AU2009240481B2 - Libraries of genetic packages comprising novel HC CDR1, CDR2, and CDR3 and novel LC CDR1, CDR2, and CDR3 designs - Google Patents

Libraries of genetic packages comprising novel HC CDR1, CDR2, and CDR3 and novel LC CDR1, CDR2, and CDR3 designs Download PDF

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Publication number
AU2009240481B2
AU2009240481B2 AU2009240481A AU2009240481A AU2009240481B2 AU 2009240481 B2 AU2009240481 B2 AU 2009240481B2 AU 2009240481 A AU2009240481 A AU 2009240481A AU 2009240481 A AU2009240481 A AU 2009240481A AU 2009240481 B2 AU2009240481 B2 AU 2009240481B2
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seq
cdr3
residue
ratio
library
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AU2009240481A1 (en
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Robert C. Ladner
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Takeda Pharmaceutical Co Ltd
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Takeda Pharmaceutical Co Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/005—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies constructed by phage libraries
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/02—Libraries contained in or displayed by microorganisms, e.g. bacteria or animal cells; Libraries contained in or displayed by vectors, e.g. plasmids; Libraries containing only microorganisms or vectors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/06—Libraries containing nucleotides or polynucleotides, or derivatives thereof
    • C40B40/08—Libraries containing RNA or DNA which encodes proteins, e.g. gene libraries

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
AU2009240481A 2008-04-24 2009-04-24 Libraries of genetic packages comprising novel HC CDR1, CDR2, and CDR3 and novel LC CDR1, CDR2, and CDR3 designs Active AU2009240481B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US4752908P 2008-04-24 2008-04-24
US61/047,529 2008-04-24
PCT/US2009/041688 WO2009132287A2 (en) 2008-04-24 2009-04-24 Libraries of genetic packages comprising novel hc cdr1, cdr2, and cdr3 and novel lc cdr1, cdr2, and cdr3 designs

Publications (2)

Publication Number Publication Date
AU2009240481A1 AU2009240481A1 (en) 2009-10-29
AU2009240481B2 true AU2009240481B2 (en) 2015-07-30

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AU2009240481A Active AU2009240481B2 (en) 2008-04-24 2009-04-24 Libraries of genetic packages comprising novel HC CDR1, CDR2, and CDR3 and novel LC CDR1, CDR2, and CDR3 designs

Country Status (10)

Country Link
US (4) US9388510B2 (enExample)
EP (1) EP2281078B1 (enExample)
JP (1) JP5780951B2 (enExample)
AU (1) AU2009240481B2 (enExample)
CA (3) CA2968164C (enExample)
CY (1) CY1116306T1 (enExample)
DK (1) DK2281078T3 (enExample)
ES (1) ES2528963T3 (enExample)
PT (1) PT2281078E (enExample)
WO (1) WO2009132287A2 (enExample)

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WO2009114815A1 (en) 2008-03-13 2009-09-17 Dyax Corp Libraries of genetic packages comprising novel hc cdr3 designs
PT2281078E (pt) 2008-04-24 2015-02-05 Dyax Corp Bibliotecas de pacotes genéticos compreendendo desenhos de novas cdr1, cdr2, e cdr3 de hc e novas cdr1, cr2, e cdr3 de lc
US9687591B2 (en) 2010-03-31 2017-06-27 Agency For Science, Technology And Research Building stratified biomimetic tissues and organs using crosslinked ultrashort peptide hydrogel membranes
US8999916B2 (en) 2010-03-31 2015-04-07 Agency For Science, Technology And Research Crosslinked peptide hydrogels
SG184345A1 (en) 2010-03-31 2012-11-29 Agency Science Tech & Res Amphiphilic linear peptide/peptoid and hydrogel comprising the same
MX381912B (es) * 2010-07-16 2025-03-13 Adimab Llc Colecciones de anticuerpos.
EP2802601B1 (en) * 2012-01-09 2019-11-13 The Scripps Research Institute Humanized antibodies with ultralong cdr3s
US20140050720A1 (en) 2012-01-09 2014-02-20 The Scripps Research Institute Ultralong complementarity determining regions and uses thereof
US9120841B2 (en) * 2012-09-28 2015-09-01 Agency For Science, Technology And Research Amphiphilic linear peptidepeptoid and hydrogel comprising the same
EP2943512A4 (en) 2013-01-11 2016-06-01 California Inst Biomedical Res BOVINE FUSION ANTIBODY
DK3019533T3 (da) * 2013-07-11 2020-03-23 Scripps Research Inst Dobbeltspiraliserede immunoglobulinfusionproteiner og sammensætninger deraf
JP6687520B2 (ja) 2013-07-18 2020-04-22 トーラス バイオサイエンシズ リミテッド ライアビリティ カンパニー 極めて長い相補性決定領域を有するヒト化抗体
EP3293293A1 (en) * 2016-09-08 2018-03-14 Italfarmaco SpA Hc-cdr3-only libraries with reduced combinatorial redundancy and optimized loop length distribution
SG10201913147WA (en) 2017-07-11 2020-02-27 Compass Therapeutics Llc Agonist antibodies that bind human cd137 and uses thereof
US11718679B2 (en) 2017-10-31 2023-08-08 Compass Therapeutics Llc CD137 antibodies and PD-1 antagonists and uses thereof
WO2019099454A2 (en) * 2017-11-15 2019-05-23 Philippe Valadon Highly functional antibody libraries
EP3713961A2 (en) 2017-11-20 2020-09-30 Compass Therapeutics LLC Cd137 antibodies and tumor antigen-targeting antibodies and uses thereof
JP7497351B2 (ja) 2018-11-13 2024-06-10 コンパス セラピューティクス リミテッド ライアビリティ カンパニー チェックポイント分子に対する多重特異性結合性構築物およびその使用
CN113912675B (zh) * 2021-09-23 2023-04-11 中国药科大学 一种具有镇痛活性的蜈蚣多肽及其应用

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Also Published As

Publication number Publication date
EP2281078B1 (en) 2014-10-22
CY1116306T1 (el) 2017-02-08
CA2968164A1 (en) 2009-10-29
US20230340697A1 (en) 2023-10-26
US10683342B2 (en) 2020-06-16
DK2281078T3 (en) 2015-02-02
CA3049612A1 (en) 2009-10-29
JP2011518565A (ja) 2011-06-30
EP2281078A2 (en) 2011-02-09
US11598024B2 (en) 2023-03-07
ES2528963T3 (es) 2015-02-13
WO2009132287A3 (en) 2010-01-28
WO2009132287A2 (en) 2009-10-29
CA2722409C (en) 2017-12-12
CA2722409A1 (en) 2009-10-29
JP5780951B2 (ja) 2015-09-16
PT2281078E (pt) 2015-02-05
CA3049612C (en) 2023-01-10
AU2009240481A1 (en) 2009-10-29
EP2281078A4 (en) 2011-07-20
US20200347117A1 (en) 2020-11-05
CA2968164C (en) 2019-08-20
HK1151323A1 (en) 2012-01-27
US20110172125A1 (en) 2011-07-14
US20160355571A1 (en) 2016-12-08
US9388510B2 (en) 2016-07-12

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