PT2281078E - Bibliotecas de pacotes genéticos compreendendo desenhos de novas cdr1, cdr2, e cdr3 de hc e novas cdr1, cr2, e cdr3 de lc - Google Patents

Bibliotecas de pacotes genéticos compreendendo desenhos de novas cdr1, cdr2, e cdr3 de hc e novas cdr1, cr2, e cdr3 de lc Download PDF

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Publication number
PT2281078E
PT2281078E PT97357917T PT09735791T PT2281078E PT 2281078 E PT2281078 E PT 2281078E PT 97357917 T PT97357917 T PT 97357917T PT 09735791 T PT09735791 T PT 09735791T PT 2281078 E PT2281078 E PT 2281078E
Authority
PT
Portugal
Prior art keywords
cdr1
cdr2
novel
cdr3
libraries
Prior art date
Application number
PT97357917T
Other languages
English (en)
Portuguese (pt)
Original Assignee
Dyax Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dyax Corp filed Critical Dyax Corp
Publication of PT2281078E publication Critical patent/PT2281078E/pt

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/005—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies constructed by phage libraries
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/02—Libraries contained in or displayed by microorganisms, e.g. bacteria or animal cells; Libraries contained in or displayed by vectors, e.g. plasmids; Libraries containing only microorganisms or vectors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/06—Libraries containing nucleotides or polynucleotides, or derivatives thereof
    • C40B40/08—Libraries containing RNA or DNA which encodes proteins, e.g. gene libraries

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
PT97357917T 2008-04-24 2009-04-24 Bibliotecas de pacotes genéticos compreendendo desenhos de novas cdr1, cdr2, e cdr3 de hc e novas cdr1, cr2, e cdr3 de lc PT2281078E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US4752908P 2008-04-24 2008-04-24

Publications (1)

Publication Number Publication Date
PT2281078E true PT2281078E (pt) 2015-02-05

Family

ID=41217437

Family Applications (1)

Application Number Title Priority Date Filing Date
PT97357917T PT2281078E (pt) 2008-04-24 2009-04-24 Bibliotecas de pacotes genéticos compreendendo desenhos de novas cdr1, cdr2, e cdr3 de hc e novas cdr1, cr2, e cdr3 de lc

Country Status (10)

Country Link
US (4) US9388510B2 (enExample)
EP (1) EP2281078B1 (enExample)
JP (1) JP5780951B2 (enExample)
AU (1) AU2009240481B2 (enExample)
CA (3) CA2968164C (enExample)
CY (1) CY1116306T1 (enExample)
DK (1) DK2281078T3 (enExample)
ES (1) ES2528963T3 (enExample)
PT (1) PT2281078E (enExample)
WO (1) WO2009132287A2 (enExample)

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WO2009114815A1 (en) 2008-03-13 2009-09-17 Dyax Corp Libraries of genetic packages comprising novel hc cdr3 designs
PT2281078E (pt) 2008-04-24 2015-02-05 Dyax Corp Bibliotecas de pacotes genéticos compreendendo desenhos de novas cdr1, cdr2, e cdr3 de hc e novas cdr1, cr2, e cdr3 de lc
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US8999916B2 (en) 2010-03-31 2015-04-07 Agency For Science, Technology And Research Crosslinked peptide hydrogels
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US9120841B2 (en) * 2012-09-28 2015-09-01 Agency For Science, Technology And Research Amphiphilic linear peptidepeptoid and hydrogel comprising the same
EP2943512A4 (en) 2013-01-11 2016-06-01 California Inst Biomedical Res BOVINE FUSION ANTIBODY
DK3019533T3 (da) * 2013-07-11 2020-03-23 Scripps Research Inst Dobbeltspiraliserede immunoglobulinfusionproteiner og sammensætninger deraf
JP6687520B2 (ja) 2013-07-18 2020-04-22 トーラス バイオサイエンシズ リミテッド ライアビリティ カンパニー 極めて長い相補性決定領域を有するヒト化抗体
EP3293293A1 (en) * 2016-09-08 2018-03-14 Italfarmaco SpA Hc-cdr3-only libraries with reduced combinatorial redundancy and optimized loop length distribution
SG10201913147WA (en) 2017-07-11 2020-02-27 Compass Therapeutics Llc Agonist antibodies that bind human cd137 and uses thereof
US11718679B2 (en) 2017-10-31 2023-08-08 Compass Therapeutics Llc CD137 antibodies and PD-1 antagonists and uses thereof
WO2019099454A2 (en) * 2017-11-15 2019-05-23 Philippe Valadon Highly functional antibody libraries
EP3713961A2 (en) 2017-11-20 2020-09-30 Compass Therapeutics LLC Cd137 antibodies and tumor antigen-targeting antibodies and uses thereof
JP7497351B2 (ja) 2018-11-13 2024-06-10 コンパス セラピューティクス リミテッド ライアビリティ カンパニー チェックポイント分子に対する多重特異性結合性構築物およびその使用
CN113912675B (zh) * 2021-09-23 2023-04-11 中国药科大学 一种具有镇痛活性的蜈蚣多肽及其应用

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WO2009114815A1 (en) 2008-03-13 2009-09-17 Dyax Corp Libraries of genetic packages comprising novel hc cdr3 designs
PT2281078E (pt) 2008-04-24 2015-02-05 Dyax Corp Bibliotecas de pacotes genéticos compreendendo desenhos de novas cdr1, cdr2, e cdr3 de hc e novas cdr1, cr2, e cdr3 de lc

Also Published As

Publication number Publication date
EP2281078B1 (en) 2014-10-22
CY1116306T1 (el) 2017-02-08
CA2968164A1 (en) 2009-10-29
US20230340697A1 (en) 2023-10-26
US10683342B2 (en) 2020-06-16
DK2281078T3 (en) 2015-02-02
CA3049612A1 (en) 2009-10-29
JP2011518565A (ja) 2011-06-30
EP2281078A2 (en) 2011-02-09
US11598024B2 (en) 2023-03-07
ES2528963T3 (es) 2015-02-13
WO2009132287A3 (en) 2010-01-28
WO2009132287A2 (en) 2009-10-29
CA2722409C (en) 2017-12-12
CA2722409A1 (en) 2009-10-29
JP5780951B2 (ja) 2015-09-16
AU2009240481B2 (en) 2015-07-30
CA3049612C (en) 2023-01-10
AU2009240481A1 (en) 2009-10-29
EP2281078A4 (en) 2011-07-20
US20200347117A1 (en) 2020-11-05
CA2968164C (en) 2019-08-20
HK1151323A1 (en) 2012-01-27
US20110172125A1 (en) 2011-07-14
US20160355571A1 (en) 2016-12-08
US9388510B2 (en) 2016-07-12

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