2014-02-25 2015-09-03 Merck Sharp & Dohme Corp. Lipid nanoparticle vaccine adjuvants and antigen delivery systems
CN107207614B (zh) 2014-10-09 2022-01-11 利普泰克有限公司 嵌合蛋白
EP3236988B8 (en) * 2014-12-23 2020-08-19 INSERM (Institut National de la Santé et de la Recherche Médicale) Pharmaceutical compositions for the treatment of bacterial superinfections post-influenza
JP2018504412A (ja) 2015-01-23 2018-02-15 アイカーン スクール オブ メディシン アット マウント サイナイ インフルエンザウイルスワクチン接種レジメン
CN104610456A (zh) * 2015-01-27 2015-05-13 扬州大学 一种 h7n9 亚型禽流感亚单位疫苗的制备方法及应用
RU2015109715A (ru) * 2015-03-19 2015-08-20 Общество С Ограниченной Ответственностью "Рд-Биотех" (Ооо "Рд-Биотех") ПРОТИВОТУБЕРКУЛЕЗНАЯ ВАКЦИНА НА ОСНОВЕ РЕКОМБИНАНТНЫХ БЕЛКОВ Ag85B, TB10.4, FliC
EP3471767A4 (en) 2016-06-15 2020-01-15 Icahn School of Medicine at Mount Sinai INFLUENZA VIRUS HEMAGGLUTININS AND USES THEREOF
CN106362144B (zh) * 2016-10-31 2021-02-09 武汉三利生物技术有限公司 呼吸道合胞病毒疫苗
RU2647831C1 (ru) * 2017-03-15 2018-03-19 Федеральное государственное унитарное предприятие "Государственный научно-исследовательский институт особо чистых биопрепаратов" Федерального медико-биологического агентства Вакцина против туберкулеза
EP3606555A4 (en) 2017-04-07 2021-08-04 Icahn School of Medicine at Mount Sinai INFLUENZA VIRUS TYPE B ANTI-NEURAMINIDASE ANTIBODIES AND THEIR USES
EP3581201A1 (en) 2018-06-15 2019-12-18 GlaxoSmithKline Biologicals S.A. Escherichia coli o157:h7 proteins and uses thereof
EP3868399A4 (en) 2018-09-27 2022-07-20 Bravovax Co., Ltd. IMMUNE COMPOSITION, METHOD FOR PREPARATION AND ASSOCIATED APPLICATION
WO2020140973A1 (en) * 2019-01-03 2020-07-09 Nanjing Legend Biotech Co., Ltd. Modified immune cells expressing flagellin polypeptide
FR3114970B1 (fr) 2020-10-08 2023-06-30 Univ Tours Combinaison d’anticorps inhalés avec des agents immunomodulateurs pour le traitement ou la prévention d’inféctions respiratoires
US20240115688A1 (en) 2020-12-02 2024-04-11 Glaxosmithkline Biologicals Sa Novel Antigens
AU2022208435A1 (en) 2021-01-18 2023-08-10 Conserv Bioscience Limited Coronavirus immunogenic compositions, methods and uses thereof
KR20240027752A (ko) 2021-06-30 2024-03-04 인쎄름 (엥스띠뛰 나씨오날 드 라 쌍떼 에 드 라 흐쉐르슈 메디깔) 플라겔린의 폐 전달을 위한 에어로졸 조성물
CN114292314B (zh) * 2022-01-05 2022-08-09 武汉科前生物股份有限公司 一种鞭毛素突变体及其在制备非洲猪瘟抗原融合蛋白中的应用

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060257415A1 (en) * 2002-09-03 2006-11-16 Fondation Eurov Acc Adjuvants
WO2005077408A2 (en) * 2004-02-06 2005-08-25 Vaxinnate Corporation Compositions of pamps and listeria monocytogenes and methods of use
JP2007535924A (ja) * 2004-05-07 2007-12-13 − グスタフ ユングレン、ハンス ワクチン用アジュバントとしてのフラジェリンの使用
JP2008523818A (ja) * 2004-12-16 2008-07-10 ウェイク・フォレスト・ユニヴァーシティ・ヘルス・サイエンシズ 腫瘍免疫療法におけるフラジェリンの使用
MY157941A (en) * 2005-01-19 2016-08-15 Vaxinnate Corp Compositions of pathogen-associated molecular patterns and methods of use
ES2594102T3 (es) 2008-04-18 2016-12-15 Vaxinnate Corporation Mutantes por deleción de la flagelina y métodos para su uso
SI2300609T1 (sl) * 2008-06-25 2014-04-30 Inserm Institut National De La Sante Et De La Recherche Medicale Nove imunoadjuvantne spojine na osnovi flagelina in njihova uporaba

Also Published As

Publication number Publication date
US9527891B2 (en) 2016-12-27
EP2695941B1 (en) 2015-07-29
SI2300609T1 (sl) 2014-04-30
JP2015109837A (ja) 2015-06-18
PL2300609T3 (pl) 2014-05-30
IL209781A (en) 2013-11-28
CN102203252B (zh) 2016-08-03
RS53158B (en) 2014-06-30
EP2300609A1 (en) 2011-03-30
EP2695941A3 (en) 2014-03-05
AU2009264257B2 (en) 2013-11-07
KR101684447B1 (ko) 2016-12-08
CN102203252A (zh) 2011-09-28
US20110110962A1 (en) 2011-05-12
HRP20140109T1 (hr) 2014-03-14
BRPI0914691A2 (pt) 2015-10-20
AU2009264257A1 (en) 2009-12-30
WO2009156405A8 (en) 2010-03-25
JP5756750B2 (ja) 2015-07-29
US9956284B2 (en) 2018-05-01
CN103641898A (zh) 2014-03-19
MX2010014575A (es) 2011-06-17
WO2009156405A1 (en) 2009-12-30
CN103641898B (zh) 2018-04-17
EA201001820A1 (ru) 2011-08-30
IL209781A0 (en) 2011-02-28
EP2695941A2 (en) 2014-02-12
KR20110041479A (ko) 2011-04-21
DK2300609T3 (da) 2014-02-10
EA019138B1 (ru) 2014-01-30
JP2011525371A (ja) 2011-09-22
EP2300609B1 (en) 2013-11-20
WO2009156405A9 (en) 2010-08-19
JP6041851B2 (ja) 2016-12-14
CY1114820T1 (el) 2016-12-14
US20170021015A1 (en) 2017-01-26
ES2445798T3 (es) 2014-03-05
CA2728038A1 (en) 2009-12-30

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